Gene PKCe (Human)

PKCe

Species: Human
Alias: Hs.395751, PKCe, PRKCE, PKCepsilon, nPKC-epsilon, PKCE, MGC125657, MGC125656
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2p21,

Classification

Group: AGC
Family: PKC
Subfamily: PKCh

Sequence

Name Sequence Type Origin Length Description Download
PKCe.NA RNA Sugen Kinome 5537 None Fasta, JSON
PKCe.AA Protein Sugen Kinome 737 None Fasta, JSON
PKCe.kin_dom Protein Kinase Domain Sugen Kinome 261 None Fasta, JSON

Protein domain

Protein domains of PKCe.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD PKCe.AA C2_PKD 5-165 27 2.4e-38 131.73 In-house 1-183 (183) Show / Hide 
Range on Protein: 5-165
Range on HMM: 1-183/183
Sequence Identity: 27% (51 aa)

NGLLKIKICEAVSLKPTAWSLRHAV--GPRPQTFLLDPYIALNVDDSR----IGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANC
 | .....|.|  |||..   .| .  | .    . ||| ...||..     |||| .| || .| |  .|...| .|| |.....|.| .. ...||.|
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

TIQFEELLQ-----NGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDN----------EERVFRERMRPRK-RQG-AVR-RRVH
|. .|.. .     .|. |.  ||.||| |.| |.|..  .......            . ..| .  . .  |.| | | ...|
TMKLEDCIEMCKTNSGITHI--WINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C2 PKCe.AA C2 7-114 16 2.4e-14 54.88 SMART 1-92 (92) Show / Hide 
Range on Protein: 7-114
Range on HMM: 1-92/92
Sequence Identity: 16% (21 aa)

LLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTN---SPAWHD---EFVTDVCNGRKIELAVFHDAPIGYDDFVANCTI
.|...| ||  |.                   |||. .        .| ....|.   .| |..   .|. || . . ... |...      ||.  |.|
TLTVHIIEARNLP-------------------DPYVKVY-------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH------DFIGHCCI

Q--------------FEELLQNGSRHFE
               ....| .. .  .
PPNNPHWHQWDGCIHLSDIL-GYRH-WW
C2 PKCe.AA C2 8-99 21 8.4e-13 46.12 Pfam 1-90 (90) Show / Hide 
Range on Protein: 8-99
Range on HMM: 1-90/90
Sequence Identity: 21% (21 aa)

LKIKICEAVSLKPTAWSLRHAVGPRPQTF-LLDPYIALNVDDSRI----GQTATKQKTNSPAWHDEFVTD--VCNGRK-IELAVFHDAPIGYDDFVANCT
|.....||  |.|. |          . . . |||  . ... ..     .| ....| .| |. .|. |  . .. . ... |...  .| |||.  |.
LRVHVIEARNLPPMDW----------DKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC
C1_1 PKCe.AA C1_1 170-223 38 4.9e-21 80.87 Pfam 1-55 (55) Show / Hide 
Range on Protein: 170-223
Range on HMM: 1-55/55
Sequence Identity: 38% (21 aa)

HKFMAT-YLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGL
|.....  ..|||.|.||..|.|| .|.||..||.|  ..|.|||..  ..| . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCe.AA C1 170-220 33 2.4e-15 58.25 SMART 1-61 (61) Show / Hide 
Range on Protein: 170-220
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HKFMATYLRQPTYCSHCRDFIWGVIG----KQGYQCQVCTCVVHKRCHELIIT-------KC
|.....   .||||.|||..|||.      .|||.|..|  ..||.||. .          |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PKCe.AA C1_1 243-295 47 1.1e-23 89.79 Pfam 1-55 (55) Show / Hide 
Range on Protein: 243-295
Range on HMM: 1-55/55
Sequence Identity: 47% (26 aa)

HKFGIH-NYKVPTFCDHCGSLLWG-LLRQGLQCKVCKMNVHRRCETNVAPNCGVD
|..  | |.| ||||.|||...|| | .||..| .|..|.| || ..|.|.|| .
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCe.AA C1 243-292 27 4.3e-19 70.67 SMART 1-61 (61) Show / Hide 
Range on Protein: 243-292
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HKFGIHNYKVPTFCDHCGSLLWGLLRQ-----GLQCKVCKMNVHRRCETNVAP-------NC
|.. ....  ||.|.||....||. .|     |..| .||...| .| ..|..       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCe.AA PKC 408-668 75 1.6e-222 728.4 In-house 1-262 (262) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-262/262
Sequence Identity: 75% (197 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEP
|||.|||||||||||||||.||.||.||.||||||||.|||||.|||||||.||||.|||.||.|.|||||.|||||||||||||||||.||..|.|.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPF
. ||||||...||.|||..|.|||||||||.|||.|||.|.||||||||...||.||.|||||||||||||||. |||.||||||.|||||||||||.||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

EADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQ-NGEDAIKQHPFF
....||.||.||.||...||.|||||||||.|.||||||.|||||  .| .||..|..||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCe.AA Eta 408-668 90 6.6e-221 740.17 In-house 1-261 (261) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-261/261
Sequence Identity: 90% (237 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEP
|||||||||||||||||||.||.|||||.||||||||.|||||.|||||||||.||||||.||||.|||||||||||||||||||||||||||.||||||
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPF
|.||||||||.|||||||||||||||||||||||.||||||||||||||||.||.|||||||||||||||||||.||||||||||.||||||||.|||||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

EADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFF
|||||||||||||||||||||||.|||||||||||||||||||||...|.||.||.|||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCe.AA AGC 408-668 34 7.1e-198 517.55 In-house 1-395 (395) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-395/395
Sequence Identity: 34% (138 aa)

FNFIKVLGKGSFGKVMLAELK------GKDEVYAVKVLKKDV-ILQDD--DVDCTMTE------------KRILALARK---------HPYLTQ-LYCCF
|.|.||.||||||||.|.. |      . ...||.|||||.. |....  .|..||||            ..||.....         ||.... |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKDR--LFFVME----YVN-----GG-DLMFQIQ---RSRKFDEPRSRFYAAE-------VTSALMFLHQ-HGVIYRD-LKLDNILLDAEGHCKLADFG
|.||.  |.||||    |||     || .|....|   ....|||.|.||||||       ...|| .||. .|.|.|| ||..|||||..||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGILNG--------------------------------------------------VTTTTFCG--TPDYIAPEILQELEYGPSVDWWA--LGVLMY
.||||. .|                                                  ..|.||||  ||.|.|||||    ||...|||.  ||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMAGQPPFEADN----------EDDLFESIL------HDDVLYP----------VWLSKEAVSILKAFMTKNPHKRLGCVASQN---GEDAIKQHPFF
||..|.||| .||          ....|..|.      ...| .|          .|.|.||....| ...|.| |||||  . .   | . ||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCe.AA Alpha 408-668 66 4.3e-174 584.64 In-house 1-259 (259) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-259/259
Sequence Identity: 66% (174 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEP
|||..|||||||||||||| || || ||.|.|||||| |||||.|||.|||.|||  | |.|.|.  |||| |||.||||||||||||..||.  || ||
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPF
   |||||.  .| |||. |.|||||||||..|||||| |.||||||||.. ...|| |||||||||||||     || |||||| |||.||||||||||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

EADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFF
. . ||.||..|    | ||  .|||||.| |.|.||.| |||||   ..||  |..||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGC--GPDGEQDIREHPFF
Kinase PKCe.AA Delta 408-668 61 1.3e-149 503.3 In-house 1-259 (259) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-259/259
Sequence Identity: 61% (160 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEP
|.| |||||||||||||||||||.. ||.| |||||.|.||||.||| |.|.|||| .||.|..|.| ||||. |||||||.||||||. || ...||| 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPF
|.||||.|. ..| |||..|.|||||||||.||| .|| |.|||||||| ..   .. |||||||||||||..   |  |||||. |||||||. || ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

EADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFF
. ..||.||.||..|   ||.|..||| ..||. . ..|.||||   . .|.  |.||.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGD--IRQHCFF
Kinase PKCe.AA Akt 408-668 47 4.4e-137 440.79 In-house 1-264 (264) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-264/264
Sequence Identity: 47% (128 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVY-AVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE
|.|.|||||||||||.|.. |  ...| | ||||||.|.| . |  |.||..||   . ||....|.  |||.|.|.|||.|.|||.| . .|| |.|.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

PRSRFYAAEVTSALMFLHQHGVIYRD-LKLDNILLDAEGHCKLADFGMCKEG-ILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWA-LGVLMYEMMAG
.| |||.||. .|. .||....|||| ||. |||.|..|| .|.|||.|||. | .. .|.|||||| |.|||||.   .. .||||. ||..||||| |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QPPFEADNEDDLFESILHDDVLYP--VWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFF
.||| ... . .|. |.  .| .|   |.|.|. ....   .|.|.||||  .  |. . ||.||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLG--GGPNDAQEIKRHPWF
Kinase PKCe.AA SGK 408-668 43 4.4e-131 407.23 In-house 1-283 (283) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-283/283
Sequence Identity: 43% (124 aa)

FNFIKVLGKGSFGKVMLAELKGK------------------DEVYAVKVLKKDVIL-------QDDDVDCTMTEK-RILALARKHPYLTQLYCCFQTKDR
| |.||.||||||||.... |..                  | .||.|||.|. |.       .   .  .|.|.  || .  ||| . .|   ||||. 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNM-KHPFIVNLHYAFQTKWK

LFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQE
|.|||.|||||.. . .|| ..| |.|.||||||. .||  ||   .|||||| .|||||..|||.| ||| |||||    ||.|||||| | |||.|. 
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

LEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFF
 ... .|||| || ..|||| | |||.  |   ... |.. .   |   | .| ....   .|.| ||||   . ..   ||.||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG---TKRDFMEIKNHPFF
Kinase PKCe.AA Iota 408-668 54 1.6e-125 420.21 In-house 1-271 (271) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-271/271
Sequence Identity: 54% (148 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEP
|. |.|.|.||. ||...|.|  . .||.||.||... .|.|.|   ||| .   |  ||.|  |  ||||. |||||.|.|||||||| .|| ||  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

RSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPF
  |||.||.  || |||..|.|||||||||.|||.||| || |.||||||| .| || |||||| |||||||   .|| |||||||||||.|||||  ||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

---------EADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQ-NGEDAIKQHPFF
         .   || ||  ||   .  |  ||  | ..||.|. |.|. ||||     .|   ||.||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCe.AA PKN 408-668 51 1.1e-113 384.02 In-house 1-260 (260) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-260/260
Sequence Identity: 51% (135 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALAR--KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFD
| .| |||.| ||||.|...|. .|.||.|.|||  |.  |.|.  |.||||.. .   .||.| .|. ||||..  .|||||. ||||| .|     |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDV-FS

EPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQP
|||..|||| |   | .||.| .|||||||||.|||.||. |.||||.||||.  |  | ||||||...|||.| .  |   |||| ||||.|||. | .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFF
||  |.|...|..|. ||| || .|| ||..|..  . ||| .|||  |..   . || .|||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLG--AGERDAEDIKMQPFF
Kinase PKCe.AA S_TKc 408-668 35 1.4e-105 357.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNG--GDLMFQIQRSRK--
. .....|||.||||...  |. ....|.|..|          . .. | .||    .||.. .|| .||. |.|..||||..|  |||.  |.. ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP-SVDWWALGVLMY
    |.| . |||.... .|| ..|.||.|.|||| .|||||   | |..|||....        |||||||.|.|||.|    ||. ..|||..|...|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFF
||..|.|||.  ... .|. |.          |.|| ....  ..|.| ||...    ..| .||.||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCe.AA AktR 408-668 41 4.7e-104 351.99 In-house 1-268 (268) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-268/268
Sequence Identity: 41% (113 aa)

FNFIKVLGKGSFGKVMLAELK-GKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE
| ..|.|||| ||||.|.. |   ...|| |..||  | .    . | ||. |..   .|| . .|. |||||. |||.|||. ||.| . .....||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PRSRFYAAEVTSALMFLHQH-GVIYRDLKLDNILLDAEGHCKLADFGMCK-EGIL-NGVTTTTFCGTPDYIAPEILQE-LEYGPSVDWWALGVLMYEMMA
 ..|||.|..  || .||||  .|||||| .||||| .|| |..|||. | ...  .  ....||||| |.|||....   .. ||||||.|.. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQPPFEADNEDDLFESILHDD---VLYPVWLSKEAVSILK-AFMTKNPHKRLGCVASQNGEDAIKQHPFF
|.|||...|  ..|..|.  .   . ||. .|... ....   . ||| ||||   . || . || ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGY--YCNGWEEIKSHPWF
Kinase PKCe.AA Pkinase 408-668 31 5.8e-86 296.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 408-668
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTM-TEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGG----DLMFQIQ--R
. .....|.||||.| ..  ||  ...|||..||. .  . |.  .  .| .|..   .||.  .||..|..||.. .||||..||    ||.  |.  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SRKF--DEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHC----KLADFGMCKEG-ILNGVTTTTFCGTPDYIAPEILQ-ELEYGPSVDWWA
...|  .|   .||. .. ..| ..|..|.|.||||..|||.| .||.    |..||| .|   . |.. .|||||||.|.|||...   .|||.||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLMYEMMAGQPPFEAD------NEDDLFESILHDDVLYPVWLS---------------------KEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQH
.|...|||. |.|||  .      ... ... |.. .. .. . .                     .|. ...|   .|.|.||..        . |.||
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-------AEQILQH

PFF
|.|
PWF
Kinase PKCe.AA S_TK_X 669-732 37 2.9e-28 101.16 SMART 1-79 (79) Show / Hide 
Range on Protein: 669-732
Range on HMM: 1-79/79
Sequence Identity: 37% (30 aa)

KEIDWVLLEQ--KKIKPPFKPRIK----TKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEE---------FKGFSYFG
..|||  |..  |.|.|||||.||      .|..|||..||.|.|.|| .|........|.|         | ||.|. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCe.AA TyrKc 408-662 21 8.7e-17 48.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 408-662
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALA-RKHPYLTQLY-CCFQTK------DRLFFVMEYVNGGDLMFQIQ
  ..|.|| | ||.|.....|   .  |||.||.|       .   | | ||.     .|| . .|| .| | .      . |. ||||. .|||   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RSRK-FDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILN-------GVTTTTFCGTPD------YIAPEILQELEYG
..|. .  .    ..  . .   .||....| |||   |.|.......| .|||.....           . ...  .  .        ||| ... .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PSVDWWALGVLMYEMMA-GQPPFEA-----DNEDDLFESILHDDVLYPVWL---------SKEAVSILKAFMTKNPHKRLGCVASQNGEDAI
.  | |. ||.|.|..  ||.| .       . ....| . . . . .            ..|  .| |     .|..|    .     . .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase PKCe.AA Pkinase_Tyr 408-555 24 1.5e-15 53.33 Pfam 1-159 (270) Show / Hide 
Range on Protein: 408-555
Range on HMM: 1-159/270
Sequence Identity: 24% (40 aa)

FNFIKVLGKGSFGKVMLAELK----GKDEVYAVKVLKKDVILQD---DDVDCTMTEKRILALARKHPYLTQLYCCFQ-TKDR--LFFVMEYVNGGDLMFQ
  |.|.||.|.||.|.....|    ...   |||.|| .   ..   .|    | | .|.    .|| . .|| .    ..   .. ||||. .|||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF---MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IQR----SRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCK
 ..     .... ..   ..... ... .|.... | |||   |.|.. ....| .|||...
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCe.AA Pkinase_C 688-734 38 1.1e-14 54.94 Pfam 1-46 (46) Show / Hide 
Range on Protein: 688-734
Range on HMM: 1-46/46
Sequence Identity: 38% (18 aa)

RIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGED
..| ..|. ||| .||.| |..| .|.    ...||.| ||.|  .|
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCe.AA Pkinase_Tyr 575-608 33 0.051382 7.45 Pfam 182-217 (270) Show / Hide 
Range on Protein: 575-608
Range on HMM: 182-217/270
Sequence Identity: 33% (12 aa)

APEILQELEYGPSVDWWALGVLMYEMMA-GQPP-FE
||| ... ..    | |. ||||.|..  |. | ..
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYP