Gene PKCd (Human)

PKCd

Species: Human
Alias: nPKC-delta, PKCd, PKCdelta, MGC49908, PRKCD, MAY1, PKCD
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3p13-p21.1,

Classification

Group: AGC
Family: PKC
Subfamily: PKCd

Sequence

Name Sequence Type Origin Length Description Download
PKCd.NA RNA Sugen Kinome 2738 None Fasta, JSON
PKCd.AA Protein Sugen Kinome 676 None Fasta, JSON
PKCd.kin_dom Protein Kinase Domain Sugen Kinome 255 None Fasta, JSON

Protein domain

Protein domains of PKCd.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD PKCd.AA C2_PKD 2-154 33 1.2e-80 274.22 In-house 1-183 (183) Show / Hide 
Range on Protein: 2-154
Range on HMM: 1-183/183
Sequence Identity: 33% (61 aa)

APFLRIAFNSYELGSL-------------QAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAA----EEPVSEV
..|.|....... ...             .|..||..|.|.|...|...........|||.|.||||...||.|.||||.||||.|..|    ...|.|.
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

TVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVD----CKQ-------SMRSEDEAKFPTMN-RRG-AIKQAKIH
|.......|.||.|.|....|..|.||.||......| ||.|    |..       .|..|.....|..| ||| |...||||
TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C1_1 PKCd.AA C1_1 159-211 38 8.2e-18 69.04 Pfam 1-55 (55) Show / Hide 
Range on Protein: 159-211
Range on HMM: 1-55/55
Sequence Identity: 38% (21 aa)

HEFIAT-FFGQPTFCSVCKDFVWG-LNKQGYKCRQCNAAIHKKCIDKIIGRCTGT
| .... .| |||||..|..|.|| | .||.||..|.  .|..|  |    | . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCd.AA C1 159-208 33 7.1e-16 59.98 SMART 1-61 (61) Show / Hide 
Range on Protein: 159-208
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HEFIATFFGQPTFCSVCKDFVWGLNKQ-----GYKCRQCNAAIHKKCIDKIIG-------RC
| .... | .||.|..|....||. ||     ||.|. |. ..|||| ||.          |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCd.AA C1_3 170-201 25 7.3e-07 18.96 Pfam 1-30 (30) Show / Hide 
Range on Protein: 170-201
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCI
 .|..|.  . .    .|.| ||.  .|..|.
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1_1 PKCd.AA C1_1 231-283 49 2.8e-26 98.44 Pfam 1-55 (55) Show / Hide 
Range on Protein: 231-283
Range on HMM: 1-55/55
Sequence Identity: 49% (27 aa)

HRFKVH-NYMSPTFCDHCGSLLWG-LVKQGLKCEDCGMNVHHKCREKVANLCGIN
|....| |. .||||.|||...|| | .||.||..|..|.||.| .||...|| |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCd.AA C1 231-280 30 2.4e-20 74.81 SMART 1-61 (61) Show / Hide 
Range on Protein: 231-280
Range on HMM: 1-61/61
Sequence Identity: 30% (19 aa)

HRFKVHNYMSPTFCDHCGSLLWGLVKQ-----GLKCEDCGMNVHHKCREKVAN-------LC
|... ... .||.|.||....||. ||     |..|..|....|.|| .||..        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCd.AA PKC 349-603 67 1.2e-204 669.54 In-house 1-262 (262) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-262/262
Sequence Identity: 67% (177 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELY
| |.|||||||||||.|.|.||. ||.|||.|||||.. ||||||||.||||| ||...|||||| |.|||.|.||||||..||||||.|||. .||...
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPF
.|.||||||.|.|||||.||||||||||||||||..||||||||||||||.......||||||||||||||||. .|..|||||.||||.|||..|||||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

HGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGV-------TGNIKIHPFF
||.||||||.||. |.||||||..||...|........|.||||.       ...|. ||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCd.AA Delta 349-603 77 2.8e-188 631.79 In-house 1-259 (259) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-259/259
Sequence Identity: 77% (201 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELY
|.|||||||||||||.|.||||. .|.|||.|||||||.||||||||||.|||.||.|.|||.||.||||||.|||||||.|||||||||||...||...
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPF
||.|||.||.|||||||.||||||||||||||||.|||||||||||||||..||..|||||||||||||||..| ||..||||||||||.||||||||||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

HGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGV----TGNIKIHPFF
||.||||||.||..|.|.||||||||.||.|.|||||.|.|||||    .|.|..|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKCd.AA AGC 349-603 34 3.2e-183 478.78 In-house 1-395 (395) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-395/395
Sequence Identity: 34% (136 aa)

FIFHKVLGKGSFGKVLLGELK------GRGEYFAIKALKKDV-VLIDD--DVECTMVE------------KRVLTLAAE---------NPFLTH-LICTF
| |.||.|||||||| | . |      . |.|.|.| |||.. ..|..  .||.||.|            ...|...           .||... | ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKDH--LFFVME----FLN-----GG-DLMYHIQ---DKGRFELYRATFYAAE-------IMCGLQFLHS-KGIIYRD-LKLDNVLLDRDGHIKIADFG
|.|||  |.||||    ..|     || .|..|.|   ..|||.  || |||||       | ..|..||| .|||.|| ||..|.|||.|||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKENIFGE--------------------------------------------------SRASTFCG--TPDYIAPEILQGLKYTFSVDWWS--FGVLLY
.|||.. ..                                                   |..||||  ||.|.|||||    |....||||  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLIGQSPFHGD----------DEDELFESIR------VDTPHYP----------RWITKESKDILEKLFEREPTKRLGVTGN---------IKIHPFF
|||.|..||.||          ...|.|..|.       . ...|          ||...| ||...||....|.||||  ||         || ||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCd.AA Alpha 349-603 61 4.4e-148 498.26 In-house 1-259 (259) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-259/259
Sequence Identity: 61% (160 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELY
| | .||||||||||.|.| ||  | .||| |||||.  |||||||||||||| |    |||. .  .||| | |.||||. ||||||||||  |.|   
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPF
 | ||||||  || |||.|||||||||||||.||..||||||||||||||.....   |||||||||||||     |  |||||.||||||||. || ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

HGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTG----NIKIHPFF
 |.||||||..|   .. ||. . ||..||   .  ..| |||| ..    .|. ||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCd.AA Eta 349-603 61 6.6e-142 477.74 In-house 1-261 (261) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-261/261
Sequence Identity: 61% (160 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELY
| | |||||||||||.| |.||..| .||| |||||.. |||||||| |||.|.||.. |||| | |.||||| ||||||. ||||||..||   .|.  
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPF
|| |||||..| |.||| .|.|||||||||.|||..|| |.|||||||| |  .   .||||||||||||||| ..|  ||||| .|||.|||. ||.||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

HGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTG------NIKIHPFF
  | ||.|||||  |   || |. ||   ||   . . |.|||| .       .|. ||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCd.AA Akt 349-603 47 1.1e-126 406.98 In-house 1-264 (264) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-264/264
Sequence Identity: 47% (126 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYF-AIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFEL
| | |||||||||||.| . |  .... |.|.||||. .  . || |. |...|     .||.. |   |||.|.|.|||.. |||.| ||.| |.||  
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

YRATFYAAEIMCGLQFLHSKGIIYRD-LKLDNVLLDRDGHIKIADFGMCKEN-IFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWS-FGVLLYEMLIG
 || ||.|||......||||.||||| ||. |.|.|.||||...|||.|||| |    .. |||||| |.|||||.|  .| .||||. .|...|||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QSPFHGDDEDELFESIRVDTPHYP--RWITKESKDILEKLFEREPTKRLGVTGN----IKIHPFF
. ||. .| ...|. |      .|  .|| .| ||....| .. |.|||| . |    || ||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCd.AA PKN 349-603 51 7.50000000001e-110 371.25 In-house 1-260 (260) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-260/260
Sequence Identity: 51% (134 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLA--AENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFE
| .  |||.| |||||| ..|. |||.|||||||  ..  |.||  |.|||..  .  .  |||  |.  |||..| .||||.. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHED-VFS

LYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQS
  || |||| .. |||.|| . ||||||||||.|||..|..||||||.|||..    | |||||||...|||.|    ||  ||||  |||.||||.| .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTG----NIKIHPFF
|| ||||.|.|..|  |   |||..  |. .|. .|  . | .||| .     .||..|||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCd.AA SGK 349-603 38 2.3e-108 335.85 In-house 1-283 (283) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-283/283
Sequence Identity: 38% (109 aa)

FIFHKVLGKGSFGKVLLGELKGR------------------GEYFAIKALKKDVVL-------IDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHL
|.| ||.||||||||.. . |.                   .  .|.| |.|. ..           .  .| |. |.      ||.  |   ||||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGL
.|||...|||.. ||.|  ..|   || |||||| | |  |||. ||||||| .|.||| .||... ||| |||.|  .   .|||||| | |||.|.. 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

KYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVT---GNIKIHPFF
 .  .||||. | .||||..|  ||   .  .... |.      |. .. . .|... | ...|.||||     . || ||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase PKCd.AA S_TKc 349-603 35 1.1e-98 335.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNG--GDLMYHIQDKGR--
. .....|||.|||| ..  |. |...||| .|          | .. | ..|      |.. .|. .||. |||..|||...|  |||. .|...||  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTF-SVDWWSFGVLLY
    |   .| ||...| |.|...||.|||.|||| .|.|||.  ||||.|||....        .||||||.|.|||.|   .|.. ..||||.|..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIK------IHPFF
||| |. ||.  .....|. |.          ..| ||...|.....|.||...    .      .||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCd.AA RSK 352-603 37 4.8e-98 332.04 In-house 1-278 (278) Show / Hide 
Range on Protein: 352-603
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

HKVLGKGSFGKVLLGELK---GRGEYFAIKALKKDVVLIDD-DVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR---
.||||.|..||| |   .     | ..| | ||| ..   . |.. || | ..| .    ||. .|  .|||...|. .||...||.| .|.| ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDR---DGHIKIADFGMCKENIFG-ESRASTFCGTPDYIAPEILQ---GLK-YTFSVDWWSFGV
|   .| ||.||| . ...||..|||.||||..|.|.|    .||||. ||| ||..    .... |||.| .|.|||.|    . . .. ..||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMLIGQSPFHG---DDEDELFESIRVDT--PHYPRW--ITKESKDILEKLFEREPTKRLGV----TGNIKIHPFF
|.|||| |..||.|   .. .|... |.  .  .  |.|  ...| ||.. |...|.| ||||     .  || ||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKCd.AA AktR 349-603 39 7.6e-97 328.04 In-house 1-268 (268) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-268/268
Sequence Identity: 39% (105 aa)

FIFHKVLGKGSFGKVLLGELK-GRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFEL
| ..|.|||| |||| | . |   ....|.| .||         . |  |. ..   . .||.  |  .||||..|||.||.  ||.| .|.. |..|. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

YRATFYAAEIMCGLQFLHSK-GIIYRDLKLDNVLLDRDGHIKIADFGMCK-ENIF-GESRASTFCGTPDYIAPEILQG-LKYTFSVDWWSFGVLLYEMLI
 .| ||.|.|  .|..||..  ||||||| .| ||| |||.||.|||. | ...   . .| .||||| |.|||...    ...|||||.||...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQSPFHGDDEDELFESIRVDT---PHYPRWITKESKDILE-KLFEREPTKRLG-V---TGNIKIHPFF
|. ||  ..  ..|..|.  .   . ||  .... ||... ||. . |.||||     .  || ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKCd.AA Pkinase 349-603 32 1.3e-83 288.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 349-603
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTM-VEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGG----DLMYHIQ--D
. .....|.||||.| ..  || |. .|.| .||.    . |.. .   | ...      |.   |...|..|||. .|||...||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KGRF--ELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHI----KIADFGMCKE--NIFGESRASTFCGTPDYIAPEILQ-GLKYTFSVDWW
.|.|  .   . ||. .| .||...||.|||.||||..|.|.|..|||    ||.||| .|   .  ..  ..||||||.|.|||... | .|. .||.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVLLYEMLIGQSPFHGD------DEDELFESIRVDTPHYPRWIT---------------------KESKDILEKLFEREPTKRLGVTGNIKIHPFF
|.|..||||| |. || |.      |...... |.   .|.... .                     .| ||........ |.||..    |. ||.|
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-AEQILQHPWF
Kinase PKCd.AA S_TK_X 604-667 37 3.9e-28 100.72 SMART 1-79 (79) Show / Hide 
Range on Protein: 604-667
Range on HMM: 1-79/79
Sequence Identity: 37% (30 aa)

KTINWTLLEK--RRLEPPFRPKVK----SPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSA---------FAGFSFVN
. |.|  |..  ...||||.||.|    ||.| ||||.|| .|...|.  |..|..||.|..         |.||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCd.AA Pkinase_C 623-669 46 1.3e-18 68.75 Pfam 1-46 (46) Show / Hide 
Range on Protein: 623-669
Range on HMM: 1-46/46
Sequence Identity: 46% (22 aa)

KVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPK
.||||.| |||| || .|.......|.. . |.||..| ||..|||.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCd.AA TyrKc 349-610 24 1.7e-16 44.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 349-610
Range on HMM: 1-280/280
Sequence Identity: 24% (75 aa)

FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHL------------ICTFQTK-----DHLFFVMEFLN
  . |.|| | ||.| .|..|   .  |.| ||.|                .  .  |   ...|            .|| |       . |. |||.  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP

GGDLMYHIQDKGR-FELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKEN----IFGESRASTFC----GTPD-----YIAP
.|||  ....... . .     ..  | || ..||||..| |||   |.|.......||.|||....       |||          |. .       ||
HGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EILQGLKYTFSVDWWSFGVLLYEML-IGQSPFHG-----DDEDELFESIRVD----TPHY--PRW----ITKESKDILEKLFEREPTKRLGVTGNIKIHP
| ..  |.|.  | |||||...|..  ||.|  |      . .|..| ..       |..  |       ..|  .| ..  ...| .|          |
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDR----------P

FFKTINWTL
 |..|   .
TFSEIHECF
Kinase PKCd.AA Pkinase_Tyr 422-496 29 2.1e-09 32.48 Pfam 81-159 (270) Show / Hide 
Range on Protein: 422-496
Range on HMM: 81-159/270
Sequence Identity: 29% (23 aa)

HLFFVMEFLNGGDLMYHIQD----KGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCK
... |||.  .|||  . ..    |... . .   ....| .|...|.||..| |||   |.|.......||.|||...
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCd.AA Pkinase_Tyr 516-548 42 3e-05 18.41 Pfam 182-216 (270) Show / Hide 
Range on Protein: 516-548
Range on HMM: 182-216/270
Sequence Identity: 42% (15 aa)

APEILQGLKYTFSVDWWSFGVLLYEMLI-GQSP-F
||| ..  |.|   | ||||||..|..  |..| .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY
Kinase PKCd.AA Pkinase_Tyr 349-383 35 4.7e-05 17.75 Pfam 1-39 (270) Show / Hide 
Range on Protein: 349-383
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

FIFHKVLGKGSFGKVLLGELK----GRGEYFAIKALKKD
 .| |.||.|.||.| .|..|    . .   |.| || .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG