TRRAP

Species: Human
Alias: PAF400, TR-AP, STAF40, Tra1, TRRAP, FLJ10671, PAF350/400
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 7q22.1,

Classification

Group: Atypical
Family: PIKK
Subfamily: TRRAP

Sequence

Name Sequence Type Origin Length Description Download
TRRAP.NA RNA Sugen Kinome 13253 None Fasta, JSON
TRRAP.AA Protein Sugen Kinome 3877 None Fasta, JSON
TRRAP.kin_dom Protein Kinase Domain None 326 None Fasta, JSON

Protein domain

Protein domains of TRRAP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FATC TRRAP.AA FATC 1814-1825 41 30.697681 0.56 Pfam 1-12 (33) Show / Hide
Range on Protein: 1814-1825
Range on HMM: 1-12/33
Sequence Identity: 41% (5 aa)

KVLDPEKQADML
. |..| |.|.|
EPLSVEQQVDRL

FAT TRRAP.AA FAT 2849-3204 21 3.3e-105 352.48 Pfam 1-408 (408) Show / Hide
Range on Protein: 2849-3204
Range on HMM: 1-408/408
Sequence Identity: 21% (91 aa)

PYLVLECAWRVSNWTA--MKEALVQVE------------VSCPKEMAWKVNMYRGYLAI--CHPEEQQLSFIERLVEMASSLAIREWRR-LPHVVSHVHT
  | .|.|||...|    |.| . ..              ..|.|. |. . ....|..  .| .....   .|....| .| ..||.. ||. ... | 
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTY-EAHRYIDKARQLLDTEWTACLPGESYNRHY

PLLQAAQQIIELQEAAQINAGLQPTNLG-RNNSLHDMKTVVKTWRNRLPIV-SDDLSHWSSIFMWRQHHYQ---GKPTWSGMHSSSIVTAYENSSQHDPS
|...  |...||.|..|. ... ..|.. ..||....|....||..|||..  .....|..|..||||...    . .                      
PVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM----------------------

SNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHT------------IPTVPI------------VDCFQKIRQQVKCYLQLA-GVMGKNECMQG
.. ...| |  .  .|.. ...||.|. ... . |....|            .| . .            ...||..|....|..|   ||  .||.. |
NSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-G

L----EVIESTNLKYFTKEMTA-EFYALKGMFLAQI----------NKSEEANKAFSAAVQMHDVLVK-AWAMWGDYLENIFVKER-------------Q
|    |||..|||.|| ... | ..|...||.....          ....|.......|.. .. . | ||..|. | ...| ...             .
LTYNLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMI

LHLGVSAITCYLHACRHQNESKSRKYLAKVLW
... | |..|..|.......|.||......||
IQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW

Kinase TRRAP.AA PIKK 3514-3791 29 3.7e-142 478.58 In-house 1-290 (290) Show / Hide
Range on Protein: 3514-3791
Range on HMM: 1-290/290
Sequence Identity: 29% (85 aa)

IARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVE
..|||.|...|..|.......|||||.||.||||..   .....|...||.||..|.|.||.|..|..||||......|...|....|.|.......|.|
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCK---GHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKE

IYKQRCAKKGIEHDNPISR---------------YYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIG
||||.|.||.|.|......               ||......|....|..... .......|....|..|.|.|....||.....|..|...|...|...
IYKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMC

FAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTV
.....|.|....||...|...||......|......|...|.....||||||.|........||.|........|..|..|............
MVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase TRRAP.AA TRRAP 3514-3559 89 2.9e-37 129.24 In-house 1-46 (46) Show / Hide
Range on Protein: 3514-3559
Range on HMM: 1-46/46
Sequence Identity: 89% (41 aa)

IARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRR
||||||||||||||||||||||||||||||||||||||.|....||
IARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDICKINARR

Kinase TRRAP.AA PI3_PI4_kinase 3557-3704 16 8.3e-16 60.15 Pfam 14-181 (300) Show / Hide
Range on Protein: 3557-3704
Range on HMM: 14-181/300
Sequence Identity: 16% (30 aa)

SRREERVLQLL-----------------------RLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDN-----
.|...|..|..                       || |.|. |.... .|.. .. .|... .|.....|. |..... || .  . |....|.|     
CRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMVKCKHKHFNKEHKM

PISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNA-TDYWTFRKMFTIQLALIGFAEFVL
 . ...|... .         .. . ...| .....|.  | .| . ..|.| ...|..|. |. ..| .. . ..|
WMKMWPDWWHLM---------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYIL

Kinase TRRAP.AA PI3Kc 3557-3846 16 1.9e-10 2.7 SMART 10-336 (336) Show / Hide
Range on Protein: 3557-3846
Range on HMM: 10-336/336
Sequence Identity: 16% (56 aa)

SRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLAT-----------------
 |...|..|..|| | .. | ||. .|.| .. .......|.....|. |.. .| .| | .. .|... |  . .. |.| .                 
LRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMYMMIWHQQAC

VQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNA-TDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGD
. .  .| ...  . .. | . ....   |..| . .||..  |.|..|. || ..|    . ..| .    .. . .  .||..    | .  . . . 
HWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKK

LDA----NRPVPFRLTPNISEFLT----TIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEI-IAWHKKTQEDTSSPLSAAGQPE---------NM
.      .  ||||||... .         |. |     .  . | . ..  ..  .. . ..|.| . |...  |..  .| .. ...          .
PGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLDHLSDEEAAQYF

DS----QQLVSLVQKAVTAIMTRLHNLAQF
.     . ......   |.... .||.||.
MQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase TRRAP.AA ATR 3513-3791 17 5.6e-05 12.43 In-house 2-267 (267) Show / Hide
Range on Protein: 3513-3791
Range on HMM: 2-267/267
Sequence Identity: 17% (48 aa)

KIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLV
 || |   |||.       ... ..| .||.|   .|      . |.. |  .   |.| |. |  |  .| .      |. .  |  ..|     ..| 
YIAGFDDMVEILASLQ-KPKKISLKGSDGKFY---IMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLR

EIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPR--SMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLN
 | ..    |..         | .   ..    . | . . . .| ..  ..||  .. ..| ...|| ...... |. .    | .    ... |    
PILDKLWKEKKQ---------YMQFYQLRQCMDKKSRE-EWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRH

PEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTV
 . . | . .| .    .   |      ..    |||||| |.   .  ..  |     .. . .|. .    . ..... 
TDNILIDKINGECVHVDYNC-IFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase TRRAP.AA PI3_PI4_kinase 3743-3755 26 12.475234 0.33 Pfam 223-241 (300) Show / Hide
Range on Protein: 3743-3755
Range on HMM: 223-241/300
Sequence Identity: 26% (5 aa)

RPVPFRLTP------NISE
..||||.|.      ....
ERVPFRWTHWPQAKKPMVH

FATC TRRAP.AA FATC 3850-3877 39 2.5e-05 20.08 Pfam 6-33 (33) Show / Hide
Range on Protein: 3850-3877
Range on HMM: 6-33/33
Sequence Identity: 39% (11 aa)

ESKVNTLVAAANSLDNLCRMDPAWHPWL
|  |. |.. | . .|||.|.. | ||.
EQQVDRLIQEATDPENLCQMYIGWCPWW