Gene PLK4 (Human)

PLK4

Species: Human
Alias: SAK, STK18, PLK4
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 4q28,

Classification

Group: Other
Family: PLK
Subfamily: SAK

Sequence

Name Sequence Type Origin Length Description Download
PLK4.NA RNA Sugen Kinome 3830 None Fasta, JSON
PLK4.AA Protein Sugen Kinome 970 None Fasta, JSON
PLK4.kin_dom Protein Kinase Domain Sugen Kinome 254 None Fasta, JSON

Protein domain

Protein domains of PLK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PLK4.AA SAK 12-265 79 9.90000000001e-201 673.14 In-house 1-254 (254) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-254/254
Sequence Identity: 79% (202 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSEN
..|..|||||.||.||||..|||..||||||||||.|.|.||||||.|||.|||||||||||||||||||.|||||||||||||||.||.|.|..||.|.
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

EARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPF
|||||||||..||||||||||.||||||||.||||.|..||||||||||||||||||||.||||||||||||||.||||.|||||||||.||||||||||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

DTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
|||.||||||||..|.|.||..||.||.||||..||.||..|..||.||.||||
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase PLK4.AA PLK 12-265 46 1.4e-177 582.74 In-house 1-258 (258) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-258/258
Sequence Identity: 46% (120 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSEN
...|..|||| || .|....|||. ..|||...|. |.| .. .....|..||.||.||.|......|||...||.|||.|||.....|.|.|.|...| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIA--TRSAHGLESDVWSLGCMFYTLLIGRP
|.|..|.||..|..|||.|.|.||||.|.||.|..||..||.||||||.|....|...|.|||||||.||..  ... |..|.|.|||||..||||||.|
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFDTDTVKNTLNKVVLADYEMPSF--LSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
||.|..||.|..... ..|..|.   .| ||||||...|..||..|.... .|.|||.
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase PLK4.AA Aur 12-265 36 2.4e-111 295.01 In-house 1-257 (257) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-257/257
Sequence Identity: 36% (95 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRV-KPFSE
|..| .||||.|  || |   .|.  .|.|...|. . | .|.. ...|.||. .|.|| ||..|.||.|....||.||   .||. ..|..   | |.|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

NEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR-NMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRP
..|  .| ||. .  |.|| .| |||.   |.||   | ||||.||| ...    ...  |.|||  |..||.  .  |. . |.|.|| . | |. |.|
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPN-NNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCP

PFDT-DTVKNTLNKVV-LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
||   .. . |. ..    |...||..|.|||||| ..|...|  |..|  .. ||..
PFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase PLK4.AA AGC 12-265 23 1.1e-108 281.63 In-house 1-395 (395) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

FKVGNLLGKGSFAGVYRAESIH------TGLEVAIKMIDKKA-MYKAG--MVQRVQNE------------VKIHCQLK----------HPSILE-LYNYF
|..  ..|||||  || ..  .      ||   |.|...||  ...    ||.....|             .|  ...          || |   |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDSNY--VYLVLEMCH---------NG-EMNRYLKN--RVKPFSENEARHFMHQ-------IITGMLYLHS-HGILHRD-LTLSNLLLTRNMNIKIADFG
.| ..  .|.|.| .           | |.  .|..  . . |.|..||... .       |. .. |||| .|| ||| | . |.||... .||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATQLKMPH--------------------------------------------------EKHYTLCG--TPNYISPEIATRSAHGLESDVWS--LGCMFY
|...... .                                                  .. .|.||  ||.|..|||     .| . | ||  |||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

TLLIGRPPFDTDT----------VKNTLNKVV------LADYEMP----------SFLSIEAKDLIHQLLRRNPADRLS----------LSSVLDHPFM
 .|.|.|||  |.           . . .|.         . ..|          ...| |||||| .|| ..|..||            . . .||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PLK4.AA PLK-Unclassified 12-265 42 2.1e-107 363.1 In-house 1-264 (264) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-264/264
Sequence Identity: 42% (112 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR------V
 ..| .|||| || .| . .| |  . |.| |.|  ..|    |.  .| ||| .|.|. |   .  |||. .||..||.| || .. |.| |       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA--HGLESDVWSLGCMFYT
|  .| |.. .  ||. .  |||...| |||| | |..|. ||..||.|||||| |.   || .| |||||||.|||   .   |. |.|.||.||. ||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLIGRPPFDTDTVKNTLNKVVLADY--EMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
||||.||| |  ||.|. |.   .|  . |. .| .||||| . |  ||. |....  ..|||.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase PLK4.AA S_TKc 12-265 34 5.70000000001e-102 345.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHN--GEMNRYLKNRVKP--
.......|||.|. ||..  ..|| .||||.|.          .....|..|. . .|| |  || .|.| ...|.|.|.| .  |.. .|.|.| ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGL-ESDVWSLGCMFYT
   |.| .||..|.||. .. |.|||||.||||  .|.||..  .|||.|||||.||       .|.||||.|..||.     .|  ..|.||.||..| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLD-------HPFM
.| |.|||.  ... ...|..          | ||||.| ..|...|..|..   .|        ||..
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PLK4.AA CAMK 17-265 23 7.6e-100 322.44 In-house 1-425 (425) Show / Hide 
Range on Protein: 17-265
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

LLGKGSFAGVYRAESIHTG------------LEVAIKMIDKKAMYK-------------------------AGMVQRVQNEVKIHCQ-------LKHPSI
 ||.|||. |.... ..|.             .||||.|||| . .                         . . ..|..|..|. .       |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LELYNYFEDSNY-------------------VYLVL---EMCHNGEM----NRYLKNR--------------VKPFSENEARHFMHQIITGMLYLHSHGI
. || ..||..|                   .|.|.   |.| .||.      |.. .               . |.| |||....||. .. |.|||.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLTLSNLLLTRNM-----------------NIKIADFGLATQLKM-----------------------PHEKHYTLCGTPNYIS-PEIATR------
 |||| . |.||. |.                 ||||.|||.|....                        . .| .| |||| |.. ||.  .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------SAHGLESDVWSLGCMFYTLLIGRPPFDTD-------------TVKNTLNKVVLADYE-MPSFLSI-----------------------EAKD
          .| ..|.||.|.. |..| |.|||. |             . .... |.  ..|.  |...|.                       |.||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIHQLLRRNPADRLSLSSVLDHPFM
|| ..|...| .|.... .|.||.|
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PLK4.AA CAMKL 12-265 33 1.8e-93 298.67 In-house 1-297 (297) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-297/297
Sequence Identity: 33% (99 aa)

FKVGNLLGKGSFAGVYRAES-IHTGLEVAIKMIDKKAMYK-------------AGMVQRVQNEVKIHCQLK---HPSILELYNYFEDSNY------VYLV
...|  ||||||. |  |.  ..|| .||||.|||| . .               .. |.. |..|. .|.   || |  ||  .|....      .|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEMCHNGE--MNRYLKNRV---KPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNM--NIKIADFGLATQLKM----PHEKHYTLCGTPNY
.| | .||  .  |....    ....|.|||..  ||. .. |.||||| |||. . |.||. |.  ||||.|||.... .     | .|  | ||.|.|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

ISPEIATR---SAHGLESDVWSLGCMFYTLLIGRPPFDTDTVK-------NTLNKVVLADYEMP--SFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
 .|||  .   . .| . |.||.| . |... |. ||| ||..       . ..|.    |..|  ...| ...|||...| .|| .| ..  .. ||.|
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase PLK4.AA PLK1 12-265 39 3.3e-90 296.71 In-house 1-253 (253) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-253/253
Sequence Identity: 39% (101 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSEN
.. |  |||| ||  |  .  .|   .| |.. |. . |    ...  |..|| ||.|. | .....|||...||.|||.|.   .    | | |.  | 
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRR-KAITEP

EARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPF
|.|..|.||. |..|||   |.|||| | || |  ....|| ||||||.. .  |.  ||||||||| ||. ..  |  | |.||.||..|.||.|.|||
ECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPF

DTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
.| ..|.|  ..  ..| .|| .|  |..||...|  .|  |   . ||   |.
ETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase PLK4.AA PLK2 12-265 39 7e-90 289.61 In-house 1-257 (257) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-257/257
Sequence Identity: 39% (103 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHN----GEMNRYLKNRVKP
.  | ||||| ||  | .  . |.   |.| . .    |      . .|. .| ||.|. | . . .|||   .|..|| |        |   .| | . 
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVR-HH

FSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIG
  | | | .| ||. |. |||...|.|||| |.|. .. || .|| |||||  |  . . | |.|||||||.||.  |  |. |||.|.|||  ||.|.|
LTEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCG

RPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
|||| |   | |   .  . | ||. ||  |. || ..|. .|.|| ||  ...| | 
RPPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase PLK4.AA Pkinase 12-265 31 3e-87 300.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQN--EVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNG----EMNRYLK-NR
...|  .|.|||. ||..  . || .||.| |.|.   | .. |.  .  |..|.  |.|| |..|| .|||....|.|.| | .|    .  .|..  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VKPF--SENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNI----KIADFGLATQL-KMPHEKHYTLCGTPNYISPEIAT-RSAHGLESDVWS
 ..|  ||.|....| ||. |. |.||.||.|||| ..|.|. .|..|    ||.||||| |.   . .  .|.||||.|..||.   .. .| ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCMFYTLLIGRPPFDTD------TVKNTLNKVVLADYEMPSFLS---------------------IEAKDLIHQLLRRNPADRLSLSSVLDHPFM
.||..| .| |||||. .      . .  ....  .... ... .                      |.||.|  .|...|..|..   .| ||..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PLK4.AA MARK 12-265 35 8.3e-81 263.89 In-house 1-262 (262) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-262/262
Sequence Identity: 35% (94 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFE--DSNY-VYLVLEMCHNGEMNRYLKNR-VKP
.|..  .|.||.| |. | ..||| .||||...|. . .    . |. |..|. .|.|| | .|. ..|  ...  .||..| . .||.  |.|..   .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNM--NIKIADFGLATQLKMPHEKHYTLCGTPNYISPEI-ATRSAHGLESDVWSLGCMFYTL
 .|.|||.. .||. .. |.||..| |||. . |.|.  |.  ||||.|||....  .| .|  | |||| | .|||   .   | . |.||||   |..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI-PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LIGRPPFDTDT--VKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
. |. ||| ||   |.   |..  .|. |...| |...||..||  || .| ... .. ||.|
VCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase PLK4.AA Pkinase_Tyr 12-158 33 2.1e-27 93.43 Pfam 1-158 (270) Show / Hide 
Range on Protein: 12-158
Range on HMM: 1-158/270
Sequence Identity: 33% (53 aa)

FKVGNLLGKGSFAGVYRAESI----HTGLEVAIKMIDKKAMYK-AGMVQRVQNEVKIHCQL-KHPSILELYNYFE-DSNY--VYLVLEMCHNGEMNRYLK
 . |  ||.|.|  ||...       |...||.||.  .|| .   . .   .|.|| .|| .|| |. ||     ..    .|.|.| . .| .  ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

NR---VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLA
..    .|..  .  .. .||  || ||.|... ||||   | |.|.|. .||.|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase PLK4.AA TyrKc 12-265 23 8.3e-19 69.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL--KHPSILELYNYFEDS-------NYVYLVLEMCHNGEMNRYLK
 . |  || | |  ||... .   ..||.||. . |      ..   .| .| |.|  .|| |. || .  ..         ...|.| . .|  . ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP-----HEKHYTL----CGTP----NYISPEIATRSAHG
.. . ..  .  .|..||  || ||||... ||||   | |...|  .||.||||.  ..        .. |.     .|         .||    .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

LESDVWSLGCM---FYTLLIGRPPFDT-----DTVKNTLNKVVLADYEMPSFL---------SIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
 .||||| | .    .|.  | .|         . .  ...|   .. ..            . |  ... |  ...|.|| . | .  | ..
TKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
POLO_box PLK4.AA POLO_box 892-956 25 1.5e-15 61.02 Pfam 1-74 (74) Show / Hide 
Range on Protein: 892-956
Range on HMM: 1-74/74
Sequence Identity: 25% (19 aa)

FVKNVGWATQLTSGAVWVQ-FNDGSQLVVQAGVS-SISYTS--PNGQTTRYGENEKL-----PDYIKQKLQCLS
.  . |.  ||. | |.|. |||.........   ...|..  ||.|...|  .. |     |  ...||..|.
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK