Gene PKCt (Human)

PKCt

Species: Human
Alias: PKC-theta, PKCt, MGC141919, Hs.89615, MGC126514, Hs.PRKCQ, nPKC-theta, PRKCQ, PRKCT
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 10p14-p15,

Classification

Group: AGC
Family: PKC
Subfamily: PKCd

Sequence

Name Sequence Type Origin Length Description Download
PKCt.NA RNA Sugen Kinome 3290 None Fasta, JSON
PKCt.AA Protein Sugen Kinome 706 None Fasta, JSON
PKCt.kin_dom Protein Kinase Domain Sugen Kinome 255 None Fasta, JSON

Protein domain

Protein domains of PKCt.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD PKCt.AA C2_PKD 2-155 28 1.9e-42 146.13 In-house 1-183 (183) Show / Hide 
Range on Protein: 2-155
Range on HMM: 1-183/183
Sequence Identity: 28% (52 aa)

SPFLRIGLSNFDCGSCQSC------------QGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKN----VDLISET
..|.|. |   | ..  .              .||  |||.| |.| .|.. .    |||.|.|| |...||.|.  ||. ||..  .      . ..|.
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

TVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSD----TKD--------MNEFETEGFFALHQRRG-AIKQAKVH
|. |  ..|.| .|.|.|.||..|.|||. ... ..| |  |     ..        |.    ... ..  ||| |...||.|
TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C1_1 PKCt.AA C1_1 160-212 40 5.2e-19 73.45 Pfam 1-55 (55) Show / Hide 
Range on Protein: 160-212
Range on HMM: 1-55/55
Sequence Identity: 40% (22 aa)

HEFTAT-FFPQPTFCSVCHEFVWG-LNKQGYQCRQCNAAIHKKCIDKVIAKCTGS
| . .. .|.|||||..| ||.|| | .||..|..|.  .|..|  || ..| ..
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCt.AA C1 160-209 35 1.8e-17 65.32 SMART 1-61 (61) Show / Hide 
Range on Protein: 160-209
Range on HMM: 1-61/61
Sequence Identity: 35% (22 aa)

HEFTATFFPQPTFCSVCHEFVWGLNKQ-----GYQCRQCNAAIHKKCIDKVIA-------KC
| . .. | .||.|..|....||. ||     ||.|. |. ..|||| ||| .        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCt.AA C1_3 171-202 25 9.6e-05 13.57 Pfam 1-30 (30) Show / Hide 
Range on Protein: 171-202
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCI
 .|..| . . .    .| | ||.  .|..|.
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1_1 PKCt.AA C1_1 232-284 50 2.3e-25 95.37 Pfam 1-55 (55) Show / Hide 
Range on Protein: 232-284
Range on HMM: 1-55/55
Sequence Identity: 50% (28 aa)

HRFKVY-NYKSPTFCEHCGTLLWG-LARQGLKCDACGMNVHHRCQTKVANLCGIN
|....  |.|.||||.||| ..|| |..||.||..|..|.||||..||...|| |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCt.AA C1 232-281 27 1.2e-19 72.57 SMART 1-61 (61) Show / Hide 
Range on Protein: 232-281
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HRFKVYNYKSPTFCEHCGTLLWGLARQ-----GLKCDACGMNVHHRCQTKVAN-------LC
|... ... .||.|.||. ..||...|     |..| .|....|..|..||..        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCt.AA C1_3 243-274 21 1.008168 3.34 Pfam 1-30 (30) Show / Hide 
Range on Protein: 243-274
Range on HMM: 1-30/30
Sequence Identity: 21% (7 aa)

TFCEHCGTLLWGLARQGLKCDACGMNVHHRCQ
 .|. ||. . .  . . .|  |  ..| .| 
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
Kinase PKCt.AA PKC 380-634 66 2e-203 665.44 In-house 1-262 (262) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-262/262
Sequence Identity: 66% (175 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLS
| ..|.|||||||||.||| |.|....|||.|||||...||||||||.|||||.|||.||||||..|.|||...|||||||.||||||.|||....|...
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPF
.|.|||||||..|||||.|||.||||||||.|||..|||||||||||||||.....|.|||||||||||||| .|.|..|||||.||||.|||..|||||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

HGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV-------RGDIRQHPLF
||.||.|||.||..|||.|||||.|||.... ... ..||||||.       ..|||.||.|
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCt.AA Delta 380-634 78 6.7e-189 633.85 In-house 1-259 (259) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-259/259
Sequence Identity: 78% (203 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLS
|..||.|||||||||.|||.|..|...|||.|||||||.||||||||||.|||.||||||||.|.||||||||.||||||||||||||||||.||.||..
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPF
||.|||.|||.||||||.|||.||||||||.|||.||||||||||||||||.|..|..|||||||||||||. ||||||||||||||||.||||||||||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

HGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV----RGDIRQHPLF
||.||.|||.||..|.|.||||..|||||.|.|||.|.|||||||    .||||||..|
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKCt.AA AGC 380-634 32 8.49999999999e-185 482.95 In-house 1-395 (395) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-395/395
Sequence Identity: 32% (131 aa)

FILHKMLGKGSFGKVFLAEFK------KTNQFFAIKALKKDV-VLMDD--DVECTMVE------------KRVLSLAWE---------HPFLTH-MFCTF
| ..|..||||||||.|.. |       |....|.| |||.. .....  .||.||.|            ...|...           |||... ....|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKEN--LFFVMEYLN---------GG-DLMYHIQ---SCHKFDLSRATFYAAE-------IILGLQFLHS-KGIVYRD-LKLDNILLDKDGHIKIADFG
|.|..  |.|||||..         || .|..|.|    . .|| .|| |||||       |.|.|..||| .||..|| ||..|||||.|||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKENMLGD--------------------------------------------------AKTNTFCG--TPDYIAPEILLGQKYNHSVDWWS--FGVLLY
.|||.| ..                                                  ..|.||||  ||.|.|||||    |....||||  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLIGQSPFHGQ----------DEEELFHSIR------MDNPFYP----------RWLEKEAKDLLVKLFVREPEKRLGVRGD---------IRQHPLF
|||.|..||.|.          ...|.|..|.      .... .|          ||. .|||||. ||....|||||| .|.         |..|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCt.AA Alpha 380-634 62 3.3e-145 488.71 In-house 1-259 (259) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-259/259
Sequence Identity: 62% (162 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLS
|   . ||||||||| ||| | |.  .||| |||||.  |||||||||||||| |    |||. |  .|||   |.||||| ||||||||||   ||  .
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPF
 | ||||||  || |||.|||.||||||||..|| .||||||||||||||| .|. | ||||||||||||| . | |  |||||.||||||||. || ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

HGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV----RGDIRQHPLF
 | ||.||| .|   |. ||. . |||.|.   . ...| ||||     . |||.|| |
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCt.AA Eta 380-634 60 1.7e-139 469.75 In-house 1-261 (261) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-261/261
Sequence Identity: 60% (158 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLS
|   |.||||||||| ||| | |.. .||| |||||.. |||||||| |||.|||| .||||| ..|.||||. ||||||| ||||||..||   ||| .
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPF
|| |||||... |.||| .|..||||||||||||..|| |.|||||||| .. .  | ||||||||||||||  ..|  ||||| .|||.|||. ||.||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

HGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRG------DIRQHPLF
  . |..|| ||  |.  || ||.|||  .|   . . |.||||         .||||| |
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCt.AA Akt 380-634 47 1.2e-130 419.84 In-house 1-264 (264) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-264/264
Sequence Identity: 47% (126 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFF-AIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDL
| . |.|||||||||||.. |.|.... |.|.||||. .. . || |. |...|     |||.. .   |||...|.|||.| |||.| ||.| . .|. 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

SRATFYAAEIILGLQFLHSKGIVYRD-LKLDNILLDKDGHIKIADFGMCKEN-MLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWS-FGVLLYEMLIG
.|| ||.|||||....||||.|.||| ||. |||.||||||...|||.|||| .  . ||.|||||| |.|||||.|. .  .||||. .|...|||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QSPFHGQDEEELFHSIRMDNPFYP--RWLEKEAKDLLVKLFVREPEKRLG-VRG---DIRQHPLF
. ||. || ...|. | . .  .|  .|. .|.|||. .|  . |.||||   .   .|..|| |
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCt.AA SGK 380-634 38 2.5e-111 345.16 In-house 1-283 (283) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-283/283
Sequence Identity: 38% (109 aa)

FILHKMLGKGSFGKVFLAEFKKT------------------NQFFAIKALKKDVVL-------MDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENL
|.. | .||||||||.... |..                   .|.|.| |.|. ..           .  .| |. |.     |||.      ||||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ
.|||.|.|||.. ||.|   .|  .|| ||||||.. |  |||. |.||||| .||||| .||... ||| |||..    .| |||||| | |||.|..|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

KYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVR---GDIRQHPLF
 .  .||||. | .||||..|  ||  .. ....  |.      |.    .|.||.  |  ..|.|||| .   ..|..|| |
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase PKCt.AA PKN 380-634 50 6.8e-109 368.07 In-house 1-260 (260) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-260/260
Sequence Identity: 50% (132 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLA--WEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFD
| .  .||.| |||| |...|.|....|||||||  ..  |.||  |.|||..  .    ||||  .|  |||.|  .|||||. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

LSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQS
  || |||| ..||||.|| . |.||||||||.|||..|..||||||.|||.|    .| ||||||...|||.|  . |   ||||  |||.||||.| .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLF
|| | ||||.| .|  |.  |||.|  || ... .|  . ||.|||       ||. .| |
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCt.AA AktR 380-634 41 7.69999999999e-107 361.25 In-house 1-268 (268) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-268/268
Sequence Identity: 41% (111 aa)

FILHKMLGKGSFGKVFLAEFK-KTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDL
| ..|.|||| ||||.|.. | ......|.| .||         . |  |. ..     |||.  .. .|||||.|||.|||  ||.| .|.....||. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SRATFYAAEIILGLQFLHSK-GIVYRDLKLDNILLDKDGHIKIADFGMCK-ENML-GDAKTNTFCGTPDYIAPEILLG-QKYNHSVDWWSFGVLLYEMLI
..| ||.|.|.|.|..||..  |.||||| .|||||.|||.||.|||. | ..|   | |...||||| |.|||...  . .| |||||.||...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQSPFHGQDEEELFHSIRMDN---PFYPRWLEKEAKDLLV-KLFVREPEKRLG-V---RGDIRQHPLF
|. ||  .. ...|..|.  .   . ||  . ...|||.  ||. . |.||||       .|. || |
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKCt.AA S_TKc 380-634 35 6.4e-101 342.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNG--GDLMYHIQSCHK--
. ... .|||.||||...  |||.. .||| .|          | .. | ..|.    ||.. ... .||. ..|..||||..|  |||. .|... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNH-SVDWWSFGVLLY
    |.  .| ||...|...|...||.||..|||| .|||||.  ||||.|||....        .||||||.|.|||.|   .|.. ..||||.|..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIR------QHPLF
||| |. ||.  .....|. |.           .||||.. |.....||||...    .      .|| |
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCt.AA RSK 383-634 40 6.7e-101 341.51 In-house 1-278 (278) Show / Hide 
Range on Protein: 383-634
Range on HMM: 1-278/278
Sequence Identity: 40% (113 aa)

HKMLGKGSFGKVFLAEFK---KTNQFFAIKALKKDVVLMDD-DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK---
.|.||.|..|||||  ..   .|.| .| | ||| ..   . |.. || | ..|..   |||. . . .|||.. |. .|||..||.| .|.|       
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDK---DGHIKIADFGMCKENMLG-DAKTNTFCGTPDYIAPEILL---GQK-YNHSVDWWSFGV
|. ..| ||.|||.| ...||..||..||||..|||.|    .||||. ||| ||.. .    .|.|||.| .|.|||.|    .|. .....||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMLIGQSPFHG---QDEEELFHSIRMDN--PFYPRW--LEKEAKDLLVKLFVREPEKRLGV----RGDIRQHPLF
|.|||| |..||.|   .. .|..  |.  .  .  |.|  | .|||||. |.. |.|.||||       .|.||| |
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKCt.AA Pkinase 380-634 31 5.8e-84 290.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTM-VEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGG----DLMYHIQ--S
. ... .|.||||.|...  |.|.. .|.| .||.   .. |.. .   | ...     ||.   ....|..| .. .||||..||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

CHKF--DLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHI----KIADFGMCKEN-MLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDWWS
  .|  .   . ||. .|. ||...||.||..||||..|||.|..|||    ||.||| .|      .  ..||||||.|.|||... ||.| ..||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGVLLYEMLIGQSPFHGQ------DEEELFHSIRMDNPFYPRWLE---------------------KEAKDLLVKLFVREPEKRLGVRGDIRQHPLF
.|..||||| |. || |.      |. ...  |..  . .... .                     .|.||.. ... . |.||..   .| ||| |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-AEQILQHPWF
Kinase PKCt.AA S_TK_X 635-698 44 1.2e-29 105.77 SMART 1-79 (79) Show / Hide 
Range on Protein: 635-698
Range on HMM: 1-79/79
Sequence Identity: 44% (35 aa)

REINWEELER--KEIDPPFRPKVK----SPFDCSNFDKEFLNEKPRLSFADRALINSMDQNM---------FRNFSFMN
|.|.|. |..  ||| |||.||.|    ||.| ||||.|| .|.|.|. .|..|.|||.||.         ||.|....
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCt.AA Pkinase_C 654-700 46 2.6e-17 64.11 Pfam 1-46 (46) Show / Hide 
Range on Protein: 654-700
Range on HMM: 1-46/46
Sequence Identity: 46% (22 aa)

KVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPG
.|||| | ||||.|| .|.|.... |.  . |.||. ||.|.. || 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCt.AA TyrKc 380-628 25 1.9e-16 43.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 380-628
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW-EHPFLTHMF--CTFQTK-----ENLFFVMEYLNGGDLMYHIQ
  | |.|| | ||.|.... |   .  |.| ||.|       .|  | | |...    .|| .  ..  || |       | |. ||||  .|||  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SCHK-FDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLG-------DAKTNTFCGTPD------YIAPEILLGQKYN
.... . ..    ..  |  | ..||||... |||   |.|.......||.|||....   .       | .. .  .  .        ||| .   |..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

HSVDWWSFGVLLYEML-IGQSPFHG-----QDEEELFHSI----RMDNPFY--PRW----LEKEAKDLLVKLFVREPEKRLG---VRGDI
.  | |||||...|..  ||.|  |      . .|... .    ||. | .  |        .|  ..  .   ..||.|     .. ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKCt.AA Pkinase_Tyr 451-527 27 3.5e-10 35.11 Pfam 77-159 (270) Show / Hide 
Range on Protein: 451-527
Range on HMM: 77-159/270
Sequence Identity: 27% (23 aa)

KEN--LFFVMEYLNGGDLMYHIQSC----HKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK
.|   .. ||||  .|||  . ..     .......   ....|  |...|.||... |||   |.|.......||.|||...
GEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCt.AA Pkinase_Tyr 547-592 36 7e-06 20.46 Pfam 182-230 (270) Show / Hide 
Range on Protein: 547-592
Range on HMM: 182-230/270
Sequence Identity: 36% (18 aa)

APEILLGQKYNHSVDWWSFGVLLYEMLI-GQSP-FHGQDEEELFHSI-R
||| .   |...  | ||||||..|..  |..| . | . ||... | .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE
Kinase PKCt.AA Pkinase_Tyr 380-414 33 0.000301 15.01 Pfam 1-39 (270) Show / Hide 
Range on Protein: 380-414
Range on HMM: 1-39/270
Sequence Identity: 33% (13 aa)

FILHKMLGKGSFGKVFLAEFK----KTNQFFAIKALKKD
 .. |.||.|.||.|.... |    .|..  |.| || .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG