Gene PKN3 (Human)

PKN3

Species: Human
Alias: PKN3, PKNBETA, pknbeta, RP11-545E17.1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9q34.13,

Classification

Group: AGC
Family: PKN

Sequence

Name Sequence Type Origin Length Description Download
PKN3.NA RNA Sugen Kinome 3385 None Fasta, JSON
PKN3.AA Protein Sugen Kinome 889 None Fasta, JSON
PKN3.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of PKN3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HR1 PKN3.AA HR1 18-85 34 8.7e-21 77.67 Pfam 1-74 (74) Show / Hide 
Range on Protein: 18-85
Range on HMM: 1-74/74
Sequence Identity: 34% (26 aa)

DEKEVIRRAIQKELKIKEGVENLRRV---ATDRRH----LGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGP
. .. .|. |..|.||||| ||.||.   .||..     . ..|| ||.||...|.|. .|..|..|    .|. 
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN3.AA HR1 105-177 34 5.8e-21 78.3 Pfam 1-74 (74) Show / Hide 
Range on Protein: 105-177
Range on HMM: 1-74/74
Sequence Identity: 34% (26 aa)

RHLEALRRQLHVELKVKQGAENMTHTC--ASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPE
. |..||.....|.|.|.||||| . .  ... .| ||.....|||||.|. |...|||..  |... ..  .|.
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN3.AA HR1 178-250 27 1.7e-19 73.09 Pfam 1-74 (74) Show / Hide 
Range on Protein: 178-250
Range on HMM: 1-74/74
Sequence Identity: 27% (21 aa)

LLAEELQHRLHVEAAVAEGAKNVVKLL---SSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLR
.  ..|......| .. |||.|.....   . .. . ||.....|..|.||.||...|| .||.| ..... || .
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKH-RKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
C2_PKD PKN3.AA C2_PKD 354-438 16 0.000104 13.1 In-house 67-174 (183) Show / Hide 
Range on Protein: 354-438
Range on HMM: 67-174/183
Sequence Identity: 16% (18 aa)

WDQTFVIPLERARELEIGVHWRDW---RQLCGVAFLRLEDFLD-----NACHQLSLSLVPQGLLFAQVTFCDPVIERRPRL---------------QRQE
|...|.  ....|...| .  ..    .  .. .  .|||        ..   . . | ||| ...|.    .. .... .               .|| 
WNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAECTMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQR

RIFSKRRG
. |  |||
PGFNRRRG
Kinase PKN3.AA PKN 559-818 75 4.2e-197 661.09 In-house 1-260 (260) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-260/260
Sequence Identity: 75% (197 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPE
|||.|||||||||||||.|.|.||.||||||||||....|||.|||.|||||.|.|....||||..|.|||||..|.|||.|...||||||.||||||.|
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDVFSE

PQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECP
|.|.||.||||||||.|||.|||||||||||||||..|..|||||||||||.|.||||||||||||||||||||...|||||||||||||.|||||||||
PRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGECP

FPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFF
||||.||||||||||.|..|| ||||........||.|.||.||||||.|||.||.||||
FPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKN3.AA AGC 559-818 33 8.99999999999e-170 443.21 In-house 1-395 (395) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-395/395
Sequence Identity: 33% (132 aa)

FRCLAVLGRGHFGKVLLVQFK------GTGKYYAIKALKKQE-VLSRD--EIESLYCE------------KRILEAVGCTG-------HPFLLS-LLACF
|. | |.|.|.|||| ||. |      .||||||.| |||.. .. ..  ..|  . |            ..||| .  |.       |||. . |  .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTSSH--ACFVTEFVP---------GG-DLMMQIHED----VFPEPQARFYVAC-------VVLGLQFLHE-KKIIYRD-LKLDNLLLDAQGFLKIADFG
|. .|   .|| |..|         || .|.......    .|.|..|||| |.       .||.|..||. ..||.|| ||..|.|||..| .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGIGFG--------------------------------------------------DRTSTFCG--TPEFLAPEVLTQEAYTRAVDWWG--LGVLLY
|||||.. |                                                  |||.||||  |||..|||.|    |..|.|||.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGECPFPGDT----------EEEVFDCIV------NMDAPYP----------GFLSVQGLEFIQKLLQKCPEKRLGAGEQD-----AEEIKVQPFF
|||.|  || ||.          ..|.|. |       | . ..|           ..|..   .|.|||.| ||||||.|..|     |||||  |.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKN3.AA PKC 559-818 50 6.9e-134 436.44 In-house 1-262 (262) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-262/262
Sequence Identity: 50% (133 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHED-VFP
|. | |||.| ||||.|.  ||| .|||||.|||  ..  | .|. ..|||.|.  .   |||| .|  |||| ..  || |.| ||||| .| .   |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWK--HPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFK

EPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
|..|||| | ....||||||| |||||||||| |||. |  ||||||.|||..  ||.||||||||...|||.|  . |. .|||| .|||.|||..|  
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQD---AEEIKVQPFF
|| |..|.|.|..| . .  ||  ||.   . ......| ||||||...|.   ...|.  |||
PFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKN3.AA Akt 559-818 44 4.7e-114 366.0 In-house 1-264 (264) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-264/264
Sequence Identity: 44% (118 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYY-AIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQI-HEDVF
|. | |||.| ||||.||. | |.|.| |.|.|||.  . ....|    |..||. .    |||. .|   |||. . .||.....||.|   . .. .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN---HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

PEPQARFYVACVVLGLQFLHEKKIIYRD-LKLDNLLLDAQGFLKIADFGLCKEG-IGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWG-LGVLLYEML
.|..||||.| ..|....||.| ||||| ||. |.|.|..| ....|||||||. |  .|.| ||||||| ||||.| .  .|.|||||| ||...|||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

VGECPFPGDTEEEVFDCIVNMDAPYP--GFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFF
 |  ||  .  .. |. | | .  .|   ..| .   .| .||.| |.||||.|..||.|||  |.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKN3.AA Delta 559-818 48 6.5e-105 354.84 In-house 1-259 (259) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-259/259
Sequence Identity: 48% (126 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDV-FP
|  ..|||.| ||||.|. .||. ||||||.|||. ||  |..|. . |.|.|     . ||||  |.  ||| .|  || |.. |||||  | .   | 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLAL--AWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFD

EPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
|  |||| . ...||||||.| ||||||||||.||| .| .||||||.||| .    ..|||||||...|||..  . |...||||  |||.||||.|  
EKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQS

PFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFF
|| |. |.|.|..|.|    || ... .  . ..||... ||||||  .  . .|.  .||
PFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKN3.AA Eta 559-818 48 7.69999999999e-104 351.28 In-house 1-261 (261) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-261/261
Sequence Identity: 48% (127 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHED-VFP
|  . |||.| ||||.| . |||.  |||| |||. ..  |..|   .|||||  .    |||| .| .||||.    || |.| ||||| ||     | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRIL--SLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFD

EPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
|| |||| | |.. |.|||.. .|||||||||.|||..|  |.||||.|||||  |  |.||||||...|||.|    |  .|||| .|||.|||. |. 
EPRARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQP

PFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGE--QDAEEIKVQPFF
||  | |...|. |.. |  || .|. .  . ..  . | |.||||. .   . ..|.  |||
PFEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKN3.AA SGK 559-818 42 1.6e-102 317.43 In-house 1-283 (283) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-283/283
Sequence Identity: 42% (121 aa)

FRCLAVLGRGHFGKVLLVQFKGT------------------GKYYAIKALKKQEVL-------SRDEIESLYCEK-RILEAVGCTGHPFLLSLLACFQTS
|. | |.| | ||||..|. |..                  .| ||.| |.|| ..        . |      |.  ||  .    |||. .|   ||| 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNM---KHPFIVNLHYAFQTK

SHACFVTEFVPGGDLMMQIH-EDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVL
    || ..| ||..   .  |  |||..||||.| .|. |  ||...||||||| .|.|||.|| ... |||||||||   | |.||||||| ||||||
WKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

TQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFF
  . . |.|||| || .||||..|  ||     .. .| | | ..  | . |..  . || |||| |.||||.  .|..|||  |||
RKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase PKN3.AA Alpha 559-818 48 1.4e-101 343.75 In-house 1-259 (259) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-259/259
Sequence Identity: 48% (127 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-DVFP
|  | |||.| ||||.|   |||   |||| |||  .   | .|    |||.|   |    ||| ..  ||||     || |.| ||||| .|     | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGK--PPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFK

EPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
||.| || | .  || ||||| |||||||||| .||| |  ||||||.|||..  .. | ||||||...|||.   . | ..||||  |||||||..|  
EPHAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQP

PFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFF
|| |. |.|.|  | .  . ||  .|.   . .. .| | | ||||.| .. ..|.  |||
PFDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKN3.AA S_TKc 559-818 36 4.1e-96 326.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-231/231
Sequence Identity: 36% (100 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPG--GDLMMQIHEDV-
.. | ..|.| |||| ... |.||...||| .|          |... | .||.     .||..  |. .||. .| ..|.|...|  |||.  |..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTR-AVDWWGLGVL
      ||| .||||.. ....|...|...||.|||| .|.|||    .||.||||...        .||||||...|||||    |.. ..||| .|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDA--EEIKVQPFF
|||||.|. |||  .....|. |.          | ....||.|.||| ||||..| |  .  ..||  |.|
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKN3.AA RSK 562-818 38 1.2e-94 320.74 In-house 1-278 (278) Show / Hide 
Range on Protein: 562-818
Range on HMM: 1-278/278
Sequence Identity: 38% (108 aa)

LAVLGRGHFGKVLLVQFK---GTGKYYAIKALKKQEVLSRDE-IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVF-
| |||.| .||| |....    ||..|| | ||| ..  |.  ..    | .|||...  .|||. .|   ||| ..   ..|...||.| . . . .. 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQ--QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

---PEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDA---QGFLKIADFGLCKEG-IGFGDRTSTFCGTPEFLAPEVLT----QEAYTRAVDWWGL
    |  |.|| | .|| ...||...||.||||..| |.|    .| .|. |||.||.. . .. .| |||.| |..|||.|.    |.....|.||| |
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLLYEMLVGECPFPG---DTEEEVFDCIVNMD--APYP--GFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFF
|||.||||.|  || |   .. .|... | . .   . |   .||    ..|.|.|.. |.||||.| |||||||  |.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKN3.AA AktR 559-818 41 9.6e-91 307.78 In-house 1-268 (268) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-268/268
Sequence Identity: 41% (113 aa)

FRCLAVLGRGHFGKVLLVQFK-GTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIH-EDVF
|. ...||.| |||| ||| |  ..|.||.| .||..   |  .. .. |. |.|.  |  |||.  |  |||| ..  |. |..|||.|   .  .  |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEM--CCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

PEPQARFYVACVVLGLQFLHEK-KIIYRDLKLDNLLLDAQGFLKIADFGLCK-EGIG-FGDRTSTFCGTPEFLAPEVLTQ-EAYTRAVDWWGLGVLLYEM
 | ||||| | ..|.|..||.. .||||||| .|.|||  | .||.|||| | ...    ... .|||||| .|||..|. . ....|||| .|...|||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LVGECPFPGDTEEEVFDCIVNMD---APYPGFLSVQGLEFIQ-KLLQKCPEKRLGAGEQDAEEIKVQPFF
..|  ||  .  .. |. | . .    |||  .| |  ..|| |||.| |.|||| .  ..||||  |.|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKN3.AA Pkinase 559-818 30 6e-80 276.71 Pfam 1-293 (293) Show / Hide 
Range on Protein: 559-818
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLY-CEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGG----DLMMQIH-
.... ..|.| ||.| . . ||||| .|.| .||..  |  ... .   | .|.  ..   ||. . |. .|....| ..|.|...||    ||.  |. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--EDVF--PEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFL----KIADFGLCKEG-IGFGDRTSTFCGTPEFLAPEVLT-QEAYTRAVDW
  . .|  .| ...||.  .. ||...|...||.||||..|.|.| .| .    ||.||||.|   .  .  ..||||||...||||.  .. |...||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WGLGVLLYEMLVGECPFPGD------TEEEVFDCIVNMDAPYPGFLS---------------------VQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQ
|..|..||||| |. ||||.      .. .... |   . ... . .                       ...|| ..|.|.|.||..     ||.|.  
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

PFF
|.|
PWF
Kinase PKN3.AA S_TK_X 819-883 30 2.3e-17 64.94 SMART 1-79 (79) Show / Hide 
Range on Protein: 819-883
Range on HMM: 1-79/79
Sequence Identity: 30% (24 aa)

RTTNWQALLA--RTIQPPFVPTLC----GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQA--------AFRDFDFVS
| ..|..|..  ..|.|||.|...    .| |...|. |||  .| |||. | .. .. |..         ||.|..| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKN3.AA TyrKc 559-812 22 3.2e-14 7.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 559-812
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

FRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTS-------SHACFVTEFVPGGDL--MM
 . . .||.|.||.| . . |      |.| ||.        .| .. | ||.  .|   || .. |...  ..          . |.|..|.|||    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLG-GHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGF---GDRTSTFCG----TPEF------LAPEVLTQEAY
. |.. .. ..   .   .  | ..||.|..| |||   | |.....  ||.||||....      | ....          .      .|||..    .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TRAVDWWGLGVLLYEML-VGECPFPG-----DTEEEVFDCIVNMDAPYPGFL-----SVQGLEFIQKLLQKC----PEKRLGAGEQDAEEI
| . | |  ||...|..  |. | ||      . .||. .. . . . .        .|   . . .. ..|    ||.|    |   |..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PKN3.AA Pkinase_C 838-885 31 4.8e-10 38.64 Pfam 1-46 (46) Show / Hide 
Range on Protein: 838-885
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

TLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSER
....| | ..|. |||  || .||  . . ... .|..||.| .|.. 
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase PKN3.AA Pkinase_Tyr 619-707 25 2.5e-09 32.24 Pfam 63-159 (270) Show / Hide 
Range on Protein: 619-707
Range on HMM: 63-159/270
Sequence Identity: 25% (25 aa)

HPFLLSLLACFQ-TSSH--ACFVTEFVPGGDL--MMQIH---EDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCK
|| ...|...    . .   . |.|..|.|||    . |   .. .. ..   . . .  |...|..|..| |||   | |.. ... ||.||||..
HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKN3.AA Pkinase_Tyr 726-761 39 0.004355 11.08 Pfam 181-218 (270) Show / Hide 
Range on Protein: 726-761
Range on HMM: 181-218/270
Sequence Identity: 39% (15 aa)

LAPEVLTQEAYTRAVDWWGLGVLLYEMLV-GECP-FPG
.|||..    .| . | |  |||..|..  || | .||
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG
Kinase PKN3.AA Pkinase_Tyr 559-573 40 0.857441 3.31 Pfam 1-15 (270) Show / Hide 
Range on Protein: 559-573
Range on HMM: 1-15/270
Sequence Identity: 40% (6 aa)

FRCLAVLGRGHFGKV
 . . .||.|.||.|
ITFGKKLGEGAFGEV