Gene NEK4 (Human)

NEK4

Species: Human
Alias: NEK4, pp12301, STK2, MGC33171, NRK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3p13-p21.1,

Classification

Group: Other
Family: NEK
Subfamily: NEK4

Sequence

Name Sequence Type Origin Length Description Download
NEK4.NA RNA Sugen Kinome 3709 None Fasta, JSON
NEK4.AA Protein Sugen Kinome 841 None Fasta, JSON
NEK4.kin_dom Protein Kinase Domain Sugen Kinome 256 None Fasta, JSON

Protein domain

Protein domains of NEK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK4.AA NEK4 6-261 74 3.2e-219 734.55 In-house 1-257 (257) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-257/257
Sequence Identity: 74% (191 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDG-LLYIVMGFCEGGDLYRKLKEQKGQLLP
||...||||||||||.||.||||.||||.||..|.|||.|||.|||.||||||||||||||.||||||...| .||||||||||||||||||.||.|.|.
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

ENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKH
|.|||||||||||||||.||||||||||||||.|||..||||.||.||.|||.||||||.|.||||||||||.|.|.||.||||.|.||||||||.||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYI
||.|||||||.|.||.|..||||..||..|..|...||.|.|..|||...|...|||
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK4.AA NEK 6-261 46 2.2e-161 542.41 In-house 1-286 (286) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-286/286
Sequence Identity: 46% (134 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQ-----YVIKKLNLRNASSRERRAAE-QEAQLLSQLKHPNIVTYKESWEGGD-GLLYIVMGFCE-GGDLYRK---
| .....|.||.|.|..|....|||.     ||.|| |. | |..|...|  .|...|.||||||||.|..|..  . . |.||| .|| |||||.|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LKEQK--GQLLPENQVVEWFVQIAMALQYLHEK-----HILHRDLKTQNVFLTRTNI----IKVGDLGIARVLENHCDMAST-LIGTPYYMSPELFSNKP
.|.||  |....|.|...||.|...||.|.|..     .|||||.|.||.|||. |.    .|.||.||..||.. .|||.| ..|||||||||...|||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNYKSDVWALGCCVYEMATL--KHAFNAK--DMNSLVYRIIEG-KLPPMPRD--YSPELAELIRTMLSKRPEERPSVRSILRQPYI
||.|||.|.|||..|||.||  ||.|.|.  .|.||...|..| . || |    ||..| .||. || | ||.|||...|| .|.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK4.AA NEK1 6-261 47 2.4e-132 445.99 In-house 1-276 (276) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-276/276
Sequence Identity: 47% (130 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKES-WEGGDGLLYIVMGFCEGGDLYRKLKEQ--KGQL
| |....|.||.| . ||||. ||..||||  |. . .. || ..  |. .|. .||||||.||||  |.| |.||||| .|.||||..| ..|  ||.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLT--RTN---------------IIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY
 .| |   ||.|| .||.. | . |||||.|.||.|||  .                 ..|.|| ||||.| .  . |.| |||||| |||.  ||||| 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYI
|||.|.|||  ||  ||||.|.|. .  || .|..|  || |. || || .|.  |... |. |||| .|| .| |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK4.AA NEK8 6-261 37 5e-118 338.58 In-house 1-278 (278) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-278/278
Sequence Identity: 37% (104 aa)

YCYLRVVGKGSYGEVTLVKHRRDG--KQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKG-QL
|   ||||.|. |...|   . |.  .. ..|  |.   |..||..|  | |.|| | ||||. | .. .  |. | |.|  ..|| ||... .|..  .
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFM-EDNTLMIEMEYADGGTLYQMIQHQQNKLF

LPEN----------------QVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRT-NIIKVGDLGIARVLENHCDMA-S-TLIGTPYYMSPELFSNKPY
..|                 ...  |.|.  |. ..|.. ||||||||||.|.||  ...|.|| ||. ..     |. . |..|||||||||. . |||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

NYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEG-KLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYI
| |||.|||||  |||..|| || |     ||  |. . .  | .  ||.|.  |..  |.. || |||.  |. .| .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK4.AA S_TKc 6-261 31 1.7e-94 321.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEG--GDLYRKLKEQKG---
|  ||..|||..|.| ...|...|... ||...         . ...| |.|.. .|||||.......   . ||.|| .|.|  |||.. .|....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-QLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY-KSDVWALGCCVYE
 . .|| ..  .. ||. ||.|.|...|.||||| .|..|..   ||..| |.||.|       .|..|||.||.||..   .|.. |.|.|..||..||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILR-------QPYI
|.. .  |       .....|           |||. ..|| .| | ||.||..  .|.        |..
MLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK4.AA Pkinase 6-261 27 2.3e-82 284.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQ--EAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGG----DLYRKLK-EQ
|. .|..|.||.|.| . .|. .||....|....|...| .....    |.|..  |.|||||......|  .. .|.|| .||||    ||.. .. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

KGQL-LPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNII----KVGDLGIARVL-ENHCDMASTLIGTPYYMSPELFS-NKPYNYKSDVWA
.| . ..|...  .. ||. .|.|.|.. |.||||| .|... ... |    |..| |.|... . .   ..|. |||.||.||.   ...| .|.|.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCCVYEMATLKHAFNAK------DMNSLVYRIIEGKLPPMPRDYS--------------------PELAELIRTMLSKRPEERPSVRSILRQPYI
.|| .|||.. .  |  .      |.. ...|| ...|.      .                    .|. ..|. .| | |..||. . ||  |..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK4.AA NEK-Unclassified 6-261 35 5.5e-79 261.1 In-house 1-258 (258) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-258/258
Sequence Identity: 35% (93 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQ--LL
|  .  .|.|  | | ||.|    |  .....  |    . ..       .||||.|| |||| .|.     | |    .|.||.| |... . .    .
YDKITTLGQGGGGAVYLVRHQI-SKRHLVQQISKR----KKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFY-TQDYCDGGNLDRRIQKHRKKNEPF

PENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLK
 |  .  |..|. ||.|| | . |.|||||.||.|||   ..  || ||.|...   | | | .||. .||||    .||| .||||.||| .|||.|  
DEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCE

HAFNAKDMNSLVYRIIEGKL------PPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYI
 .| .. | .. . |  .         |  . ||  | ..||.|| . .. |||   |. |.||
PFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK4.AA NEK11 6-261 42 7.1e-77 261.7 In-house 1-259 (259) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-259/259
Sequence Identity: 42% (111 aa)

YCYLRVVGKGSYGEVTLV---KHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQK--G
|     .| ||.| | ||   | .|     |.| .        |   |  ||||||.|.|| || .  |.   |    |.  .||| ||  ...| |  |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFC-IITEYCEGRDLDYRIQEYKQAG

QLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMA
.. ||||..|||.|. .   |.||. ||||||| .|.|| . |..|.|| |..|.|   ||.| || ||| |||||    . |  |||.|.| | .||| 
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMC

TLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYI
 . |||   .  |.| .|.||. | .|  |  ||  ..  || | |  |||   ||. ||.
CMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK4.AA NEK2 6-261 31 3.9e-67 225.09 In-house 1-319 (319) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-319/319
Sequence Identity: 31% (101 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVT-YKESWEGGDGLLYIVMGFCEGGDL---YRKLKEQKGQ
|  | . |.||.| .  |..  |||  | | ..  .  . |. .   |  .|.||||||||  |          ||||| .||||||     | . .. |
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKER-Q

LLPENQVVEWFVQIAMALQYLHE------------------KH---ILHRDLKTQNVFLTRTNI------------------------------------
 ..|  .   . |.  |||  |                   .    |||||.|  |.||                                         
YMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYS

---IKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTM
   .| || | ||.|.     | | .|||||||||. .  .|| |||.|..|| .|||..|.  | |.    |   | .|.  . |  || .| |.|  |
QVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

LSKRPEERPSVRSILRQPYI
.   .. |||.  ||..| |
INVDHYHRPSIEEILQHPQI
Kinase NEK4.AA Ciliate-E2 6-261 22 1.6e-66 227.33 In-house 1-365 (365) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQY------------------VIKKLNLRNASSRERRAAEQEAQLL----------------SQLKHPNIVTYKES
|  ... |.|..| | ..|.....||.                   ||. .. . . .. .. .|| ...                .||.||||. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WEG-GDGLLYIVMGFCEGGDLYRKLKEQ---KGQLLP------ENQVVEWFVQIA---------------MALQYLHEKH-ILHRDLKTQNVFLTRTNII
..   |  .|.|| .|.||||.  .|..   ... ..      |... . . ||.                ||.|||.|. |.|||.| .|...     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVGDLGIAR-VLENHC------------------------------DMASTLIGTPYYMSPELFSNKP---------YNYKSDVWALGCCVYEMATLKHA
|. |.|... . ....                              .|. |..|||.||.|| ...|.         |.||.|.|.||.. ||| . |. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNAKDMNSLVYRIIEG---KLPPM---------------PRDYSPELAELIRT----MLSKRPEERPS-VRSILRQPYI
|         ...|.    ..|.                . . |.|   ||.     || | ||.|..    ||  |..
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK4.AA STE 6-261 23 3.6e-66 226.13 In-house 1-359 (359) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-359/359
Sequence Identity: 23% (86 aa)

YCYLRVVGKGSYGEVTLVKHRR---------------DGKQYVIKKLNLRNASS---------------RERRAAEQEAQLLSQLK--HPNIVTYKESWE
.  ....|||..|.| . ...                 |. . ||..||.| ..                |.   ..| .......  |||||.|  . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GG------DGLLYIVMGFCEGGDLYRKLKE--QKGQLLP----------ENQVVEWFVQIAMA-LQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIAR
 .      |. |.|.| ...|| |   .|.   .|. |.          |.|.    .||  . |.|||..|| |||.| .|..|     .|  | |.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLENHCD----------------MASTLIGTPYYMSPELFSN------KPYNYKSDVWALGCCVYEMATLKHAFNA-KDMNSLVYRIIE-----------
 |.....                .  |..||| .|.||  ..      |.|..|.|.| |||.. |||| |. .   ..|  . . ...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GKLPPMPR-------------------DYSPELAELIRTMLSKRPEERPSVRSILR--QPYI
   |. || |                     .|||. . |.  | | |..||..   |.   | |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK4.AA TKL 12-259 21 4.6e-64 219.14 In-house 1-364 (364) Show / Hide 
Range on Protein: 12-259
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

VGKGSYGEVTLVKHRR--------DGKQYVIKKLNLRN-------------------------ASSRERRAAEQEAQLLSQLKHPNIVTYKE-----SWE
.|.|..|||   |.|         .||  ..||.. .|                          .|..|   |.|. ..|.|.||||| ..      .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKH--------ILHRDLKTQNVFLTRTNI--------------
       |..| |.||| .|.||.|.  |          .| . |  .|| ...||| ..        |.|||||..|... . .               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

IKVGDLGIARVLENHCD-------------------MASTLIGTPYYMSPELFSNK----------------PYNYKSDVWALGCCVYEMATLKHAFN-A
.|..|.|..|..... .                   . .| .|||..|.||.. ..                .|. |.||.. | . .|..| .. .   
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

KDMNSL---------VYRIIEGKLPPMP------------RDYSPELAELIRTMLSKRPEERPSVRSILRQP
. |  .         .... .|. ||.|             |  |....|.    .  ||.|||   || . 
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase NEK4.AA Pkinase_Tyr 6-202 26 2e-35 120.63 Pfam 1-210 (270) Show / Hide 
Range on Protein: 6-202
Range on HMM: 1-210/270
Sequence Identity: 26% (56 aa)

YCYLRVVGKGSYGEVTLVKHR----RDGKQYVIKKLNLRNASSRE--RRAAEQEAQLLSQL-KHPNIVTYKESWEGGDGL--LYIVMGFCEGGDLYRKLK
   ... |.|..||| . . .     .. .  .|.|   .|....  |..  .||....|| .||||| .       ..   .|||| ....|||.  |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EQ--KGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVL---ENH-CDMASTLIGTPYYMSPELFSNKPYNYKSDVW
..   .| |.  . ... .|||....||..|.. |||| . |. .|..|..|..| | || .   ..      .. .  . . .|| .... .. |||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGKFTTKSDVW

ALGCCVYEMATL
. | . .|. |.
SFGVLMWEIFTY
Kinase NEK4.AA TyrKc 6-259 22 2.6e-28 101.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL--KHPNIVTYKESWEGG------DGLLYIVMGFCEGGDLYRKLKE
   ... | | .||| . . .    |  .|.|.        |..  .||.....|  .|||||        .      .. |.||| ....|||   |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENH--------CDMASTLIGTP-----YYMSPELFSNKPYN
 ... |.  . ... .|||   .|||.|.. |||| . |. ... ...|..| | .| ....          ....  |.        |.|| .  . ..
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

YKSDVWALGCCVYEMATLKHAFNA------KDMNSLVYRIIEGKLPPMPRD--------YSPELAELIRTMLSKRPEERPSVRSILRQP
 |||||. | | .|. |.            ..   .. .. .|. .| | .         ..|. .....     ||.||. . | .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF