Gene TSSK4 (Human)

TSSK4

Species: Human
Alias: TSSK4, MGC133264, C14orf20, TSSK5, STK22E, c14_5117
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q11.1,

Classification

Group: CAMK
Family: TSSK

Sequence

Name Sequence Type Origin Length Description Download
TSSK4.NA RNA Sugen Kinome 1422 None Fasta, JSON
TSSK4.AA Protein Sugen Kinome 328 None Fasta, JSON
TSSK4.kin_dom Protein Kinase Domain Sugen Kinome 269 None Fasta, JSON

Protein domain

Protein domains of TSSK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TSSK4.AA TSSK 25-293 46 1.2e-180 597.67 In-house 1-289 (289) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-289/289
Sequence Identity: 46% (139 aa)

YEVGKAIGHGSYGSVYEAFYTKQKVM----------------VAVKIISKKKASDDYLNKFLPREIQVMKV-LRHKYLINFYRAIESTS-RVYIILELAQ
|.||| ||||||. ||.|...|.|..                ||.|||..|||..||||||||||||.|.. |.|...|.|| ..|... ..|...|.|.
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

GGDVLEWIQRY------GACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCG
.||.||.|||.      ||..|..|.|||.|.  ...|.||. .||||||.||.||||..|.|..|||||...|...|..|          .|||.|.||
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRC----------CHLSKTFCG

SFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDD--TNLKKLLRETQ-KEVTFPA--NHTISQECKNLILQMLR-QATKRATILDIIKDSWV
|.|||.|||||| ||.|...|.||||||||..|....||||  .|..|.|...| ..|.||.  ...||||||.||..||. ....|..| .|....|.
SYAYAAPEILRGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase TSSK4.AA CAMK 30-293 23 4.90000000001e-104 336.17 In-house 1-425 (425) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-425/425
Sequence Identity: 23% (100 aa)

AIGHGSYGSVYEAFYTKQK------------VMVAVKIISKKKASD-------------------------DYLNKFLPREIQVMKV-------LRHKYL
 .|.||.| |.... .. .            . ||.|||.|||..|                         ..  |...|||..||        |.|. .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

INFYRAIES-------------------TSRVYIIL---ELAQGG----DVLEWIQRY---------------GACSEPLAGKWFSQLTLGIAYLHSKSI
|..| ..|.                   ....|...   |...||    |....|..                |  .|  | ..| |.  ...|.||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKLENLLLDKWE-----------------NVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHL----------SQTYCGSFAYAC-PEILRG----
||||||.||.|||. .                 |.||.|||||.......   . ..| . . . |            .|.||. .|.. ||.|.|    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------LPYNPFLSDTWSMGVILYTLVVAHLPFDDT-------------NLKKLLRETQKEV-TFPANH----------------------TISQEC
          || .. .| ||.|||||.... ..||..              |...|..  .|   .||  .                      ..||||
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KNLILQMLRQ-ATKRATILDIIKDSWV
|.|| .||.   .||.|| .. .. |.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase TSSK4.AA CAMKL 25-293 32 6.7e-99 316.26 In-house 1-297 (297) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-297/297
Sequence Identity: 32% (102 aa)

YEVGKAIGHGSYGSVYEAFYTKQ-KVMVAVKIISKKKAS-DDYLNKF-----------LPREIQVMKVLR---HKYLINFYRAIESTSR------VYIIL
|..|| .|.||.| |  |  ..  ...||.||| |||.. |.. .|            . |||| || |.   |.  | .|  ||  .       .|...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELAQGGD--VLEWIQRYGA----CSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWE--NVKISDFGFAKM---VPSNQPVGCSPSYRQVNCF
|...||.   ...|.. |      .|. | . | |.  ...|.||. |||||.|.||.|||.    |.||.||||. |   .              ..  
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC--------------IFGP

SHLSQTYCGSFAYACPEILRG--LPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLK-------KLLRETQKEVTFPANH-TISQECKNLILQMLRQ-ATK
 ..  | ||| .|..|||. |   ||. .  | ||.|||||..|. .||||| ...       .|.... .  ..|  .  .| .|..|| .||    .|
GQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEK

RATILDIIKDSWV
|.|| .| .. |.
RPTIHQIMNHPWM
Kinase TSSK4.AA MARK 25-293 35 1.3e-88 289.77 In-house 1-262 (262) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-262/262
Sequence Identity: 35% (99 aa)

YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIE--STSR-VYIILELAQGGDVLEWIQRY--GA
|...| ||||||. |. |  .. .. ||.||. |.| .|    | . |||..|| | |.. | .. .||   ... .|.|.|.| ||.....|.    | 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

CSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWE--NVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNP
 .|..| . |.|.  .. |.|||.|||||.|.||.|.|.    |.||.||||.  .|..|                   | ||. .|..|||. . ||. 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK----------------LNTFCGTPPYMAPEIFLKKPYDG

FLSDTWSMGVILYTLVVAHLPFDDTN--LKKLLRETQKEVTFPANHTISQECKNLILQMLR-QATKRATILDIIKDSWV
.  |.||.||.||..|. ..|||...  .|.| .. ....     | .| ||.||| ..|     .|.|| .| |..|.
PKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH-VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase TSSK4.AA S_TKc 25-293 27 2e-82 281.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-231/231
Sequence Identity: 27% (77 aa)

YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQG--GDVLEWIQRYGA---
||... ||.|..|.|| .  .| .  ||.|||.          . . ||||..|  .|......| .... ...|...|.. |  ||... |...|    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---CSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYN
    .|  | ... |. ....|.||. |.||||| ||.|||.  ..||.|||.|. .                       |.||.  |  ||.|   .|.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

PFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTISQECKNLILQMLR-QATKRATILDIIK-------DSWV
.. .| || |.||| ...   ||.  .......              |.|.|..| ..|.   .|| |. .. .       . |.
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TSSK4.AA Pkinase 25-293 28 1.5e-71 248.78 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASD--DYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGG----DVLEWIQ--R
|..|. || ||.|.||..   .   .||||||.|.....  |. .  | .|||.|| |.|.. . .|.. |. ...|...|...||    |  ..|.  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

YGAC--SEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENV----KISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEIL
.|.   ||  . ... |.  |..|.||..|.|||||.||.|.|.  ..    ||.|||.|| .               .  ..  .|.||.  |. ||..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------------Y-NNS-MTTFCGTPWYMAPEVI

RGLPYNPFLSDTWSMGVILYTLVVAHLPFDDT------NLKKLLRETQK-EVTFPANHTIS-------------------QECKNLILQMLRQ-ATKRAT
|| .| .  .| ||.|.||| ..  ..||..       . ....... . .. |.   ..|                   .||| .|  .|..  .|| |
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

ILDIIKDSWV
. .| .. |.
AEQILQHPWF
Kinase TSSK4.AA ULK 25-293 26 1.4e-65 224.21 In-house 1-329 (329) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-329/329
Sequence Identity: 26% (89 aa)

YEVGKAIGHGSYGSVYEAF-YTKQ---KVMVAVKIISKKKASD-------DYLNKFLPREIQVMKVLR----HKY----LINFYRAIEST--SRVYIILE
|.. . .|.||.| ||...   ..   ...||.|.|.|.| .        .|. ..| .||..|| |     ||.     . .|   |..    .|||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LAQGGDVLEWIQRYGACSEPL----------AGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDK--WEN----------VKISDFGFAKMVPSN---QP
. .|||  . |.... ..|.           | . | |.  |  .||.. |.|||.|..| |...  . .          .||.||||||.| ..   | 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VGCSPS-YRQVNCFSHLSQT-YCGSFAYACPEILRGL----PYNPFLSDTWSMGVILYTLVVAHLP----FDDTN---LKKLLRET--------QKEVTF
. .. .             . .||.  | .|.|| |.    ||. . .| ||.|.|.| ...   |    | |..   ..||.. .        ..   |
MMMTCVNE-----------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQF

P---ANHTISQECKNLILQML-RQATKRATILDIIKDSWV
|   .. .||.|||.|| .|| .. ..| .. ....  |.
PKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase TSSK4.AA Ciliate-E2 25-293 22 3.1e-61 208.94 In-house 1-365 (365) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

YEVGKAIGHGSYGSVYEA--FYTKQKV---------------------MVAVKIISKK----KASDDYLNK-------FLPREIQVMKVLRHKYLINFYR
|.. | || |..||||..    .....                     ..|.||..|.    . . .....       ..  | .... | |...|..| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

AIE--STSRVYIILELAQGGDVLEWIQ------------RYGACSEPLAGKWFSQLTL---------------GIAYLHSKS-IVHRDLKLENLLLDKWE
. .  ... .|...|..|||| ...|.              .  .|  ... . |..                .. |||||  |.|||.|.||.|.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NVKISDFGFAK-----------------MVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPY--------NPFLSDTWSMGVILYTLVVA
 .||.|||..|                 .   ..    .|.| .   . .. .|.||.  | .||||.| .|          . .| ||.||||| ..  
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

HLPFDDTNLKKLLRETQKEVTFP----------------ANHTISQECKNLILQ----ML-RQATKRAT-ILDIIKDSWV
 .||       .    |... ||                 .. .|||||.|| .    || ..  || | . .|..  | 
KPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TSSK4.AA Ciliate-E2-Unclassified 25-293 22 3.6e-55 189.62 In-house 1-352 (352) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-352/352
Sequence Identity: 22% (84 aa)

YEVGKAIGHGSYGSVYEAFYTKQKVMV-----AVKIISKKKASDDYLNKFLPREIQVMKVLR-------------------HKYLINFYRAIESTSRVYI
|...| ||.|..|.||..   |||  .     . ||...|. .  . .  . .|.. |. .                    | ...... . ...  .||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ILELAQGGDVLEWIQRYGA-----------------CSEPLAG-----KWFSQLTLGIAYLHSKS-IVHRDLKLENLLLDKWE---NVKISDFGFAK---
..|...||| ...|. ..                   .|  |      ..| |. .|. |||.|  |.|||.|.||.|.|.     ..||.|||..|   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

---------MVPSNQPVGCSPSYRQVNCF-SHLSQTYCGSFAYA----CPEILRGLPYNP---FLSDTWSMGVILYTLVVAHLPFDDTNLKK--------
                        . . . .....| ||.  |      ||.|.|  |.    . .| ||.||||| ..   .||.|.| ..        
QNNNCDTNQQ-------------QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQW

--------LLRET-QKEVTFPANH------TISQECKNLIL----QMLRQATK-RATILDIIKDSWV
        |...  ||.. ||         ..|.|.|..|     .||    . | |. .|..  | 
INNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase TSSK4.AA AMPK 25-177 37 2.3e-49 144.74 In-house 1-154 (254) Show / Hide 
Range on Protein: 25-177
Range on HMM: 1-154/254
Sequence Identity: 37% (57 aa)

YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAI-ESTSRVYIILELAQGGDVLEWIQRYGACSEP
| .|| || |..| |  .  .  .  ||.||. |.|  |.   . . |||. .|..||  .|  |. | |...  ....| ..||.  ..| . |  .| 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

LAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQ
 | . | |   |. |.|   |||||||.||||||.  |.|| |||  .|   ..
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGE
Kinase TSSK4.AA ULK 25-185 28 2.8e-44 153.44 In-house 1-213 (324) Show / Hide 
Range on Protein: 25-185
Range on HMM: 1-213/324
Sequence Identity: 28% (60 aa)

YEVGKAIGHGSYG-SVYEAF-YTKQ--KVMVAVKIISKKKASD-------DYLNKFLPREIQVMKVLR---HKY--LINFYRAIEST--SRVYIILELAQ
|.. . .|.||.|  ||...   ..  .. ||.|.|.||| ..       .|. ..| .|||.|| |    |..   . .|   |..    .|||.|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDVLEWIQRYGACSEPL----------AGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDK--WEN----------VKISDFGFAKMVPSN---QPVG-
|||  . |.... ..|            | . | |.  |  .||.. |.|||.|..|.|. .  . .          .||.||||||.| .|   | .  
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

---------CSPSY
         ..| |
TCVNEKRIKGTPLY
Kinase TSSK4.AA QIK 25-169 33 5.7e-44 152.4 In-house 1-164 (272) Show / Hide 
Range on Protein: 25-169
Range on HMM: 1-164/272
Sequence Identity: 33% (56 aa)

YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGA-----
|.....|| | .. |  |     |  ||.||| | .   ..|.|   ||.|.||.|.| . |  |  .|. .  ||. | ...|.  . .  .|      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCY-REVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

---------------CSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGF
                .|. | .||.|. ....|.|.. ||||||| ||.|||.  |.|| ||||
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGF
Kinase TSSK4.AA Pkinase_Tyr 25-173 28 1.1e-28 97.82 Pfam 1-161 (270) Show / Hide 
Range on Protein: 25-173
Range on HMM: 1-161/270
Sequence Identity: 28% (46 aa)

YEVGKAIGHGSYGSVYEAFYT----KQKVMVAVKIISKKKASDDY--LNKFLPREIQVMKVL-RHKYLINFYRAIE-STSR--VYIILELAQGGDVLEWI
 . || .|.|..|.||.. ..    ..|. ||||.. | .|...   . .|.  |...|| | .|. ....| ..        .||..|....|| |.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QRY----GACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMV
..     .. . .   ..  |   | .||.|| ..||||   | |...   |||.||| |. .
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase TSSK4.AA AMPK 197-293 41 3.5e-25 71.75 In-house 158-254 (254) Show / Hide 
Range on Protein: 197-293
Range on HMM: 158-254/254
Sequence Identity: 41% (41 aa)

TYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQ-KEVTFPANHTISQECKNLILQMLRQA-TKRATILDIIKDSWV
| |||  || ||.  | .|.    |.|| ||||| .. . ||||| |  .| .     |.. |..  .|.|.|.|| .||.   .||.|| || ...| 
TACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKF--LSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase TSSK4.AA ULK 186-293 26 1.9e-22 76.53 In-house 186-324 (324) Show / Hide 
Range on Protein: 186-293
Range on HMM: 186-324/324
Sequence Identity: 26% (37 aa)

RQVNCFS---HLSQTYC------GSFAYACPEILRGL----PYNPFLSDTWSMGVILYTLVVAHLP----FDDTNLK--KLLR--------ETQKEVTFP
..|.. .    . ||..      |.  | .|.|| |.    ||. . .| ||.|.|.| ..    |    | |..|.  ||..        . .. . ||
KHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFP

---ANHTISQECKNLILQML-RQATKRATILDIIKDSWV
   ..  ||.|||.|| .|| .. ..| .. .|..  |.
KPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase TSSK4.AA QIK 196-293 40 9e-21 75.33 In-house 175-272 (272) Show / Hide 
Range on Protein: 196-293
Range on HMM: 175-272/272
Sequence Identity: 40% (40 aa)

QTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTISQECKNLILQMLR-QATKRATILDIIKDSWV
.|.||| .|| ||.. |  |.   .| |||||.|| ||   ||||  .|.. ||.   .  |     .||.|  || .||   ...| ||  |..  | 
MTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQN-LRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase TSSK4.AA TyrKc 25-296 20 6.2e-16 34.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-296
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVL--RHKYLINFYRAIEST-------SRVYIILELAQGGDVLEWIQ
 . || .|.| .| ||.. ..   ..|||| . . .     .  |. ||...|. |  .|. ....| .. .          ..|..|.. .|| .. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFM-REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RYGA-CSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTY------CGS----FAY
...   . .   ..  |   | .||||| ..||||   | |...   ||||||| .. . .    |              ...|      .|        
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------------ESKDYYRKKEHKGGKTMLPIRW

ACPEILRGLPYNPFLSDTWSMGVILY-TLVVAHLPFDD-----TNLKKLLRETQKE--VTFPANH------TISQECKNLILQMLRQ-ATKRATILDIIK
  || ..   .. . || || || ..  .     |  .      . . ...  ..      |.|.      . ..|  ....|  .  . .| |  .|  
MAPECINYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--

DSWVLKF
   . .|
---HECF