Gene Trb1 (Human)
Trb1
Sequence
Protein domains of Trb1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Trb1.AA | Trbl | 96-338 | 69 | 2.1e-204 | 651.71 | In-house | 1-256 (256) | Show / Hide |
Range on Protein: 96-338 Range on HMM: 1-256/256 Sequence Identity: 69% (179 aa) LLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKD-------------FGDMHSYVRSRKRLREEEA .|...|.|||..|...|||.|..||||||..||...|||..||.|..|..|.||||||.|||.|||.. .||||||||.||||.|||| CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVILGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEEA ARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRY ||||.|...|||||||..|||.|||||.|||..||||.|.||||||..||.||||.|.||||||||||||||.|.|.|||||||.|||||||||.||||| ARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGRY PFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWF |||||.|..||.||||||||||||.|||||||||.|||||||||.||..||||||| PFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF |
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| Kinase | Trb1.AA | CAMK | 164-338 | 21 | 3.3e-64 | 205.5 | In-house | 148-425 (425) | Show / Hide |
Range on Protein: 164-338 Range on HMM: 148-425/425 Sequence Identity: 21% (61 aa) FGDMHSYVRSR---------------KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEER---------------TQLRLESLEDTHIMK | |. .|.... .|. |.||.|.|.||.|||..||. || |||. ... .. .. . ... FDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD G-----------------------EDDALSDKHGCPAYVS-PEILNTTG------------TYSGKAADVWSLGVMLYTLLVGRYPFHDS---------- . |.. ... |.|.|.. ||.|| | .| |...|.||.||.||..|.|..|| .. PGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEW ---DPSALFSKIRRGQFC-IPEH-----------------------ISPKARCLIRSLLRREPSERLTAPEILLHPWF ... || ||..|.. .|.. .|. ...|||..|...|..|.|. ..| |||. IGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | Trb1.AA | SgK495 | 166-341 | 37 | 1.4e-41 | 126.5 | In-house | 1-171 (171) | Show / Hide |
Range on Protein: 166-341 Range on HMM: 1-171/171 Sequence Identity: 37% (67 aa) DMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAA . .| ||| | |. .| .|. | || || |||| | . |. . . | | | |. | |||.||..| | || . NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTH-QITITNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGR-PYRGKPS DVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE--HISPKARCLIRSLLRREPSERLTAPEILLHPWFESV |.| |||.|.|.| | .|| || | || ||. . ||. .| ||||.|| .|..|||| ... |.| DMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVI-----EAV |
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| Kinase | Trb1.AA | MELK | 139-338 | 33 | 7.7e-41 | 137.12 | In-house | 55-254 (254) | Show / Hide |
Range on Protein: 139-338
Range on HMM: 55-254/254
Sequence Identity: 33% (68 aa)
SHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDD
.| .| . .| | | .. .| |.| |. ...|| |||. .|.|||||.|. | ||| ..| .| .|.| . ||. |
RHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLF--DEDHHLKLIDFGLCAKTKGRKD
AL--SDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH
| ||| ||... | | |||||.|..||.|..| || | .... || .| . |...||... |.| .| .| |. ..| |
YHNLQTCCGSPAYAAPELIQGK-QYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNH
PWF
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PWV
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| Kinase | Trb1.AA | CAMKL | 246-338 | 35 | 1.8e-37 | 117.05 | In-house | 197-297 (297) | Show / Hide |
Range on Protein: 246-338 Range on HMM: 197-297/297 Sequence Identity: 35% (37 aa) PAYVSPEILNT-TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPS-------ALFSKIRRGQFCIP--EHISPKARCLIRSLLRREPSERLTAPEILLH |.| .|||.. | |...|.||.||.||....|..|| | . . |. ||..| ...| |.| .| |||..| . |..| |. .|. | PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH PWF ||. PWM |
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| Kinase | Trb1.AA | MARK | 244-338 | 43 | 3.1e-36 | 116.06 | In-house | 167-262 (262) | Show / Hide |
Range on Protein: 244-338 Range on HMM: 167-262/262 Sequence Identity: 43% (42 aa) GCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD--PSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWF | |.| .|||.. | |...|.||||| ||....|..|| ... |. ||.||...|| |.|...| ||..|| |.|| |. ||. |||. GTPPYMAPEIFLKKP-YDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | Trb1.AA | PLK | 248-338 | 41 | 3.7e-34 | 108.69 | In-house | 166-258 (258) | Show / Hide |
Range on Protein: 248-338 Range on HMM: 166-258/258 Sequence Identity: 41% (39 aa) YVSPEIL--NTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH--ISPKARCLIRSLLRREPSERLTAPEILLHPWF |..||.| | .| .| . .|.||||...||||.|. || .| ..|. ....||| ||. |. ||...|.. |.||.|. .|| ||.| YIAPEVLDGNKQG-HSYE-VDCWSLGCIMYTLLIGKPPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF |
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| Kinase | Trb1.AA | AMPK | 244-338 | 41 | 3.4e-33 | 95.94 | In-house | 161-254 (254) | Show / Hide |
Range on Protein: 244-338 Range on HMM: 161-254/254 Sequence Identity: 41% (39 aa) GCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWF | | | .||. | | |.|| || || .| |. || |.. ..|. ||. |.. ||...||.|. ||...|. | .|.| .| |||| GSPCYAAPEMISGK-LYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | Trb1.AA | RSK | 244-338 | 34 | 2.5e-31 | 110.38 | In-house | 170-278 (278) | Show / Hide |
Range on Protein: 244-338 Range on HMM: 170-278/278 Sequence Identity: 34% (38 aa) GCPAYVSPEILN---TTGTYSGKAADVWSLGVMLYTLLVGRYPFHD---SDPSALFSKIRRGQ--FCIP--EHISPKARCLIRSLLRREPSERLT----- . .|. ||.|. |... ||.|.||||| .|..|.|. ||. .... .. .|..|. . .| . .|. |. ||| .| |.|. ||. YTIEYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQD APEILLHPWF | ||. |||| AEEIKQHPWF |
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| Kinase | Trb1.AA | S_TKc | 104-338 | 26 | 5.8e-28 | 100.14 | SMART | 14-231 (231) | Show / Hide |
Range on Protein: 104-338 Range on HMM: 14-231/231 Sequence Identity: 26% (67 aa) HVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEK-DF--GDMHSYVRSRKR------LREEEAARLFKQIVSAVA | .. ..|||. .|. . .| . |. . | || . .|. .. |...| | ||...| ..|.| . | .|.....||..|.. KVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALE HCHQSAIVLGDLKLRKFVFSTEERTQLRL------ESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD .||. |. ||| ... .. . | . | | |..||.| |.....|.||.|..|| .|.|. ||. . YCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--Q PSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILL-------HPWF . ..| ||. || |. .|| .|...|..|.|| |.| |||| MQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Trb1.AA | TSSK | 247-338 | 34 | 2.8e-27 | 86.57 | In-house | 193-289 (289) | Show / Hide |
Range on Protein: 247-338 Range on HMM: 193-289/289 Sequence Identity: 34% (34 aa) AYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHD--SDPSALFSKIR-RG-QFCI--PEHISPKARCLIRSLLRREPSERLTAPEILLHPWF ||..|||| |..|..||||.|| ||....|. || | |.. . .. .. .| . ..||. .. |||..|. .|..|....||. |.| AYAAPEILRGI-PYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM |
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| Kinase | Trb1.AA | Pkinase | 246-338 | 26 | 3.9e-27 | 97.03 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 246-338 Range on HMM: 175-293/293 Sequence Identity: 26% (32 aa) PAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDS------DPSALFSKIRRGQFCIPEHIS---------------------PKARCLIRSL | |..||... .|.| |...|.||.|..|| .| || || .. |. ... .|..... .. . . .. .|... PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC LRREPSERLTAPEILLHPWF |.. |..|.||..|| |||| LCKDPKKRPTAEQILQHPWF |
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| Kinase | Trb1.AA | CAMKL | 139-202 | 32 | 2.7e-15 | 45.13 | In-house | 70-149 (297) | Show / Hide |
Range on Protein: 139-202 Range on HMM: 70-149/297 Sequence Identity: 32% (26 aa) S---HSNITGIVEVILGETK------AYVFFEKDFGD---MHSYVRSR----KRLREEEAARLFKQIVSAVAHCHQSAIV . | || . ||| ... | . | | .. |.... .|. |.|| |.|.||||||..||. || NIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIV |
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| Kinase | Trb1.AA | MARK | 165-208 | 47 | 5.1e-15 | 45.7 | In-house | 87-132 (262) | Show / Hide |
Range on Protein: 165-208 Range on HMM: 87-132/262 Sequence Identity: 47% (22 aa) GDMHSYVRSR--KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKL |....|.... || |||| |.|.|||||| ||. || |.|. GELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP |
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| Kinase | Trb1.AA | AMPK | 140-208 | 38 | 7.3e-13 | 34.58 | In-house | 58-128 (254) | Show / Hide |
Range on Protein: 140-208 Range on HMM: 58-128/254 Sequence Identity: 38% (27 aa) HSNITGIVEVI-LGETKAYVFFEKD-FGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKL | .|. ||| .| ... | |. .|. ...|| |.||.|.|.||.|.| ||. || |||. HPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKP |
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| Kinase | Trb1.AA | TSSK | 165-197 | 41 | 2.3e-10 | 30.19 | In-house | 102-140 (289) | Show / Hide |
Range on Protein: 165-197 Range on HMM: 102-140/289 Sequence Identity: 41% (16 aa) GDMHSYVRSR------KRLREEEAARLFKQIVSAVAHCH ||. .|.. | ..|.||.| ..|.|.||||..|| GDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCH |
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| Kinase | Trb1.AA | Pkinase | 137-202 | 21 | 1e-06 | 24.25 | Pfam | 57-130 (293) | Show / Hide |
Range on Protein: 137-202 Range on HMM: 57-130/293 Sequence Identity: 21% (16 aa) LPSHSNITGIVEVILGETKAYVFFEKDFG-----DMHSYVR--SRKRL--REEEAARLFKQIVSAVAHCHQSAIV | .| || . .. ... |. .| | | ..|.. ..... |.|. . ..||......||. |. L-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII |
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| Kinase | Trb1.AA | PLK | 165-208 | 37 | 6.2e-05 | 12.12 | In-house | 84-128 (258) | Show / Hide |
Range on Protein: 165-208 Range on HMM: 84-128/258 Sequence Identity: 37% (17 aa) GDMHSYVRSR-KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKL .... | . | ||| |.|. . |||... . || |. |||| RSLMHYHKRRAKRLTEPEVRYYMYQIVQGLKYLHQHRIIHRDLKL |
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| Kinase | Trb1.AA | RSK | 172-208 | 37 | 0.000169 | 12.78 | In-house | 93-132 (278) | Show / Hide |
Range on Protein: 172-208 Range on HMM: 93-132/278 Sequence Identity: 37% (15 aa) RSRKR---LREEEAARLFKQIVSAVAHCHQSAIVLGDLKL . .|. . |.||. . .||.|| | || |. |||. QKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKP |
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| Kinase | Trb1.AA | TyrKc | 111-338 | 14 | 0.000284 | -153.54 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 111-338 Range on HMM: 1-280/280 Sequence Identity: 14% (45 aa) IHTGREL---------RCKVFPIKHYQD----KIRPYI------------QL-PSHSNITGIVEVILGE-------TKAYVFFE-KDFGDMHSYVRSRKR |. |..| ... .. ..... .| ..| || .. |.. . .. .| . || ..| |.... ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMK---------GEDD------ALSDKH----GCP-----AYVSP | .. || . .. |. .. || | . . ..| ..|| .. |. .| KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP EILNTTGTYSGKAADVWSLGVMLY---TLLVGRYPFHD-----SDPSALFSKIRRG-QFCIPEH--------ISPKARCLIRSLLRREPSERLTAPEILL | . .|... . |||| ||... |. | | . ... .. ....| .|.. ... .... ...|..| | || ECI-NYGKFT-TKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-- HPWF | | HECF |
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