Gene smMLCK (Human)
smMLCK
Sequence
Protein domains of smMLCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| I-set | smMLCK.AA | I-set | 33-123 | 43 | 4.3e-34 | 118.2 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 33-123 Range on HMM: 1-92/92 Sequence Identity: 43% (40 aa) PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS-GGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTV | |. .|... ..|| ||.|| .|.|.|.|||.|...|||... . |. .. .|| .| | | .| ||||| ||| .| ..|.|||| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | smMLCK.AA | IGc2 | 45-113 | 30 | 2.2e-14 | 55.06 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 45-113 Range on HMM: 1-56/56 Sequence Identity: 30% (21 aa) KEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSG .|| .. .. ...|.|.|...| . |||. . .| | | .||.|.|||.|.| | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | smMLCK.AA | IG | 39-124 | 24 | 2.9e-12 | 47.97 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 39-124 Range on HMM: 1-58/58 Sequence Identity: 24% (22 aa) PRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDR---GKYTCEATNGSGARQV--TVELTVE |. . ||| |.... | |..|. |.| | .|| | |.|.|| .| . ...|||. PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| V-set | smMLCK.AA | V-set | 33-119 | 16 | 0.005521 | 12.12 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 33-119 Range on HMM: 1-128/128 Sequence Identity: 16% (21 aa) PAFILP--PR----NLCIKEGATAKFEGRVR-GY----PEPQVTWHRNGQPI--------------------------TSGGRFLLDCGIRGTFSLVIHA . .. . || . .||...... .. .| .. ...| | || .| ... .. ...||| |. QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN VHEEDRGKYTCEATN-----GSGARQVTV ....| | |.| ..| . ..|| LQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 58-72 | 73 | 0.02914 | 10.53 | Pfam | 32-46 (101) | Show / Hide |
Range on Protein: 58-72 Range on HMM: 32-46/101 Sequence Identity: 73% (11 aa) GYPEPQVTWHRNGQP |||.||.||..|||| GYPPPQITWYLNGQP |
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| I-set | smMLCK.AA | I-set | 161-250 | 43 | 1.2e-35 | 123.43 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 161-250 Range on HMM: 1-92/92 Sequence Identity: 43% (40 aa) PKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQP-SARVSVSEKN-GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI ||| .|. .|.|.||. ||.|..|| |.|||.|.|.. ||.| | |....... | . |.| .|..|| |.||| ..| .|.|. .||| . PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 167-251 | 20 | 2.9e-14 | 54.63 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 167-251 Range on HMM: 1-58/58 Sequence Identity: 20% (18 aa) LGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDV---GVYTCLVVNGSGKASM--SAELSIQ . |.||||. ...| .. |..|. |.| .| .| |.|.| . .|.... ...|..| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 173-240 | 32 | 7.2e-12 | 46.68 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 173-240 Range on HMM: 1-56/56 Sequence Identity: 32% (22 aa) KEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSG .||| .. |. ||.| |...|.| . ||. . . |.| | .| |.|||.. | | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 146-271 | 13 | 8.9e-05 | 18.3 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 146-271 Range on HMM: 1-128/128 Sequence Identity: 13% (21 aa) APAVET-RPS--IWGECPPKFATKLGRVVVKEGQMGRFSCKITGRP----QP-QVTWLK-GNV-------------------------PLQPSARVSVSE . |.. |. .| |.|.|||. ...|. . . .. ...| . .. . . . ..|.. QSQVTQHPPRGCPW------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNP KNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDV .. | |. . .| |.|.| | |. ... . |. | SKNDFSLTISNLQPSDSGTYYCAVWNC--------------------NEDYFGHGTRLTV |
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| IGv | smMLCK.AA | IGv | 177-235 | 18 | 0.000701 | 9.82 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 177-235 Range on HMM: 1-76/76 Sequence Identity: 18% (14 aa) MGRFSCKITGRPQPQVTWLKG-------NVPL-----QPSARVSVSEKN------GMQVLEIHGVNQDDVGVYTCLV . ||| .| ...|.. ..| . ..|...| .| . |..... .| |.|.| . SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 186-214 | 22 | 0.095539 | 8.69 | Pfam | 32-67 (101) | Show / Hide |
Range on Protein: 186-214 Range on HMM: 32-67/101 Sequence Identity: 22% (8 aa) GRPQPQVTWLKGNVPL-------QPSARVSVSEKNG |.|.||.||.....|. . . ... . .| GYPPPQITWYLNGQPMVPNEKTEAITTTSEQDPETG |
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| I-set | smMLCK.AA | I-set | 414-504 | 36 | 2.1e-29 | 102.3 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 414-504 Range on HMM: 1-92/92 Sequence Identity: 36% (34 aa) PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDA-GSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQV |||. ||...||.| .|..| |.|.| |.|.| || | |.| . . . .| | . | ... .|.|.|.|.|.| |. .|. .|.| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| I-set | smMLCK.AA | I-set | 514-600 | 35 | 1.7e-27 | 95.86 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 514-600 Range on HMM: 1-92/92 Sequence Identity: 35% (33 aa) PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQ----YARSTCEA-GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV |.|. ..|| | ||.. ..| |.|.| | ..|. .|||.. . . |.. | . | |... |.| |.||| |.| .|...|.| .|| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | smMLCK.AA | IGc2 | 526-590 | 38 | 5.7e-20 | 73.58 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 526-590 Range on HMM: 1-56/56 Sequence Identity: 38% (25 aa) IEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALG .|||...|.| ..| |.| |.|. |||.. . .|.|... ||| |.|||.|.|. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | smMLCK.AA | IG | 420-505 | 25 | 1.5e-15 | 58.95 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 420-505 Range on HMM: 1-58/58 Sequence Identity: 25% (23 aa) PQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDS---GTYSCTASNAQGQLSC--SWTLQVE |. ..||| .||...| || .. |. | . ... || ||| |.|. || .. . ||.|. PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IG | smMLCK.AA | IG | 520-601 | 25 | 4.8e-15 | 57.22 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 520-601 Range on HMM: 1-58/58 Sequence Identity: 25% (22 aa) LKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDH---GTYTCLAENALGQVSC--SAWVTVH . | ||.. .|.| | .|.|. |.| .. ||| |||.| |. ||... ....||. PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 426-494 | 27 | 2.9e-13 | 51.3 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 426-494 Range on HMM: 1-56/56 Sequence Identity: 27% (19 aa) KENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQG .| |.| ..|...| | |.. |. |.|. .. .| . .. |||.|.|.|.|. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 296-504 | 9 | 8.7e-05 | 18.34 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 296-504
Range on HMM: 1-128/128
Sequence Identity: 9% (23 aa)
NCSSPQ--RGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQD
. | .| ||
QSQVTQHPPRGC-PW-------------------------------------------------------------------------------------
VVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVS-GI----PKPEVAWFL-EGT----------------------PVRRQEGSIEVYE
. .|.| |.|...| .| . . . |. . . | |.....
----------------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSG
DAG--SHYLCLLKARTRDSGTYSCTASNA-QGQLSCSWTLQV
. . . .| . ... ||||| | ..| .. . .|.|
NPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
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| IGv | smMLCK.AA | IGv | 482-585 | 15 | 0.003744 | 2.53 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 482-585 Range on HMM: 1-76/76 Sequence Identity: 15% (19 aa) SGTYSCTASNAQGQLSCSWTLQ-------VERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGV--------A | |.||..|. . ..| | .| .| . .| |. . SVTLSCKFSGFTF--YMHWYRQPPDSTPKGKGLEWMGY-----------------------------------------SYKGRFTWSKDNITRWSKNQF ELHIQDALPEDHGTYTCLA |.... ||| |||.| YLTMSNLRPEDTGTYYCAR |
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| V-set | smMLCK.AA | V-set | 516-600 | 18 | 0.005304 | 12.18 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 516-600 Range on HMM: 1-128/128 Sequence Identity: 18% (24 aa) FSSVLK--DC------AVIEGQDFVLQCSVR-GT----PVPRITWLLNGQPI------------QYARS------------TCE------AGVAELHIQD |.| . | |||. |.|... .. .. .|.| || .| .. ... . . |.|.. QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN ALPEDHGTYTCLAENA-LGQVSCSAWVTV . |.| |||.| . | .. . ..|| LQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 526-560 | 34 | 0.006354 | 12.89 | Pfam | 10-59 (101) | Show / Hide |
Range on Protein: 526-560 Range on HMM: 10-59/101 Sequence Identity: 34% (17 aa) IEGQ-----DFVLQC----SVRGTPVPRITWLLNGQPI------QYARST .|.| |..| | | | |.|||.||||| .. .| LEWQYQENMEVVATCVFPWSCGGYPPPQITWYLNGQPMVPNEKTEAITTT |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 414-461 | 29 | 21.43987 | 0.3 | Pfam | 1-54 (101) | Show / Hide |
Range on Protein: 414-461 Range on HMM: 1-54/101 Sequence Identity: 29% (16 aa) PKFESKPQSQEVK--ENQTVKFRCE----VSGIPKPEVAWFLEGTPVRRQEGSI | | .| .|.. ||..| ..| .| | | . | |.| |. .|... PEIEPPPTQLEWQYQENMEVVATCVFPWSCGGYPPPQITWYLNGQPMVPNEKTE |
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| I-set | smMLCK.AA | I-set | 623-712 | 38 | 1.3e-31 | 109.83 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 623-712 Range on HMM: 1-92/92 Sequence Identity: 38% (35 aa) PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQE-SEDFHFEQRG-TQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV | |.| ..|..|. |. .. ..||.|.|||.| |...| .... |. ... ..| ..| |..|.|.|.|.||| | ||.||. . | ||| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 629-713 | 26 | 7.9e-14 | 53.18 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 629-713 Range on HMM: 1-58/58 Sequence Identity: 26% (24 aa) LSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDT---GTYTCEAWNSAGEVRT--QAVLTVQ . . |. |. ||.| || .. |. | | .| |||. |||.|.|. .|.. . |||| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 635-702 | 33 | 1.1e-10 | 42.72 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 635-702 Range on HMM: 1-56/56 Sequence Identity: 33% (23 aa) MDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG | .||.| ..||| |.. |.. | ... . .| |..| ||| |.|||.| |..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 623-712 | 18 | 9e-06 | 21.69 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 623-712 Range on HMM: 1-128/128 Sequence Identity: 18% (24 aa) PIFLQG--LS----DLKVMDGSQVTMTVQVS--------------------GNPPPEVI-----WLHN----GNEIQESEDFHFEQRGT--QHSLCIQEV ...... . . | | ||.. ..| |..| ..| . .| . . . .. ..| . .. || |. . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL FPEDTGTYTCEAWNS-AGEVRTQAVLTV |.|.|||.| .||. . . ||| QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 647-679 | 20 | 4.894578 | 2.59 | Pfam | 31-69 (101) | Show / Hide |
Range on Protein: 647-679 Range on HMM: 31-69/101 Sequence Identity: 20% (8 aa) SGNPPPEVIWLHNGNEI------QESEDFHFEQRGTQHS .|.||| ..|. ||.. ..... .. .|... GGYPPPQITWYLNGQPMVPNEKTEAITTTSEQDPETGLY |
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| I-set | smMLCK.AA | I-set | 721-811 | 31 | 1.6e-20 | 72.12 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 721-811 Range on HMM: 1-92/92 Sequence Identity: 31% (29 aa) PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNE-DVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLML | |. ||..|... |... .| . ||| |.| |..||. | |. .. . ... . || ..||| .|.|.. .|..||..| ..| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 727-812 | 17 | 5.2e-09 | 37.17 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 727-812 Range on HMM: 1-58/58 Sequence Identity: 17% (16 aa) PRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHA---GQYEILLKNRVGECSC--QVSLMLQ |. ||...|..| ..| .. ...|. |.. .||| .. | | . |. .. . | | PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 733-801 | 30 | 2e-06 | 28.8 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 733-801 Range on HMM: 1-56/56 Sequence Identity: 30% (21 aa) SLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVG |||| . | .|.| |..||.. |. | . || .| |.| ..| |. . |..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 721-786 | 17 | 0.0002 | 17.09 | Pfam | 1-102 (128) | Show / Hide |
Range on Protein: 721-786 Range on HMM: 1-102/128 Sequence Identity: 17% (18 aa) PWFISK--PR----SVTASLGQSVLISCAIAGDP----FP-TVHWLRDGKAL--------------------------CKDTGHFEVLQNEDVFTLVLKK . ... || .||...||||...| |. . ...| |. . .|.. .| . . . |.| ... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN VQP .|| LQP |
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| I-set | smMLCK.AA | I-set | 1098-1187 | 36 | 1.2e-25 | 89.51 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1098-1187 Range on HMM: 1-92/92 Sequence Identity: 36% (34 aa) PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKT-TKFIILSQEG-SLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTV | | ||..|| | ||. . ..|||. ||| .. |. .|. |.. .. . ...| .. |... |.| | |.|||.| .|.|||....|| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 1104-1188 | 24 | 1.4e-12 | 49.0 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1104-1188 Range on HMM: 1-58/58 Sequence Identity: 24% (22 aa) LQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDR---GLYKCVAKNDAGQAEC--SCQVTVD . | | || . |.| || .| |. | .. ||| | | |.|. .||... . ..|| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 1110-1177 | 27 | 1.4e-12 | 49.06 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1110-1177 Range on HMM: 1-56/56 Sequence Identity: 27% (19 aa) AEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAG || . |.| .. .| ..| |. |. | . ...|. . |||.|.| |.| | .| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 889-1187 | 7 | 3.6e-05 | 19.65 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 889-1187
Range on HMM: 1-128/128
Sequence Identity: 7% (24 aa)
QQEVEQ--LDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLG
|..|.| . .
QSQVTQHPPRGC-PW-------------------------------------------------------------------------------------
GKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTD
----------------------------------------------------------------------------------------------------
NEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDP----PA-TIIWTL-NGK-------------------------TLKTTKFIILSQEGSLCSV
|.|.||....|.|..|.|. . .| | | .... . .. .|.
-------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSL
SIEKALPEDRGLYKCVAKN-DAGQAECSCQVTV
.| .. |.| | | |...| . .. . . ..||
TISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
|
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| C2-set_2 | smMLCK.AA | C2-set_2 | 1125-1149 | 35 | 14.467292 | 0.91 | Pfam | 34-61 (101) | Show / Hide |
Range on Protein: 1125-1149 Range on HMM: 34-61/101 Sequence Identity: 35% (10 aa) PPATIIWTLNGKTL---KTTKFIILSQE ||. |.| |||... . |. |. ..| PPPQITWYLNGQPMVPNEKTEAITTTSE |
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| I-set | smMLCK.AA | I-set | 1238-1327 | 27 | 1.3e-21 | 75.89 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1238-1327 Range on HMM: 1-92/92 Sequence Identity: 27% (25 aa) PQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQE-SEHMKVENSE-NGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTV |...| | |..|. ||.... .|||. | . .| | ..... |..... ... . ..|||. . .. | || ..|..|. .. ..||| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 1244-1328 | 20 | 4.1e-10 | 40.85 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1244-1328 Range on HMM: 1-58/58 Sequence Identity: 20% (18 aa) PEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHC---GCYTLLVENKLGSRQA--QVNLTVV |. . |..||.|.| |. . .|. ||| .. |. | |. .. |. .. ..||| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 1250-1317 | 25 | 0.001376 | 9.29 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1250-1317 Range on HMM: 1-56/56 Sequence Identity: 25% (17 aa) RAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLG . |.||.| ..|| . .| | .... ... ||| .. |. | || ...|. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 1237-1327 | 16 | 0.010001 | 11.23 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 1237-1327 Range on HMM: 1-128/128 Sequence Identity: 16% (21 aa) PPQIIQ-FPE----DQKVRAGESVELFGKVT-GT----QPITCTWMK-FRK-------------QIQESEHMKVENSENGSK------------LTILAA . |. | |. | |.||.| ... .. .. . .|.. . ... | ..... .|.. ||| . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL RQEHCGCYTLLVENK-LGSRQAQVNLTV . .. |.|. | | .. .. ..||| QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| FN3 | smMLCK.AA | FN3 | 1331-1413 | 23 | 1.8e-13 | 52.0 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 1331-1413 Range on HMM: 1-69/69 Sequence Identity: 23% (23 aa) PDPPAGT--PCASDIRSS------SLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD----HEYKFRVRAINV--YGTS |.|| . . ..|. |. |.|||| . .|. . | .| |. .||.|||||.| .| . PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| Kinase | smMLCK.AA | MLCK | 1464-1719 | 66 | 2.7e-243 | 649.47 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-257/257 Sequence Identity: 66% (170 aa) YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECI |.|.| || ||||.|.| .||.| | || ||.|....|.|||...||.|||.||||.|.|| ||||.| ..||..|..|||||||||.||||.|||||.| YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI KYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGS-LKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFM .||||| |||...|.|.|||||||||||||...|...||.|||||||....... .||.|||||||||||.||.|.|..|||||.|||||.| ||||||| HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM GDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL ||||.||..||||. ||||||.||.|||.||||||.||.||...|.....||||||| GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL |
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| Kinase | smMLCK.AA | DAPK | 1466-1719 | 43 | 8.3e-132 | 365.39 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1466-1719 Range on HMM: 1-264/264 Sequence Identity: 43% (115 aa) IEERLGSGKFGQVFRLVEKKTRKVWAGKFFK--AYSAK----EKENIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIID--EDFE . |.||.|.| | . .|.| | |.|| | . . |.| ||.| . ||... ...| . ....|| ||||||| . |. MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREEC- LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR--IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYIL |.| . .. |.|| ||| | | . |.||||||.||| .. ||.|||||.|...|. .. .||||.||||..||||.. |||||||||| ||. LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM VSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL || ||| ||. ||..|.. ||..| |. | ||||| || || . |. ..||||||. LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI |
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| Kinase | smMLCK.AA | DAPK | 1464-1719 | 47 | 8.8e-123 | 355.99 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-264/264 Sequence Identity: 47% (127 aa) YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAK------EKENIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFE ||. |..||| | | . ||.| | |.|| | . |.| |.|| . || . |..| | .|..|| ||||||| . ... YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKE-C LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR--IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYIL |.| | .. || .|| ..| |.|.|||||||| .. ||.||||||.| | | .||||||||||..|||| | .||||||||| ||| LNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYIL VSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL || |||.||. |||||.| .||.| | . | ||||| || || | |. .|||||| LSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI |
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| Kinase | smMLCK.AA | CAMK | 1469-1719 | 24 | 3.4e-119 | 385.91 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 1469-1719
Range on HMM: 1-425/425
Sequence Identity: 24% (105 aa)
RLGSGKFGQVFRLVEKKTR------------KVWAGKFFKAY----------------------------SAKEKENIRQEISIMNC-------LHHPKL
||.| ||.|.. ..|.| . .| |. . ..| ..|.|.||.||. |.|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VQCVDAFEE-------------------KANIVMVL---EIVSGGEL----FERIIDE--------------DFELTERECIKYMRQISEGVEYIHKQGI
... ...| . ...||. | .||||| |..|.. .. .||||. .|.||| ..|.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
VHLDLKPENIMCVNKTG---------------TRIKLIDFGLARRLENAG------------------------SLKVLFGTPEFVA-PEVINY------
||.|||||||..... . ||.||||.|.... .| .||||..| |||.|.
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
--------EPIGYATDMWSIGVICYILVSGLSPFMGD-------------NDNETLANVTSATWDFDDEAFDE------------ISDD--------AKD
...|...||||.|||.||...| .|| || ||.|.. ..... .||... |.. |||. .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD
FISNLLKKDMKNRLDCTQCLQHPWL
.|...|..| ..|. ..|||.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | smMLCK.AA | CAMK1 | 1464-1719 | 38 | 4.2e-108 | 315.35 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-276/276 Sequence Identity: 38% (106 aa) YDIEERLGSGKFGQVFRLVEKKT---RKVWAGKFF--KAYSAKEK----ENIRQEISIMN-C--LHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERII | . ...|.| |..|.. ..|.| | .| | . | .|.. |....||.|| . ..|| ... . .|.. . .|.| |.|||||.||. YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV DEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTRIK--LIDFGLARRLENAG-SLKVLFGTPEFVAPEVINY---EPIGYATDM . . ||.. . |.|| . |||.|..|||| ||||||. ...| . || ..||||...... .| .|||..|||||... .| ..| || EKG-NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM WSIGVICYILVSGLSPFMGDN-DNETLANVTSATWDFDDEAFDEISDD-AKDFISNLLKKDMKNRLDCTQCLQHPWL |||||| ||| | .|| ..| ||| .. .... ..|. .|.||| |||||...|..| |.|..|.|||.|||. WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | smMLCK.AA | Trio | 1464-1719 | 36 | 1e-107 | 277.13 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-258/258 Sequence Identity: 36% (94 aa) YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECI |.. | .| | |. | | ..| |.. | || | .. || ..| ... |.|| ... |..| . .|| ..||| ... . ....|.| . YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFI-PYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRW-GSYCESEVK KYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTG--TRIKLIDFGLARRLENA--GSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLS ||.|. |.| | | ..| |||.||||.| . . .||..||| | | . . . |.|||.|||.|. .|..|.|| |||||. |.. || | TYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGIS PFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL || ...| ||..|. .| .. | .| .||.|| .| | | .||||||. PFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF |
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| Kinase | smMLCK.AA | Pkinase | 1464-1719 | 35 | 2.2e-102 | 351.23 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-293/293 Sequence Identity: 35% (104 aa) YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQ----EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGG----ELFERII-DED | |....||| ||.|.. ..|.|.|..| | .| ..|...... ||.||. |.|| |.. |.||.| .| ||.| . || .||..| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH FEL--TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR---IKLIDFGLARR--LENAGSLKVLFGTPEFVAPEVIN-YEPIGYATDMWS . .|.||..||.|| .|.||.|..||.| |||||||... ..|. .|..|||||. . | . .... |||...|||||. ....|.. |||| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS IGVICYILVSGLSPFMGD------NDNETLANVTSATWDFDDEAFDEIS-----------------DDAKDFISNLLKKDMKNRLDCTQCLQHPWL .|.|.|....| || |. .... .... .. ..|| . ..|| ...||||...|.||.| |. ..|.|||||. CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | smMLCK.AA | S_TKc | 1464-1719 | 33 | 2.1e-96 | 327.52 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-231/231 Sequence Identity: 33% (92 aa) YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSG--GELFERIIDEDFE----- |.| . .|.| ||.|.. ..||| .. | | | |.||.||.|. ||| .|.. |.|.. .. ||.| ..| |.||..| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY-ATDMWSIGVICYILV ..| .. .||.|| ...||.|..||.| |||||||.. . .||..||||||.| . . |||...||||. . |. . |.||.|.| |... FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML SGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQ-------HPWL .| || ...... .. |..|||||...|.|| ..|. . ..|| |||. CGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | smMLCK.AA | Ciliate-E2a | 1464-1719 | 34 | 1.5e-92 | 272.7 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-275/275 Sequence Identity: 34% (96 aa) YDIEERLGSGKFGQVFRLVEKKTRKV-WAGKFFKAYSAKE--KENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDED-FELTE |... .|.|.||.|. |.| | . || |... .. ||.. .||.|| .| || . . . .| . |. .|.| ..||||...|. . | . YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI RECIKYMRQIS-EGVEYIHKQGIVHLDLKPENIMCV--NKTG---TRIKLIDFGLARRL--ENAGSLKVLFGTPEFVAPEVINYEPI------GYATDMW | ..|.|. .|..|.|...|.| |||||||. .|.. . ||.||||||.. ... ||| .|||||.|.. . .. ||| QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW SIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEA-FDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL |.||| |||..| .|| | . ||.| .. ||.. . ..|...||... .|.|| |.|....|.|.||| SCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | smMLCK.AA | DRAK | 1467-1719 | 37 | 1.4e-90 | 281.71 | In-house | 2-259 (259) | Show / Hide |
Range on Protein: 1467-1719 Range on HMM: 2-259/259 Sequence Identity: 37% (98 aa) EERLGSGKFGQVFRLVEKKTRKVWAGKFFKA--YSAKEKENIRQEISI-MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFE-RIIDEDFELTEREC .| ||| | . ..| | . .| || | ...| .|| . |.| |... . .| . ....||| .|||.|. . |.. ..|.. AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDV IKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPF .. |||| ||| | |.. |||||||| ||. . ||..|||..| ..|. . . |||..||||. ||.|| |||||||||. |.. ...||| QRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISPF MGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL .|| || |. |. .| |. .|. | ||| |. .. |. ..||.|||| VGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL |
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| Kinase | smMLCK.AA | Ciliate-E2 | 1464-1719 | 22 | 8e-83 | 281.47 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-365/365 Sequence Identity: 22% (86 aa) YDIEERLGSGKFGQVFRLVEKKTRKVW------------------AGKF--FKAYSAKEKENIRQEISIMNCLH----------------HPKLVQCVDA |.. . .|.| ||.|.. .|..| ..|. | .. ...|.| |||.||.... || ....... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--EKANIVMVLEIVSGGELFERIIDEDFE----------LTERECIKYMRQISE---------------GVEYIHKQG-IVHLDLKPENIMCVNKTGT |. . || .|.| ..||.||..|.. . .||.|....|.|| . ..||.|... |.| |.|||||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ RIKLIDFGLARRLEN----------AGSLKVLF-----------------------GTPEFVAPEVINYEP---------IGYATDMWSIGVICYILVSG ||.|||||.... . .. .. . |||...|||..|... .|. |.||.||| |....| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG LSPFMGDNDNETLANVTSATWDFDDE--------------AFDEISDDAKDFISN----LLKKDMKNRLD-CTQCLQHPWL || . . .||. . ....|...||.|.. .|.|| ..|.. |.|.|||. KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | smMLCK.AA | CDPK | 1464-1719 | 36 | 9.5e-81 | 247.42 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-271/271 Sequence Identity: 36% (101 aa) YDIEERLGSGKFGQVFRLVEK-KTRKVW-AGKFFKAY--SAKEK-ENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLE--IVSGGELFERIIDEDFE |.|.. ||.| ||||.. ..| || . | | . . ||. .. .|| |. | || .. .. . |. |.| ...|||||..||.. YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH- LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIM-CVNKTGT----RIKLIDFGLARRLENA-----GSLKVLFGTPEFVAPEVINYEPIGYATDMWS .||.| ..|||| | |.|...||| |||||||. . .|... ||.||.|.... . . .. .||| .||||.. . | || FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWS IGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL .||| ||| .| || |.||.|....| .|... .|.|||.||| |...| .| |.|. . |.||||| CGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | smMLCK.AA | TyrKc | 1464-1719 | 21 | 3e-14 | 7.64 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1464-1719 Range on HMM: 1-280/280 Sequence Identity: 21% (63 aa) YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCL--HHPKLVQCVDAFEEK-------ANIVMVLEIVSGGELFERIIDED .. ||.| ||.|.. . | ..| | | |... .| ...|..|| | ||| .|... . .. . .|.| ...| | ... . ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR FELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENA-------GSLKVLF--GTPEFV-----APEVINYEPIGY .|. .. .... ||..| ||.|.....| || |.. .. ..| ||||.| ... .. |. . |||.||| PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT ATDMWSIGVICY-ILVSGLSPFMG-----DNDNETLANVTSA-TWDFDDEAFDE-----ISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL ..| || || .. |. | .| | .. | ...| . . ... . .|. . .. . | ..| ... | . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | smMLCK.AA | Pkinase_Tyr | 1464-1586 | 26 | 1.1e-09 | 33.46 | Pfam | 1-137 (270) | Show / Hide |
Range on Protein: 1464-1586 Range on HMM: 1-137/270 Sequence Identity: 26% (36 aa) YDIEERLGSGKFGQVFRLVEK-----KTRKVWAGKFFKAYSAKE---KENIRQEISIMNCL-HHPKLVQCVDAFE-EKAN--IVMVLEIVSGGELFERII . . ||.| ||.|.. . | .. .| | | | .. .| .| .|..|| | |||..|... . .. | .|.| . .| | . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR DE---DFELTERECIKYMRQISEGVEYIHKQGIVHLDL . . || . ... .||..| || . ....| || KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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| I-set | smMLCK.AA | I-set | 1809-1899 | 53 | 1e-48 | 167.81 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1809-1899 Range on HMM: 1-92/92 Sequence Identity: 53% (49 aa) PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRE-SRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV |.|.....|.|| ||..|||.|...|.|.|.|.||||.| .|. |...|..||.||...|.||.|. || ||||.|.||.|||.|||||.| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | smMLCK.AA | IGc2 | 1821-1889 | 30 | 3e-17 | 64.56 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1821-1889 Range on HMM: 1-56/56 Sequence Identity: 30% (21 aa) VEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLG || .... |. .|.|||.. |.| .|.. .| .| |..| .|. .|||.| |. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | smMLCK.AA | IG | 1815-1900 | 16 | 8e-13 | 49.85 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1815-1900 Range on HMM: 1-58/58 Sequence Identity: 16% (15 aa) IRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDD---AKYTCKAVNSLGEATC--TAELIVE . ..|.||. ... | .. .. |. |.| .| .| . |.| | |.... ...|.|. PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| V-set | smMLCK.AA | V-set | 1816-1899 | 15 | 0.079769 | 8.12 | Pfam | 10-128 (128) | Show / Hide |
Range on Protein: 1816-1899 Range on HMM: 10-128/128 Sequence Identity: 15% (19 aa) R----DLEVVEGSAARFDCKIE-GY----PDPEVVWFKDDQSI---------------------------RESRHFQIDYDEDGNCSLIISDVCGDDDAK | ..|.|| ... |. .| .. . |... |. .....|. . . ....|| ||.. .| . RGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPS-KNDFSLTISNLQPSDSGT YTCKAVNS-LGEATCTAELIV |.| . |. . .|.| YYCAVWNCNEDYFGHGTRLTV |
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