Gene ROR1 (Human)

ROR1

Species: Human
Alias: MGC99659, NTRKR1, ROR1, dJ537F10.1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p31.3,

Classification

Group: TK
Family: Ror

Sequence

Name Sequence Type Origin Length Description Download
ROR1.NA RNA Sugen Kinome 3382 None Fasta, JSON
ROR1.AA Protein Sugen Kinome 937 None Fasta, JSON
ROR1.kin_dom Protein Kinase Domain Sugen Kinome 307 None Fasta, JSON

Protein domain

Protein domains of ROR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set ROR1.AA I-set 58-148 29 4.8e-20 70.52 Pfam 1-92 (92) Show / Hide 
Range on Protein: 58-148
Range on HMM: 1-92/92
Sequence Identity: 29% (27 aa)

LTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTI-YGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFV
 . . .  ... . |.||.. |.|.|.|||.. |||...|. .  .| ... .  . ..|.|.| .  |.|   |||||    ...|  | |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 ROR1.AA IGc2 70-138 30 1.3e-17 65.72 SMART 1-56 (56) Show / Hide 
Range on Protein: 70-138
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

SLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKE
  ||...| |...||| |.|.|.| . |.             ....|.|.|    | || .|.|.| . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG ROR1.AA IG 64-149 21 7.8e-13 49.88 SMART 1-58 (58) Show / Hide 
Range on Protein: 64-149
Range on HMM: 1-58/58
Sequence Identity: 21% (20 aa)

MNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDT---GYFQCVATNGKEVVSS--TGVLFVK
   .| ..|.|..|.| ||     .|.|.                       |.| |.   |.   | ..|.||  . ...|  .  | |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set ROR1.AA V-set 31-149 15 1e-06 24.61 Pfam 1-128 (128) Show / Hide 
Range on Protein: 31-149
Range on HMM: 1-128/128
Sequence Identity: 15% (23 aa)

ETELSV--SAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAELHCKVSGNP----PP-TIRWFKNDAPVVQEPRRLS-----------------
  ....  .. . |.                       .| ..||...|.|..| ..    .. .| |..   |  | |. ..                 
QSQVTQHPPRGC-PW----------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYP

-FRSTIY--------GSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVK
 |. ..            |.|.||   |.|   |...|. |..  .|.  . 
RFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGv ROR1.AA IGv 74-133 18 0.000739 9.59 SMART 1-76 (76) Show / Hide 
Range on Protein: 74-133
Range on HMM: 1-76/76
Sequence Identity: 18% (15 aa)

TAELHCKVSGNPPPTIRWFKNDA-----------PVVQEPRRLSFRSTIYGSR----------LRIRNLDTTDTGYFQCVA
...| ||.||.   .. |..               ..     .. | |. ..           |...||.  |||.. |  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY----SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
Fz ROR1.AA Fz 170-297 27 6.9e-56 172.35 Pfam 1-143 (143) Show / Hide 
Range on Protein: 170-297
Range on HMM: 1-143/143
Sequence Identity: 27% (39 aa)

CQPYR--GIACARFIGNRTVYMESLHM----QGEIENQ----ITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVL
|||.|  .  | ....|.|... .||.    |.|.|.|    |.. .....||.|||.||...... ||...||.|... ..|.|. .||. ||..... 
CQPIRNDIPMCHGMPYNMTWMPNLLHHETGTQKEAELQWEMMIHQWWPLVHTSTHLSPKCHPHIQFFLCSMYFPMCTDGFHHPPPIPPCRSMCEAVKEQG

CQTEYIF------ARSNPMILMRLKLPNCEDLPQPESPEAANCI
|. ....      .|..|.........||. .|.... ....|.
CEPVMQMMEDKKHRRMYPFGFHWPEMLNCNKFPHHHD-DRHMCM
KR ROR1.AA KR 311-393 45 1.7e-48 168.35 SMART 1-90 (90) Show / Hide 
Range on Protein: 311-393
Range on HMM: 1-90/90
Sequence Identity: 45% (41 aa)

HKCYNS--TGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELN----GGHSYCRNPGNQKEAPWCFTLDENFK-SDLCDIPACDS
. ||.   .|..|||||..|.||..||.|.||||| | |.. .||...    ..| |||||....| |||.| |.|.   . ||||.|..
RDCYWGDDNGESYRGTVNTTWSGHPCQRWDSQYPHLHWFYPEWFPCAGQLGLLEHNYCRNPDGDSEGPWCYTMDPNVRDWEYCDIPQCED
Kringle ROR1.AA Kringle 313-391 48 2.2e-34 120.16 Pfam 1-85 (85) Show / Hide 
Range on Protein: 313-391
Range on HMM: 1-85/85
Sequence Identity: 48% (41 aa)

CYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTF-TALRFPEL---NGGHSYCRNPGNQKEAPWCFT-LDENFKSDLC-DIPAC
||   |. ||||.|.|.|||.||.|.||.|| | | |. .||      |.| ||||| .. ..|||.|  |  .  . | |||.|
CYHGNGENYRGTWSTTESGRPCQRWDSQTPHRHPFYTPENFPCKGLGEGKHNYCRNPDGDERGPWCYTQTDPRVRWEYCSDIPRC
Kinase ROR1.AA Ror 473-779 75 3.6e-272 910.48 In-house 1-308 (308) Show / Hide 
Range on Protein: 473-779
Range on HMM: 1-308/308
Sequence Identity: 75% (233 aa)

VRFMEELGECAFGKIYKGHLYLPG-MDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHS
||||||||||.|||.|||||..|. |.|...|||||.|....|.||..|.||..|||.|||||||||||..|..||.||||||.|.||||||||||||||
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

DVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSS
|.|||||.|..|||||||.|||||||||||||||||||.|||.||||||.|.||..||||||.||.|.|||.||||.|.||..|||||.||||||||||.
DHGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSE

DSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTT
||||||||||||||.|.|.|||||.||||||||.|.|.||||...||...||||.|||.|||||||||||||.|||||..||.|.|||..||.|.|||||
DSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIHSRLRSWDNLSNHNSSTQTSGANNTTQTT

SLSASPVS
|||.||||
SLSTSPVS
Kinase ROR1.AA Pkinase_Tyr 473-746 43 5.9e-143 484.78 Pfam 1-270 (270) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-270/270
Sequence Identity: 43% (123 aa)

VRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQ--WTEFQQEASLMAEL-HHPNIVCLLGAVT-QEQP--VCMLFEYINQGDLHEFLIM
..|...||| |||..|||...  . .. . ||.|.||..  ..|  . .| .||..| .| ||||||.|.|..| |..|  ... .||   |||...|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

RSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYY-RVQSKSLLPIRWMPPEAIM
..             . | .|.. | |....|||.|||||.|. ..| ||||||.|..|...|||.| ||.| ||. ||| |..... |||.||.||.|.
HR-------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

YGKFSSDSDIWSFGVVLWEIFSFGLQP-YYGFSNQEVIEMV-RKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL
||||.. ||.|||||..||||..| || |.| ||.||.|.. .... .|| |.||. .|.||..||.. |..||.|..|| .|
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ROR1.AA TyrKc 473-746 41 5.6e-141 475.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-280/280
Sequence Identity: 41% (127 aa)

VRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAEL--HHPNIVCLLGAVTQE-------QPVCMLFEYINQGDLHEF
... ..|||.|||..|||...       . ||.|.||..       .| .||..| .|  ||||||.|.|..||.       .|.....||   |||...
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSA-------DYYRV----QSKS
|  . |.                | . |.|....|||.|||||.|. ..| ||||||.|.||...||||| ||||.||.        ||||.    ..|.
LRKHRPK----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

LLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYG-----FSNQEVIEMVRKRQLLPCSED--------CPPRMYSLMTECWNEIPSRRPRF
.||||||.||.|.||||.. ||.|||||..||||..| |||.|      ||||||| |...  .|. ..        ||. ||..|..||.| |. ||.|
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

KDIHVRL
..|| ..
SEIHECF
Kinase ROR1.AA Trk 473-746 43 7.50000000001e-115 387.86 In-house 1-275 (275) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-275/275
Sequence Identity: 43% (121 aa)

VRFMEELGECAFGKIYKGHLY-LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHS
...  |||| ||||.. .  | |.. .   .||.|||||  . .  ..|| || |. .| |..|| . |  | ..|  | ||| . ||| ..|  . |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

DVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYS-ADYYRVQSKSLLPIRWMPPEAIMYGKFS
..     ..   .  |  .. |.|| |||.|| |. |  ||| |.|.|| |.|..| |||.| |.||..||  |||||  .  |||||||||.||| ||.
MC-YAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFT

SDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQL-LPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL
 .||.||||||.||.|..| ||.|. ||.|||| . . .. | . . ||. .| .|  ||   | .|   |||| ..
YESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase ROR1.AA TK 473-746 25 2.2e-114 385.02 In-house 1-486 (486) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

VRFMEELGECAFG---KIYKGHLYLPGMDHA---------------------QLVAIKTLKDYNNPQQWTEFQ-------------QEASLMAELH----
... ..||| .||   ..||| .. .. ...                     . ||.|.||. .. .|  .|.             .||. |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVCLLGAVTQE------------QPVCMLFEYINQGD----LHEFLIMRSPHSDVGCSSDEDG---------------------------------
 ||||| |.|..||.            .|.... || . ||    |...|  ..|.    ... ...                                 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------TVKSSLDHGDFLH-------------------IAIQIAAGMEYLSSHFF------VHKDLAARNILIGEQLH-----------VKISDLG----
      .. ..|.. |.|.                   .. |||.|||||.|. .      || ||||||.|.||...           .||.| |    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSREIYS------------------------ADYYRVQSKSLLPIRWMPPEAIM---------YGKFSSDSDIWSFGVVLWEIFSFGLQPYYG-FS
    |.|.|||                         |||| ||.  ||||||.||...         ||||.. ||.|||||..||||..| .||||  |
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------QEVIEMVRK--------------RQLLPCSEDCP--------------PRMYSLMTECWNEIPSRRPRFKDIHVRL
|         |||.|..|.              |  .|. ..||              . .| ||..||.. |..||.|...| .|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ROR1.AA Musk 473-746 45 2.9e-109 362.29 In-house 1-282 (282) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-282/282
Sequence Identity: 45% (127 aa)

VRFMEELGECAFGKIYKGHL-YLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHS
. .  ..|| ||| ..      |   .   .||.| |||    |    || || .|||  ||||| |||     .| |.||||  .||| |||  .||| 
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

DVGCSSDEDG-------TVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAI
    .... |          . |   . | .| |||.|| |||   ||| ||| || ||.|.  |||.| ||||.||..|||. .     ||||||||.|
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

MYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL
.| .|. .||.|..||.||||||..|||||| .  |||  .|    | | | ||  .| || .||.  |. || |..||  .
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase ROR1.AA TK-Unique 473-746 35 7.2e-97 328.13 In-house 1-294 (294) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-294/294
Sequence Identity: 35% (104 aa)

VRFMEELGECAFGKIYKGHLYLPG--MDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELH-HPNIVCLLGAVTQEQ-PVCMLFEYINQGDLHEFLI-MR
... ...||.||| ...| .  .    |. . ||.|.|||......  .| .|...| ||  ||||| .||. |  . |.....||. .|.|  .|  .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SPHSDV--------GCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSS--HFFVHKDLAARNILIGEQLHVKISDLGLSREIY-SADYYRVQSKSLLPI
 .....        .  ...|.  ..... .|..|.|.||| |||||.|  . .||.||.|||.|..| . .||.|.|..|..|   .| . .|.. .||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMPPEAIM--YGKF-SSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDC-PPRMYSLMTECWNEIPSRRPRFKDIHVRL
|||.||..   .| . .. ||.|||||..||||..| .||.| .. ...|..|.   .|  | | ...||.|| .||.. |. || | .|  ||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ROR1.AA UTK 473-746 34 1.7e-92 313.62 In-house 1-296 (296) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-296/296
Sequence Identity: 34% (104 aa)

VRFMEELGECAFGKIYKGHL-YLPGMDHAQLVAIKTLK-DYNNPQQWT---EFQQEAS---LMAELH-HPNIVCLLGAVTQEQPVCMLFEYINQGDLHEF
|.....||. ||| ..|...   ..    ..||.|... . . .|. .   .|  ||    .|. .| |||.. |.| .|||.| ... ||  .|||  .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQ-------LHVKISDLG---LSREIY---------SAD
|   .|  .             .|.  . |. | .||.||.||.|. ||| ||||||.|....       . .||.|.|   .||...         ...
LRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESY

YYRVQSKSLLPIRWMPPEAIMYG-KFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKR--QLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKD
||. |.   .||||| |||. .. .|.. ||.||||||.|||...| .|| | ||..|.. |...  ...|| .||| ..| ||..||.  |..||.|.|
YYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

IHVRL
.  ..
LVQQM
Kinase ROR1.AA InsR 473-748 35 2e-88 297.12 In-house 1-278 (278) Show / Hide 
Range on Protein: 473-748
Range on HMM: 1-278/278
Sequence Identity: 35% (101 aa)

VRFMEELGECAFGKIYKG--HLYLPGMDHAQ-LVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSP
.    |.|. .||..| |     .|..  .   .||||...       .|| .||| | |  . ..| ||| ... ||     |   .|||  .|  | |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

HSDVGCSSDEDGTVK---SSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMY
          .. ..   .    ....  |..|. || || .  ||| |||.|| .. . . ||| | |. | ||  ||||   |..||.|||.|| .  
EEEF-----NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKD

GKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMV-RKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS
|.|.. ||.|||||||||. ..| ||| | || .| . . . . .|   | ||.... ||  ||   |. || |.||   |. 
GVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase ROR1.AA DDR 473-746 36 2.4e-85 289.85 In-house 1-306 (306) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-306/306
Sequence Identity: 36% (113 aa)

VRFMEELGECAFGKIYKGHLYLPG--------MD----HAQLVAIKTLKDYNNPQQWTEFQQEASLMAELH-HPNIVCLLGAVTQEQPVCMLFEYINQ-G
 .| | .||  || .    .  .         .|    |. ||| |.|.   .     .| .|.  |. .  ||||| |.|. ||. | ||. ||    |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLHEFLIMRSPH--SDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLG--LSREIYSADYYRVQS----
||  |.  . .   .  .|..| .   |.... .  ..|. |||.|| ||.|  ||| |||.||.|.|. .|.|| | |  .||  || |||||.     
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR

-KSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFG-LQPYYGFSNQEVIE----MVRK---RQLLPCSEDCPPRMY-SLMTECWNEIPSRRPRFK
 .  .||||| .|.|. |||.. ||.|.||| .||.|.|   |||   ..  |||    . |.    ..||    ||   |  ||..||.  .|.|| |.
QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE

DIHVRL
 ||  |
EIHKFL
Kinase ROR1.AA CTKA 596-746 46 1.3e-66 222.81 In-house 137-290 (290) Show / Hide 
Range on Protein: 596-746
Range on HMM: 137-290/290
Sequence Identity: 46% (71 aa)

AIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSA-DYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYY
| ||||||.||..  ||| |||.||.|.|   |.||.|.|..|   .   || |.|....|.||| |||.  ||||. ||.|.|||.||||.|.|  |. 
AMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWR

GFSNQEVIEMVRKR--QLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL
. | ||| . .     . ||    ||  .|..|.|||   |  || |  .   |
HMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase ROR1.AA Eph 599-746 45 1.7e-63 212.1 In-house 114-264 (264) Show / Hide 
Range on Protein: 599-746
Range on HMM: 114-264/264
Sequence Identity: 45% (69 aa)

IAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSAD----YYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYY
||.|| |||.. .|| ||||||||. ..|  |.||.||||.. . .     |  .  .  ||||  |||| |.||.| ||.||.|.|.||. |.|  || 
IASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYW

GFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL
  |||.||. . .   ||   |||. .. || .||   ...||.|..|.  |
DMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase ROR1.AA Pkinase 473-737 21 1.1e-36 130.75 Pfam 1-282 (293) Show / Hide 
Range on Protein: 473-737
Range on HMM: 1-282/293
Sequence Identity: 21% (67 aa)

VRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTL-KDYNNPQQWTEFQQ--EASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQG----DLHEFLI
 .. . .|. .||. ||.|    |     .||.|.. |. ...... .     |...|..|.||||| |..... .. ..| .|| . |    ||.... 
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

MRSPHSDVGCSSDEDGTVKSSL--DHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHV----KISDLGLSREIYSADYYRVQSKSLLP----
                  . ..  .  .  ... ||. |.||. |. ..| ||   |||| .. |.    ||.| ||.. ..        ..| .     
T---------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCG

-IRWMPPEAIM-YGKFSSDSDIWSFGVVLWEIFSFGLQPYYGF----SNQEVIEMVRKRQLLPCSEDCP-----------------------PRMYSLMT
 ...|.|| |. . . .. .|.||.|..|.| .. |  |..|     .  . ..|....   | ..|.|                       . . ....
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

ECWNEIPSRRP
 |..  |..||
WCLCKDPKKRP
Kinase ROR1.AA S_TKc 473-750 23 3e-36 127.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 473-750
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

VRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQ--GDLHEFLIMRSPH
 ......|. |||| ||..         ..|||| .|          ...| ... . |||||| |...    . ..| .||...  |||....  | .|
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

SDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFS
             .. ..  .  ... ||. ..||. || ..| ||   |||. |  |.||.| ||.|..         .       .|.|| .   ...
-----------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYG

S-DSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHV-----RLRSWE
   .|.||.|..|.| .. |  |..    |.......           .| . ...  |..  |..||   ..       ..  | 
KCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ROR1.AA Eph 473-564 37 1.8e-22 72.16 In-house 1-95 (264) Show / Hide 
Range on Protein: 473-564
Range on HMM: 1-95/264
Sequence Identity: 37% (36 aa)

VRFMEELGECAFGKIYKGHLYLPGMDHAQ---LVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFL
..  . .|.  || ...|.| ||  . ..   .|||||||.    .|. .|  |||.|    ||||. | | ||. .||  . || . | | .||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFL
Kinase ROR1.AA CTKA 473-561 32 2.5e-19 61.47 In-house 1-97 (290) Show / Hide 
Range on Protein: 473-561
Range on HMM: 1-97/290
Sequence Identity: 32% (32 aa)

VRFMEELGECAFGKIYKGHLYLPGMD-------HAQLVAIKTLKDYNNPQQWTEFQQEASLMA--ELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLH
   | ..||  .| ...  |  |  |         ..||.| |||  .  .  .|  || . .   .||||.. ||| .||..|  |  |..  ||||
HCIMFKIGEGHYGQVFRAWL-MPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLH