Gene NEK3 (Human)

NEK3

Species: Human
Alias: HSPK36, MGC29949, NEK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 13q14.3,

Classification

Group: Other
Family: NEK
Subfamily: NEK1

Sequence

Name Sequence Type Origin Length Description Download
NEK3.NA RNA Sugen Kinome 2255 None Fasta, JSON
NEK3.AA Protein Sugen Kinome 506 None Fasta, JSON
NEK3.kin_dom Protein Kinase Domain Sugen Kinome 254 None Fasta, JSON

Protein domain

Protein domains of NEK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK3.AA NEK1 4-257 60 2.6e-198 665.13 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-276/276
Sequence Identity: 60% (166 aa)

YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKS-FSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGH--LYIVMEYCDGGDLMQKIKQQ--KGKL
|.....|||||||.|.||.|....|....|||...|. ......|..|...||||||||||..|||||..|.  |||||||||||||||||..|  ||||
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLT--QNG---------------KVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN
|.||.|..||.|.||..||||....|||||||.|||||  .||               .|||||||.||.|...|..|||..|||||..|||..|.||||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIV
|||||||||.|||||||||||.||.||||.||.|||...|.|.|||||||.||.|||||||.||||....|.|...
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK3.AA NEK 4-257 44 2e-159 535.95 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-286/286
Sequence Identity: 44% (127 aa)

YMVLRMIGEGSFGRALLVQHESSNQM-----FAMKEIRLPK-SFSNTQNSR-KEAVLLAKMKHPNIVAFKESFEAEG--HLYIVMEYCD-GGDLMQK---
| ....||.||||.. .|.. | ...     ...|.| . . |  ..||.  .|. .|...||||||....||. |.  .|.||||||. ||||.||   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKQQK--GKLFPEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLTQNGK----VKLGDFGSARLLSNPMAFACT-YVGTPYYVPPEIWENLP
||.||  ||.|.|..|..||.||||.....|..     ..||||||..||||| |..    ||.|||| ...|.. . .|.| .||||||  ||...| |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNNKSDIWSLGCILYELCTL--KHPFQAN--SWKNLILKVCQG-CISPLPSH--YSYELQFLVKQMFKRNPSHRPSATTLLSRGIV
||||||||||||.|||.|||  ||||.|.  ....|..|...|   .|.|||  || .|| |. ||....|..|||.. .|.. ..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK3.AA NEK4 4-257 43 6.4e-101 341.58 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-257/257
Sequence Identity: 43% (113 aa)

YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLP-KSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGH--LYIVMEYCDGGDLMQKIKQQKGKLFP
|  .. .| ||.|   ||.|      . || . |   |   ..   .|| || ..|||||| .|||.| |    ||||| .|.|||| .| ||||... .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKH
|  ...|| |  ..   .|.|..|||| |  |||||.   .|.|||| .| | |   .| | .|||||  ||.. | ||. ||||||||| .||. ||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIV
 |.|     || .. ||   |.|  || .|| ||.|| .. |  |||   ..    .
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK3.AA NEK8 50-257 40 3.6e-96 275.07 In-house 50-278 (278) Show / Hide 
Range on Protein: 50-257
Range on HMM: 50-278/278
Sequence Identity: 40% (92 aa)

EAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPED-----------------MILNWFTQMCLGVNHIHKKRVLHRDIKSKN
| ..|..  ||||..  ..|. .. | |.|||.||| | |.|  |..||| |                  |||  |.|||..|.|.|.. .||||.|  |
EIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQN

IFLTQN-GKVKLGDFGSARLLSNP--MAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQG-CISPLPSHYSY
||.|   . ||.|||| .  ..    |. . | ||||||  ||. |  |||.|||.|.|||.|||.|.||  | |    .|..|  |.    |...||| 
IFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSN

ELQFLVKQMFKRNPSHRPSATTLLSRGIV
|.  || .  .  |  ||||  ....  .
EMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK3.AA S_TKc 4-257 31 1.5e-93 317.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDG--GDLMQKIKQQKG----K
| .|| ||.|.||.  ...| .... .|.|.|.        .. |.|  .| | .||||| ....|.  .|||.|||||||  |||.. ||....    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

LFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN-KSDIWSLGCILYELC
 ||| ..  .. |.|......|.....|||.|  ||.|..   .|..|||.||.|        |..|||.|..||.    .|.  |.|.||.||||||..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLS-------RGIV
. . ||.    . .. |..           | |.  .........|..||.|  .|           .
CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK3.AA Pkinase 4-255 28 8.4e-86 296.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNT-QNSRK--EAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGG----DLMQKIK-QQK
| ..| ||.||||.  . .| ......|.|.|....  |.  |. |.  |. ......||||| ....|| ..|.|.|||||.||    ||.  |. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKL-FPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKV----KLGDFGSARLL-SNPMAFACTYVGTPYYVPPEIWE-NLPYNNKSDIWSL
|.. |.|. . ....|.. |....|.....|||.|. ||.. .|| .    |..|||.|...   .   . |..|||.|..||.   . .|  |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYELCTLKHPFQAN----SWKNLILKVCQGCISPLPSHYS-----------------------YELQFLVKQMFKRNPSHRPSATTLLSR--G
||||||... . ||.      .  . . ..|.    ||.....                        |.. ..| .....|. ||.|. .|     
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK3.AA NEK2 4-257 33 1.4e-72 243.7 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-319/319
Sequence Identity: 33% (107 aa)

YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRK-----EAVLLAKMKHPNIVAFKESF--EAEGHLYIVMEYCDGGDLMQKIKQQKG
| ||  ||.|||||   | . |    .. |||       . |   .     |  .| . |||||| .      ...  |||||||| |||| | ||  . 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEIC----YGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRK

--KLFPEDMILNWFTQMCLGVNHIHK------------------KR---VLHRDIKSKNIFLTQNGK---------------------------------
  . ..|  |.  ..|.|.    .|.                  .    .||||||  |||| ...                                  
ERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPM

------VKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLV
      ||||||| || |     || |.||||||  ||  . ..|| ||||||.||..||.|.|. |||| . . |  |. ||  ...|. || .|. ..
DYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEII

KQMFKRNPSHRPSATTLLSRGIV
  | . ...||||   .|    .
HFMINVDHYHRPSIEEILQHPQI
Kinase NEK3.AA NEK-Unclassified 4-257 34 3.5e-70 231.46 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-258/258
Sequence Identity: 34% (91 aa)

YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGK--LFPE
|  .  .| |  |   || |  |     .. |   |     ||     ..|....|| || . .||     |.   .|||||.| ..|. . .|   | |
YDKITTLGQGGGGAVYLVRHQISKRHL-VQQISKRKKKKKRQN---KIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDE

DMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHP
  |  |. ||   |  || ....||| |  |||||.   | .|||| .| .      | | |||. .  ||. .  ||||.||.||||||.||.||    
GRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPF

FQANSWKNLILKVCQGCI------SPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIV
| . .   .  |. |.         |  . ||  || ... | .||.  |||||....   .
FDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK3.AA CAMK 9-253 19 5.5e-69 221.2 In-house 1-421 (425) Show / Hide 
Range on Protein: 9-253
Range on HMM: 1-421/425
Sequence Identity: 19% (82 aa)

MIGEGSFGRALLVQHESSN------------QMFAMKEIRLPKSFS---------------------------NTQNSRKEAVLLAK-------MKHPNI
 .|.||||   |..| ...            | .|.| |   |  .                           . .| |.|  .. |       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAFKESFE------------AEGH--------LYIVM---EYCDGG----DLMQKIKQQKG-------------KLFPEDMILNWFTQMCLGVNHIHKKR
. . | .|               .        .|.||   |||.||    || ..|.....             . |.|.    .| |.| .|...|.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VLHRDIKSKNIFLTQN-----------------GKVKLGDFGSARLLSN-----------------------PMAFACTYVGTPYYVP-PEIWEN-----
. |||.|  || |..|                 ...|. ||| |. .                         .     |..|||.|.. ||. .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------LPYNNKSDIWSLGCILYELCTLKHPFQAN-------------SWKNLILKVCQGCISPLPSHYSY-----------------------ELQ
          .|. |.|.||.|.||| . . . ||..              . ..|  |...|  .  |.. |                        | .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

FLVKQMFKRNPSHRPSATTLLS
 |...| ...|..|....  |.
DLIRKMLQVDPEKRMTIEQCLN
Kinase NEK3.AA Ciliate-E2 4-257 21 7.8e-69 234.99 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YMVLRMIGEGSFG-----RALLVQHES------------------SNQMFAMKEI--RLPKSFSNTQNSR----------KEAVLLAKMKHPNIVAFKES
| ....||.|.||     .  .||...                   ....||| .  .  ..... ..            .|  .| ...||||. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--AEGHLYIVMEYCDGGDLMQKIKQQKGKL---------FPEDMILNWFTQMCL---------------GVNHIHKKR-VLHRDIKSKNIFLTQNGKV
|.   . ..|.|||||.||||.. ||..| |          | |  |.. ..| .                .....|.|  ..|||||  ||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGSARLLSNP-----------MAFACT---------------------YVGTPYYVPPEIWENLP---------YNNKSDIWSLGCILYELCTLKH
|. ||| .. ....           .                          ..|||.|..||| .. .         |. |.||||||.||||... |.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFQANSWKNLILKVCQGCISPLP------------------SHYSYELQFLVKQ----MFKRNPSHRPS-ATTLLSRGIV
||         ..  . |   .|                   . | | . | |.    |....|. |.. .  .|   . 
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK3.AA NEK11 4-257 41 1.2e-67 231.04 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-259/259
Sequence Identity: 41% (107 aa)

YMVLRMIGEGSFGRALLV---QHESSNQMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GK
|..   .| ||||   ||   .      .  .|||       | |     || ||....|| || |  ||       |. |||.| || ..|.  |  ||
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

LFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCT
.|||  |. || |. |||  .| .|.||||.||||||| .|  .|.|||| .|||      | |  ||| |. ||      |  ||||||| |||||.| 
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCC

LKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIV
. | |   ..  ..|..  |    ||  |  ||  .. .|  .||| ||||  .|    .
MDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK3.AA Ciliate-E2-Unclassified 4-257 25 5.4e-64 218.91 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAV--------------------------LLAKMKHPNIVAFKESFEAEGHLYI
| ... ||.|.||   ..||.. .| .|||..   |. .. |.. ..                            .|  ..||.|| . . |. . ..||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYM--KKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYCDGGDLMQKIKQQKG---------------KLFPEDMIL-----NWFTQMCLGVNHIHKK-RVLHRDIKSKNIFLTQNG---KVKLGDFGSARLLS
|||||.||||.| ||..|.               | |.|  ..     ..| | ..| ...|.|  ..|||||  ||....||   ..|. |||... . 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

NP---------------MAFACTYVGTPYYV----PPEIWENLPYNNK----SDIWSLGCILYELCTLKHPFQANS----------------WKNLILKV
..                  ..| .|||.|     .||. ..  |...    .||||||.||||... ..||..|.                 |.|. . 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

CQG--CISPLPS-----HYSYELQFLVK----QMFKRNPSHRPSATTLLSRGIV
.|.  .... |      | | | . ...    .|.| ||. |...  .|   . 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NEK3.AA Pkinase_Tyr 49-198 26 2.6e-22 76.21 Pfam 52-210 (270) Show / Hide 
Range on Protein: 49-198
Range on HMM: 52-210/270
Sequence Identity: 26% (43 aa)

KEAVLLAKM-KHPNIVAFKESFE-AEGH--LYIVMEYCDGGDLMQKIKQQ--KGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVK
.|| .. .. .||||| .       ...  .||||||. .|||    ...   .. ..  ..|.. .| . | .. . |.  |||.  .|. .| |..||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LGDFGSARLLSNPMAFACTYVGT------PYYVPPEIWENLPYNNKSDIWSLGCILYELCTL
 .||| ||..  .     .....      . . .|| . .  .. |||.|| |  ..|..|.
ICDFGLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase NEK3.AA TyrKc 4-260 21 1.1e-21 79.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-260
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YMVLRMIGEGSFG---RALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKM--KHPNIVAFKESFEAE-------GHLYIVMEYCDGGDLMQKI
   ....||| ||   .. .       .. | | ..  .     .  ..|| .. |   .|||||..      .       . |.|||||...||| . .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNP--------MAFA-----CTYVGTPYYVPPEIWENLP
.  ..| .. .  |.. .| . | ...|.|.. |||.   |. .. |. || .||| .| . .         .  .     . ..      .|| .    
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YNNKSDIWSLGCILYELCTL-KHPFQA-----NSWKNLILKVCQGCISPLPSH--------YSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARL
.. |||.|| |  ..|..|. . |         |.. .| .| ||   | | .         . |.  . ||  ...|. ||. ...     . ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase NEK3.AA NEK8 4-20 41 0.110505 0.44 In-house 1-17 (278) Show / Hide 
Range on Protein: 4-20
Range on HMM: 1-17/278
Sequence Identity: 41% (7 aa)

YMVLRMIGEGSFGRALL
|   | .| |.|| . |
YERIRVVGRGAFGICWL
Kinase NEK3.AA Pkinase_Tyr 4-17 35 6.771875 0.27 Pfam 1-14 (270) Show / Hide 
Range on Protein: 4-17
Range on HMM: 1-14/270
Sequence Identity: 35% (5 aa)

YMVLRMIGEGSFGR
   ....|||.||.
ITFGKKLGEGAFGE