Gene PKACa (Human)

PKACa

Species: Human
Alias: Hs.169269, Calpha, cPKA, MGC48865, MGC102831, PKACA, PRKACA, PKACa
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.13-p13.2,

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
PKACa.NA RNA Sugen Kinome 2689 None Fasta, JSON
PKACa.AA Protein Sugen Kinome 351 None Fasta, JSON
PKACa.kin_dom Protein Kinase Domain Sugen Kinome 255 None Fasta, JSON

Protein domain

Protein domains of PKACa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PKACa.AA PKA 44-298 69 4.6e-213 714.11 In-house 1-263 (263) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-263/263
Sequence Identity: 69% (184 aa)

FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV-KLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP
||.|.||||||||||||..||..||.||||.|.||..|.|||.||..|||.|||....||.| |....|.|...|||||||||||||||.||. ||||.|
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

HARFYAA-QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFF
||.|||| ||||..|||||...|||||||||.|||..|.|..|||||||.|..|||||||||||||||||.|| |..|.|||||||.|||||.||||||.
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFY

AD--QPIQIYEKIVSGKVRFPSHFSSDL---KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
..  .|.||||||..||..||.||.||.   |||...|||||||||.||.|||||||||||||
DHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PKACa.AA AGC 44-298 35 4.6e-196 512.75 In-house 1-395 (395) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-395/395
Sequence Identity: 35% (143 aa)

FERIKTLGTGSFGRVMLVKHK------ETGNHYAMKILDKQK-VVKLK--QIEHTLNE------------KRILQAVN----------FPFLVK-LEFSF
|| .|..|.||||.|.||..|       ||  ||||.|.|.. .|..|  ..|||..|            ..||. .|           ||.|| | .||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDNSN--LYMVMEYVP---------GG-EMFSHLR---RIGRFSEPHARFYAAQ-------IVLTFEYLHS-LDLIYRD-LKPENLLIDQQGYIQVTDFG
.|...  ||.||||.|         || |.|.||.   . |||.|..||||||.       ||| .||||| .. |.|| |||||.|.|..|.|  ||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKRVKG-----------------------------------------------------RTWTLCG--TPEYLAPEIILSKGYNKAVDWWA--LGVLIY
..|....                                                     ||||.||  ||||.||||.    |.||.|||.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMAAGYPPFFAD----------QPIQIYEKIV------SGKVRFP----------SHFSSDLKDLLRNLLQVDLTKRFGNLKN-----GVNDIKNHKWF
|| .|||||..|          .| ....||       . ||.||          ..||...|||.. ||..| .|| |...|     |...||||.||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKACa.AA Akt 44-298 50 8.8e-144 462.54 In-house 1-264 (264) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-264/264
Sequence Identity: 50% (132 aa)

FERIKTLGTGSFGRVMLVKHKETGNHY-AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP
|. .| || ||||.|.||| | |.. | |||.| |.. .. .|.|||. |..||| .|.||.|.| .|| .. .||.||.|..||| |.||.| .||||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

HARFYAAQIVLTFEYLHSLDLIYRD-LKPENLLIDQQGYIQVTDFGFAK-R-VKG--RTWTLCGTPEYLAPEIILSKGYNKAVDWWA-LGVLIYEMAAGY
 ||||.|.|.|  |.||| . |||| |||||.|.|..|.| .|||| .|   .|   .| |.|||||||||||.. .|. ||||||. ||...|||  | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFFADQPIQIYEKIVSGKVRFP--SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
|||....  | ..|| ...|.||  . .| . |||.. ||. | .|| |. .|....||.| ||
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKACa.AA SGK 44-298 43 2.2e-133 414.5 In-house 1-283 (283) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-283/283
Sequence Identity: 43% (124 aa)

FERIKTLGTGSFGRVMLVKHKET------------------GNHYAMKILDKQKVV-------KLKQIEHTLNEK-RILQAVNFPFLVKLEFSFKDNSNL
|. .|..| ||||.|..||||..                  .  ||||.| || ..       | |.  |.. |.  ||. .. ||.|.| ..|     |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPEIILSK
|.||.|| |||||.||.| ..|.|. ||||||.||.  |||||.| |||||||||.| | ||..  |||| .|     .  | | ||||||||||... .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
.. ..|||| || . |||  | |||.     | |..| ... ..|  .|.| .||.  ||| | .|| |  |..  .|||| .|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase PKACa.AA AktR 44-298 45 5.9e-131 441.36 In-house 1-268 (268) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-268/268
Sequence Identity: 45% (123 aa)

FERIKTLGTGSFGRVMLVKHK-ETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQ-AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE
|...| || | ||.|.||..| ...  ||||...|.| ....|..||..|. |..  .|.||.|||...|.....|. .|||.||||.|.||.....|||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PHARFYAAQIVLTFEYLHSL-DLIYRDLKPENLLIDQQGYIQVTDFGFAK----R-VKGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAA
  ||||.|||.| .||||.  . |||||||||.|.|. |..  |||| .|    .    .. ..||||||.|||.|.  ||.||.|||||.|..|||| .
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GYPPFFADQPIQIYEKIVSGK-VRFPSH--FSSDLKDLLR-NLLQVDLTKRFGNLKNGVNDIKNHKWF
|.|||....  |...|| .   ..|| .  ||| .|||.   ||. . .|| |  .||  .||.|.||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKACa.AA RSK 47-298 41 1.5e-111 376.89 In-house 1-278 (278) Show / Hide 
Range on Protein: 47-298
Range on HMM: 1-278/278
Sequence Identity: 41% (115 aa)

IKTLGTGSFGRVMLVKHK---ETGNHYAMKILDKQKVVKLKQ-IEHTLNEKRILQAVN-FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGR---
.| ||.|..| | |.. .    || .||||.|.| |.|. .  ..||. | .||....  ||.|.|  .|.... ||..|||..|||.| ||.. ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRV----KGRTWTLCGTPEYLAPEIIL----SKGYNKAVDWWALGV
|||  |.||.|.|||. |.||... |.||||||| | |.   .| | .|||||.|      ...| | |.| ||.|||..      .|..||.||| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMAAGYPPFFA---DQPIQIYEKIVSGK--VRFP--SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
|.||| .|.||| .   ... .| ..| .||  ...|  .  | . |||.| .|..|  || |  ......||.|.||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKACa.AA S_TKc 44-298 39 4.2e-109 369.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-231/231
Sequence Identity: 39% (106 aa)

FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPG--GEMFSHLRRIGR---
.| ....| |.||.|....||.|| ..|.||..          ||...| .||.  . |..|||  .| | ..|||||||..|  |..|..... ||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK-AVDWWALGVLIYEMAA
   |.| |||||..||..  ||.||.  |.|||||||.|.|.   | ..|||.|...     |.||||.|.|||..   ||.| ..|||..|...|||..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV--NDIKNHKWF
|||||   |. ....||.          |...||..|..||.| .|| .  .      |||.| ||
GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKACa.AA PKG 44-298 44 6e-108 364.93 In-house 1-260 (260) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-260/260
Sequence Identity: 44% (115 aa)

FERIKTLGTGSFGRVMLVKHKETG-NHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP
...| ||| | |||| ||. ..     .|.|.. |. .|. .|.||  .||.|..  . .| |.|   |.|.  .|| ||   |||. . ||  |.| ..
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
 .|||.| .|  |.|||.  .||||||||||. |..||.   ||||||...  ..||| |||||| |||||| ||   .||.||||.|..|   | ||| 
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFS

ADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
.  |...|  | .|  .. ||.. .   ... . |     | | |..|||.|||| ||||
GSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PKACa.AA Ciliate-E2b 44-298 36 1.8e-106 324.51 In-house 1-272 (272) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-272/272
Sequence Identity: 36% (103 aa)

FERIKTLGTGSFGRVMLVKH-KETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFS
.. || || | || | ||.  |.| . ||||   | ....     | |.|| .|. .|.||..|.  ||||. ..|..||.. |.|.|. .| ||   .|
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---G---RTWTLCGTPEYLAPEIIL-----SKGYNKAVDWWALGVLI
.  ..|| |.|.|..||||..  ||||.|||| ..|..||.   |.| ||  .   .   || |..|||.|.|||||       |||. .|| |..|.  
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

YEMAAGYPPFF--ADQPIQIYEKIVSG--KVRFPSHFSSDLK------DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
||.  ||.|.   .. |..||..|...  .. |||...  ..       .|    .|.| .... |       |.|.||
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWL-------KSHPWF
Kinase PKACa.AA p70 44-298 37 8.8e-98 331.15 In-house 1-299 (299) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-299/299
Sequence Identity: 37% (111 aa)

FERIKTLGTGSFGRVMLVKHKE---TGNHYAMKILDKQKVVK-LKQIEHTL-------------------------NEKRILQAVNFPFLVKLEFSFKDN
||..| || | .| |..|.      ||  |||| | | |.|   |  .||                           |  || .|. ||...| ..|..|
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRT-----------WTLCG
. || . || .||| | || | | . |  |.||.. |..  |.||... ||||||||| . .||| .  ||||  |    .|             .|.||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
|.|| ||||.. .|.|.|||||.||.|.| |  | ||| .. . .. .||  ||  .. |   . . .||.. ||  . |.| |   . . ||. |..|
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase PKACa.AA Ciliate-E2 44-298 26 3.7e-95 322.44 In-house 1-365 (365) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-365/365
Sequence Identity: 26% (103 aa)

FERIKTLGTGSFGRVMLVKHKETGNH-----------------------YAMKILDKQKVVKLKQIEHTL----------NEKRILQAVNFPFLVKLEFS
.. || .|.|.|| | ..|......                        |||||. |...  .||..| .          |||.||. .|.|...|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DNSNLYMVMEYVPGGEMFSHLR-------------------RIGRFSEPHAR-------FYAAQIVLTFEYLHSLD-LIYRDLKPENLLIDQQGYI
|.  |..|.|.||||. ||..|....                    |.....  ..       ||.|.|.| .|||||    |.||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

QVTDFGFAKRVKG----------------------------------RTWTLCGTPEYLAPEIILSKG---------YNKAVDWWALGVLIYEMAAGYPP
 ..|||..|...                                    ..|.||||.|.||||. .|.         |....|.|.|||..|||  |.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FFADQPIQIYEKIVSGKVRFP------------------SHFSSDLKDLLRN----LLQVDLTKRFGNLKNGVNDIKNHKWF
|        ...|  .|..||                   . | . |||...    .||.|  ||..    | ..|.||.||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PKACa.AA Pkinase 44-298 32 4e-92 317.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 44-298
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL-NEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGG----EMFSHLR--RI
.......| ||||.| . .|| ||  .|.||..|..  . |...|.. .| .|.. .| |. |.|  .| |....||||||..||    . |....  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI----QVTDFGFA----KRVKGRTWTLCGTPEYLAPEIIL-SKGYNKAVDWWAL
|.|  || ...||. ||.   ||.||   |.|||||||.|||..|.|     ..|||.|       .. ..|.||||.|.|||.|. ...| ..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLIYEMAAGYPPFFAD------QPIQIYEKIVSGKVRFPSHFS---------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
|...|||. |.|||  .       ..|....| .....|..  .                     ...||.....|..| .|| .       .|..|.||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase PKACa.AA TyrKc 44-289 21 8.1e-15 16.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 44-289
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV--NFPFLVKLEFSFKDN-------SNLYMVMEYVPGGEMFSHLR
 . .|.|| | ||.|.. . |      | | | . .      .|  ..| ||.  .  . | .|.|     .          |..||||.|.|   ..||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RIGR-FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR-------TWTLC----GTPE-----YLAPEIILSKGYN
. .. .. ..   .. ||    |||||  .| |||   | |.. .. . ..||| .. ..                  |.        .||| |  . ..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KAVDWWALGVLIYEMAA-GYPPFFA-----DQPIQIYEKIVSG-KVRFPSH--------FSSDLKDLLRNLLQVDLTKR--FGNLKNGV
 . | |. ||...|.   | .|          .....|.. .|   . | .         .... .. .   . |  .|  | ...   
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKACa.AA S_TK_X 299-351 24 1.2e-13 52.57 SMART 1-79 (79) Show / Hide 
Range on Protein: 299-351
Range on HMM: 1-79/79
Sequence Identity: 24% (19 aa)

ATTDWIAIYQ--RKVEAPFIPKFK----GPGDTSNFD-DYEEEEIRVSINEK-------------------CGKEFSEF
. .|| ..|.  ...|.||.|| |    .|.|||||| ...||... .  ..                   ..  .  |
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKACa.AA Pkinase_Tyr 44-254 26 3e-06 22.05 Pfam 1-232 (270) Show / Hide 
Range on Protein: 44-254
Range on HMM: 1-232/270
Sequence Identity: 26% (62 aa)

FERIKTLGTGSFGRVMLVKHK----ETGNHYAMKILDKQKVVKLKQ--IEHTLNEKRILQAV-NFPFLVKLE-FSFKDNSN--LYMVMEYVPGGEMFSHL
 . .|.|| |.||.|.. . |    .|. . | |.| |.     .|  .|  ..| .|.    . | .|.|     ..     .|.||||.|.| . ..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RR----IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-------KGRTWTLCGTPEYLAPEIILSKGYNKAVDW
|.     .... ..   ...||    |||.|  .| |||   | |.. .. . ..||| |. .       . |. .       .||| |  . .. . | 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDV

WALGVLIYEMAA-GYPP-FFADQPIQIYEKI-VSG
|. |||..|.   |  | .    . ..||.|  .|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG