Gene ROCK1 (Human)

ROCK1

Species: Human
Alias: p160ROCK1, Hs.ROCK1, MGC131603, ROCK1, MGC43611, Hs.198533, P160ROCK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 18q11.1,

Classification

Group: AGC
Family: DMPK
Subfamily: ROCK

Sequence

Name Sequence Type Origin Length Description Download
ROCK1.NA RNA Sugen Kinome 6650 None Fasta, JSON
ROCK1.AA Protein Sugen Kinome 1354 None Fasta, JSON
ROCK1.kin_dom Protein Kinase Domain Sugen Kinome 263 None Fasta, JSON

Protein domain

Protein domains of ROCK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ROCK1.AA DMPK 76-338 67 9.5e-292 732.65 In-house 1-270 (270) Show / Hide 
Range on Protein: 76-338
Range on HMM: 1-270/270
Sequence Identity: 67% (183 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEK
.|..||||||.|||||.||||.|..|||||...|.||.||...|.||||||||...||.|..||.|||||..||||||||||||||..|||.|.  .||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGD--GYYGRECDWWSVGVFLYEM
.||||.||.|||...||.||..|||.||||||||..||.||||||.|||||..||||...|||||||||||||.....|  |.||.|||||||||..|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LVGDTPFYADSLVGTYSKIMNH-KNSLTFPDDND--ISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFF
|.|.|||||||||.||.||||| ||.| ||||.   .|.|||.|||..|.|||.||||||.|..|.| ||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase ROCK1.AA ROCK 76-338 88 3.1e-216 724.67 In-house 1-263 (263) Show / Hide 
Range on Protein: 76-338
Range on HMM: 1-263/263
Sequence Identity: 88% (233 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWA
....||||||||||||||||||..||||||.|||||||||||||||||||||||.|||.|.|||.|||||||||||||.|||||||||||||||||||||
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEKWA

RFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGD
||||.||||||||||||||||||||||||||||.||||||||||||||||.||||||||||||||||||||||||.||.|||||||||||||.|||||||
RFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGD

TPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFF
||||||||||||||||.|||||.||||..|||.||.|||.||||||.|||||||..||.| ||
TPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase ROCK1.AA AGC 76-338 32 5.1e-180 470.32 In-house 1-395 (395) Show / Hide 
Range on Protein: 76-338
Range on HMM: 1-395/395
Sequence Identity: 32% (131 aa)

YEVVKVIGRGAFGEVQLVRHK------STRKVYAMKLLSKFE--------MIKRSDSAF-------FWEERDIMAFAN----------SPWVVQ-LFYAF
.|..||||.|.||.| |||.|      .| |.|||| |.| .        |...  ...       .||||.|.. .|          .|..|. |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDRY--LYMVMEYMP--------GGDLVNLMSNY------DVPEKWARFYTAE-------VVLALDAIHS-MGFIHRD-VKPDNMLLDKSGHLKLADFG
||...  ||.||||||        ||..  .....        .|..||||.||       .||||. .|| ||.|||| .||.|.|||. ||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TCMKMNKEG-------------------------------------------------MVRCDTAVG--TPDYISPEVLKSQGGDGYYGRECDWWS--VG
 | .....|                                                 ..|. | .|  ||.|..||.|        ||..|||||  .|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWWSFGLG

VFLYEMLVGDTPFYADSLV----------GTYSKIMNH----KNSLTFP--------DDNDISKEAKNLICAFLT-DREVRLGRN-------GVEEIKRH
...||||.| .|||.|. .           .. ||||.    .. ..||        .|  .|.|||.||  .|. |.| ||| .       |.||||.|
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

LFF
 .|
PWF
Kinase ROCK1.AA GEK 76-338 56 1.8e-137 462.98 In-house 1-269 (269) Show / Hide 
Range on Protein: 76-338
Range on HMM: 1-269/269
Sequence Identity: 56% (151 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEK
.|..|||||||||||  |. |.| .|||||.| |.||.||.. | | ||||.. .  . |. .| |||||..|||.||.|  ||||. |.| ..  .||.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEML
 |||| ||.|.|.|..| ....|||.||||.|||. ||..||||| |..|||.|||.   |||||||||||.|.  ..| | ||.||||||.||..||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

VGDTPFYADSLVGTYSKIMNHKNSLTFPDDND---ISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFF
 |.|||||.||| ||.||||||. . ||...    .|.||| ||.  .  .|.||||||... |.| ||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase ROCK1.AA CRIK 76-338 47 4.3e-128 410.6 In-house 1-272 (272) Show / Hide 
Range on Protein: 76-338
Range on HMM: 1-272/272
Sequence Identity: 47% (130 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEK
.||  .||.| ||.||.|| | |  .|||| . | ..  . . .|| ||||||. .||||. || |||||.  || .|||.|||||  ||. .|    | 
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGD----GYYGRECDWWSVGVFLY
 |||| || ..|.  .| ||..|||.||.| |.|  || ||||||   |||....|     ||||||. |||| .  |.    | || .|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLVGDTPFYADSLVGTYSKIMN------HKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFF
|| .| |||  |. . |||.|||       .  | ||||  .| .. .||   |...  ||   . | .. | ||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF
Kinase ROCK1.AA S_TKc 76-338 35 2.4e-99 337.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 76-338
Range on HMM: 1-231/231
Sequence Identity: 35% (100 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPG--GDLVNLMSNYD----
||....||.||||.| ..|||.| ...|.| ..            .. |..|.   . |..|.|...|||  .|||||||..|  |||  .. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGR-ECDWWSVG
    || .||||......||. .||.|.||||.||.| |||.  |.|..||| . ..        .| .|||.|..||||        ||. .|||||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

VFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLT-DREVRLGRNGVEE----IKRHLFF
. |||||.| .||.   .  .. ||.              |.|||..|.  |. | | |..   . .    || | .|
CILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ROCK1.AA RSK 79-338 39 4.6e-93 315.48 In-house 1-278 (278) Show / Hide 
Range on Protein: 79-338
Range on HMM: 1-278/278
Sequence Identity: 39% (110 aa)

VKVIGRGAFGEVQLVRHK---STRKVYAMKLLSKFEMIKRS-DSAFFWEERDIMAFAN-SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV---
.|| |.|..|.| |.| .    |...|||| |.| ....|  | .  ..||.|..  . .| .|.|.||||.. .||..|||..||.|    ..      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

-PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDK---SGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK---SQGGDGYYGRECDWWS
  |. |.|| ||.|||.. .|. |.|||| ||.|.|.|    .||.|| ||| | ... .   . .| ..| .|. ||.||    |||   ... |||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGG---HDKACDWWS

VGVFLYEMLVGDTPFYA---DSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLT-DREVRLG--RNGVEEIKRHLFF
 || .||||.| .||..   ..   .  .|.. | |||.| .. .|.|||.|| . |. | . |||  ....||||.| .|
LGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase ROCK1.AA Akt 76-338 40 8.5e-90 287.22 In-house 1-264 (264) Show / Hide 
Range on Protein: 76-338
Range on HMM: 1-264/264
Sequence Identity: 40% (110 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVY-AMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEK
 ...||.|.|.|| | ||. |.| |.| ||| |.|   |..   .    || |    |.| .|.| |.||.  .||.||.|..||.| ....   . .|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

WARFYTAEVVLALDAIHSMGFIHRD-VKPDNMLLDKSGHLKLADFGTCMKMN-KEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWS-VGVFLYE
 |||| ||..||... ||.. | ||  || | |.|| ||..|.||| | |.| .    ...|  ||| |..||.|. .|    ... .|||. .|...||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC-KENIIKDHDKTKTFCGTPEYLAPEILNGNG----HTKAVDWWGSLGCVMYE

MLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLT-DREVRLG--RNGVEEIKRHLFF
|. |  |||..     . ||.| .  . ||| . ||.|.|.||   |. |.. |||   |...||||| .|
MMCGRPPFYNQDHHQMFKKIKNQP--VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase ROCK1.AA NDR 76-218 55 9.9e-88 270.59 In-house 1-149 (350) Show / Hide 
Range on Protein: 76-218
Range on HMM: 1-149/350
Sequence Identity: 55% (83 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN--SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN---LMSNYDV
.|..|.||.|||||| |||.|.|...|||| . | ||...   |    |||||| |.  .|||| |.|.|||. ||| ||||.||||.     | ...|.
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

-PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFG
 .| ||||| || |.|....|.||.||||.|||| |.|| ||.|| |||
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase ROCK1.AA MAST 76-218 46 1e-76 233.71 In-house 1-147 (337) Show / Hide 
Range on Protein: 76-218
Range on HMM: 1-147/337
Sequence Identity: 46% (70 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKR--SDSAFFWEERDIMAFANSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYD--
.| .|.|..||.| | ||.||.|.. .||| . .  .|..   |..|   ||.| ...  |.|| .||.||   ..||.|||||| |||   |...|   
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFV--ERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNC

VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFG
 ||  |..|.|| ||.|. .||.| .|||.||||||.|. ||.||.|||
MPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase ROCK1.AA MAST 76-218 48 2.2e-73 235.82 In-house 1-144 (334) Show / Hide 
Range on Protein: 76-218
Range on HMM: 1-144/334
Sequence Identity: 48% (71 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKR--SDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPE
.| .|.|..||.| | ||.||.|.. .||| . | .||..   |. .   ||.| |.. .|.|| .||.|| ..||.|||||| |||.  |...|   .|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQV--ERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDE

KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFG
  |..|.||.||.|. .||.| .|||.||||||.|..|| ||.|||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase ROCK1.AA Pkinase 76-338 32 2.3e-72 251.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 76-338
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFW-EERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG----DLVNLMS---N
|.....||.|.||.| . .||.|.|..|.| ..| .  .  | . ..  |  ||.  |.| .|.|...|.|....||||||..||    ||  ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

YDV--PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHL----KLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDW
  .  .|. ..||  ... .|. .||||.||||.||.| |.|. ||.    |..||| . ...    . ..| .|||.|..|||..   |. |||...|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDM

WSVGVFLYEMLVGDTPFYAD------SLVGTYSKIMNHKNSLTFPDDNDIS-----------------KEAKNLICAFLT-DREVRLGRNGVEEIKRHLF
||.|. ||||| | .||. .      .    . .||  ...  .| ...||                 .|.| .|.  |. | . |..    |.|. | .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPW

F
|
F
Kinase ROCK1.AA NDR 234-338 45 1.8e-54 166.07 In-house 241-350 (350) Show / Hide 
Range on Protein: 234-338
Range on HMM: 241-350/350
Sequence Identity: 45% (51 aa)

AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSL-----TFPDDNDISKEAKNLICAFLT-DREVRLGRN
.||||||. |||.. ..|   |. .|||||.|. .|||||| .||..|.   |. |||| |. .     .|| .  .|.||..||  ... |.. |||..
TVGTPDYMAPEVFQQKTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSH

G--VEEIKRHLFF
|  |.||| | ||
GKGVDEIKSHPFF
Kinase ROCK1.AA MAST 235-338 41 1.2e-38 115.23 In-house 229-337 (337) Show / Hide 
Range on Protein: 235-338
Range on HMM: 229-337/337
Sequence Identity: 41% (47 aa)

VGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVG-TYSKIMNHKNSLTFPDD------NDISKEAKNLICAFLT-DREVRLGR
.||||||.|||.  ||    ||   ||||.|. .|| ||| .|| .|.    . ..| ||.. . .|..      . .|.||. ||  .|. .  .||| 
CGTPDYIAPEVILGQGT---YGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGA

NGVEEIKRHLFF
||..|||.| ||
NGADEIKQHPFF
Kinase ROCK1.AA MAST 235-338 39 1.7e-35 111.62 In-house 225-334 (334) Show / Hide 
Range on Protein: 235-338
Range on HMM: 225-334/334
Sequence Identity: 39% (45 aa)

VGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHK---NSLTFP----DDNDISKEAKNLICAFLTD-REVRLGR
.||||||.|||.. ||    .|   ||||.|. .|| ||| .||  |.   ....| |..   ... ..    ||. .|.||. ||  .|.   ..||| 
CGTPDYIAPEVILGQGT---HGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

N-GVEEIKRHLFF
| |..|.|.| ||
NNGADEVKQHPFF
Kinase ROCK1.AA TyrKc 76-332 20 5.5e-12 -28.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 76-332
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA--NSPWVVQLFYAFQDD-------RYLYMVMEYMPGGDLVNLMS
 .  |..|.|||||| . . |  ..| | | | .         . | .|  ||     . | .|.|. .  ..         |..||||||.||| .   
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKE-------GMVRCDTAVGTPD-----YISPEVLKSQGGD
..   .. |    .   .    . .||...||||    | |... .. | .||| . .   .        . |  .  |. .       .||..     .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

GYYGRECDWWSVGVFLYEML-VGDTPFYA-----DSLVGTYSKIMNHKNSLTFPDDND------ISKEAKNLICAFLTD--------REVRLGRNGVEEI
| .  . | || || ..|..  |..| .       |    . ....  . .  |...        ..|  ...              .|.      .|..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Kinase ROCK1.AA Pkinase_Tyr 76-163 29 3e-06 21.78 Pfam 1-96 (270) Show / Hide 
Range on Protein: 76-163
Range on HMM: 1-96/270
Sequence Identity: 29% (29 aa)

YEVVKVIGRGAFGEVQLVRHK-----STRKVYAMKLLSKFEMIKRS--DSAFFWEERDIMAFANSPWVVQLFYAFQ-DDRY--LYMVMEYMPGGDLVN
 .  |..|.|||||| . . |      . .| | | | |    ..     .|. | .  . . . | .|.|  .   ...   .|.||||||.||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase ROCK1.AA Pkinase_Tyr 190-218 37 0.035593 7.99 Pfam 128-156 (270) Show / Hide 
Range on Protein: 190-218
Range on HMM: 128-156/270
Sequence Identity: 37% (11 aa)

HSMGFIHRDVKPDNMLLDKSGHLKLADFG
.|...||||.   | |...... | .|||
ESKNCIHRDLAARNCLVTENNVVKICDFG
S_TK_X ROCK1.AA S_TK_X 341-401 22 8.3e-11 43.14 SMART 1-79 (79) Show / Hide 
Range on Protein: 341-401
Range on HMM: 1-79/79
Sequence Identity: 22% (18 aa)

DQWAWETLR----DTVAPVVPDLS----SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLP----------FVGFTYYS
... |..|.     . .| .|...    |..||||||. ....   .| . | .. ... .          | ||||  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Pkinase_C ROCK1.AA Pkinase_C 358-403 36 5.3e-09 34.96 Pfam 1-46 (46) Show / Hide 
Range on Protein: 358-403
Range on HMM: 1-46/46
Sequence Identity: 36% (17 aa)

DLSSDIDTSNFDDLEEDKGEEET-FPIPKAFVGNQLPFVGFTYYSNR
 ..|..||||||. ..|   ..|  . .  . |.|.||.|||| .  
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
HR1 ROCK1.AA HR1 458-537 17 9e-06 23.88 Pfam 1-74 (74) Show / Hide 
Range on Protein: 458-537
Range on HMM: 1-74/74
Sequence Identity: 17% (14 aa)

IKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLAN
 .|....|... | . .   |  . . ....   .|     .....| . ..|. ..... |..|||.|.. .|. . .|
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKH-----RKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
Rho_Binding ROCK1.AA Rho_Binding 948-1014 62 6e-38 131.6 Pfam 1-72 (72) Show / Hide 
Range on Protein: 948-1014
Range on HMM: 1-72/72
Sequence Identity: 62% (45 aa)

LTKDIEILRRENEELTEKMKKAEEEYKLEKEEE--ISNLKAAFEKN---INTERTLKTQAVNKLAEIMNRKD
||||.. |..|.|||..||||..||....||||  ....||.|||.   ..|||||||||||||||||||||
LTKDVANLANEKEELNNKMKKQQEELQKLKEEEQQMNQIKAQFEKCRAKLQTERTLKTQAVNKLAEIMNRKD
HR1 ROCK1.AA HR1 1073-1108 27 0.786046 6.11 Pfam 40-74 (74) Show / Hide 
Range on Protein: 1073-1108
Range on HMM: 40-74/74
Sequence Identity: 27% (10 aa)

RNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPS
| ..|..| . .. ||.|| .| .| ..... . |.
RQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
C1 ROCK1.AA C1 1229-1281 25 8.5e-13 49.76 SMART 1-61 (61) Show / Hide 
Range on Protein: 1229-1281
Range on HMM: 1-61/61
Sequence Identity: 25% (16 aa)

HEFIPTLYHFPANCDACAKPLWHVFKP---PPALECRRCHVKCHRDHLDKKED------LIC
| .. . .  |..|. | |..|..||.   .....|..|..||| ...||  .      . |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH ROCK1.AA PH 1119-1319 9 1.1e-08 36.07 SMART 1-82 (82) Show / Hide 
Range on Protein: 1119-1319
Range on HMM: 1-82/82
Sequence Identity: 9% (19 aa)

SRIEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDVEMEPVQQA
  .||||..       . .||| ..|. .. ...| |.       |.........  ||. .                                      
VIKEGWLYKKS-----K-RWKKRWFVLFNDCLYYYKDK------KPKGSIPLSDC-TVRE-P--------------------------------------

EKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACS-QDEQKKWVTHLVKKIP
                                                                   .  ...    ....|. ..|...|.... | | 
-------------------------------------------------------------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIH

KN
.|
NN
PH ROCK1.AA PH 1119-1203 22 2.7e-08 32.56 Pfam 1-67 (92) Show / Hide 
Range on Protein: 1119-1203
Range on HMM: 1-67/92
Sequence Identity: 22% (19 aa)

SRIEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANE
 ..||||..      || .||| ..|. ......| |..    ..| ........  |..|. .        . | .||| . ..
VIKEGWLHKKG----KRKSWKKRWFVLFNNCLYYYKDDK----YRPKGSIPLSDC-QVTKVPDN--------KRPHCFQIRT-DR
C1_1 ROCK1.AA C1_1 1229-1271 22 1.6e-05 23.96 Pfam 1-43 (55) Show / Hide 
Range on Protein: 1229-1271
Range on HMM: 1-43/55
Sequence Identity: 22% (10 aa)

HEFIPT-LYHFPANCDACAKPLWH-VFKPPPALECRRCHVKCHRD
| ....  .  |. |. |....|.  ..  ... |. ||..|| .
HHWVHHWNFKQPTFCCHCGEFCWGWLGH--QGWKCQWCHYNCHHR
PH ROCK1.AA PH 1301-1317 17 18.869881 0.67 Pfam 76-92 (92) Show / Hide 
Range on Protein: 1301-1317
Range on HMM: 76-92/92
Sequence Identity: 17% (3 aa)

SQDEQKKWVTHLVKKIP
|..| . |.... . . 
SEEEMNDWMQAIQSACR