TIE2

Species: Human
Alias: VMCM1, TEK, HPK-6, VMCM, TIE2, CD202B, TIE-2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9p21.2,

Classification

Group: TK
Family: Tie

Sequence

Name Sequence Type Origin Length Description Download
TIE2.NA RNA Sugen Kinome 4817 None Fasta, JSON
TIE2.AA Protein Sugen Kinome 1124 None Fasta, JSON
TIE2.kin_dom Protein Kinase Domain Sugen Kinome 269 None Fasta, JSON

Protein domain

Protein domains of TIE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ig_Tie2_1 TIE2.AA Ig_Tie2_1 23-118 67 9.3e-77 253.61 Pfam 1-99 (99) Show / Hide
Range on Protein: 23-118
Range on HMM: 1-99/99
Sequence Identity: 67% (67 aa)

AMDLILINSLPLVSDAET-SLTCIASGWRPHEPI-TIGRDFEALMNQHQD-PLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKM
.||.||||..|.|||||| |||||||.|.||||| |||.||...|||||| |.|...|..|.|.||||||.||.|.|.|||.|..||||.|.||.||||
IMDVILINPDPVVSDAETPSLTCIASDWHPHEPILTIGQDFPRPMNQHQDLPQEFPHDEPRPWPKKVVWKWEKRSHIFGAYYCQIRVRGQARRIYTMKM

EGF_2 TIE2.AA EGF_2 224-251 32 5.3e-07 25.38 Pfam 1-29 (29) Show / Hide
Range on Protein: 224-251
Range on HMM: 1-29/29
Sequence Identity: 32% (10 aa)

CTACMN-NGVCHED-TGECICPPG-FMGRTC
|  | . .|.|  . .| | |..| . | .|
C--CNGHHGTCNNQGCGKCQCDDGWWQGDHC

EGF TIE2.AA EGF 219-252 32 1e-06 29.14 SMART 1-32 (32) Show / Hide
Range on Protein: 219-252
Range on HMM: 1-32/32
Sequence Identity: 32% (13 aa)

ECNHLCTACMNN-----GVCHEDTGECICP-PGFMGRTCE
||      | ..     |.|.  . .| || ||..| .||
ECA----PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE

Laminin_EGF TIE2.AA Laminin_EGF 230-268 23 0.000774 16.72 Pfam 10-59 (59) Show / Hide
Range on Protein: 230-268
Range on HMM: 10-59/59
Sequence Identity: 23% (12 aa)

N-GVCHE-------DTGECI-CPPGFMGRTCEKACELHTFGR---TCKERC
| . |.         ||.|  | ....|| |.  |.  ..|.   .  . |
NDDQCDPDDEHCGKHTGQCHNCKHNVTGRHCDR-CKPGYWGDPWCDPPQGC

EGF TIE2.AA EGF 224-250 27 0.001146 15.32 Pfam 1-36 (36) Show / Hide
Range on Protein: 224-250
Range on HMM: 1-36/36
Sequence Identity: 27% (10 aa)

CTA----CMNNGVCHED--TGECICPPG---FMGRT
|.     |...| |..   . .|.||||   . |..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

EGF TIE2.AA EGF 267-299 23 0.072199 10.33 SMART 1-32 (32) Show / Hide
Range on Protein: 267-299
Range on HMM: 1-32/32
Sequence Identity: 23% (9 aa)

RCSGQEGCKSYV-----FCLPDPYGCSCA-TGWKGLQCN
 |.   .|          |.   | | |.  |..| .| 
ECA---PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE

EGF TIE2.AA EGF 268-297 25 7.516007 2.57 Pfam 1-36 (36) Show / Hide
Range on Protein: 268-297
Range on HMM: 1-36/36
Sequence Identity: 25% (9 aa)

CSGQ-EGCKSYVFCLPDP--YGCSCATG---WKGLQ
|. .  .|.   .|.. |  | | |. |   ..| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

EGF_2 TIE2.AA EGF_2 264-298 27 23.837123 1.45 Pfam 1-29 (29) Show / Hide
Range on Protein: 264-298
Range on HMM: 1-29/29
Sequence Identity: 27% (11 aa)

CKERCSG-QEGCKSYVFCLPDPYG---CSCATG-WKGLQC
|   |.| .. | ..        |   |.|  | | | .|
C---CNGHHGTCNNQ--------GCGKCQCDDGWWQGDHC

EGF_2 TIE2.AA EGF_2 315-340 38 9e-06 21.59 Pfam 1-29 (29) Show / Hide
Range on Protein: 315-340
Range on HMM: 1-29/29
Sequence Identity: 38% (12 aa)

CSCNN-GEMCDRFQG---CLCSPG-WQGLQC
| ||. .. |... |   | |..| ||| .|
C-CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC

EGF TIE2.AA EGF 310-341 28 0.395978 1.89 SMART 1-32 (32) Show / Hide
Range on Protein: 310-341
Range on HMM: 1-32/32
Sequence Identity: 28% (11 aa)

DCKLRCSCNNGE-----MCDRFQGCLCS-PGWQGLQCE
.|     | .|       |     | |  ||..| .||
ECA---PCHHGGCEQHGTCI-SYTC-CPGPGYTG-RCE

EGF_2 TIE2.AA EGF_2 302-311 36 0.538532 6.6 Pfam 19-29 (29) Show / Hide
Range on Protein: 302-311
Range on HMM: 19-29/29
Sequence Identity: 36% (4 aa)

CHPG-FYGPDC
|..| ..|..|
CDDGWWQGDHC

EGF TIE2.AA EGF 329-339 35 2.071507 4.44 Pfam 23-36 (36) Show / Hide
Range on Protein: 329-339
Range on HMM: 23-36/36
Sequence Identity: 35% (5 aa)

CLCSPG---WQGLQ
| | ||   ..| .
CQCPPGYLGYTGKR

Laminin_EGF TIE2.AA Laminin_EGF 315-342 28 23.386204 0.82 Pfam 1-42 (59) Show / Hide
Range on Protein: 315-342
Range on HMM: 1-42/59
Sequence Identity: 28% (12 aa)

CSCN-NG----EMCDR-------FQG-CL-CSPGWQGLQCER
| || .|    . ||.       ..| |. | .. .| .|.|
CDCNPHGSVNDDQCDPDDEHCGKHTGQCHNCKHNVTGRHCDR

FN3 TIE2.AA FN3 444-528 18 0.00097 19.67 SMART 1-69 (69) Show / Hide
Range on Protein: 444-528
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

LPKPLNA--PNVIDTGHN------FAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPR----TEYELCVQLVRRGEGGEG
 . | |   . | |.. .       ...  . .|           . |.                 .|.  |.|     ||||  |. | ....|||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK-PP----------IVGYR-----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

FN3 TIE2.AA FN3 543-625 15 5.5e-07 30.46 SMART 1-69 (69) Show / Hide
Range on Protein: 543-625
Range on HMM: 1-69/69
Sequence Identity: 15% (15 aa)

LPPPRG---LNLLPKSQT------TLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR----EQYVVRARVNTK-AQGEW
 .||..   | . . . |      ...|.|.|         |.                       . . .|.|      .|..| |. .. ..|| 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----IVGYR-----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

FN3 TIE2.AA FN3 639-721 17 8.9e-14 53.02 SMART 1-69 (69) Show / Hide
Range on Protein: 639-721
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

PPQPEN---IKISNITHS------SAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPE----TAYQVDIFAENN--IGSS
|. |.|   ......| .      |...||.          ...|.                     | ..||.|     | |.. . |.|    |..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Kinase TIE2.AA Tie 832-1092 85 2.9e-230 709.12 In-house 1-267 (267) Show / Hide
Range on Protein: 832-1092
Range on HMM: 1-267/267
Sequence Identity: 85% (228 aa)

EGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS
|||||||.||.||||||.|..|||.||||||.||||||.|||||.||.|||||||||.||||||||||.||||||.||||||||||||.|||||||....
EGNFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREHT

T------ASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYG
|      ||||||||.|||||||||||.||||||.||||||||||||.||||.||||||||||.||||||||||||||||||||||||||||.|||||||
TRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYG

VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
|||||||||||||||||||||||||||||||.|.|.|||||||||||||||..|||||.||||.|.|
VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL

TyrKc TIE2.AA TyrKc 824-1092 40 4.90000000001e-141 475.75 SMART 1-280 (280) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-280/280
Sequence Identity: 40% (122 aa)

IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLG-HHPNIINLLGACEHR-------GYLYLAIEYAPHGNLLDFLR
|.. ...|||.||.| |.. |     .. |.| .||.|    ..||  |....|||| |||||..|.|.| .        . |..  ||.|||.|.|.||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVY--------VKKT----MGR--LP
|.|                 |. ..||.|. ..|.||.||..|..|||||||||.|||||...||.||||||  . .        ....     |.  ||
KHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG-----MTCAELYEKLPQGYRLEKPLN--------CDDEVYDLMRQCWREKPYERPSFAQI
.||||.|..||...|| |||||.||..||| ..|..|| |     |. .|..|.. ||||...| |        | ||.|..|.|||.|.| .||.|..|
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

LVSL
   .
HECF

Pkinase_Tyr TIE2.AA Pkinase_Tyr 824-1092 44 6.1e-140 474.57 Pfam 1-270 (270) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-270/270
Sequence Identity: 44% (125 aa)

IKFQDVIGEGNFGQVLKARIK--KDGLRMDAAIKRMKEYASKDD--HRDFAGELEVLCKLGHHPNIINLLGACE-HRGY--LYLAIEYAPHGNLLDFLRK
|.|  ..|||.||.| |.. |  .|. ... |.| .||.|....  ..||  |......|||||||..|.|.|  ...   .|.  ||.|||.|||.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

SRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY-VKKTMGRLPVRWMAIESLNY
 |            .    |. ..||......|.||.||..|..|||||||||.||.|| |.||.||||.|     . | .|.. |.||..||| |..||
HR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY

SVYTTNSDVWSYGVLLWEIVSLGGTP-YCGMTCAELYEKL-PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
...|| |||||.|||.|||...|..| | ||. .|.||..  .|||...| || ||.||||.|||...| .||.|..|.  |
GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase TIE2.AA TK 824-1092 25 2.2e-119 402.12 In-house 1-486 (486) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-486/486
Sequence Identity: 25% (125 aa)

IKFQDVIGEGNFG---QVLKARIK-----------------------KDGLRMDAAIKRMKEY--ASKDDHRD--------------FAGELEVLCK-LG
|.. ...|||.||   .| |.. .                       |.| ... |.| .||   .|.....|              .| |....|  ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNIINLLGACEHR------------GYLYLAIEYAPHGN----LLDFLRKSRVLETDPAFAIAN----------------------------------
|||||..|.|.| .             . ...  ||.|||.    |.|.|||.|  .....  ..|                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------STASTLSSQQLLH-------------------FAADVARGMDYLSQK------QFIHRDLAARNILVGENYV-----------AKIADFGLSR-
         ..|. ..||.                   .....|.|| ||..|      .|.||||||||.|||||.|           .||||||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----------------------------------GQEVYVKKTMGRLPVRWMAIESLN---------YSVYTTNSDVWSYGVLLWEIVSLG-GTPYCGMT
                                  .|. | ... |.||.|||| |.||         | ..|| |||||.|||.|||...| ...| ||.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

---------CAELYEKLPQG--------------YRLEKPLNCD--------------DEVYDLMRQCWREKPYERPSFAQILVSL
         ..|..|.| .|              .|...| .|               .|.||||.|||...| .||.|.|..  |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase TIE2.AA FGFR 824-1092 43 7.79999999999e-114 384.48 In-house 1-293 (293) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-293/293
Sequence Identity: 43% (128 aa)

IKFQDVIGEGNFGQVLKARIK---KD--GLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR
     ..||| |||| .|  |   .|     .  |.| .|. .. .|  |   |.|..   | |.|||||||.|   | ||  .||..|||| ||||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

VLETDPAFAIA-------NSTAST--------LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG---QEVYVKKTMGRL
  . |  . .         ... .        |.. .|  .|  |||||.||  .  |||||||||.||...|| ||.||||.|.    . | |.| |||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMT-CAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
|. ||| |.|   |||. |||||||||||||  .||.|| .     |||. |  |.|.||| ||  |.| .|.|||..|| .||.|.|.  .|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL

Kinase TIE2.AA TK-Unique 824-1092 40 4.1e-111 375.45 In-house 1-294 (294) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-294/294
Sequence Identity: 40% (118 aa)

IKFQDVIGEGNFGQVLKARIKK----DGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRG-YLYLAIEYAPHGNLLDFLRKSR
....||||||.|||| .. ...    .. .  .|.|  |..|.. |..||  |.... .|| ||||...||.|   .   ....||.| |||...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

VLETDP--------AFAIANSTAST--LSSQQLLHFAADVARGMDYLSQ--KQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKK-TMGRLPV
    ..         |. .... .|  .|...|.||| ..|.|| ||..  |...||||.|||.|..|..|.||.|||..|     .||... . ||.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAIESLN--YSVY-TTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNC-DDEVYDLMRQCWREKPYERPSFAQILVSL
|||| |||   . .| || |||||.|||.|||..||..|| ||  ... |....|||...| .|  .|.| ||..||...| |||||.||.  |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase TIE2.AA Src 824-1092 37 2.9e-90 306.2 In-house 1-255 (255) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-255/255
Sequence Identity: 37% (104 aa)

IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETD
||. . .|.|.|| | ..  ..   ... |.| .|.     .  .|  | ... ||  |.....|.  |      |   ||  ||.|||.|.|       
IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-------

PAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE----VYVKKTMGRLPVRWMAIESLNYSVYTTNS
      ... ..|. .||. .|| ||.||.||.....|||||||||.||||| |.|.||||| |  .    .|. ..  ..|..|.| | .|| ..|. |
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYD-LMRQCWREKPYERPSFAQILVSL
||||.|.||.|||. | .|| ||| .|  ... .|||. .| || ||.|. .|.|||...| .|| |. .   |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase TIE2.AA UTK 824-1092 33 5.2e-89 302.02 In-house 1-296 (296) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-296/296
Sequence Identity: 33% (101 aa)

IKFQDVIGEGNFGQVLKARIKKDG---LRMDAAIKRMK-EYASKDDHR---DFAGELE---VLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDF
... . .|.|.||.| ||| ...    . || |.|  . . .. ....   ||  |     .. .. .|||...|.| |   . .....||.. |.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRKSRV-LETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGEN-------YVAKIADFG---LSRGQE------------
||..|  ..              |.. |.|..|.|.|||| ||....|.||||||||.||...       .|.||||||   .||.              
LRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESY

VYVKKTMGRLPVRWMAIESLNYS-VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG--YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQ
 | .   .|.|.|||| |.|..   .|| |||||.||..|||.. | .|| ||. ... . .  |  ||...|  | ..||.||..||.  | |||.| .
YYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

ILVSL
..  .
LVQQM

Kinase TIE2.AA RTKB 824-1092 36 3.2e-83 280.38 In-house 1-264 (264) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-264/264
Sequence Identity: 36% (99 aa)

IKFQDVIGEGNFGQVLKARIKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLE
..     |.| ||.| .| ..  .       | |..|  ||  .. ||  |. |.  || |||.| ..| | .   . | .|.. .||| |.||..|  .
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

TDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR-GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNS-
 .|          .|...||. |. ..|.|| .|.|.. |||||.|||.||. .   ||.|||..|  ..  ...|  |||..|||.||. .. ||| | 
HNPQ---------SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSG

DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
||||.||  ||| |||||||     ... . |  |.||.||     .....|..|| . . .||.|. .. ..
DVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF

Kinase TIE2.AA Fer 824-1093 28 3.3e-79 269.35 In-house 1-283 (283) Show / Hide
Range on Protein: 824-1093
Range on HMM: 1-283/283
Sequence Identity: 28% (84 aa)

IKFQDVIGEGNFGQVLKAR-----IKKDGLRM---DAAIKRMKEY-ASKDDHRDFAGELEVLCK-LGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDF
.......|||.|| | |.|     .|. ..     . . |..|.  |.|.  ..|  |  .. . .  |||.. . | | ..  ... .|....|.|...
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD-HPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE-NYVAK--IADFGLSRG----QEVYVKK-TMGRLPVRWM
|.|.                 |.|  ... .....|.||.|| .|. ||||.||||.|... . . |  |.|||.||     .. | .| .. ..|.||.
LKKNKNK--------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWL

AIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG----MTCAEL-----YEKLPQGYRLEKPLNCDDEVYDLMR-QCWREKPYERPSFAQILVSLN
| |.... .|....||||.||..||| . | .|| |    |.....       .   ||..  |... .|.. .|  ||| ..| .||....|   |.
APETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase TIE2.AA VEGFR 936-1092 50 4.6e-72 245.73 In-house 170-332 (332) Show / Hide
Range on Protein: 936-1092
Range on HMM: 170-332/332
Sequence Identity: 50% (82 aa)

LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG----QEVYVKKTM-GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWE
| .. |. ..  |||||..|. .  |||||||||||. ||.| || ||||.|        ||.|.  |||| .|||.||.   |||| ||||||||.|||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

IVSLGGTPYCGMT-CAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
| |||| || |     |.. .|  |||...|  |  |.|. | .||.. | |||.|.   . |
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL

Kinase TIE2.AA Ret 941-1094 49 4.4e-66 224.69 In-house 137-293 (293) Show / Hide
Range on Protein: 941-1094
Range on HMM: 137-293/293
Sequence Identity: 49% (78 aa)

LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGT
.. ||  . .|| |||    .||||||||.|| |  . || ||||.|       |||.  .|.|| |||||||   |||| |||||.|||.|||| .|. 
IISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGAN

PYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR
|| | .   |.. |  ||| . | ||  |.| .|||||.. |  ||.|. |   . .
PYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK

Kinase TIE2.AA S_TKc 824-1096 25 9.3e-47 162.58 SMART 1-231 (231) Show / Hide
Range on Protein: 824-1096
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPH--GNLLDFLRKSRVLE
 .. ..||.| ||.| |.| ||       |||..|        ...  |...| |  |||||..|...... ..||.  ||...  |.|.|...| .   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTT-NSD
..          . ..  .  .... ......|. ....|||||   |||. |  . ||.||||.|        |       .|| | |    |..  .|
LR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCD

VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV-----SLNRML
.|| |..|.| .. | .|..  . .....|.            ..|. |..|.|..  | .||.  ..|       .   .
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase TIE2.AA Pkinase 824-1092 22 1.5e-46 165.69 Pfam 1-293 (293) Show / Hide
Range on Protein: 824-1092
Range on HMM: 1-293/293
Sequence Identity: 22% (70 aa)

IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKD--DHRDFA-GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHG----NLLDFLRK
...  .||.|.||.| |.. |..|     |.|..|    |.  | ...   |.... .| .||||. |....| ....|.  ||...|     | |... 
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

SRVLETDPAFAIANSTASTL--SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA----KIADFGLSRG--QEVYVKKTMGRLPVRWMAIE
              .   ..  | ... ...  ..||..|. .. .|||||   |||. .|..     ||.||||..      ..  |      ..|| |
--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE

SLN-YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM----TCAELYEKLPQGYRLEKPLNCD-----------------------DEVYDLMRQCWREKPY
 .. .. |.. .|.||.|..|.| .. | .|..|     . .. .... .  . . . ...                       .|  |... |.. .|.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

ERPSFAQILVS--L
.||...||| .  .
KRPTAEQILQHPWF

Kinase TIE2.AA VEGFR 824-918 37 1.5e-18 66.68 In-house 1-101 (332) Show / Hide
Range on Protein: 824-918
Range on HMM: 1-101/332
Sequence Identity: 37% (38 aa)

IKFQDVIGEGNFGQVLKAR---IKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEH---RGYLYLAIEYAPHGNLLDFLRKS
.|   ..|.| ||||..|    |.|       | |..|| |  . ||    ||..|  .||| |  |.||.|      | |   .|| ..|||...||  
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

R
|
R

Kinase TIE2.AA Ret 824-918 35 1.4e-16 53.14 In-house 1-100 (293) Show / Hide
Range on Protein: 824-918
Range on HMM: 1-100/293
Sequence Identity: 35% (36 aa)

IKFQDVIGEGNFGQVLKA---RIKKDGLRMDAAIKRMKEY-ASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRG--YLYLAIEYAPHGNLLDFLRKS
  . |. ||| ||||.||   .|.        |.|  |.  |.    .|   |...| |.  ||..| |.|||   .   . | .||.  | |  ||| |
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLL-KQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R