Gene SCYL2 (Human)

SCYL2

Species: Human
Alias: FLJ10074, KIAA1360, SCYL2, CVAK104
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 12q23-q24.1,

Classification

Group: Other
Family: SCY1

Sequence

Name Sequence Type Origin Length Description Download
SCYL2.NA RNA Sugen Kinome 5525 None Fasta, JSON
SCYL2.AA Protein Sugen Kinome 933 None Fasta, JSON
SCYL2.kin_dom Protein Kinase Domain Sugen Kinome 296 None Fasta, JSON

Protein domain

Protein domains of SCYL2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SCYL2.AA SCY1 47-327 37 1e-147 497.01 In-house 1-337 (337) Show / Hide 
Range on Protein: 47-327
Range on HMM: 1-337/337
Sequence Identity: 37% (127 aa)

WKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRG-VQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPIS----
|||.|||||.|.||..|||||||.|.|..|......|...... ...|.|||||..|...||||||.||....||..|..|.|||..|.|..|...    
WKIHNGTKKYTGQECSVFVFDKKNIEKWHKDSWWEEICEFLKKQAKRLKRLRHPNILQYIHPLEESKDCMMYATEEIFQPLENVLKKWDNKKSCQTQKTQ

-------------PDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMG---------FDFCVSSTNPSEQEPKFPCKEW-
             ...||.||...|...|..|....|||||....|||.||.||.|..||.|.|||.|         .||.....|. .|.|.|||.|| 
DVDFGQNTQPQRPYHKKDWKLDELEVCWGIFQILDALSFLHNDCHMVHNNICPESIFVNKNGDWKIGGDDDDAGGWGMDFVCDIQNGNPQMPWFPCQEWR

------------DPNLPSLCLPNPEYLAPEYILS-------------VSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSL
            |...|..|.|||..||||||..             ..|..||||.|||.....|.|..||... |... |..|.|...|.........
EMDYISVSSTKPDNKYPPPCQPNPDWLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNP-YSTFHRYMEQWNAMSHCWW

TNIPEEVREH----VKLLLNVTPTVRPDADQMTKIPFF
..||.|..||    .. ||...||.|||..|......|
DHIPKELQEHLGHCYCHLLHQDPTCRPDPQQFLQHCYF
Kinase SCYL2.AA Ciliate-E2 160-327 18 1.8e-15 49.57 In-house 153-365 (365) Show / Hide 
Range on Protein: 160-327
Range on HMM: 153-365/365
Sequence Identity: 18% (41 aa)

QVSE---------------GLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFC--VSSTNPSEQEPKFPCKEWDPNL--PSLCLP------------
|. .               .| .|||  . .| .| ||||..      ||  | ..  ..  |  ... |  ||..       | .              
QILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFN

----NPEYLAPEYILSVS---------CETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSF-----SRQLDQLSRLGSS--SLTNIPEEVREHVKL--
    .|.|.||| . . .           ...|..||| ..|    .  | .. .||  .. .     .. .. .  .  .  |  ....|.    |   
TICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFG

--LLNVTPTVRPD-ADQMTKIPFF
  .|.. |  |.. ..|  . |.|
KRMLQKDPEKRITGWEQILNHPWF
S_TKc SCYL2.AA S_TKc 32-327 17 5.7e-15 42.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 32-327
Range on HMM: 1-231/231
Sequence Identity: 17% (55 aa)

FDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFA---SLAN
....|.| .|. |  .|  .     |...||. . .                ....| .| | . .|| . .     ..  |.| ...| .     .|  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFD

VLGNWEN--LPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLC
.. .     |..|...... |          . |. ..| ..||  . .|  . |||| |..    ||  | ..                       . .
YIKKRGRHGLRFPFPEHARFY----------MYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTF

LPNPEYLAPEYILSVSCET-ASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTK--
   |.|.||| .   .  . ..|..|.| ..|  .  |.| |. . | ..|                    ..|... .. .|.. |. || | .  .  
CGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----IPFF
      |.|
WDIKCHPWF
Kinase SCYL2.AA Ciliate-E2-Unclassified 153-327 17 1.3e-14 47.11 In-house 139-352 (352) Show / Hide 
Range on Protein: 153-327
Range on HMM: 139-352/352
Sequence Identity: 17% (37 aa)

ETK-----YGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSG---AWKIMGFDFCVSSTNPSEQEPKFP---CKEWDPNLPSLCLPNPEYL----APEY
..|     . . |. .||..||.. . .| .|.||||.....|     || .| ..  . ...... ..     . |.... . .  .|.|.    |||.
QAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV

ILSVSCE----TASDMYSLGTVMYAVFNKGKPIFEVNKQDIYK--------------SFSRQLDQLSRLGSSSL----TNIPEEVREHVK----LLLNVT
. .   .     ..|..||| ..|.    |.. |. |......               .. ....     ...      ....|. . ..     .|.. 
LQGQNYDHSKAYKCDIWSLGVILYEMLF-GYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKN

PTVRPDADQMTKIPFF
|  |....|  . |.|
PNKRITFEQILNHPWF
Kinase SCYL2.AA TKL 159-325 12 1.9e-07 22.91 In-house 139-364 (364) Show / Hide 
Range on Protein: 159-325
Range on HMM: 139-364/364
Sequence Identity: 12% (29 aa)

LQVSEGLSFLHSSVK-------MVHGNITPENIILNKSGA--------------WKIMGFDFCV-SSTNPSEQEPKFPCKEWDPN--------LPSLCLP
|... |...|||.         ..| .....|| ... .                ||  | ..   |.. . .  .  ..|              . .  
LDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME---SAEHQNNRKTTMTQCG

NPEYLAPEYILSV----------------SCETASDMYSLGTVMYAVFNKGKPIFEVN--------------KQDIYKSFSRQLD-----QLSRLGSSSL
.| ..||| .                   .  ...|.|| | |.. ..   .| .. .              .....|.    ..      . . . .  
TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPC

TNIPEEVREHVKLLLNVTPTVRPDADQMTKIP
...|.....  .   .  |. || ... .|. 
PDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase SCYL2.AA Dicty3 163-199 15 5.1e-07 19.0 In-house 122-184 (351) Show / Hide 
Range on Protein: 163-199
Range on HMM: 122-184/351
Sequence Identity: 15% (10 aa)

EGLSFLHSSVKMVHGNITPENIILNKSG--------------------------AWKIMGFDF
..|...| . . .|..|...||.|..                             ||. .|..
KTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDIQCYYSNEINWKLIDFGL
Kinase SCYL2.AA Akt 230-257 48 1e-06 17.4 In-house 166-194 (264) Show / Hide 
Range on Protein: 230-257
Range on HMM: 166-194/264
Sequence Identity: 48% (14 aa)

PEYLAPEYILSVSCETASDMYS-LGTVMY
||||||| .. . .  |.| .. || |||
PEYLAPEILNGNGHTKAVDWWGSLGCVMY
Kinase SCYL2.AA SGK 230-257 42 2e-06 15.38 In-house 189-216 (283) Show / Hide 
Range on Protein: 230-257
Range on HMM: 189-216/283
Sequence Identity: 42% (12 aa)

PEYLAPEYILSVSCETASDMYSLGTVMY
||||||| ..   .  . | ..||.|.|
PEYLAPEVLRKQPHDRTVDWWCLGCVLY
Kinase SCYL2.AA Pkinase 230-327 23 3e-06 23.17 Pfam 175-293 (293) Show / Hide 
Range on Protein: 230-327
Range on HMM: 175-293/293
Sequence Identity: 23% (28 aa)

PEYLAPEYIL-SVSCETASDMYSLGTVMYAVFNKGKPIFEVNK-----QDIYKSFSRQLDQLSRLGSSSLTNIP-----------------EEVREHVKL
|.|.||| |. .    ...||.|.| ..| ... |.|.|  ..      | .. . | ..   .  .. . .|.                 || .. .| 
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

LLNVTPTVRPDADQMTKIPFF
.|.. |. || |.|  . |.|
CLCKDPKKRPTAEQILQHPWF
Kinase SCYL2.AA PLK1 153-327 25 5e-06 15.47 In-house 100-253 (253) Show / Hide 
Range on Protein: 153-327
Range on HMM: 100-253/253
Sequence Identity: 25% (44 aa)

ETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSL
|..| . |. ||  .||   |..|  .   |. ||     ||   || .  .   . | |            ||   | |.||| .         |..|.
ECRYYMYQIVEGCQYLH-NNKIIHRDLKLGNLFLNDHLQVKIG--DFGLATKCEYDGERKK----------TLC-GTPNYIAPEVLNKKGHSFEVDIWSI

GTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPFF
| .|| .   |.| ||       |.      .. .   .  ..| .  .. .. .|.  || || ..|. .. ||
GCIMYILL-FGQPPFET------KCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase SCYL2.AA WEE 158-188 45 7e-06 15.7 In-house 117-147 (297) Show / Hide 
Range on Protein: 158-188
Range on HMM: 117-147/297
Sequence Identity: 45% (14 aa)

LLQVSEGLSFLHSSVKMVHGNITPENIILNK
|.....||...||.  |||  | |||| ..|
LVDICQGLHHIHSNCGMVHMDIKPENIFISK
Kinase SCYL2.AA AGC 230-257 43 6.9e-05 6.99 In-house 271-296 (395) Show / Hide 
Range on Protein: 230-257
Range on HMM: 271-296/395
Sequence Identity: 43% (13 aa)

PEYLAPEYILSVSCETASDMYS--LGTVMY
|||.||| .    .  | | .|  || .||
PEYMAPEIL----YGKACDWWSFGLGCLMY
Kinase SCYL2.AA AGC 295-327 20 0.002014 3.12 In-house 353-395 (395) Show / Hide 
Range on Protein: 295-327
Range on HMM: 353-395/395
Sequence Identity: 20% (9 aa)

NIPEEVREHVKLLLNVTPTVRPD----------ADQMTKIPFF
.. .| .  .| ||.. |. |.           |..  . |.|
WFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase SCYL2.AA Ciliate-E2 32-87 17 0.01342 4.72 In-house 1-71 (365) Show / Hide 
Range on Protein: 32-87
Range on HMM: 1-71/365
Sequence Identity: 17% (13 aa)

FDVGRHIASGGNG---LA----------WKIFNGTKKSTKQ----EVAVFVFDKKLIDKYQKFEKDQIIDSLK
... . | .|. |   ..           ||.. .|.   |    .|... . .| . |.|.... |.|. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMR
Kinase SCYL2.AA WEE 229-257 33 0.27472 0.16 In-house 196-227 (297) Show / Hide 
Range on Protein: 229-257
Range on HMM: 196-227/297
Sequence Identity: 33% (11 aa)

NPEYLAPEYILSV--SCETA--SDMYSLGTVMY
...|.||| ||.   .. ..  .| .||| ..|
DSRYMAPE-ILQGYYHYTHLYKADIFSLGITIY