Gene SLK (Human)

SLK

Species: Human
Alias: MGC133067, STK2, KIAA0204, SLK, bA16H23.1, se20-9
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 10q24.33-q25,

Classification

Group: STE
Family: STE20
Subfamily: SLK

Sequence

Name Sequence Type Origin Length Description Download
SLK.NA RNA Sugen Kinome 5629 None Fasta, JSON
SLK.AA Protein Sugen Kinome 1235 None Fasta, JSON
SLK.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of SLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SLK.AA SLK 34-292 76 1.2e-186 626.33 In-house 1-259 (259) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-259/259
Sequence Identity: 76% (198 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQ
|||||||||||||||||||.||..|.||||.|..|.||||||||||||||..|.|||||||..|.||.|.||..||||.|||||..|.|||.||||.|||
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

VVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEP
.|||....|||.||.||.|||||||||||.|.|||..||||||||||..|.|.||.|||||||||||||||||.||.|||||||.|||||||||||..||
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
||||.|||||||||.|||||||.|||.||..|||||||||.|....||||.||.||..|
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase SLK.AA STE20 34-292 44 8.20000000001e-154 517.29 In-house 1-288 (288) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-288/288
Sequence Identity: 44% (129 aa)

WEIIGELGDGAFGKVYKAQNKETSVL----AAAKVIDTKSE----EELEDYMVEIDILASCDHPNIVKLLDAFYYE----NNLWILIEFCAGGAVDAVML
.|.. ..| |..|||||| .|.|  .    .| |... ...    .|.|| . ||.|.. |.|||||| .......    ..|||..|.|.|| .  .| 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ELER-----PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTR----TIQ-RRDSFIGTPYWMAPEVVMCETSK
   ....     |..|.|| ..|...| .|.||| |.|||||.||.||| | ||..|||||||.|. |.    |.| .|..|.||||||||||..|....
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIA--KSEPPTLAQ--PSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
| .||||.|.||||||.||||| |||.....|||....|.  . .|||| .  |..||..|.||..|||.|... |.|.||||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase SLK.AA STE 34-292 33 9.20000000001e-130 437.39 In-house 1-359 (359) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-359/359
Sequence Identity: 33% (122 aa)

WEIIGELGDGAFGKVYKAQNKE---------------TSVLAAAKVIDTKSE-----------------EELEDYMVEIDILASCD--HPNIVKLLDAFY
||.|...| ||||.|||| |..               | .. | |... ...                 ||..... ||.|.  |.  |||||| .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YE-------NNLWILIEFCAGGAVDAVML---ELERPLT----------ESQIQVVCKQTLDA-LNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSA
.|       ..|||  |...|| .| ..    .  .||.          |||| ..|.|.| . |.|||...|||||.|..|||.     .||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KNTR---------------TIQ-RRDSFIGTPYWMAPEVVMCETSK-DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS-----------
. |                |.| .|..|.||| ||||||....... | .||.|.|.||||.|.||||. .||.|...|||... |...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----EPPTLAQ-----------------PSRWSSNFKDFLKKCLEKNVDARWTTSQLLQ--HPFV
    .||.| .                 |..||..||||..|||.|. . |.|.||||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase SLK.AA MST 34-292 47 2.7e-121 387.32 In-house 1-254 (254) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-254/254
Sequence Identity: 47% (124 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY--YENNLWILIEFCAGGAVDAVMLELERPLTESQ
 .|.. || |..|.|||| .|.|. . | |.. .  .| |..   || |.  |. ..|||. . ..  ..| .|| .|.|..| |  .|    |.|.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEI
| .....||  | ||||||.||||.||||||   .|  ||||||||.  | |   |...||||||||||| .   .|   ||.||| |||||| ||||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ--EIK---YDCKADIWSLGITAIEMAEG

EPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
.|| ... |||.. .| .. |||.  |..||..| ||..||| || . |||  |||||||.
MPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase SLK.AA YSK 34-292 41 2.4e-107 324.3 In-house 1-257 (257) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-257/257
Sequence Identity: 41% (109 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVID-TKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLE-LERPLTESQ
. .    | | || |||. .. |    | |.||  ..|.| ||   || .|..|| |.| | . ..     |||  |.|.|| .   |      .. |..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEI
| .. .  | .| ||| .. |||| || |.| . .||.||.||||... | | ..|. |.||||||||||...| |.   ||.|||.|||||| .|||  
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSY---YDFKADIWSLGITAYEMAKG

EPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
|||. .. ||||.  | |..||.|   . .| .||.|   ||.|.   | . ..|| | |.
EPPYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase SLK.AA S_TKc 34-292 33 7e-101 342.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAG--GAVDAVMLELERP-----
.||. ..| ||||||||...|.|  . | |.|.       |. . ||.|| . .|||||||.|.|.  ..|..  |.| |  | .  .. .  |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDY-KADVWSLGITL
..| ... ...|...||.|.|...|||||||  |||..    ||..|||....        ..|.|||..|||||.        .|.. |.|.||.|..|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQ-------HPFV
.||.  .|| .    | ...|. .            |. .|||..|||.|. . |.|  ..||       ||..
YEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SLK.AA KHS 34-292 45 8.3e-96 322.74 In-house 1-258 (258) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-258/258
Sequence Identity: 45% (118 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQ
.|..  .| | .| ||||...... ||| |||    .....    || ..  | |||||    ..  .. ||| .|.| ||..  .  ..  ||.| || 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIY-HVTGPLSELQIA

VVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEP
 ||..|| .|.||| .. .|||.|  ||| | .||.|||||||||. | || .| |||||||||||||   |  .   |.   |.|..||| ||.||. |
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--RKGGYNQLCDIWAVGITAIELAELQP

PHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
|  .| |||.|. ..||  .||.| . ..||..| .|.| .| ||   | | ..|||||||
PMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase SLK.AA PAKA 34-292 38 3e-94 319.4 In-house 1-260 (260) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-260/260
Sequence Identity: 38% (102 aa)

WEIIGELGDGAFGKVYKAQNKETSVL--AAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELER----PL
 . . ..| || |.||.| |..|      | |... | .   |  . || .. .| |.|||. .|.. ..  ||. .|. .||    |  . ..    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIE
.|.||  ||...| .|...|....||||.|  |||   ||..|..|||  |  |.  |.|..  ||||||||||.     . . ||.| |.||||| .||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVI-----RRKQYDEKVDIWSLGIMAIE

MAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
|.| |||. . .| | .  ||.   | . .| .||..|.|||.|||...|| |.....||.||| 
MIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase SLK.AA PAKL 34-292 43 2.4e-93 316.44 In-house 1-256 (256) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-256/256
Sequence Identity: 43% (113 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYE-NNLWILIEFCAGGAVDAVMLELERPLTESQI
 |.   ||.|..| ||||  |.|    | |||  |   | .|   ||.||  |  ||||        . |..||| ..|. | .  .|   .  |.| ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

QVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQ-RRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEI
 |. .|||  | |||   ||||| || ||| . |...|.|||||| .   .      . ||||||||||..     .  .|..|.|.||||||.||||. 
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEII-----NKQNYNNKCDIWSLGITAIEMADG

EPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
.||| ...||| .. |    |||.. |  ||  | ||| .|. |    ||  ..|| ||| 
FPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase SLK.AA Pkinase 34-292 30 5e-91 313.52 Pfam 1-293 (293) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV----EIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGG----AVDAVML-ELE
..|.. .| |.||.|||...| |. . | |.|. ..|.. .|.      || |.....|||||.|.|.|........  |.| ||       ...  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RPL--TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDI----KLADFGVSAKN-TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKAD
...  .| ... ...|.| .|.|.|...|||||||  |||.  .|.|    |..|||....  .   .  ..| |||..|||||..    ....|..|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVD

VWSLGITLIEMAEIEPPHHEL----NPMRVLLKIAKSEPPTLAQPSRWS---------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV
.||.|..|.||.  .||  .     | .. . .|..  .| |  .. |.                     ...|||.|.||.|.   |.|  |.||||..
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SLK.AA NinaC 34-292 41 6.5e-89 301.69 In-house 1-267 (267) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-267/267
Sequence Identity: 41% (110 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDIL-ASCDHPNIVKLLDAFYYEN-----NLWILIEFCAGG-AVDAV--MLELE
|||. . | | .|||.|..||.   .|| |. .  .. . |.   |  || . |||||.|.    .|         ||. .|.|.|| ..| |  .| ..
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHD-EEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCG

RPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGIT
| . |  |  . . .. .|  || |..|||| |  ||| | .| .|| ||||||  . |  ||   .|||.||||||. |. . |  ||  .||||||||
RRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGIT

LIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
 ||..  .||  .. ||| . ||    |||| .|  |.  | ||  .||||.   | . ...|.|||.
AIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase SLK.AA MSN 34-292 43 2.1e-87 288.65 In-house 1-265 (265) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-265/265
Sequence Identity: 43% (117 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILAS-CDHPNIVKLLDAFY------YENNLWILIEFCAGGAV-DAVMLELER
.|..  .| |..|.||| . . |. ||| ||.| . .|| |.   ||..|     | ||.    ||        .. ||. .|||. |.| | |    ..
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEE-EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITL
 | |  |  .|.  |  | .|| .|.||||.|  |.|.| . ..|| ||||||.  ||. || .||||||||||||. |. . |. |||..|.||.||| 
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
||||| .||  .. ||| |. | .  ||.|   ..||  |..|. ||| ||   | .| |.|.|||.
IEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase SLK.AA Pkinase_Tyr 34-177 30 1.4e-22 77.13 Pfam 1-158 (270) Show / Hide 
Range on Protein: 34-177
Range on HMM: 1-158/270
Sequence Identity: 30% (48 aa)

WEIIGELGDGAFGKVYKAQNK----ETSVLAAAKVI-DTKSEEE--LEDYMVEIDILASC-DHPNIVKLLDAFY-YENN--LWILIEFCAGGAVDAVMLE
 ... .|| ||||.|||.  |    .| .  | |.. .. ..|.  .|| | |. |. .  .|||||.|. . .  .    ..|  |....|  .    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

L---ERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS
    ..||| ...   | |  ....||.....||||| | |.| | .. .| .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase SLK.AA TyrKc 34-292 23 6.8e-19 70.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASC--DHPNIVKLLDAFYYE-------NNLWILIEFCAGGAVDAVMLELE
 . . .|| ||||.|||.. |   .  | |..   .   .|| | |. |. .   .|||||.|. .   .         |.|. |....|. .    . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRT--------IQRRDSFIGTP-----YWMAPEVVMCETSKDRP
. |. ..    | |  .  .|||....||||| | |.| . .. .| .||| | . .            |  .  |.       |||||.      ... 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGK

YDYKADVWSLGITLIEMAE-IEPPHHE-----LNPMRVLLKIAKSEPPTLAQPSR--------WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
.  | |||| |... |.    ..|. .     ... .|. .. . .   . ||           ..   .  |.| . . . | | |..  | . 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SLK.AA Pkinase_Tyr 196-280 23 2e-06 22.72 Pfam 180-260 (270) Show / Hide 
Range on Protein: 196-280
Range on HMM: 180-260/270
Sequence Identity: 23% (21 aa)

WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPP-HHELNPMRVLLKI-AKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDAR
|||||. .        .  | |||| |... |.    | |   .. . .|. .|  . .   ...|   .    | .|.| ... . |
WMAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDR
PKK SLK.AA PKK 851-990 37 9.3e-41 146.52 Pfam 1-144 (144) Show / Hide 
Range on Protein: 851-990
Range on HMM: 1-144/144
Sequence Identity: 37% (54 aa)

KLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKK--EVINEVEKAP--KELRKELMK
|.|.|.||. ..|.|.......... |.|..|.||||.||..||..|...|...|||. ||||.. .|.. ||..||  |.  |||| |  .| ||. ||
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

RRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIE
...||. | .  |||||| ....... ...... ... .|...|
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE
PKK SLK.AA PKK 1019-1160 51 5e-65 227.15 Pfam 1-144 (144) Show / Hide 
Range on Protein: 1019-1160
Range on HMM: 1-144/144
Sequence Identity: 51% (74 aa)

KHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTA-TPDQDRDKIKQFAAQEEKRQK
|||| |.|.|||.|.||||.||||||| |||.|.....||... |||||| ||||..|.|...||.|||.||.|.... .| |...|..||  |...|.|
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

NERMAQHQKHENQMRDLQLQCEANVRE-LHQLQNEKCHLLVEHE
.|.  ..|||..|..... ||| |..| . |.|||..|.|.|||
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE