PDHK3

Species: Human
Alias: PDK3, PDHK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Xp22.11,

Classification

Group: Atypical
Family: PDHK
Subfamily: PDHK

Sequence

Name Sequence Type Origin Length Description Download
PDHK3.NA RNA Sugen Kinome 2162 None Fasta, JSON
PDHK3.AA Protein Sugen Kinome 415 None Fasta, JSON
PDHK3.kin_dom Protein Kinase Domain None 126 None Fasta, JSON

Protein domain

Protein domains of PDHK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BCDHK_Adom3 PDHK3.AA BCDHK_Adom3 25-189 39 2.9e-83 287.7 Pfam 1-199 (199) Show / Hide
Range on Protein: 25-189
Range on HMM: 1-199/199
Sequence Identity: 39% (80 aa)

SPLSIKQFLDFGRDNACEKT---SYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLE-Y---------------ENKSPED----
.|||..|...||| |.||||   |..|...|||.|||. .|| ..||..|.. |.. .|..|| ||| ||.| .               . |..||    
TPLSLRQMMQFGRPNPCEKTLFKSAQFCHEELPIRLAHRIRELQNLPYGLNKMPHIQQVYNWYYQSFEELRECFPKPISELKHLRYYEPPPKTLEDWLHD

-PQVLDNFLQVLIKVRNRHN-DVVPTMAQGVIEYK-EKFGFDPFIST----NIQYFLDRFYTNRISF---RMLINQHTLLFG-GDTNPVH---PKHIGSI
  .    | ..|.....||. .|||||||||.|.| ...| |....     .|||||||||..||.    ||||.||..||. . .|| |   |...|.|
YNEK---FCDMLRDIKDRHDRNVVPTMAQGVLEWKCRYYGQDNQPDDLHWFQIQYFLDRFYMSRIGINFIRMLIGQHIALFEFNYHNPHHFEHPDYVGII

DP
..
CT

Kinase PDHK3.AA PDHK 236-361 83 6.8e-103 348.13 In-house 1-125 (125) Show / Hide
Range on Protein: 236-361
Range on HMM: 1-125/125
Sequence Identity: 83% (105 aa)

YVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYA
||||||.|||||||||.||||||..|.|| .||..|..||||||||.||.||.|||||||||||||||||||||||..|..||||||||||||||.||||
YVPSHLYHMLFELFKNAMRATVEHHENRK-IYPPIKVMVTLGKEDLTIKMSDRGGGVPLRKIDRLFNYMYSTAPRPQMETSRAAPLAGFGYGLPICRLYA

RYFQGDLKLYSMEGVGTDAVIYLKAL
.|||||||||||||.|||||||||||
KYFQGDLKLYSMEGYGTDAVIYLKAL

Kinase PDHK3.AA PDHK 236-361 69 5.8e-98 331.76 In-house 1-140 (140) Show / Hide
Range on Protein: 236-361
Range on HMM: 1-140/140
Sequence Identity: 69% (97 aa)

YVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPR----PSL----------EPTRAAPL
|||.||.|||||||||.||||.|..|||...||..|..|.||.|||.||.||.|||||.||||||||||||||||    |..          |..||||.
YVPMHLYHMLFELFKNAMRATMEHHEDRPYNYPPIKVMVALGDEDLTIKMSDRGGGVPHRKIDRLFNYMYSTAPRSTQDPRMSPLFGHLDMHETSRAAPM

AGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKAL
.||||||||.||||.||||||.||||||.|||||||||||
HGFGYGLPICRLYAKYFQGDLQLYSMEGYGTDAVIYLKAL

Kinase PDHK3.AA HATPase_c 236-361 23 5.3e-19 68.37 Pfam 1-120 (120) Show / Hide
Range on Protein: 236-361
Range on HMM: 1-120/120
Sequence Identity: 23% (31 aa)

YVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPL------RKIDRLFNYMYSTAPRPSLEPTRAAPLAG--FGYG
 .| .| ... .|  |....| |         . ..  |.  .....| ..| | |.|        .|.|.|   |.| |       |     |  .|.|
GDPDRLHQVVWNLVDNAIKHTPEG--------GHITVRVHRDDDHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPD-----SR-RKYGGGLTGLG

LPISRLYARYFQGDLKLYSMEGVGTDAVIYLKAL
| |.| ... ..|.. . | .| ||  ...|.  
LYICRRIVEQHGGTIWVESEPGGGTTFTFTLPLE

Kinase PDHK3.AA HATPase_c 236-362 20 8.5e-12 46.44 SMART 1-130 (130) Show / Hide
Range on Protein: 236-362
Range on HMM: 1-130/130
Sequence Identity: 20% (30 aa)

YVPSHLFHMLFELFKNSMRATVELYED-------RKEGYPAVKTLVTLGKEDLSIKISDLGGGVPL------RKIDRLFNYMYSTAPRP--SLEPTRAAP
  | .| ..| .| .|. ..| | . |       . .|   |.          .| ..| | |.|        .|.|.|  .|.|.. |  . .. |.  
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH--------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRK

LAG--FGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALS
  |  .|.||.|.. ... ..|....       |  ...|.   
YGGGLTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER