Gene PIM1 (Human)

PIM1

Species: Human
Alias: PIM, PIM1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6p21.1-p21.31,

Classification

Group: CAMK
Family: PIM

Sequence

Name Sequence Type Origin Length Description Download
PIM1.NA RNA Sugen Kinome 2751 None Fasta, JSON
PIM1.AA Protein Sugen Kinome 404 None Fasta, JSON
PIM1.kin_dom Protein Kinase Domain Sugen Kinome 253 None Fasta, JSON

Protein domain

Protein domains of PIM1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PIM1.AA PIM 129-381 69 7.4e-209 700.15 In-house 1-260 (260) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-260/260
Sequence Identity: 69% (180 aa)

YQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG--FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT
|||||.||.||||.||.|.|..|| .|||||||||.|..|||.|..|..|||||..|.|.||.  ..|||||||||||||.|....|||.|.||||||||
YQVGPELGRGGFGTVYAGHRICDNQQPVAIKHVEKERVKDWGMLCDGQQVPMEVCMLWKCSSIGGHHGVIRLLDWFERPDGFMIVMERPYPCQDLFDFIT

ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYD
|.|.|.|...|.|||||...|.|||.|.||||||||||||||.|.||.||||||.||.|.|||||||||||||.||||||.||||||.|.|||||.||||
EQGPLNEDMCRFFFWQVWATVHHCHQCHVLHRDIKDENILIDMNTGEVKLIDFGAGAMLHDTVYTDFDGTRVYCPPEWIRHHRYHGREATVWSLGVLLYD

MVCGDIPFEHDEEIIR----GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
|||||||||.|.||.|    |...|||.||.||..||||||...||.|...|.|.|||||
MVCGDIPFENDQEICRAHLLGELHFRQHVSHECCQLIRWCLTFKPSHRCSLEQILNHPWM
Kinase PIM1.AA Pkinase 129-381 29 6.3e-94 323.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE-----LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP---VQDL
|..|  .|||.||.|| .......  ||.| ..|.....| .     |       .|. ..|.... .  ..||.||||..|.  ...|  |    |.||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------SEIQIMKRLNHPN--IVRLYDWFEDKDHIYMVMEYCEGGLYVMDL

FDFIT--ERGAL--QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA---LLKDTVYTDFDGTRVYSPPEWIRYHRY
||.|.  ..|..  .|. ......|.|... .||..|..|||.| |||||| |.|..    |..|||. .   . ... .|.| ||. | .||.|| ..|
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

HGRSAAVWSLGILLYDMVCGDIPFEHD---EEIIRGQVFFRQRVS-------------------------------SECQHLIRWCLALRPSDRPTFEEI
.|... .||.|..|| |.||  || ..   .. .. .. .... .                               .||...|.|||.. |..|||.|.|
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

QNHPWM
 .|||.
LQHPWF
Kinase PIM1.AA CAMK 134-381 21 2.5e-92 297.78 In-house 1-425 (425) Show / Hide 
Range on Protein: 134-381
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

LLGSGGFGSVYSGIRVSDN------------LPVAIKHVEKDRISD----------------------WGELPNGTRVPMEVVLLKKVSSG-----FSGV
 ||.|.|| |. .|. ...              |||| ..|....|                      | .  .  .|. |. ..||....        .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLLDWFE--------RPDS------------FVLIL---ERPEPV---QDLFDFITER---------------GALQEELARSFFWQVLEAVRHCHNCG
|.|....|        .. .            .....   |  .     .||||.|.|.               | ..|. || .|.|...||..||...
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VLHRDIKDENILIDLNR----------------GELKLIDFGSGALLKDTV-------------------------YTDFDGTRVYSP-PEWIRY-----
. |||.| ||||.| |                 . .|.||||  . ...                           ...| ||  | . ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------HRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------------------EEIIRGQVFFRQR----------------VSSE--------CQ
        ..|.|... .||.|..|| |.||  ||..|                   | |..|.  |                   .| |        |.
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

HLIRWCLALRPSDRPTFEEIQNHPWM
.|||..|   |..|.| |.. |||||
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PIM1.AA CAMKL 129-381 31 1.7e-74 237.13 In-house 1-297 (297) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-297/297
Sequence Identity: 31% (94 aa)

YQVGPLLGSGGFGSVYSGIR-VSDNLPVAIKHVEKDRIS--DWGE--------LPNGTRVPMEVVLLKKVSSG-FSGVIRLLDWFERPDS------FVLI
|..|. || |.|| |  ..     .  |||| ..|..|.  .| .        . .  |.  |. ..|....|    .|.|.. .| |.       ..|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LERPEPVQ-DLFDFITERGA----LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG-ELKLIDFGSGALLK------DTVYTDFDGTRVY
.|  .    ||||.| ..|     ..|. || .|.|...|| .||..|. ||||| ||||.| |    .|.|||| ... .      .   . | |.  |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

SPPEWIRY-HR-YHGRSAAVWSLGILLYDMVCGDIPFEHD------------EEIIRGQVFFRQ---RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
 .|| .   .. |.|. . .||.|..|| ||||  ||. |            ...|... ..     .|| .|..|||. |   |..||| ..| |||||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase PIM1.AA S_TKc 129-381 30 1.8e-72 247.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITER
|... ..|.|.||.|| .. ....  |||| .               ..  |. .|||   .   ...|.|.|.  |.. ...|  .  . ||||.| .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

GA------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGR-SAAVWSLG
|       . |  ||....|...|. .||. |..|||.| ||||.|    ..|..|||. ..|     | | ||. | .|| .     .|. .. .||.|
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

ILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN-------HPWM
..|| |.||  ||. ... .  ..      |.|. ..|| ||   |..|||  |. .       |||.
CILYEMLCGYPPFP-QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PIM1.AA PASK 129-381 32 7e-58 179.33 In-house 1-260 (260) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-260/260
Sequence Identity: 32% (84 aa)

YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD--WGELPNGTRVPMEVVLLKKVS-SGFSGVIRLLDWFERPDSFVLILERPEPV--QDLFDF
|     .|.| .| |.  |. .... | .| . | ..    | . .   ..|.|. .. ..       ....|| ||  | . |  |        |||||
YTSIQQMGEGAYGYVWMCIHNECRYIVVVKFIFKEKVCEDCWVRDRKCGCIPLEIHIMQTLNKNPHENIVKVLDFFENDDFYQLVMEKHGSGGCMDLFDF

ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGIL
|  .  . |.||   | ||  || . |  |..||||||||. || . .  ||||||| | ..    .  | ||  |  ||     .| |.   .|.||..
IDRHPNMDEHLASYIFRQVVAAVKYLHEQGIVHRDIKDENVIIDEH-FTIKLIDFGSAAYMERGKFFYTFCGTIEYCAPEVLMGNPYRGPEQEMWALGVT

LYDMVCGDIPFEHDEEIIRGQVFFR--QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
|| ..    ||   ||.. ... |   . || ||  ||   |   |  |.| ..| . ||.
LYTLMFKENPFCNIEETLEAEIHFPNAEHVSEECMSLIKSMLNRCPEKRCTMHQIITDPWL
Kinase PIM1.AA MARK 129-381 35 1.8e-55 179.83 In-house 1-262 (262) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-262/262
Sequence Identity: 35% (95 aa)

YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE--RPDS-FVLILERPEPVQDLFDFIT
| ..  .| |... |. .. .  .  |||| .|| ...|  .. |  |   |. ..||..  .  .|.|.. .|   .   ..||.|  .  ..|.|.| 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMR---EIEIMKKLD--HPNIIKLFHVIEQDTEQHQIYLIMEYAS-GGELYDYIK

ER--GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR-GELKLIDFGSGALL-KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGI
..  | |.||.|| .| |...||  ||. .. ||||| |||||| |.    |.|||| ..    ..  . | ||  | .|| . . .| |. . .||||.
AHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV

LLYDMVCGDIPFE--H--DEEI----IRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
.|| ||||  ||.     ..|.     ||.  .  .|| ||..||.. | . |..||| ||| .||||
VLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase PIM1.AA Ciliate-E2 129-381 19 5e-44 149.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-365/365
Sequence Identity: 19% (75 aa)

YQVGPLLGSGGFGSVYSG--IRV---------------------SDNLPVAIKHVEKDRISDWGELPNGT--------RVPMEVVLLKKVSSGFSGVIRL
| .  ..|.|.||||| .  ..|                      ..  .|.| ..|. |  .    .          .  .|  .|..... .  .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPN--IIKM

LDWFE--RPDSFVLILERPEPVQDLFDFITER-----------GALQEELARSFFWQVLE---------------AVRHCHNCG-VLHRDIKDENILIDL
 ..|.    ... |..|  .  .||||.| ..           . . |. .. ...|.|.               |....|. . ..||||| ||||.  
YECFQEKDDNNIYLVMEYCQ-GGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

NRGELKLIDFGSGA---------------------------------LLKDTVYTDFDGTRVYSPPEWIRY--------HRYHGRSAAVWSLGILLYDMV
    .|.||||                                     ... ..  . ||  | .|| ...        . ... .. .||||..|| |.
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

CGDIPFEHDEEIIRGQVFFR------------------QRVSSECQHLIRW----CLALRPSDRPT-FEEIQNHPWM
.|  ||   ..|. ... |.                  . .| ||..||.     .|   |. |.| .|.| ||||.
FGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PIM1.AA Ciliate-E2-Unclassified 129-381 22 4e-42 143.9 In-house 1-352 (352) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-352/352
Sequence Identity: 22% (79 aa)

YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV---VLLKK---------------VSSGFSGVIRLLDWFERPDSFVLI
| ..  .|.||||.||  .. ....  |.|   | .| .     |     |     .  ||               ...    .......|.  . . ..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LERPEPVQDLFDFITERGA-----------------LQEELAR-----SFFWQVLEAVRHCHNCG-VLHRDIKDENILIDLNRG--ELKLIDFGSGA---
.|  |  .||...|..|.                  ..|. |.      .|.|.|..  ..|  . ..||||| ||||.| | .  ..|.||||.     
MEYCE-GGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------LLKDTVYTDFDGTRVYS----PPEWIRYHRYHGR---SAAVWSLGILLYDMVCGDIPFE----------------------HDEEI
               .|.  ...| ||  |     .|| .. . | ..   .. .||||..|| |. |  ||.                        ..|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

IRGQVFFR--------QRVSSECQHLIR----WCLALRPSDRPTFEEIQNHPWM
. ....|.        ...| |....|.     .|  .|. |.|||.| ||||.
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase PIM1.AA MELK 129-381 33 1.3e-41 139.85 In-house 1-254 (254) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-254/254
Sequence Identity: 33% (89 aa)

YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG
|.|   .|.|||. |     .  |  |||| ..|... .  .||   ||  |.  ||...     . .|    |  | . ...|   |  ..||.| .. 
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGH--DLP---RVKTEMDALKNLR--HQHICQLYHYIETEDKIFMVMEYC-PGGEMFDYIIRQD

ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTD----FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLY
 |.|| .| || |.. |. . |  |  |||.| ||.|.| .  .|||||||  |  |  .         |   |  || |.  .| |  | |||.|||||
RLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDH-HLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLY

DMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
 ..|| .||. |        |..|     . .| | ..|.|  |   |  |    .. ||||.
VLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase PIM1.AA QIK 219-381 31 7.1e-41 142.12 In-house 84-272 (272) Show / Hide 
Range on Protein: 219-381
Range on HMM: 84-272/272
Sequence Identity: 31% (59 aa)

DLFDFITERGA--------------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-YTDFDGTRV
..|| ... |                     ..|. ||  |||.. || .||. .. |||.| ||||.| |  . |..||| . . |       . |.  
EMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNM-NIKIADFGFSNWFKQGQLLMTWCGSPP

YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
|  ||      | |  . .||.|..|| .||| .||  .        .. |..     .|..|.||||  | . |. | | . | .|.||
YAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase PIM1.AA TSSK 219-279 47 1.8e-24 77.22 In-house 103-168 (289) Show / Hide 
Range on Protein: 219-279
Range on HMM: 103-168/289
Sequence Identity: 47% (32 aa)

DLFDFITER------GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG
||...| .|      |||.||.|| .|.|  .||..||...| |||.| |||| | . . .||.|||
DLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKH-WNIKLTDFG
Kinase PIM1.AA TSSK 316-381 36 4.4e-17 52.58 In-house 212-289 (289) Show / Hide 
Range on Protein: 316-381
Range on HMM: 212-289/289
Sequence Identity: 36% (29 aa)

VWSLGILLYDMVCGDIPFEHD---------EEII-RGQVFFR---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
|||.|. || ||||  ||  |         ...  ..  | .   . .|.||..|||  |...|. ||. .||..|.||
VWSMGVILYIMVCGCMPFD-DDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase PIM1.AA TyrKc 129-381 21 2.3e-10 -54.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV--SSGFSGVIRLLDWFERP-------DSFVLILERPEPVQD
 . |  ||.| || || |.     ..||.| . .|                |  ...|.  .     ..||.     .       .   ...|  .   |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGH--HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GD

LFDFITERGA-LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKD------TVYTDFD---GTR--V---YSPPEW
| |.. ...  |. .   || ||. .  .. |  .. |||.   |.|.. |.   |  ||| | ..  |      . | .     |..  .     .|| 
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

IRYHRYHGRSAA--VWSLGILLYDMV-CGDIPFEHD-----------EEIIRGQVFFRQRV---------SSECQHLIRWCLALRPSDRPTFEEIQNHPW
|.|...   . .  ||| |.... .   |. | . .           | . .|    .            ..|   ....| .  |.|||||.||  |  
INYGKF---TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

M
.
F
Kinase PIM1.AA TSSK 129-158 23 0.00138 7.62 In-house 1-46 (289) Show / Hide 
Range on Protein: 129-158
Range on HMM: 1-46/289
Sequence Identity: 23% (11 aa)

YQVGPLLGSGGFGSVYSGIRVSDNLP----------------VAIK
|.||  .|.| .. ||..   ....                 ||||
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIK
Kinase PIM1.AA Pkinase_Tyr 129-158 38 0.001926 12.28 Pfam 1-34 (270) Show / Hide 
Range on Protein: 129-158
Range on HMM: 1-34/270
Sequence Identity: 38% (13 aa)

YQVGPLLGSGGFGSVYSGIRV----SDNLPVAIK
 . |  ||.| ||.|| |.      ....|||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase PIM1.AA Pkinase_Tyr 356-378 43 0.021668 8.72 Pfam 247-269 (270) Show / Hide 
Range on Protein: 356-378
Range on HMM: 247-269/270
Sequence Identity: 43% (10 aa)

HLIRWCLALRPSDRPTFEEIQNH
.|.. | .  |.|||||.||...
DLMKQCWHYDPEDRPTFSEIHEQ