RSKL1

Species: Human
Alias: humS6PKh1, RPS6KC1, RSKL1, RPK118
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q32.3,

Classification

Group: AGC
Family: RSKL

Sequence

Name Sequence Type Origin Length Description Download
RSKL1.NA RNA Sugen Kinome 4206 None Fasta, JSON
RSKL1.AA Protein Sugen Kinome 1066 None Fasta, JSON
RSKL1.kin_dom Protein Kinase Domain Sugen Kinome 235 None Fasta, JSON

Protein domain

Protein domains of RSKL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PX RSKL1.AA PX 9-128 28 8.2e-17 60.18 Pfam 1-120 (120) Show / Hide
Range on Protein: 9-128
Range on HMM: 1-120/120
Sequence Identity: 28% (37 aa)

ADLARFYTVTEPQRH----PRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGR---FDETVIEERRQC
 ....  .|..|..|    ......|...  . ...  ....|  ||.||||| .|||.| . ..        .||.   ..|||   ||| .||.||| 
DHFLQ-VHVVDPETHKHYGDKMHYYYVYEIHMNTNP--FQKKEWHVWRRYSDFHWLHKQLKRHFP-----MCIIPPLPPKHWFGRYNNFDEEFIEKRRQM

AEDLLQFSANIPALYN-SKQLEDFFKGG
 |. ||  ...| | | .. . ||.   
LEQYLQRVCQHPELCNHCEVFHDFLHPD

PX RSKL1.AA PX 9-128 22 1e-15 59.47 SMART 1-142 (142) Show / Hide
Range on Protein: 9-128
Range on HMM: 1-142/142
Sequence Identity: 22% (33 aa)

ADLARFYTVTEPQRHPRGY--TVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGR-----------------
 ....  ||.|...|...|  . .....  ........|..  |..||||| .||. |   ..... ..  .||.    .|.|                 
DHIFI-ITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEK-RMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFN

-FDETVIEERRQCAEDLLQFSANIPALYN----SKQLEDFFKGG
 ||| .||.||.  |. ||  ...| . |    .. . .||   
NFDEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS

MIT RSKL1.AA MIT 236-314 37 2.7e-28 101.26 SMART 1-81 (81) Show / Hide
Range on Protein: 236-314
Range on HMM: 1-81/81
Sequence Identity: 37% (31 aa)

KRDYLEKAGELIKLALKKEE--EDDYEAASDFYRKGVDLLLEGVQGE-SSPTRREAVKRRTAEYLMRAESISSLYGKPQLDD
.|||..|| |.|..|.| .|  . |||.| . |.||.|.|..|...| ....||.|.... .|||.|.|.|.. .   .|. 
QRDYYQKAIEYITQAVKADEDEWGDYEQAIEHYQKGIDYLMQGIKYEKPDEKRRHAIWAKCREYLDRMEEIKNCHDW-RLCP

MIT RSKL1.AA MIT 239-307 33 2.2e-25 91.3 Pfam 1-71 (71) Show / Hide
Range on Protein: 239-307
Range on HMM: 1-71/71
Sequence Identity: 33% (24 aa)

YLEKAGELIKLALKKEE-EDDYEAASDFYRKGVDLLLEGVQGESSPTRREA-VKRRTAEYLMRAESISSLY
||.|| ||.| |....| . .||.| . |.............|..|..||| ......||. ||| | .. 
YLQKAIELVKKAVEADEDAGNYEEAIQCYQEAIEYFMQAIKYEPNPKWREARLRQKMQEYMDRAEQIKEHL

Kinase RSKL1.AA RSKL 341-416 40 8.1e-32 73.52 In-house 2-77 (436) Show / Hide
Range on Protein: 341-416
Range on HMM: 2-77/436
Sequence Identity: 40% (31 aa)

RVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYI
|| |.|.||..| |  |  ||. . | .    ||.. ..||  || |. | .|  ||...|| | | ..| |||..
RVVGIIKKVQVVQDPATGNTFYVMKLPRCHMVSRDCSIFIPHNVPYMTQLVRYFVSEDHIFLHLEHVQPGQLWSFL

Kinase RSKL1.AA Pkinase 385-417 32 5.764499 0.96 Pfam 60-96 (293) Show / Hide
Range on Protein: 385-417
Range on HMM: 60-96/293
Sequence Identity: 32% (12 aa)

PNMVCLHKYIISEESVFLVLQHAEGG----KLWSYIS
|| | |. .  .. .. .|. ..|||     |..|||
PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

Kinase RSKL1.AA RSKL 814-1056 38 6.8e-203 502.6 In-house 105-436 (436) Show / Hide
Range on Protein: 814-1056
Range on HMM: 105-436/436
Sequence Identity: 38% (128 aa)

TEESLFRICSPLSGAN-EYIASTDTLKTEEVLLFTDQTDDLAKEEPTS--------------------------------LFQRDSETKGESGLVLEGD-
| |    ||..||... .........|.|.|....|....|.|...||                                ..|.|.|...... ....| 
TSEVTVQICHNLSQYHDRHMQFQCGVKQERVQAMMDPHFSLMKPSDTSSGCTVGQDRIGMEPPRTSDFTIAGNSRPAAQIHYQQDEEYMPRAVAYFQSDS

------------------------KEIHQIFEDLDKKLALASR--------------------FYIPEGCIQRWAAEMVVALDALHREG-IVCRDLNPNN
                        ..||..||..||......|                    ..|||.||..||.||||||.|||.|| ..||||||.|
KSQPCRHNHIQSRRQNHSPNSSPVQKIHWVFEQADKEMFYCYRWRIRQCVQKQRALRRCGWNYWDIPEQCIRQWACEMVVALHALHAEGHVICRDLNPDN

ILLNDRGHIQLTYFSRWS-------EVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP---ECVSEEA
|||...||||||||..||       .|...|...|...||||||||.|.|.||||||||.||||.|||.|..|..|||.||..||.|.||   |.||..|
ILLDQKGHIQLTYFGQWSGLTSDDNWVCQQCNREAVTNMYCAPEVGQIWELTEACDWWSYGAVLYELLCGMSLYQCHPHGIQRHTQLQMPSEKEWVSHHA

RSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
..|..|||||||.||||.|..||..||.||||
KDLLTQLLQFNPMERLGMGQGGVDEIKAHPFF

Kinase RSKL1.AA AGC 882-1056 23 2e-70 180.38 In-house 122-395 (395) Show / Hide
Range on Protein: 882-1056
Range on HMM: 122-395/395
Sequence Identity: 23% (65 aa)

IHQIFEDLDKKLALA---SRFYIPEGCIQRWAAE-------MVVALDALHR-EGIVCRD-LNPNNILLNDRGHIQLTYFSRWSEVEDSC-----------
. ..  ...  | |     ... .| ... .|||       .| ||. ||.  ||..|| | | ||||...||| || |  . |. ...           
L-YCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMK

-----------------------------------------DSDAI---ERMYCAPEVGAITEETEACDWWS--LGAVLFELLTGKTLVECH--------
                                          .         | |||.      . ||||||  ||....|.|||..    .        
FHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHP

---PAGINTHTT---------LNMP----------ECVSEEARSLIQQLLQFNPLERLGAGVA-----GVEDIKSHPFF
   |. .              . .|          . .|.||..||..||. .| .|||.|       |.|.||.||.|
FRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase RSKL1.AA MAST 1018-1056 56 1.1e-19 56.18 In-house 301-337 (337) Show / Hide
Range on Protein: 1018-1056
Range on HMM: 301-337/337
Sequence Identity: 56% (22 aa)

ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
.|.|.||. ||..||| ||..||||.  |...||.||||
DCMSPEAQDLIKKLLQPNPKKRLGAN--GADEIKQHPFF

Kinase RSKL1.AA Akt 1014-1056 37 1.6e-16 49.22 In-house 220-264 (264) Show / Hide
Range on Protein: 1014-1056
Range on HMM: 220-264/264
Sequence Identity: 37% (17 aa)

LNMP--ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
...|  . .| |...|| .||. .| .|||.|  ....||.||.|
VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF

Kinase RSKL1.AA AktR 1008-1056 40 3.3e-16 59.08 In-house 217-268 (268) Show / Hide
Range on Protein: 1008-1056
Range on HMM: 217-268/268
Sequence Identity: 40% (21 aa)

INTHT--TLNMPECVSEEARSLIQ-QLLQFNPLERLGAGVAGVEDIKSHPFF
|....    . |...|.....||| .||. || .||| . .| |.|||||.|
IKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF

Kinase RSKL1.AA RSK 1013-1056 43 8.3e-16 54.56 In-house 233-278 (278) Show / Hide
Range on Protein: 1013-1056
Range on HMM: 233-278/278
Sequence Identity: 43% (20 aa)

TLNMP--ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
.|.||  . .|.||..||...|. .|  |||.|  ..|.||.||.|
SLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase RSKL1.AA SGK 1011-1056 43 2e-15 43.64 In-house 239-283 (283) Show / Hide
Range on Protein: 1011-1056
Range on HMM: 239-283/283
Sequence Identity: 43% (20 aa)

HTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
.  |..|  .| .|..|||.||| .| .|||.  .. ..||.||||
NQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF

Kinase RSKL1.AA NDR 1012-1056 40 7.6e-15 41.59 In-house 299-350 (350) Show / Hide
Range on Protein: 1012-1056
Range on HMM: 299-350/350
Sequence Identity: 40% (21 aa)

TTL-----NMPECV--SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
.|.     . |...  |.||  ||..|.  .| .|||..  ||..|||||||
QTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF

Kinase RSKL1.AA Pkinase 967-1056 20 1.1e-14 53.01 Pfam 177-293 (293) Show / Hide
Range on Protein: 967-1056
Range on HMM: 177-293/293
Sequence Identity: 20% (25 aa)

YCAPEVGA-ITEETEACDWWSLGAVLFELLTGKTLVECHP----AGINTHTTLNMPEC-----------------------------VSEEARSLIQQLL
|.||||    .. . ..|.||.| .|.|.|.|...   .       ..    ...  .                             .|||....|  .|
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

QFNPLERLGAGVAGVEDIKSHPFF
...| .|..      |.|. ||.|
CKDPKKRPT-----AEQILQHPWF

Kinase RSKL1.AA RSK 1017-1056 47 1.6e-14 48.45 In-house 232-271 (271) Show / Hide
Range on Protein: 1017-1056
Range on HMM: 232-271/271
Sequence Identity: 47% (19 aa)

PECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
.. .|.|| .|. ..|  .|  |||||  |||.||.||.|
WDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF

Kinase RSKL1.AA S_TKc 861-1056 23 6.3e-14 27.27 SMART 1-231 (231) Show / Hide
Range on Protein: 861-1056
Range on HMM: 1-231/231
Sequence Identity: 23% (59 aa)

LFQRDSETKGESGLVLEGDKEI-------------------------------HQIFE----------------DLDKKLALASR----FYIPEGCIQRW
    .   ||  | |  . .                                 . .|.                || . .    |    |..||  ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

AAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF--SRWSEVEDSCDSDAIERMYCAPEVGAITEETE-ACDWWSLGAVLFELLTGKTLVECHPA
..... ||. .|. ||. ||| | ||||..  || .. |  .|        ..    . |.||||      .  .|||||.| .|.|.|.|... .    
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----

GINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGV--EDIKSHPFF
  . ......    |.||...|...||..| .|..|  |    .|||.||.|
--QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase RSKL1.AA p70 910-948 48 2e-13 45.13 In-house 134-172 (299) Show / Hide
Range on Protein: 910-948
Range on HMM: 134-172/299
Sequence Identity: 48% (19 aa)

AAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF
..| ..||  ||  ||. ||| | |..|| .||. || |
LSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDF

Kinase RSKL1.AA SGK 910-946 56 4.7e-13 36.19 In-house 131-167 (283) Show / Hide
Range on Protein: 910-946
Range on HMM: 131-167/283
Sequence Identity: 56% (21 aa)

AAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLT
||| | ||. ||   |. ||| | |||| . ||. ||
AAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLT

Kinase RSKL1.AA NDR 911-946 47 6.2e-12 32.44 In-house 111-146 (350) Show / Hide
Range on Protein: 911-946
Range on HMM: 111-146/350
Sequence Identity: 47% (17 aa)

AEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLT
||||.|....|. |.. ||. | |.|.. .||| ||
AEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLT

Kinase RSKL1.AA NDR 967-997 50 7.1e-12 32.25 In-house 247-278 (350) Show / Hide
Range on Protein: 967-997
Range on HMM: 247-278/350
Sequence Identity: 50% (16 aa)

YCAPEVGAI-TEETEACDWWSLGAVLFELLTG
| |||| .  |. ...|||||||....|.|.|
YMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVG

Kinase RSKL1.AA AktR 910-999 33 2.3e-11 40.3 In-house 107-203 (268) Show / Hide
Range on Protein: 910-999
Range on HMM: 107-203/268
Sequence Identity: 33% (35 aa)

AAEMVVALDALHRE-GIVCRDLNPNNILLNDRGHIQLTYF--SR------WSEVEDS-CDSDAIERMYCAPEVGAITEE---TEACDWWSLGAVLFELLT
.|... ||. || .  |. ||| | ||||   ||. .| |  |.       .|...| |.. .    | |||.  ||..   . ..|||..|....|..|
FAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPE----YMAPEM--ITKKKGHNKSVDWWAFGIFIYEMVT

GKT
| .
GCP

Kinase RSKL1.AA RSK 910-946 52 3.4e-10 33.83 In-house 110-149 (278) Show / Hide
Range on Protein: 910-946
Range on HMM: 110-149/278
Sequence Identity: 52% (21 aa)

AAEMVVALDALHREGIVCRDLNPNNILLND---RGHIQLT
.|| |.|.. ||  ||. ||| | |||..|   .||| ||
MAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLT

Kinase RSKL1.AA MAST 911-946 55 3.9e-10 26.47 In-house 109-144 (337) Show / Hide
Range on Protein: 911-946
Range on HMM: 109-144/337
Sequence Identity: 55% (20 aa)

AEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLT
|| | .|. ||  ||| ||| |.|.|.   ||| ||
AETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLT

Kinase RSKL1.AA p70 1014-1056 44 5.1e-10 32.6 In-house 257-299 (299) Show / Hide
Range on Protein: 1014-1056
Range on HMM: 257-299/299
Sequence Identity: 44% (19 aa)

LNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
|..|   ..|.| ||..||  .| .|.|||   ..||..||||
LKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF

Kinase RSKL1.AA RSK 967-999 41 6.8e-10 32.72 In-house 174-210 (278) Show / Hide
Range on Protein: 967-999
Range on HMM: 174-210/278
Sequence Identity: 41% (16 aa)

YCAPEVGAIT----EE--TEACDWWSLGAVLFELLTGKT
|.|||.  ..    ..  ..||||||||....|.|||..
YMAPEM--LKRANQQGGHDKACDWWSLGVLMYEMLTGCP

Kinase RSKL1.AA Akt 910-946 47 2.3e-09 26.0 In-house 106-143 (264) Show / Hide
Range on Protein: 910-946
Range on HMM: 106-143/264
Sequence Identity: 47% (18 aa)

AAEMVVALDALHREGIVCRD-LNPNNILLNDRGHIQLT
.||.. |...||  .|. || | | |||.   ||| ||
CAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLT

Kinase RSKL1.AA RSK 910-946 46 2.9e-09 29.44 In-house 107-147 (271) Show / Hide
Range on Protein: 910-946
Range on HMM: 107-147/271
Sequence Identity: 46% (19 aa)

AAEMVVALDALHREGIVCRDLNPNNILLNDR----GHIQLT
.||   |.. ||  ||| ||| | |||. |     ||| ..
MAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKIC

Kinase RSKL1.AA SGK 967-998 43 5.4e-08 20.29 In-house 191-222 (283) Show / Hide
Range on Protein: 967-998
Range on HMM: 191-222/283
Sequence Identity: 43% (14 aa)

YCAPEVGAITEETEACDWWSLGAVLFELLTGK
| |||| .  .   . |||.||.||.|...|.
YLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGL

Kinase RSKL1.AA RSK 979-999 57 1.6e-07 23.17 In-house 183-203 (271) Show / Hide
Range on Protein: 979-999
Range on HMM: 183-203/271
Sequence Identity: 57% (12 aa)

TEACDWWSLGAVLFELLTGKT
..||||||.|....| ||| |
DQACDWWSFGVLMYEMLTGCT

Kinase RSKL1.AA Akt 979-997 50 2.8e-07 19.26 In-house 180-199 (264) Show / Hide
Range on Protein: 979-997
Range on HMM: 180-199/264
Sequence Identity: 50% (10 aa)

TEACDWWS-LGAVLFELLTG
| |.|||. ||.|..|...|
TKAVDWWGSLGCVMYEMMCG

Kinase RSKL1.AA p70 967-998 43 4.6e-07 21.8 In-house 204-235 (299) Show / Hide
Range on Protein: 967-998
Range on HMM: 204-235/299
Sequence Identity: 43% (14 aa)

YCAPEVGAITEETEACDWWSLGAVLFELLTGK
|.|||.   .    |.||||||. ..  |||.
YMAPEILMRCGHNHAVDWWSLGCLMYDMLTGG

Kinase RSKL1.AA MAST 983-997 53 3e-06 14.23 In-house 251-265 (337) Show / Hide
Range on Protein: 983-997
Range on HMM: 251-265/337
Sequence Identity: 53% (8 aa)

DWWSLGAVLFELLTG
||||.| ...|.|.|
DWWSMGIIMYEFLVG

Kinase RSKL1.AA Pkinase 879-943 23 2.1e-05 20.2 Pfam 72-147 (293) Show / Hide
Range on Protein: 879-943
Range on HMM: 72-147/293
Sequence Identity: 23% (18 aa)

DKEIHQIFEDLDK-----KLA--LA--SRFYI--PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHI
...|. ..| ...      |.  .   ..  .  .|  ..... ... .|. .|..||. ||| | |||....|||
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHI