Gene PLK3 (Human)

PLK3

Species: Human
Alias: PLK3, FNK, CNK, PRK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p34.1,

Classification

Group: Other
Family: PLK
Subfamily: PLK2

Sequence

Name Sequence Type Origin Length Description Download
PLK3.NA RNA Sugen Kinome 2369 None Fasta, JSON
PLK3.AA Protein Sugen Kinome 646 None Fasta, JSON
PLK3.kin_dom Protein Kinase Domain Sugen Kinome 253 None Fasta, JSON

Protein domain

Protein domains of PLK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PLK3.AA PLK2 62-314 70 4.6e-229 745.22 In-house 1-257 (257) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-257/257
Sequence Identity: 70% (180 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSR----KSLAHIWKARHTL
|..|.||||||||||||.||..|...||||..|.|||||||||||...||||||.|.|||||.|.|||||.|||||.||.|||    ||.||.||.||.|
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

LEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGS
.|||||||.|||.|||.||||..|.|||||||||||..|||.|.|||||||||||.|....|.||||||.|||||.||||..|.|.|.|||.|||.|||.
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCGR

PPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF
||||||.||||||||...||..|..||.|||.|.|..|...|.||||.|.|.|||||
PPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase PLK3.AA PLK 62-314 59 1.5e-190 625.57 In-house 1-258 (258) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-258/258
Sequence Identity: 59% (153 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKAR-HTLLEP
| .|..|||||||.|||.|| .|.  ||.||.|.|...|||||||. .|||.||.|.|..||.| |.|||..|.||.||.|...||.|..|.| ..| ||
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL--LRQGHGPEADVWSLGCVMYTLLCGSP
|||||..|| .|||||||..|.||||||||.|...||..|.||||||.|||....||||.||||||.|||||   .|||. |.|.|||||.|||||.|.|
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFETADLKETYRCIKQVHYTLPAS--LSLPARQLLAAILRASPRDRPSIDQILRHDFF
||||.|.||||..||. ||..|..  .| .|..|....|.  |..||.|||||.|.||
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase PLK3.AA PLK-Unclassified 62-314 50 5e-132 444.91 In-house 1-264 (264) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-264/264
Sequence Identity: 50% (132 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKAR-------
| .|..|||||||.||.... ||   ||.|.|| |   |  .|.| ..||..| .| |..||.| | ||| .|.|| ||.|. ..| .. | |       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

HTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL--LRQGHGPEADVWSLGCVMYT
  | |.||..|. ||. .||||||..| |||||||| |...|||.| .|||||..||  ...|||||||||| |||.|    |||. | |.||.||. ||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLCGSPPFETADLKETYRCIKQVHYTLP--ASLSLPARQLLAAILRASPRDRPSIDQILRHDFF
|| | ||||| | | ||. ||.  |  |  . .|  |. |.  ||   |  ||.||||. |.|.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase PLK3.AA PLK1 62-314 54 8.70000000001e-127 418.91 In-house 1-253 (253) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-253/253
Sequence Identity: 54% (139 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE
| ||| |||||||.||| .|..|   .|.||.|.| . |.|||.|.  ||..||.|.|||||.| |.||| .|.|| ||||.|.||  . | | .. |||
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFE
 |||..||. | .|||.  |.|||||||| |. .....|.|||||| ..|    ||||.||||||.||||| ..||  | |.||.||.||.|| |.||||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

TADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF
|  |||||  ||.  |..| ..| ||.||. ..| . |  || |.|.|. .||
TKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase PLK3.AA S_TKc 62-314 32 2e-99 337.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSR--KSLAHIWKARHT---
| ..|..|||.|...| .....||  .|.|.|.          |.|..||....  .| .||..  .|.| |..|...|.|.    .| .. | | .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGP-EADVWSLGCVMYT
   . | ..|.|..||...|.|.|..||.|||||  | ...|  ..|..|||||..|       .|.||||.|.|||||   |.|. ..|.||.||..| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILR-------HDFF
.||| |||.  ....... |.          | .|....  .|.  |..||.. ..|.       | .|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PLK3.AA CAMK 67-314 20 9.2e-94 302.47 In-house 1-425 (425) Show / Hide 
Range on Protein: 67-314
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

LLGKGGFARCYEATDTETG------------SAYAVKVIPQSRVAK-------------------------PHQREKILNEIELHRDLQ-------HRHI
 ||.|.|.  .......|.              .|.|.|. ... .                         |. |.....|||... ||       |..|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFSHHFEDADN-------------------IYIFL---ELCSRK----S-LAHIWKARH--------------TLLEPEVRYYLRQILSGLKYLHQRGI
... ...||...                   .|...   |.||        . .| . ..               . | |.|.| |||.|...|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKLGNFFITENM-----------------ELKVGDFGLAARLEP-----------------------PEQRKKTICGTPNYVA-PEVLLR------
 |||||. |  ...|.                  .|. |||.|....|                       . |  || |||| |.| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGHGPEADVWSLGCVMYTLLCGSPPFETA-------------DLKETYRCIKQVHYT-LPASLSL-----------------------PARQ
        ...||..|.||.|...|..||| |||.               ...|... |..  |.  |  .|                         ...
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLAAILRASPRDRPSIDQILRHDFF
|.  .|.  | .|..|.|.|.| ..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PLK3.AA CAMKL 62-314 30 1.9e-87 279.1 In-house 1-297 (297) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-297/297
Sequence Identity: 30% (90 aa)

YLKGRLLGKGGFARCYEATD-TETGSAYAVKVIPQSRVA-KPHQREK-----------ILNEIELHRDLQ---HRHIVRFSHHFEDADN------IYIFL
|  |. ||||.|.    ||.   ||  .|.|.|  ..   .|. . .           |  ||.... |.   | .|... ...|. ..      ||...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCSRK---SLAHIWKARH---TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENM--ELKVGDFGLAARLEP----PEQRKKTICGTPNYV
|.||      . .| | .|    . |.| | | |||.|...|.|..|| |||.|. |  ..||.   .|. |||...  .|    |.|  || ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLLR--Q-GHGPEADVWSLGCVMYTLLCGSPPFETADLK-------ETYRCIKQVHYTLPASLSL-PARQLLAAILRASPRDRPSIDQILRHDFF
|||....  .  .||..|.||.| ..|...||  ||. ....       . |. |..  |  |  ... ..|.|.  .|   | .||.|.||..| ..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase PLK3.AA Pkinase 62-314 31 1.9e-86 298.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILN--EIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRK----SLAHIWK-AR
| .|| .|.|.|...|....  ||  .|||.|. .  .|. ...  ..  ||.... |.| .|||. . ||| |.||. .|.|       .|... .  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

HTLL---EPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMEL----KVGDFGLAARL-EPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWS
|. .   | |.. |..|||.||.|.|..||.|||||. |..| .|...    |..|||||. . . . .  .|.||||.|.||||.. .|..||..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCVMYTLLCGSPPFETA------DLKETYRCIKQVHYTLPASLS---------------------LPARQLLAAILRASPRDRPSIDQILRHDFF
.||..| .||| |||  .      | .. .. |..  .  . . .                      ......  .|.  | .||...||| |..|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PLK3.AA SAK 62-314 40 8.8e-80 271.36 In-house 1-254 (254) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-254/254
Sequence Identity: 40% (103 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKAR-HTLLEP
|  . ||||||||  | |   .|.   |.|.| .  . |    ... ||.|.|  |.|  |.    .|||.  .|. ||.|    .    | | .   | 
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

EVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPF
| | ...||. |. |||  ||.|||| | |  .| .|..|. |||||. |. |. .  |.||||||..||.  |  || ..|||||||..|||| | |||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

ETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF
.|   |.|   .    | .|| ||. |. |.  .||  | .| ... .| | | 
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase PLK3.AA MARK 62-314 34 3.1e-76 248.73 In-house 1-262 (262) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-262/262
Sequence Identity: 34% (92 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFE--DADN-IYIFLELCSRKSLAHIWKAR--HT
|  .. .|.|..|  . |... ||  .|.|...  .  .|......  |||... |.| .|... | .|  .  . ||. .|..|...| .  ||.  . 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENM--ELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQG-HGPEADVWSLGCVMYTL
| |.| | . |||.|...|.|...| |||.|. |  | ||.    |  |||....  ||.|. .| |||| | |||..|..   ||..|.|||| |.|..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI-PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LCGSPPFE--TADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF
.||. ||.  |.|.|| |. |   .|. |  .|  .|.|.  .| . | .||.|..|..| ..
VCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase PLK3.AA ULK 62-314 26 1e-66 227.94 In-house 1-324 (324) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-324/324
Sequence Identity: 26% (86 aa)

YLKGRLLGKGGFA-RCYEATDTET---GSAYAVKVIPQS-RVAKPHQRE------KILNEIELHRDLQ------HRHIVRFSHHFEDA--DNIYIFLELC
| . . |||| |.   |.... .|   . ..|.|.|...    |....|      .. |||.. . |       | |||.. . ||..  .||||..|.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

SRKSLAHIWKARHT---------LLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITEN------------MELKVGDFGLAARLEPPE---QRKK
    | .. | ...         | |.|.. ...||..|.|.||...| |||.|. |  |...              ||..|||.|  .. ..   |  .
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TIC------GTPNYVAPEVLLRQG----HG-PEADVWSLGCVMYTLLCGSPPFETADLKETY----------------RCIKQVHYTLPA---SLSLPAR
|..      ||| | ||..| .||    ..  ..|.|||||..| .| |..||..    ..|                 . ... . .|     .|   .
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

QLLAAILRASPRDRPSIDQILRHDFF
.|.   |   ..|| |...|. | .|
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase PLK3.AA STE 63-314 21 1.6e-66 227.34 In-house 1-359 (359) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-359/359
Sequence Identity: 21% (77 aa)

LKG-RLLGKGGFARCYEATDTE---------------TGSAYAVKVIP----QSRVAK-----------PHQREKILNEIELHRDLQ--HRHIVRFSHHF
..| . .|||.|   | | . .               ||  .|.|...    .. . .           . ....||.||.......  | .||..  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EDA-------DNIYIFLELCSRKSLAHIWKARHTLL--------------EPEVRYYLRQILSG-LKYLHQRGILHRDLKLGNFFITENMELKVGDFGLA
..        |...|..|...  ||  | | ..  .              |....|..|||| | |.|||. .| |||.| .| ..      |  |||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

ARLEP---------------PEQ-RKKTICGTPNYVAPEVLLR------QGHGPEADVWSLGCVMYTLLCGSPPFET-ADLKETYRCIKQ----------
..|..                 | . .|..||| . ||||...      .|..  .|.|||||..  ...| ||. .  ...  .. ..           
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-----VHYTLP-------------------ASLSLPARQLLAAILRASPRDRPSIDQILR--HDFF
      . .||                    ..| . .. ..  |.  |..||. .| |.  | |.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PLK3.AA TyrKc 62-314 23 5.1e-16 36.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 62-314
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDL--QHRHIVRFSHHFEDA-------DNIYIFLELCSRKSLAHIW-
  .|. || | | . |..| .      |||..  .       || ...|... . |  .| .|||.     .        . ..| .|...  .| .   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPP--------EQRKKT-ICGTP----NYVAPEVLLRQGHG
| |..|  ..  ..  || .|  |||.... ||||   |  ..||   |..||||.  ..            |||.  .|         |||..      
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PEADVWSLGCVMY-TLLCGSPPFET-----ADLKETYRCIKQVHYTLPASL---------SLPARQLLAAILRASPRDRPSIDQILRHDFF
.. |||| | .|.  .  | .| .       . .| ....|| ..  .            .    |.     .. | |||.  .|  |..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase PLK3.AA Pkinase_Tyr 62-274 27 1.2e-12 43.46 Pfam 1-231 (270) Show / Hide 
Range on Protein: 62-274
Range on HMM: 1-231/270
Sequence Identity: 27% (63 aa)

YLKGRLLGKGGFARCYEATDT----ETGSAYAVKVIPQSRVAKPHQ--REKILNEIELHRDL-QHRHIVRFSHHFE-DADN--IYIFLELCSRKSLAHIW
  .|. ||.| | . |..| .    .|.   |||....   | ..|  ||. ..|... . | .| .|||.      . .   ||| .|..   .| .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KA----RHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL-EPPEQ-RKKTICGTP-NYVAPEVLLRQGHGPEADVW
..    .. |  ..   . .|| .|. ||..... ||||   |  .|||.  |..|||||  . .  .  ||.. .  |    |||..       . |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SLGCVMYTLLC-GSPP-FETADLKETYRCI-KQ
| | .|. ..  |  | ..  .  | |. | ..
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
POLO_box PLK3.AA POLO_box 470-533 31 9.6e-18 69.14 Pfam 1-74 (74) Show / Hide 
Range on Protein: 470-533
Range on HMM: 1-74/74
Sequence Identity: 31% (23 aa)

YSNKFGFGYQLSSRRVAVL-FNDGTHMALSANRK-TVHYNP--TSTKHFSFSVGA------VPRALQPQLGILR
|..| |..||||   | |. |||.|...|..|.| .|.|    .. ... ..         .|  || .| .|.
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box PLK3.AA POLO_box 567-637 36 1.1e-21 83.16 Pfam 1-74 (74) Show / Hide 
Range on Protein: 567-637
Range on HMM: 1-74/74
Sequence Identity: 36% (27 aa)

VKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVA--RNRSACTYLASHLRQLGC-SPDLRQRLRYAL
 .|.... ...|.|||||||. ||||.||. .. ..||. .  .|.   ||  |.. . || ..||...|.|. 
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK