Trb3

Species: Human
Alias: C20orf97, NIPK, Trb3, SKIP3, SINK, TRIB3, LOC57761, TRB3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 20p13,

Classification

Group: CAMK
Family: Trbl

Sequence

Name Sequence Type Origin Length Description Download
Trb3.NA RNA Sugen Kinome 2519 None Fasta, JSON
Trb3.AA Protein Sugen Kinome 358 None Fasta, JSON
Trb3.kin_dom Protein Kinase Domain Sugen Kinome 245 None Fasta, JSON

Protein domain

Protein domains of Trb3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Trb3.AA Trbl 73-315 62 7.89999999999e-194 617.75 In-house 1-256 (256) Show / Hide
Range on Protein: 73-315
Range on HMM: 1-256/256
Sequence Identity: 62% (160 aa)

LLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRT-------------HGDMHSLVRSRHRIPEPEA
.|||.||...|.|.||.||.||.|||.|.|.. ..|.||..||.|.|..|..||..|.|..|.||.||             ||||||.||.|.|..|.||
CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVILGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEEA

AVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHY
|.||.||..|.|||||||.|||||||.||||.|.||.||.||.|||||..||.||||||||.|||||.||||....||||||||.|||||.|.|||.|.|
ARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGRY

PFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWL
||.||||..||.|||||....|..||..||||.||||||||.||.||..||||||.
PFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF

Kinase Trb3.AA CAMK 140-315 19 1.3e-54 174.02 In-house 143-425 (425) Show / Hide
Range on Protein: 140-315
Range on HMM: 143-425/425
Sequence Identity: 19% (55 aa)

THG----DMHSLVRSR---------------HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRER---------------KKLVLENLED
. |    |. . ....               .|..| ||. .|||.. |...||.|. | ||||.    . |...                .. .     
SGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGF

SCVLTG-----------------------PDDSLWDKHACPAYVG-PEILSSR------------ASYSGKAADVWSLGVALFTMLAGHYPFQDS-----
......                       ... ...   .|.|.  ||.|..               | |...|.||.|| |..|| |..||...     
ANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEI

--------EPVLLFGKIRRGAYALPAG------------------------LSAPARCLVRCLLRREPAERLTATGILLHPWL
        ..  || ||..| |  |                          .|. ...|.|..|...| .|.|.. .| |||.
CEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase Trb3.AA SgK495 143-313 36 1.9e-33 101.0 In-house 1-171 (171) Show / Hide
Range on Protein: 143-313
Range on HMM: 1-171/171
Sequence Identity: 36% (63 aa)

DMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAA
 .   |    |. | |. ..|  .       ||  .| |||||   |   . . .. . |      |    | | |.   |||. |..|| |  | || .
NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTH-QITITNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGRP-YRGKPS

DVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAG--LSAPARCLVRCLLRREPAERLTATGILLHP
|.| ||| ||||| | .|| || |  || ||.   | .|     |    ||.| ||  .| .||||| ..   
DMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVIEAV

Kinase Trb3.AA MELK 142-315 32 1.6e-32 108.26 In-house 82-254 (254) Show / Hide
Range on Protein: 142-315
Range on HMM: 82-254/254
Sequence Identity: 32% (59 aa)

GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKH---AC---PAYVGPEILSSRA
|.|   . ...|. | |. ..|||.  |.|. |  |   ||||   ..| .  . ||.   |   |  |       |.|    |   |||  ||... . 
GEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGL---CAKT---KGRKDYHNLQTCCGSPAYAAPELIQGK-

SYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWL
.| |  |||||.|. |.... |  ||.|    ... || .| |  |  ||  .. |.| .|  .|  |.    .| |||.
QYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV

Kinase Trb3.AA CAMKL 223-315 34 2.3e-28 87.49 In-house 197-297 (297) Show / Hide
Range on Protein: 223-315
Range on HMM: 197-297/297
Sequence Identity: 34% (36 aa)

PAYVGPEILSS-RASYSGKAADVWSLGVALFTMLAGHYPFQDSEPV-------LLFGKIRRGAYALP--AGLSAPARCLVRCLLRREPAERLTATGILLH
|.|  |||...   .| |...|.||.|| |..|. |..|| |           .|. ||..| |  |    .| ..| | | .| . | .| |.  |. |
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWL
||.
PWM

Kinase Trb3.AA GIN4 142-315 30 7.6e-28 85.68 In-house 119-293 (293) Show / Hide
Range on Protein: 142-315
Range on HMM: 119-293/293
Sequence Identity: 30% (54 aa)

GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKA
|..  .. .. ..|| ||   |||.   .. ||  ... ||||    .  |.  ... .        |  . . |      | |  ||| . .  | | |
GELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLL-DHKYNRIKIADFG-MAALETDNKLLETSCGSPHYAAPEIVMGIP-YHGFA

ADVWSLGVALFTMLAGHYPFQDS--EPVLLFGKIRRGAYALPAG--LSAPARCLVRCLLRREPAERLTATGILLHPWL
.|||| || || .| || ||..       |  |. .| | .|.   .|  |. |.| .|  .|  |..   || || .
SDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI

Kinase Trb3.AA AMPK 223-315 39 1.9e-27 78.58 In-house 163-254 (254) Show / Hide
Range on Protein: 223-315
Range on HMM: 163-254/254
Sequence Identity: 39% (37 aa)

PAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWL
| |  ||. |..  | |   |.|| || |. || |  || |..   |. ||. | | .|. ||  |. |....|.  | .|.|   |  |||.
PCYAAPEMISGKL-YCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF

Kinase Trb3.AA RSK 224-315 33 3.6e-26 92.82 In-house 173-278 (278) Show / Hide
Range on Protein: 224-315
Range on HMM: 173-278/278
Sequence Identity: 33% (36 aa)

AYVGPEILS---SRASYSGKAADVWSLGVALFTMLAGHYPFQD---SEPVLLFGKIRRGA--YALP--AGLSAPARCLVRCLLRREPAERLT-----ATG
.|. ||.|     .  .. ||.|.||||| ...||.|. |||    . .  .. .|..|     .|  . ||..|. |.| .| |.|. ||.     |  
EYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEE

ILLHPWL
|. |||.
IKQHPWF

Kinase Trb3.AA MARK 223-315 40 5.5e-26 82.06 In-house 169-262 (262) Show / Hide
Range on Protein: 223-315
Range on HMM: 169-262/262
Sequence Identity: 40% (38 aa)

PAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSE--PVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWL
|.|  |||....  | |...|.||||| |..|. |..|| ..    . |. ||.|| |  |  .|. .| |.. ||   | || |.. |. |||.
PPYMAPEIFLKK-PYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase Trb3.AA TSSK 224-315 31 9.4e-21 64.83 In-house 193-289 (289) Show / Hide
Range on Protein: 224-315
Range on HMM: 193-289/289
Sequence Identity: 31% (31 aa)

AYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQD--SEPVLLFGKIR-RGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWL
||. |||| ..  |..|..||||.|| |..|. |. || |  |..  .   .. ... . |.    ..|. .. |.| .|. .| .|.... |. |.|.
AYAAPEILRGIP-YDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKV-CFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM

S_TKc Trb3.AA S_TKc 71-315 22 1.2e-19 72.48 SMART 1-231 (231) Show / Hide
Range on Protein: 71-315
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

YVLLEPE---EGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHG---DMHSLVRSRHR------IPEPE
| .|..      |. |.. |  || .. .|. . . ..  ..   .   |... .  .|    . || ..    |   |.... ..| |      .|| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

AAVLFRQMATALAHCHQHGLVLRDLK----------------LCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAA
|. ...|.. ||..||.|| . ||||                |.|..                                 | |. ||.|    .|.....
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---------------------------TTFCGTPWYMAPEVL----GYGKCKC

DVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILL-------HPWL
|.||.|. |. ||.|  ||.  .. ..| ||.          | .|. ..| .|...|..|.||  .|        |||.
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Trb3.AA Pkinase 223-315 22 1.7e-18 66.52 Pfam 175-293 (293) Show / Hide
Range on Protein: 223-315
Range on HMM: 175-293/293
Sequence Identity: 22% (27 aa)

PAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDS------EPVLLFGKIRRGAYALPAGLS---------------------APARCLVRCL
| |. ||..   ..| |...|.||.|. |. || |. ||...      ..  .. .|... .  .   .                      ... .....
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LRREPAERLTATGILLHPWL
|.. |..|.||. || |||.
LCKDPKKRPTAEQILQHPWF

Kinase Trb3.AA CAMKL 142-185 36 9.2e-12 33.66 In-house 106-155 (297) Show / Hide
Range on Protein: 142-185
Range on HMM: 106-155/297
Sequence Identity: 36% (18 aa)

GD--MHSLVRSR----HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKL
|.  ..  ....     |.||.||  .|||.  |...||.|| | ||.|.
GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKP

Kinase Trb3.AA TSSK 141-185 37 1.8e-11 33.88 In-house 101-151 (289) Show / Hide
Range on Protein: 141-185
Range on HMM: 101-151/289
Sequence Identity: 37% (19 aa)

HGDMHSLVRSR------HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKL
|||. . .. |       ...|..|  .||||. |...|| |. | ||||.
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKC

Kinase Trb3.AA MARK 142-185 32 1.6e-10 30.81 In-house 87-132 (262) Show / Hide
Range on Protein: 142-185
Range on HMM: 87-132/262
Sequence Identity: 32% (15 aa)

GDMHSLVRSR--HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKL
|.... ....  .|..|.|| ..|||.  |.  ||... | ||.|.
GELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP

Kinase Trb3.AA AMPK 150-185 38 1.5e-07 18.52 In-house 93-128 (254) Show / Hide
Range on Protein: 150-185
Range on HMM: 93-128/254
Sequence Identity: 38% (14 aa)

SRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKL
.. |..| ||. .| |.  ..  ||.|. | ||||.
KHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKP

Kinase Trb3.AA Pkinase 141-185 24 1e-06 24.79 Pfam 84-136 (293) Show / Hide
Range on Protein: 141-185
Range on HMM: 84-136/293
Sequence Identity: 24% (13 aa)

HG----DMHSLVR--SRHRI--PEPEAAVLFRQMATALAHCHQHGLVLRDLKL
.|    | .....  .. ..  .| |.   ..|.. .|..||..| . ||||.
GGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP

Kinase Trb3.AA RSK 147-185 34 0.002274 8.61 In-house 92-132 (278) Show / Hide
Range on Protein: 147-185
Range on HMM: 92-132/278
Sequence Identity: 34% (14 aa)

LVRSRHR--IPEPEAAVLFRQMATALAHCHQHGLVLRDLKL
| . .|   . | ||.. ... . |. | ||.| . ||||.
LQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKP