Gene SPEG (Human)

SPEG

Species: Human
Alias: SPEG, APEG1, LOC729871
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2q35-q36, Secondary Group: CAMK, Secondary Family: Trio,

Classification

Group: CAMK
Family: Trio

Sequence

Name Sequence Type Origin Length Description Download
SPEG.NA RNA Sugen Kinome 10782 None Fasta, JSON
SPEG.AA Protein Sugen Kinome 3267 None Fasta, JSON
SPEG.kin_dom Protein Kinase Domain Sugen Kinome 254 None Fasta, JSON
SPEG.kin_dom2 Protein Kinase Domain Sugen Kinome 253 None Fasta, JSON

Protein domain

Protein domains of SPEG.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set SPEG.AA I-set 43-125 32 9.9e-22 76.25 Pfam 1-92 (92) Show / Hide 
Range on Protein: 43-125
Range on HMM: 1-92/92
Sequence Identity: 32% (30 aa)

PVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAP------APEP---SCLWLRRCGAQDAGVYSCMAQNERGRASCEAVLTV
|.|....|.. |  |...|. . |.|.|.|.  ||.||| |. .        .    . |. ... . |.|.|.| |.|. | |.|.| |||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 49-126 20 7.8e-08 33.28 SMART 1-58 (58) Show / Hide 
Range on Protein: 49-126
Range on HMM: 1-58/58
Sequence Identity: 20% (17 aa)

LKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWLRRCGAQDA---GVYSCMAQNERGRASC--EAVLTVL
 .   | .|..|.|.  ||     ...|.               | . .  ..|.   |.| |.|.   | ...  .. |||.
PP-VTVKEGETVTLTC-VS-----QIWWY---------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 55-115 31 0.000146 18.63 SMART 1-56 (56) Show / Hide 
Range on Protein: 55-115
Range on HMM: 1-56/56
Sequence Identity: 31% (19 aa)

CAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWLRRCGAQDAGVYSCMAQNERG
  | .|.|.  ..| | |. .|.. || ||      . | ...    |.|.|.| |.|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set SPEG.AA V-set 102-125 32 1.15254 4.12 Pfam 104-128 (128) Show / Hide 
Range on Protein: 102-125
Range on HMM: 104-128/128
Sequence Identity: 32% (8 aa)

DAGVYSCMAQNE-RGRASCEAVLTV
| |.| | . |.  .    .  |||
DSGTYYCAVWNCNEDYFGHGTRLTV
I-set SPEG.AA I-set 722-811 39 1.9e-37 129.61 Pfam 1-92 (92) Show / Hide 
Range on Protein: 722-811
Range on HMM: 1-92/92
Sequence Identity: 39% (36 aa)

PVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRS-EGRLLLRAEG-ERHTLLLREARAADAGSYMATATNELGQATCAASLTV
|.|......|.|  | .. ..| .| .|||||||.|||. ||. . |   ...|  ..||  ... ..|.|.|  .|||..|.|.| |.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
I-set SPEG.AA I-set 869-959 38 1.4e-31 109.68 Pfam 1-92 (92) Show / Hide 
Range on Protein: 869-959
Range on HMM: 1-92/92
Sequence Identity: 38% (35 aa)

PTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEG-GLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEV
|.|   . |. |.||...  . .|.|.|.|.|||... ||.||| .|.   ..| | ..|.|. ....|.| |||.|.|..|  .|.|.|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 875-960 17 1e-11 46.19 SMART 1-58 (58) Show / Hide 
Range on Protein: 875-960
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

LMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDA---GFYTCKAVNEYGARQC--EARLEVR
   ..|.||..| ..  |.      ..|.                       |.|  ... |.   | |.| |   .|  ..  ...|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG SPEG.AA IG 728-812 21 1.1e-11 46.1 SMART 1-58 (58) Show / Hide 
Range on Protein: 728-812
Range on HMM: 1-58/58
Sequence Identity: 21% (19 aa)

LQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADA---GSYMATATNELGQATC--AASLTVR
 . |.| .| .| |.| ..     |..|.                      | . .....|.   | |  .||   ||...   . |||.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 881-949 28 2.2e-10 41.77 SMART 1-56 (56) Show / Hide 
Range on Protein: 881-949
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

REGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYG
.|||.|..  .. | | | ..|..  ||.             .  .|.|  ....|.| |||.| |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGc2 SPEG.AA IGc2 734-801 29 1.9e-09 38.65 SMART 1-56 (56) Show / Hide 
Range on Protein: 734-801
Range on HMM: 1-56/56
Sequence Identity: 29% (20 aa)

APGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATNELG
 .| .| |.|. |.|| |...| | |. |             . || ..... .|.| |  .|.|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set SPEG.AA V-set 806-959 12 0.008186 11.53 Pfam 1-128 (128) Show / Hide 
Range on Protein: 806-959
Range on HMM: 1-128/128
Sequence Identity: 12% (24 aa)

AASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEP----KP-VV
. ..|..| .   |.                                                          .| |||.| ..  ..  .     .  .
QSQVTQHPPRGC-PW--------------------------------------------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYI

SWLRNRQPV------------RPDQR--------RFAEEAE------GGLCRLRILAAERGDAGFYTCKAVNE-YGARQCEARLEV
.| |  ||             . ...        || .  .      .. . |.|  ... | | |.| . |. ..  . . || |
YWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set SPEG.AA I-set 968-1058 35 8e-12 42.64 Pfam 1-92 (92) Show / Hide 
Range on Protein: 968-1058
Range on HMM: 1-92/92
Sequence Identity: 35% (33 aa)

LAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALL--KCKMHFDG-RKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTV
  .. ...|| |  || | ||| | |  . .| |.. |. |.|     ...|..||   ..|  . |  ||.|.|||. .    | .|.|.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP--DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 974-1059 18 2.3e-09 38.33 SMART 1-58 (58) Show / Hide 
Range on Protein: 974-1059
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

LQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDS---GVYTCKLSTAKDELTC--SARLTVR
 . | | .|| . ..| |.     .. |.                       | . .| ..||   |.|.|  .  . . ..  ...|||.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 980-1048 21 1e-06 29.45 SMART 1-56 (56) Show / Hide 
Range on Protein: 980-1048
Range on HMM: 1-56/56
Sequence Identity: 21% (15 aa)

GAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKD
  |. . ..| ..|  | .. |.  |  |.             .  | ...| ..|||.|||. . .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set SPEG.AA V-set 1026-1058 32 6.8e-05 18.7 Pfam 95-128 (128) Show / Hide 
Range on Protein: 1026-1058
Range on HMM: 95-128/128
Sequence Identity: 32% (11 aa)

LLLTSVHEDDSGVYTCKLSTA-KDELTCSARLTV
| .......|||.|.|  ..  .|    . ||||
LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set SPEG.AA I-set 1064-1153 43 5.1e-29 100.99 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1064-1153
Range on HMM: 1-92/92
Sequence Identity: 43% (40 aa)

PLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEE-SENLRLRQDG-GLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYV
| ||. . |||| || .|||.|...|.|||.|.|.. | |. . |.  . ..|| | ..| |  | ..||| | . |.|  |.| |.|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 1070-1154 22 6.9e-13 50.05 SMART 1-58 (58) Show / Hide 
Range on Protein: 1070-1154
Range on HMM: 1-58/58
Sequence Identity: 22% (20 aa)

LEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDE---GLYAVSAVNTHGQAHC--SAQLYVE
 . |.| ||  ... | .|      ..|.                      |.| .|  ||.   | |   |   |||...  ...|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 1076-1143 27 6.3e-09 36.9 SMART 1-56 (56) Show / Hide 
Range on Protein: 1076-1143
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

LEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHG
.||..... |. .| | | ..|.. | |..           .  .|.| .|  ||.|.|. .| | .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set SPEG.AA V-set 1105-1153 17 0.853453 4.57 Pfam 77-128 (128) Show / Hide 
Range on Protein: 1105-1153
Range on HMM: 77-128/128
Sequence Identity: 17% (9 aa)

EESENLRLRQDGG--LHSLHIAHVGSEDEGLYAVSAVNT-HGQAHCSAQLYV
. ... .. ....    ||.| .. ..|.| |   . |  ... . . .| |
RFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set SPEG.AA I-set 1188-1277 38 1.1e-19 69.32 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1188-1277
Range on HMM: 1-92/92
Sequence Identity: 38% (35 aa)

PDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQS-SDDRRMTQYR-DVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYV
| |.....|.||   . | .|||||| | |..|||..|  ... ||  .||.   . ..| .  | |  .|.|. |  |..|.| | |.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 SPEG.AA IGc2 1200-1267 23 1.3e-05 25.88 SMART 1-56 (56) Show / Hide 
Range on Protein: 1200-1267
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

GLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLG
     . |.| .|| | |.|.|.. | ...           .  .| .  | | ..|.|  .  |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG SPEG.AA IG 1194-1278 15 0.00016 22.27 SMART 1-58 (58) Show / Hide 
Range on Protein: 1194-1278
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

LQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHA---GVYKSVIANKLGKAAC--YAHLYVT
 . ..| .   . |.| |.     .|.|.                      |..  | |...   |.|  .     |.. .   ..|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
FN3 SPEG.AA FN3 1282-1368 20 4.3e-07 30.82 SMART 1-69 (69) Show / Hide 
Range on Protein: 1282-1368
Range on HMM: 1-69/69
Sequence Identity: 20% (21 aa)

PGPPDGA--PQVVAVTGR------MVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPGWAATGLRKG----VQHIFRVLSTTV--KSS
|||| .   ..|..|| .       |||.|.||           ..|.                         |||. |     .  |||   .   . .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

S
.
G
IG SPEG.AA IG 1396-1482 20 2e-08 35.2 SMART 1-58 (58) Show / Hide 
Range on Protein: 1396-1482
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

PDIVYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDM---GALTCTARNRHGTQTC--SVTLELA
|  |.|.||.... |  ..    |. |.                         |.| .|.. |    |  .|.|.  ||....  ..||.  
PP-VTVKEGETVTLTC-VS----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set SPEG.AA I-set 1443-1481 35 4.3e-07 26.59 Pfam 53-92 (92) Show / Hide 
Range on Protein: 1443-1481
Range on HMM: 53-92/92
Sequence Identity: 35% (14 aa)

DD-DQYCLRICRVSRRDMGALTCTARNRHGTQTCSVTLEL
|. . | |.| .| ..|.|  ||.|.|. |...|...|. 
DGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 SPEG.AA IGc2 1402-1471 25 0.002536 6.75 SMART 1-56 (56) Show / Hide 
Range on Protein: 1402-1471
Range on HMM: 1-56/56
Sequence Identity: 25% (18 aa)

VEGQPASVTVT-FNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMGALTCTARNRHG
 |||... |    .  .... |.   |  |.             .   |.| .|.. | |  ||.|||..|
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set SPEG.AA I-set 1485-1574 40 1.5e-34 119.77 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1485-1574
Range on HMM: 1-92/92
Sequence Identity: 40% (37 aa)

PRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTE-SSHVSFVYEE-NECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAV
|.|.    ||||  |||||| . |.|.| |.. |.||.  |.. |......|.. ....| ..   . | |.|||.|.| .||..|.||| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 1491-1575 20 1.9e-08 35.31 SMART 1-58 (58) Show / Hide 
Range on Protein: 1491-1575
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

MEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDG---GVYTCTAQNLAGEVSC--KAELAVH
 . |.| .|||...   |.      | ||                      |.. .  ..|    |.|.|.|.  .|....   ..| |.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 1497-1564 26 2e-06 28.4 SMART 1-56 (56) Show / Hide 
Range on Protein: 1497-1564
Range on HMM: 1-56/56
Sequence Identity: 26% (18 aa)

GAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAG
  |.....   ..|.| |.|.||| .  |            .. .| . .    | |.|||.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
Kinase SPEG.AA Trio 1601-1854 48 9.1e-228 591.65 In-house 1-258 (258) Show / Hide 
Range on Protein: 1601-1854
Range on HMM: 1-258/258
Sequence Identity: 48% (124 aa)

YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCT-EELLERIARKPTVCESEIRAY
|....|||||.||..||......|...||||||.....|.....|...|..|||.||...|...|..|......|||. .|||....|....||||...|
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

MRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPG--EPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPF
|.|.||..||||..|.||||.||||...|...||..|..|||||.||.|.|.  |||..|||.|||.||||....|||..||||..||.....|.|||||
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

VGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
..|.||.|.|||......|.|..|...|..|..|..|||..| . ||.|.|.|.||||
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase SPEG.AA MLCK 1601-1854 40 7.6e-102 269.04 In-house 86-342 (257) Show / Hide 
Range on Protein: 1601-1854
Range on HMM: 86-342/257
Sequence Identity: 40% (105 aa)

YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPS-QAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCT-EELLERIA-RKPTVCESEIR
|.|| |.|||.|.  .| .|.|.|...|||||.   .| |.  ..|   .  |.|  ..  |.|||  .  | . |. . .||.|||  .. .  |.|..
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

AYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEP-QYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISP
 ||||..||.|..|. ...|||.|||| .  .      |. | ||| |... |.|.   . .|||||||||.||  ||.  ||.| |||.... |.|.||
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTS--HQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSP

FVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDR-LRPTAEETLEHPWF
| |.||| |. |... .  |.. .|   | ||. |  . ||.|.  |.||.| |.|||.
FMGDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase SPEG.AA DAPK 1603-1854 36 6.7e-85 233.7 In-house 1-264 (264) Show / Hide 
Range on Protein: 1603-1854
Range on HMM: 1-264/264
Sequence Identity: 36% (97 aa)

IHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKAS----AR----REARLLARLQ-HDCVLYFHEAFERRRGLVIVTELCT-EELLERIAR--KPT
. .|.||| |.  |.  ..|.|...|||||    . ..|     |    .| . |  .. |. |   ||..| |   ... |. .  ||   ..   .  
MGEELGRGQFAVVRKCRHKSTGKHYAAKFI-KKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREEC

VCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLC
.|| . .. |.|.|||.||||. .. ||| ||.| .  |    .  . |.||| . .. .||      ||||.|||||||  | |  ||.| .||..   
LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM

LTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
|.|||||.|..   |. ||   |. |.| .| ..| .|. |  . || | . |.|||| |.||| 
LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase SPEG.AA CAMK 1606-1854 18 1.4e-83 269.11 In-house 267-691 (425) Show / Hide 
Range on Protein: 1606-1854
Range on HMM: 267-691/425
Sequence Identity: 18% (80 aa)

EIGRGAFSYLRRIVERSSG------------LEFAAKFIPSQ-----------------------------AKPKASARREARLLARLQ-------HDCV
..|||.|.  .. ......             ..|.|.|. .                             .| ... ||| ... .||       | ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LYFHEAFE--------RRRG------------LVIVT---ELCTE-EL----LERIARK---------------PTVCESEIRAYMRQVLEGIHYLHQSH
. ..|..|        .. .            ...|.   |.|.  ||    ...| ..                 ..|.| | |.||.....||.|. .
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VLHLDVKPENLLVWDGAAGEQ-------------QVRICDFGNAQELTP------------------------GEPQYCQYGTPEFVA-PEIVNQ-----
. |.| ||||.|. |   ...             .. |.||| |....|                        |.. . . ||||..| ||..|.     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------SPVSGVTDIWPVGVVAFLCLTGISPFVGE-------------NDRTTLMNIRNYNVAFEETTFLS--------------------LSREAR
          ...  .|.| .||. . .|.| .|| |.             ||. .. .|.. .  |..  |                      .| |..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

GFLIKVLVQD-RLRPTAEETLEHPWF
 .. | |. |   |.|.|. |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SPEG.AA DAPK 1601-1854 36 7.8e-72 206.43 In-house 1-264 (264) Show / Hide 
Range on Protein: 1601-1854
Range on HMM: 1-264/264
Sequence Identity: 36% (98 aa)

YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASAR--------REARLLARLQ-HDCVLYFHEAFERRRGLVIVTELCT-EELLERIARKPT
||. .||| | |.  ... |.| |.|.|||||    . .|| |        || . |  .. |. .   |...| .   |.. || .  ||   .. |  
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFI-KKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKEC

VCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLC
. | |  ..  |.|.|.|..|  |. |.| ||||    |  . . ...| ||| | .  ||.      ||||||||||||  | .  || | .||. .  
LNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYIL

LTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
| | ||| |..   || ||   |  |.|  | . |  |  |  . ||.| . | | .| |.||| 
LSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase SPEG.AA S_TKc 1601-1854 27 5.4e-66 226.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 1601-1854
Range on HMM: 1-231/231
Sequence Identity: 27% (75 aa)

YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTE---ELLERIARKPT------V
|.|...||.|||.  .. .....| ..| | |.       ..||| ..| . .|. .  ....|.    | .|.|.|     .|...| ....       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

CESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSG-VTDIWPVGVVAFLC
 | ..| ||.|..... |.|. ...| |.||||.|. .      .. ||||| | .|      . . |||...|||..   . ..   |.| .|.. . .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLE-------HPWF
|.|  ||   .. ... .|.              |.||. |. | |. | . |||| | |.       ||||
LCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SPEG.AA DRAK 1604-1854 35 1.6e-64 199.19 In-house 2-259 (259) Show / Hide 
Range on Protein: 1604-1854
Range on HMM: 2-259/259
Sequence Identity: 35% (93 aa)

HQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASAR---REARLLARLQH-DCVLYFHEAFERRRGLVIVTELCT-EELLE--RIARKPTVCESEI
 .| ||| |   |. .....| .|||||.    . . . .   .| . |   |  . |   || .| |  .. | |. .  |. .     .   .|| ..
AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDV

RAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISP
.  |||.|||.|||||  . ||| || | |       |  ..||||| .  .  ||      |||..||||| |  |..  ||.| .||.... ||.|||
QRCMRQILEGVHYLHQRNIVHLDLKPQNILLTS-EYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP

FVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
|||.    | .||   |. . | .| ..| .|. |  ...| .   |.|||| |.||| 
FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase SPEG.AA Pkinase 1601-1854 27 2e-56 198.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1601-1854
Range on HMM: 1-293/293
Sequence Identity: 27% (80 aa)

YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPK---ASARR--EARLLARLQHDCVLYFHEAFERRRGLVIVTELCTE-----ELLERIA--RK
| |.. ||.|.|.  .. .....| ..| | |. . . .    ..||  |.....||.|.... ....||... . .|.|.|       .| ..|   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PTV--CESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVW-DGAAGEQQVRICDFGNAQE--LTPGEPQYCQYGTPEFVAPEIVN-QSPVSGVTDIWP
 ..   | |.. ||.|.|.|. |.|.  ..| |.||||.|.  .|  ..  |.||||| |    . ...  .   |||...|||... ... .   |.| 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVVAFLCLTGISPFVGE------NDRTTLMNIRNYNVAFEETTFLSLS-----------------REARGFLIKVLVQDR-LRPTAEETLEHPWF
.|.. .  |.|  || |.      ...  . .|.   . |.. .  | |                 .|.. |. . | .|   |||||. |.||||
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SPEG.AA CAMKL 1601-1854 22 7.2e-45 141.03 In-house 182-478 (297) Show / Hide 
Range on Protein: 1601-1854
Range on HMM: 182-478/297
Sequence Identity: 22% (68 aa)

YDIHQEIGRGAFSYLRRIVE-RSSGLEFAAKFIP--SQA-KPKASAR-------------REARLLARLQ---HDCVLYFHEAFERRRG------LVIVT
|.| ...|.|.|.  .  .  |  | . | |.|       .|.....             ||.... .|.   |  .  ..| .| ..       ...|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCTEE---LLERIARKPT----VCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVW-DGAAGEQQVRICDFGNAQELTP-----GEPQYCQYGTP
|.|      |...| ...       |.| | | ||......|.|. .. | | ||||.|.  .|     .. |.||| . . .|     |.    . |.|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

EFVAPEIVNQ---SPVSGVTDIWPVGVVAFLCLTGISPFVGEND------RTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEH
.. ||||..    .     .|||  ||. .  ..|  || ....       . ..  ..    .... ....| ..| .. | |. .   |||... ..|
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWF
||.
PWM
Kinase SPEG.AA Ciliate-E2 1601-1854 19 1.5e-44 150.87 In-house 136-500 (365) Show / Hide 
Range on Protein: 1601-1854
Range on HMM: 136-500/365
Sequence Identity: 19% (75 aa)

YDIHQEIGRGAFS--YLR--RIVER-------------------SSGLEFAAKFI----PSQAKPKASARREAR----------LLARLQHDCVLYFHEA
|.... ||.|.|.  |.   . | .                     . ..| | .      | | . .  || .          .| .|.|. .. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--RRRGLVIVTELCTE-ELLERIARKPTVC-----------ESEIRAYMRQVLE---------------GIHYLHQSH-VLHLDVKPENLLVWDGAAG
|.   .  . .|.|.|   .|...|  ... .           | ||. .|.|.|.               ...|||. . ..| | ||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

EQQVRICDFGNAQELTPGEPQYC--------------------------------QYGTPEFVAPEIVNQSP---------VSGVTDIWPVGVVAFLCLT
   . |.|||....... . ..                                 ..|||...||||.|  .          .   ||| .||. . .|.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GISPFVGENDRTTLMNIRNYNVAFEET--------------TFLSLSREARGFLIK----VLVQD-RLRPT-AEETLEHPWF
|  ||        . .| . .. | .                ....| |.  .. |     |. |   |.| .|. |.||||
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase SPEG.AA MSK 1603-1854 24 5.9e-38 125.89 In-house 1-277 (277) Show / Hide 
Range on Protein: 1603-1854
Range on HMM: 1-277/277
Sequence Identity: 24% (67 aa)

IHQE--IGRGAFSYLRRIVERSSGLEFAAKFIP-----SQAKPKASARREARLLARLQ-HDCVLYFHEAFERRRGLVIVTELCT-EELLERIARKPTVCE
.     .| |.|.  |..| ...|...|.| ..      ..| .. ...|.. | ..| |  .   |.||     . .| |.|.  ||...| ..    |
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

SEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPG--EPQYCQYGTPEFVAPEIVNQ---SPV--SGVTDIWPVGVV
|| | .||..   . ..|| .. | | ||||.|  |.   . .|.. ||| | .....  .. .   .| .. |||....   ...  . . |.| .||.
SECRMIMRELVMAVDHMHQKGIIHRDLKPENIL-FDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI

AFLCLTGISPFV-----GE---NDRTTLMN-IRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
 .  ||| .||      ..   |  . .|  |.  .. |.     . | .|. .. . |  |   |..... . | | 
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase SPEG.AA RSK 1603-1854 25 2.3e-36 127.14 In-house 1-278 (278) Show / Hide 
Range on Protein: 1603-1854
Range on HMM: 1-278/278
Sequence Identity: 25% (72 aa)

IHQE--IGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASAR------REARLLARLQ-HDCVLYFHEAFERRRGLVIVTELCT-EELLERIARKPT--
. .   .| |...  |... . .| ..| | . ..|| .....      .| . |.| | |  .   |.||.    | ...|.|   ||.... .. .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVL-KKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-VCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPG--EPQYCQYGTPEFVAPEIVN----QSPVSGVTDIWPV
  .|.| ..||...   . .||| .. | | |||| |  |   .|  ....||| . .. .   .. .   .| |..|||...    |.  .   |.|  
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVVAFLCLTGISPFVG---ENDRTTLMNIRNYN--VAFEETTFLSLSREARGFLIKVL-VQDRLRPT-----AEETLEHPWF
||. .  ||| .|| |   .|   .. .|.. .  . ...  .  ||.||. .. | | .    |..     ||| ..||||
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQY--LSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
I-set SPEG.AA I-set 2584-2674 32 4.8e-20 70.52 Pfam 1-92 (92) Show / Hide 
Range on Protein: 2584-2674
Range on HMM: 1-92/92
Sequence Identity: 32% (30 aa)

PVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRS-EPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAV
|.| .|.||..  |||.|.. |    .| | .|| || . ||. .  . ..  .||.. | | .. .. .| |.| ||| .|. ...... |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 SPEG.AA IGc2 2596-2664 27 3.5e-11 44.39 SMART 1-56 (56) Show / Hide 
Range on Protein: 2596-2664
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

LEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLG
.||...|| |  .. |.| |.| |  ..|             ... |.| .. . ..|.|.|.|.|  |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG SPEG.AA IG 2590-2675 20 9.7e-11 42.93 SMART 1-58 (58) Show / Hide 
Range on Protein: 2590-2675
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

LKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHA---GLYECSATNVLGSITS--SCTVAVA
 . ..  ||| .|| |  .     .|.|.                       | | .. . ..   | | | ||   |...|  . |. | 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
FN3 SPEG.AA FN3 2678-2757 20 0.000132 22.55 SMART 1-69 (69) Show / Hide 
Range on Protein: 2678-2757
Range on HMM: 1-69/69
Sequence Identity: 20% (19 aa)

PGKLAP---PEVPQTYQD------TALVLWKPGDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTHLPVG----VTVRFRVACANR--AGQG
||       ..|  .  .      .. . |||         ... |                  | ||.|  |     . .|||.. |.  ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase SPEG.AA Trio 2966-3218 48 1.4e-226 588.56 In-house 1-258 (258) Show / Hide 
Range on Protein: 2966-3218
Range on HMM: 1-258/258
Sequence Identity: 48% (126 aa)

YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATY
|||.||..||||.|||.|...|||||..||..||....|..|..|||.|..|.|....|||..|.|||...||.|.|...||||.|.....|.|..|.||
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

MVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNA----LKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPF
|.|.|....|||..|.|||||||.|......||    .||.|||.||...|....|..|..|..||||||...|.|....||||..|||||.||||.|||
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

YEPDPQETEARIVGGRFDAFQLYPN-TSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
|.....||...|..|.|.....|.. .||.|..|..|||...||.||....||.|||.
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase SPEG.AA MLCK 2966-3218 34 2.2e-102 270.47 In-house 1-257 (257) Show / Hide 
Range on Protein: 2966-3218
Range on HMM: 1-257/257
Sequence Identity: 34% (90 aa)

YTFLEEKARGRFGVVRACRENATGRTFVAKIVPY-AAEGKRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLS-DRFRYSEDDVA
| ..|| .||.||.|. |.| .||.|..||...   .. |. |..|.|....|||.... .|.|. |..  |.| |     ||.     ..| ..| .|.
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

TYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAP--DNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPF
.|| |.. |....|.....|||.||.| ..     . .||.||| |. |.|   . .    || || |||.|. .|.| .||.|. ||..|..||| |||
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKK-VKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPF

YEPDPQETEARIVGG--RFD--AFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
   . .|| . .  .  .||  .|.   . |. |. | .. |  .. .|.. ..||.||||
MGDNDRETMNNVTSCEWDFDDECFD---DISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase SPEG.AA CAMK 2971-3218 20 5.9e-87 280.14 In-house 1-425 (425) Show / Hide 
Range on Protein: 2971-3218
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

EKARGRFGVVRACRENATG------------RTFVAKIVPYA-----------------------------AEGKRRVLQEYEVLRT-------LHHERI
.  ||.||.|. |..  |.            . . .||..                               .. ...|..|.|....       |.|. |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

MSLHEAYITPRY-------------------LVLIA---ESCGNRELLCGLSDRF-------------------RYSEDDVATYMVQLLQGLDYLHGHHV
 .|.|.| .|.|                   ....    | | . ||.. | |.                    |..|.....|. |......|.| |..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHLDIKPDNLLLAPD-----------------NALKIVDFGSAQPYNPQALRP----------------------LGHRTGTLEFMA-PEMVKG------
 |.|.||.|.||  .                 | .||.||| |. ..|                           .  . ||.|.|| ||...|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EPIGSATDIWGAGVLTYIMLSGRSPFYEP-------------DPQETEARIVGGRFD-AFQLYPNTS--------------------QSATL
        ...| ..|.| .||..||||.|..|||..             ...|.  .|  |..|      ...|                    |..  
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLRKVLSVHPWSRPSLQDCLAHPWL
..|| | | |. |.....||.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SPEG.AA S_TKc 2966-3218 28 2e-69 237.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 2966-3218
Range on HMM: 1-231/231
Sequence Identity: 28% (76 aa)

YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGN--RELLCGLSDRFR------Y
|..|..  .| ||.|. ||.. ||| .  ||..      .....| ..|.  ||. |  |.... .  .| .. | |..   .|.  . .| |      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGS-ATDIWGAGVLTYIMLS
.| ... || |....|.|.| |...| |.||.|.||     .|| |||.|  .         .  ||...||||..   . |  . |.|  |.. |.||.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLA-------HPWL
|. ||.    ...  ...|            |..|  |.|| | . |  ||.  ..|.       |||.
GYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SPEG.AA Pkinase 2966-3218 25 1.6e-64 225.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2966-3218
Range on HMM: 1-293/293
Sequence Identity: 25% (75 aa)

YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGK----RRVL-QEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNR----ELLCGLS--DR
|....   .| ||.|. |..  ||.... ||...  | .    .... .| .... |.|. |  |.... ..... .. | |..     .|   .|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

FRY--SEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNAL----KIVDFGSA---QPYNPQALRPLGHRTGTLEFMAPEMVK-GEPIGSATDI
 ..  ||...  || |.|.||.|.| . ..| |.||.|.|.  .. .    || |||.|   .       . . ...||...|||| .. |...|.. |.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WGAGVLTYIMLSGRSPFYEP------DPQETEARIVGGRFDAFQLYP------------------NTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
|..|.. |.||.|| ||..       |...  .|| |....    ..                  |.|...  |... | . | .||. ...| |||.
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SPEG.AA CAMKL 2966-3218 24 6e-52 163.98 In-house 1-297 (297) Show / Hide 
Range on Protein: 2966-3218
Range on HMM: 1-297/297
Sequence Identity: 24% (72 aa)

YTFLEEKARGRFGVVRACRE-NATGRTFVAKIVPYAAEGKRRVLQ----------------EYEVLRTLH---HERIMSLHEAYITPRY------LVLIA
|.....  .| ||.|. ..    ||.    ||.      .. . .                |.. .. |.   |. |..|.| . ||..      ..|. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ESCGNRE--LLCGLSDRFR----YSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDN--ALKIVDFGSAQPYNP---QALRPLGHRTGTLEFM
| |.. |  |.  .  . .     .|..   |  |.. ...|.| |.. | ||||.|.||  ..   .||.||| .  | |   .  . |  . |....|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEMVKG--E-PIGSATDIWGAGVLTYIMLSGRSPFYEPDP-------QETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
|||...|  .  .| ..||| .||. | |. |. || ...        . .. ... .    .  ..  | ..  ..|| | | |. ||.... . |||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase SPEG.AA Ciliate-E2 2966-3218 18 6.4e-51 173.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 2966-3218
Range on HMM: 1-365/365
Sequence Identity: 18% (70 aa)

YTFLEEKARGRFGVVRACRENATGRTF------------------------VAKIVPYAAEGKRRVLQEYE-------------VLRTLHHERIMSLHEA
| |..   .| ||.|. |.   ... |                        .  . ..  | . ......              .|..| |  |. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--TPRYLVLIAESCGNRELLCGLSDRF-----------RYSEDDVATYMVQLLQ---------------GLDYLHGHH-VLHLDIKPDNLLLAPDNAL
..  .  .. |. | |   .|.  . ..            ...|  ....| |.||               .| |||  . ..| ||||.|.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIVDFGSAQPYNPQ----------ALRPLGH---------------------RTGTLEFMAPEMVKGEP---------IGSATDIWGAGVLTYIMLSGRS
||.||| .. |...           . .  .                       ||...||||...|..          . . ||| .||. |.||.|. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFYEPDPQETEARIVGGRFDAFQL---------------YPNTSQSATLFLRK----VLSVHPWSRPS-LQDCLAHPWL
||        .  |  . .| ..                . . ||..  ...|     | . |  |..  ...| |||.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase SPEG.AA DRAK 2970-3218 35 2e-50 154.64 In-house 3-259 (259) Show / Hide 
Range on Protein: 2970-3218
Range on HMM: 3-259/259
Sequence Identity: 35% (91 aa)

EEKARGRFGVVRACRENATGRTFVAKIVP---YAAEGKRRVLQEYEVLRTLHHE-RIMSLHEAYITPRYLVLIAE--SCGNRELLCGLSDRFRYSEDDVA
 |..||.| ||| | .  ||. | || .     . . .. .|.|  ||   . . ..  ||| | |   ..|. |  . |    .| .      .| || 
KERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDVQ

TYMVQLLQGLDYLHGHHVLHLDIKPDNLLLA---PDNALKIVDFG-SAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRS
  | | |.|. |||   . ||| || | ||.   |   .||.||| |    |   .| .    || ...|||  . .||  |||.|  |||||.||.. |
RCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREI---MGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHIS

PFYEPDPQETEARIVGGRFD-AFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
||   | |||   |     | .  ..   |..|. | ....   |  |.. . || ||||
PFVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase SPEG.AA DAPK 3058-3218 38 2.1e-48 131.26 In-house 101-264 (264) Show / Hide 
Range on Protein: 3058-3218
Range on HMM: 101-264/264
Sequence Identity: 38% (65 aa)

SEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAP--DNA--LKIVDFGSAQPYNP-QALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTY
.|.|..  | | |.|. |||  .. |||.|| | .|.   .    .||.||| .   ..   .|      || |. ||| |  ||.. |||.|  ||.||
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDI---MGTPEYVAPEIVNYEPLSLATDMWSIGVITY

IMLSGRSPFYEPDPQETEARIVGGRFD-AFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
||||| |||   . ||| . |   . | .  .  .||..|. | |. |   |  |.. ..|| |||.
IMLSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase SPEG.AA MSK 2969-3218 26 5.1e-47 156.97 In-house 1-277 (277) Show / Hide 
Range on Protein: 2969-3218
Range on HMM: 1-277/277
Sequence Identity: 26% (74 aa)

LEEK---ARGRFGVVRACRENATGRTFVAKIVP-----YAAEGKRRVLQEYEVLRTL-HHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSE
|...   . |.|...| |.   ||  . .||..       .  .  . .|  .|. .  |  | .||.|. ..  . |. | |   ||.  .. | . .|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

DDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPD---NALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVK----GEP-IGSATDIWGAGVLT
. .. .| .|   .|..|  .. | |.|| |.|.. .     .|..|||.|   ...   ..    .||..|||||..    ...  ..| |.|. ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YIMLSGRSPFY--EPDPQ-------ETEARIVGGRFDAF-QLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
| ||.|..||   |.| |       |   ||  |.|    .   | |. |  .... | . |  |....| .|| |.
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase SPEG.AA RSK 2969-3218 27 2.9e-46 160.04 In-house 1-278 (278) Show / Hide 
Range on Protein: 2969-3218
Range on HMM: 1-278/278
Sequence Identity: 27% (78 aa)

LEEK---ARGRFGVVRACRENATGRTFVAKIVPYAAEGKR-----RVLQEYEVLRTLH-HERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFR---
|...   . | . ..| |.  .||. .  |..  |   .|     ....| ..| .   |  | .||.|. |. .| || | |   ||.  |. . .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAP---DNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVK---GEP-IGSATDIWGAGV
 |||... || ..   ...|| ... | |.||.| |..    .  .|..||| .   ...   ..    .|.|.|||||.|   ..   . | |.|  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYIMLSGRSPFYE---PDPQETEARIVGGRFDAFQLY--PNTSQSATLFLRKVLSVHPWSRPS-----LQDCLAHPWL
| | ||.|..||.     ...|. .||  |.|. . .   .. || |  ..|| | ..|  |..     ... ..|||.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFS-LTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase SPEG.AA DAPK 3010-3218 37 6.5e-39 109.81 In-house 52-264 (264) Show / Hide 
Range on Protein: 3010-3218
Range on HMM: 52-264/264
Sequence Identity: 37% (80 aa)

EYEVLRTLH-HERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALK----IVDF
|  .|| .  |. | .||..| .    ||| |     ||   | ..   .|.  . .  | |.|. ..|  |. |.|.|| |  |   |. .    |.||
EVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECLNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDF

GSAQPYNP-QALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDAFQLY-PNTSQSATLFLRKVLSVH
| |    | .  . .    || || ||| |  || | .|| |  || |||.||| |||     ||| | |   ...    |  |||. |  | |. |   
GLAHRIEPGNEFKNI---FGTPEFVAPEIVNYEPLGLETDMWSIGVITYILLSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKD

PWSRPSLQDCLAHPWL
|  |   |.|| ||| 
PKKRMTIQECLQHPWI
Kinase SPEG.AA TyrKc 2966-3218 18 3.4e-12 -25.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 2966-3218
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

YTFLEEKARGRFGVVRACRENATGRTFVA--KIVPYAAEGKRRVLQEYEVLRTL--HHERIMSLHEAYITP-------RYLVLIAESCGNRELLCGLSDR
 |....  .| ||.|. .. .    . ||  .. ..|   ..  ..| .... |  ||. |  |. . ...         | .. | . .  |.  | ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

FR-YSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQ--------ALRPL---GHRT-GTLEFMAPEMVKGEPIGSA
 .  . .|   ...|  .| .||| ... | |.   | |.. ..  || ||| .                |.    | .|   .  ||||  .     ..
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

TDIWGAGVLTY-IMLSGRSPFYE-----PDPQETEARIVGGRFDAFQLY------PNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
.|.|  ||. . |.  | .| ..      ..||  ...  |.      .      .  ..      ..     | .||. ...  |  .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SPEG.AA DAPK 2968-3029 30 1.3e-07 16.69 In-house 1-70 (264) Show / Hide 
Range on Protein: 2968-3029
Range on HMM: 1-70/264
Sequence Identity: 30% (21 aa)

FLEEKARGRFGVVRACRENATGRTFVAKIV---PYAAE----GKRRVLQEYEVLRTLH-HERIMSLHEAY
  ||  ||.| ||| ||.  ||. . || .    ...          . |  .|. .  | .. .|||.|
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVY
Kinase SPEG.AA DAPK 2966-2995 46 0.001061 6.44 In-house 1-30 (264) Show / Hide 
Range on Protein: 2966-2995
Range on HMM: 1-30/264
Sequence Identity: 46% (14 aa)

YTFLEEKARGRFGVVRACRENATGRTFVAK
|   ||   | | ||. |||  ||  . ||
YDMGEEIGSGQFAVVKKCREKSTGKEYAAK