TIF1a

Species: Human
Alias: RNF82, TRIM24, TIF1a, hTIF1, TF1A, TIF1ALPHA, TIF1A, TIF1, PTC6
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 7q24,

Classification

Group: Atypical
Family: TIF1

Sequence

Name Sequence Type Origin Length Description Download
TIF1a.NA RNA Sugen Kinome 5473 None Fasta, JSON
TIF1a.AA Protein Sugen Kinome 1050 None Fasta, JSON

Protein domain

Protein domains of TIF1a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RING TIF1a.AA RING 56-130 17 3.7e-10 40.99 SMART 1-23 (23) Show / Hide
Range on Protein: 56-130
Range on HMM: 1-23/23
Sequence Identity: 17% (13 aa)

CAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVC
|..|..      |..||| | ||. |.                                            ||.|
CPICLE------PVVLPCGH-FCY-CI--------------------------------------------CPIC

Zf-C3HC4 TIF1a.AA zf-C3HC4 56-82 30 1.6e-05 17.01 Pfam 1-33 (48) Show / Hide
Range on Protein: 56-82
Range on HMM: 1-33/48
Sequence Identity: 30% (10 aa)

CAVCHQN-IQSRAPKLLPCLHS-----FCQRCL
|..||.. ..   | ..||.|.     ||. |.
CWICHCEWKDPNNPLIHPCGHRGSLKWFCHSCI

PHD TIF1a.AA PHD 126-140 23 3.236557 2.27 Pfam 1-17 (54) Show / Hide
Range on Protein: 126-140
Range on HMM: 1-17/54
Sequence Identity: 23% (4 aa)

RCPVCSQ--ECAERHII
.|.||..   ...  .|
YCCVCQKCDWDDDGDMI

Zf-C3HC4 TIF1a.AA zf-C3HC4 127-136 30 11.533313 0.08 Pfam 1-10 (48) Show / Hide
Range on Protein: 127-136
Range on HMM: 1-10/48
Sequence Identity: 30% (3 aa)

CPVCSQECAE
|..| .|...
CWICHCEWKD

BBOX TIF1a.AA BBOX 158-205 25 2.4e-13 51.56 SMART 1-51 (51) Show / Hide
Range on Protein: 158-205
Range on HMM: 1-51/51
Sequence Identity: 25% (13 aa)

KSNQVCTSCEDNAEANGFC-VECVEWLCKTCIRA--HQRVKFTKDHTVRQK
.. ..|........|. || ..| ..||..| ..  ||..|....|.|.  
HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL

Zf-B_box TIF1a.AA zf-B_box 159-205 20 1e-06 30.69 Pfam 1-45 (45) Show / Hide
Range on Protein: 159-205
Range on HMM: 1-45/45
Sequence Identity: 20% (10 aa)

SNQVCTSCEDNAEANGFCVECVEWLCKTCIRA-HQRVKFTKDHTVRQK
.. .|  ...  ... .| .| . .|  |. . |.. . .|.|||.  
QM-YCPEHPE-EPLEYYCQDCQQCICEDCAVHGHKGNG-FKKHTVVPI

PHD TIF1a.AA PHD 181-190 40 1.250521 3.56 Pfam 45-54 (54) Show / Hide
Range on Protein: 181-190
Range on HMM: 45-54/54
Sequence Identity: 40% (4 aa)

EWLCKTCIRA
||.|. |. .
EWYCPRCKCC

BBOX TIF1a.AA BBOX 218-259 27 7.7e-14 53.23 SMART 1-51 (51) Show / Hide
Range on Protein: 218-259
Range on HMM: 1-51/51
Sequence Identity: 27% (14 aa)

QRPVFCPFHK-KEQLKLYC-ETCDKLTCRDCQLL-EH------KEHRYQFI
.||. |..|. .| ....| |.|... |.|| .  ||      . |.....
HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL

Zf-B_box TIF1a.AA zf-B_box 219-259 32 3e-09 41.27 Pfam 1-45 (45) Show / Hide
Range on Protein: 219-259
Range on HMM: 1-45/45
Sequence Identity: 32% (15 aa)

RPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKE-----HRYQFI
..  || |..| |..||..|... |.|| . .||      |... |
QM-YCPEHPEEPLEYYCQDCQQCICEDCAVHGHKGNGFKKHTVVPI

BBC TIF1a.AA BBC 266-392 31 3.6e-45 157.29 SMART 1-132 (132) Show / Hide
Range on Protein: 266-392
Range on HMM: 1-132/132
Sequence Identity: 31% (42 aa)

QKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVN-----QNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
..... ...|||..|.........||||.| .|.     .|...|||.|......|| ..|...|..|..|.. .......||||.|   ....||||..
HREKLEQHLTKLRKKHWECEDAMKQIQNIIQQVQPGHVDENHEDVEQCIRAHFDDLMNWLNRRKKMMLMDLDEQCENKQKWLMQQMQTMTQKQEQLEHCC

HFSKWAVSSGSSTALLYSKRLITYRLRHLLRA
.|. ||...|..|..|.||.||.....||...
QFCQWALNMGDCTEFLQSKKLIIFQCCHLHKQ

PHD TIF1a.AA PHD 828-873 38 1.9e-19 62.33 Pfam 1-54 (54) Show / Hide
Range on Protein: 828-873
Range on HMM: 1-54/54
Sequence Identity: 38% (21 aa)

WCAVCQN-----GGELLCCE-KCPKVFHLSCHVPTLT--NFPSGEWICTFCRDL
.|.|||      .|...||. .||. ||..|| |.|.  . |.|||.|. |.  
YCCVCQKCDWDDDGDMICCDNGCPRWFHQYCHGPPLEPEEIPEGEWYCPRCKCC

PHD TIF1a.AA PHD 828-871 35 1.2e-13 52.53 SMART 1-39 (39) Show / Hide
Range on Protein: 828-871
Range on HMM: 1-39/39
Sequence Identity: 35% (16 aa)

WCAVCQNGGELLCCE-KCPKVFHLSCHVPTLTNFPSGEWICTFCR
.| ||.  | ...|. .|.. .|. |. |.|.  |.| |.|  ||
YC-VCGK-G-MIQCDPGCDRWYHQ-CLGPPLE-PPDG-WYCPRCR

Zf-C3HC4 TIF1a.AA zf-C3HC4 846-870 32 2.540605 1.98 Pfam 26-48 (48) Show / Hide
Range on Protein: 846-870
Range on HMM: 26-48/48
Sequence Identity: 32% (8 aa)

KVFHLSCHVPTLTNFPSGEWICTFC
|.|. || .  . .  ||.. | .|
KWFCHSCIKRWWNH--SGNTQCPIC

BROMO TIF1a.AA BROMO 901-1006 40 1.9e-41 144.96 SMART 1-118 (118) Show / Hide
Range on Protein: 901-1006
Range on HMM: 1-118/118
Sequence Identity: 40% (49 aa)

TPIDKRKCERLLLFLYCHEMSL------------AFQDPVPLT---VPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSE
.|  ..||..||  ..||...              |..||.     .||||.||||||||.||||.|.. .   . .|.||.||.|.|.||  .||||||
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQY--QSMEEFVDDFMLMFNNCMTYNEPDSE

VANAGIKLENYFEELLKNLYP
|  ...||...|||... ..|
VYKMAKKLQKFFEEKWREFPP

Bromodomain TIF1a.AA Bromodomain 908-992 34 6.5e-29 96.69 Pfam 1-89 (89) Show / Hide
Range on Protein: 908-992
Range on HMM: 1-89/89
Sequence Identity: 34% (31 aa)

CERLLL--FLYCHEMSLAFQDPV---PLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYS-KPEDFVADFRLIFQNCAEFNEPDSEVANAGIK
|....    .. |. . .|..||   .  .||||.|||.|||||||...|  . . |.  ...| .|..|...|| ..|.|||.....  |
CDQIMDMKYIMEHPICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKL--KNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK