Gene TYK2 (Human)

TYK2

Species: Human
Alias: TYK2, JTK1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19p13.2-p13.3, Secondary Group: TK, Secondary Family: JakB,

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
TYK2.NA RNA Sugen Kinome 4262 None Fasta, JSON
TYK2.AA Protein Sugen Kinome 1187 None Fasta, JSON
TYK2.kin_dom Protein Kinase Domain Sugen Kinome 266 None Fasta, JSON
TYK2.kin_dom2 Protein Kinase Domain Sugen Kinome 278 None Fasta, JSON

Protein domain

Protein domains of TYK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 TYK2.AA B41 22-275 17 8.5e-53 182.64 SMART 1-232 (232) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-232/232
Sequence Identity: 17% (47 aa)

MAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQA---QVWL-PPNHILEIPRD----ASLMLYFRIRFYFRNWH
   .  ..|.... .     ..  ...|| |....| |.....||.| . ..|.|. ..    . || ....|... ..    ... |.||..||...||
SPKPRFCRVYFMDGT-----TLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWH

GMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIP-------LEEVA
|                       ..... .||....|...| .|..... . ..          ...|.|..| |......  .  .       ...|.
G-----------------------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----------HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQ

KKTSFKDCIPRSFRR-------HIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERV
|  | |...| . ..       |...|   .| |........       .... . ..|||....|..|..|.|  
KYKSYKRFLPKQWIDSIKQSFMHYQMHHKEWRKRIMEWHKNH------CGMTPEEAKLKYLQICQRWPPMYGVEHF
Kinase TYK2.AA SH2 452-539 24 1e-08 36.18 SMART 5-87 (87) Show / Hide 
Range on Protein: 452-539
Range on HMM: 5-87/87
Sequence Identity: 24% (23 aa)

HGPLLEPFVQAKLRPE---DGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQD-GAFVLEG-WGRSFPSVRELGAALQGCLLR
||..    ....|. .   || .|. .| |.|. ..|.|  .          . . . |...| | ..... |.|.|||. || .  | . |.
HGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK---------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase TYK2.AA Jak 412-455 10 0.07259 2.63 In-house 97-144 (299) Show / Hide 
Range on Protein: 412-455
Range on HMM: 97-144/299
Sequence Identity: 10% (5 aa)

AALSFVS----LVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPL
.......    . ... ..|.|. ...........  ..... |||..
PLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDV
Kinase TYK2.AA Jak 589-868 37 4.4e-139 468.34 In-house 1-299 (299) Show / Hide 
Range on Protein: 589-868
Range on HMM: 1-299/299
Sequence Identity: 37% (115 aa)

ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVC--VRGPENIMV
.....|||.|....||..|..........|.....           |...||.||..|.|......|....|.|||.|| |. ..||||  ... |..||
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHE-----------QKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMV

TEYVEHGPLDVWLR----RERGHVPM--AWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLA-EGTSPFIKLSDPGVGLGALSREER--VERIP
.||...|||| .|.    |....|..  .||| .|.|......|||.|...||.||.||||..| |.. ... ||.||.||... ....||..  .||||
MEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIP

WLAPECLPGGANSLSTAMDKWGFG-ATLLEIC----------------FDGEAPLQSRSPSEKEHFYQRQHRLPEPS--CPQLATLTSQCLTYEPTQRPS
| |||||  ....|..|||||.|| .|| |||                ..|..|.... ...|..||...||||.|.  ......|. ||..|.|.||||
WYAPECLTNCKFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPS

FRTILRDLTR
||||.|||  
FRTIIRDLNQ
Kinase TYK2.AA TK 589-866 15 2e-57 190.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 589-866
Range on HMM: 1-486/486
Sequence Identity: 15% (78 aa)

ITQLSHLGQGTRT---NVYEGRLRVEGSGDPEEGKMDDEDP--LVPGRDRGQELRVVLKVLDPSHHDIALAFYE--------------TASLMSQVS---
|| .  ||.|       ||.|..| .. ....... ... .   .... .|.. .|  |.| . ... . .| .               |. |.. .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMT-VTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSL

--HTHLAFVHGVCVRG------------PENIMVTEYVEHGP----LDVWLRRERGH-------------------------------------------
  | ..   .|||..|            .  ..|.||..||     |. .||. |..                                           
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------VPMAWKMVVAQQLASALSYLENK------NLVHGNVCGRNILLARLGLA----EGTSPFIKLSDPGVG
                                ..|....  ..|.|....||. |      |.||.... ||.|... .      .|. |..|..| |  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

LGA---LSREER-----------------------------------VERIPWLAPECLPGG-------ANSLSTAMDKWGFGATLLEICFDGEAPLQSR
      |.|.                                        | |.||||| ..        .  .|. | | || .. ||.  |..|    
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

SPSEK-------EHFYQRQ-----------------HRLPE-PSCP--------------QLATL-TSQCLTYEPTQRPSFRTILRDL
 ....       . ....                  .|.|  | ||              ..  .   ||  |.| .||.|..... |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TYK2.AA Pkinase_Tyr 589-866 26 5.8e-57 193.54 Pfam 1-270 (270) Show / Hide 
Range on Protein: 589-866
Range on HMM: 1-270/270
Sequence Identity: 26% (78 aa)

ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIA---LAFYETASLMSQV-SHTHLAFVHGVCV--RGP-
|| .  ||.|   .||.|...                      . .... |  |.| ..... .    .| . |..|.|  .| ..   .|||.  ..| 
ITFGKKLGEGAFGEVYKGTWKG--------------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN

ENIMVTEYVEHGPLDVWLRRE---RGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGA-------LSREE
. ..|.||..|| |.  ||.    .....| ..   ..| |....|||.||..|  .. ||.|...       . ..| .| |             .|..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------NNVVKICDFGLARDIYNDDYYYRKRGG

RVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAP-LQSRSPSE-KEHFYQRQHRLPEPS--CPQLATLTSQCLTYEPTQRPSFRTILRDL
    |.|.||||.  |    .|. | | || .. ||.  || |  .  |..| .|..|.. .|.| |   .. . .|  ||  |.| .||.|. |...|
GKLPIKWMAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TYK2.AA UTK 627-866 24 5.8e-20 64.99 In-house 20-296 (296) Show / Hide 
Range on Protein: 627-866
Range on HMM: 20-296/296
Sequence Identity: 24% (68 aa)

LVPGRDRGQELRVVLKVLDPSHHDIAL-----AFYETAS---LMSQVS-HTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERG-------HVPMAW
... .....|..| .||..... .         | | |    .|.|.. | ... . |||...   ..|||| | | |.  ||| |        .. .  
FTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQ

KMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSP--FIKLSDPGVGLGALSREER------------------VER--IPWLAPECLPGGA
..  | . |....||.....||.... ||.|... .   ..    ..|..| |   |..||.                    ..|  | | |||.|  ..
RLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRM-MWH-CMMVCKIADFG--RGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHT

NSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQ--HRLPE-PSCP-QLATLTSQCLTYEPTQRPSFRTILRDL
   .|. | | || .. ||.  | .|    |  .  |.  ..  .|.|  ..|| .. .|  .| .|.|  ||.|....  .
-RFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TYK2.AA Frk 655-870 27 2.3e-18 59.95 In-house 41-260 (260) Show / Hide 
Range on Protein: 655-870
Range on HMM: 41-260/260
Sequence Identity: 27% (63 aa)

FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLR--RERGH-VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGT
|   | .| .. |. |  .. || .    ...|| ..|| |  .|.   ..|. . |   . .| |.|. . |||..| .|  .  ||.|.       | 
FLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV-------GE

SPFIKLSDPGVGLGALSREE-----RVE-RIP--WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QL
.  .|. | |.    .  .|     |.. |.|  | |||      |. ..  | | ||  | ||   |  |       |  .  ..  |.|.|. || ||
HNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAA--NYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQL

ATLTSQCLTYEPTQRPSFRTILRDLTRLQ
  .  .|   .| .|| | |.   |    
YEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase TYK2.AA TKL 595-866 17 4.1e-17 58.19 In-house 1-364 (364) Show / Hide 
Range on Protein: 595-866
Range on HMM: 1-364/364
Sequence Identity: 17% (67 aa)

LGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRV-VLKVL------------------------DPSHHDIALAFYETASLMSQVSHTH
.|.|.   || |..| .|.               |. |.|..  | ..|.                         ||  . .   . | . .||. .| .
IGSGGFGEVYKGKWRGWGG-KC------------PS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPN

LAFVHGVCVRGPE-------------NIMVTEYVEHGP-LDVWLRRERGHVPMAWKMVVAQQLASALSYLEN--------KNLVHGNVCGRNILLAR---
.    |.| ..|                .|.||...|  |.. .        .  ..  |.. |....|| .        ....| .   .|||. .   
IVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

--------------LGLA-EGTSPFIKLSD-------------PGVGLGALSREERVERI---PWLAPECLPGGAN--------------SLSTAMDKWG
              . ..  |.| |.. |              .   .  ..|. .  ..    |.|||.| |  |              . |...| . 
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE---HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

FGATLLEICFDGEAPLQSRSPSEK---------EHFYQRQHRLPEP--------------SCPQLATLTSQCLTYEPTQRPSFRTILRDL
||  | ||.   .   .  .....         .  .....|.| |                |... |  .|  ..|..|||| .||  |
FGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TYK2.AA TyrKc 589-866 22 6e-16 35.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 589-866
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQV--SHTHLAFVHGVCVRG------
|| .  || |    ||.|...                           . |  |.| ...     .|.. |..|...  .| ..   .|||. .      
ITLGKKLGEGAFGEVYKGTWK---------------------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMY

-PENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSR--------EE
 .   .|.||..|| |.  ||. |....|. .   . | |.  .||. ||..|     ||.|... .        .| || |      .           
IEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYY

RV-----ER--IP--WLAPECLPGGANSL--STAMDKWGFGATLLEICFDGEAPLQS-----RSPSEKEHFYQRQHRLPEPSC----------PQLATLT
|.     ..  .|  |.||||.    |    .|. | | || .. ||. .|. |         |..|  .. .. .|.| |            . . .. 
RKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM

SQCLTYEPTQRPSFRTILRDL
.||  ..| .||.|..| ...
KQCWHEDPEDRPTFSEIHECF
Kinase TYK2.AA TK-Unique 589-866 22 6.6e-16 51.43 In-house 1-294 (294) Show / Hide 
Range on Protein: 589-866
Range on HMM: 1-294/294
Sequence Identity: 22% (72 aa)

ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDI-ALAFYETASLMSQVS-HTHLAFVHGVCVRGP-ENIM
.. .. .|.|    |. | ..                      ....  .|..| |  ...|    .|   ...|...  | ..    |.|..      .
LEVGDVIGEGAFGQVWRGEVWGIW------------------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMI

VTEYVEHGPLDVWLRRERGH-----------------------VPMAWKMVV--AQQLASALSYLEN--KNLVHGNVCGRNILLARLGLAEGTSPFIKLS
. ||.. | |.  ||. |.                         |   | ..  | |.|....||.   |. ||...| ||.||..          .|..
IMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-------DKVCKIC

DPGVGL-----GALSREERVERIP--WLAPECLPGGANSL-STAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP-SC--PQLATLTSQ
| |        |..|.... .|||  |.||| |    .   .|  | | || .. ||.  |. |  . .... .   .. .|.| | .|  ...  | ..
DFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKS

CLTYEPTQRPSFRTILRDL
|...||..|||||.|.  |
CWQWEPEERPSFRQIKHRL
Kinase TYK2.AA S_TKc 589-867 16 4.4e-15 44.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 589-867
Range on HMM: 1-231/231
Sequence Identity: 16% (49 aa)

ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTE
 . | ..|.|.   || .| .                            .| .|...         ..   .....  | ..   ..|..   .  ||.|
YEILRKIGKGAFGKVYKCRHKK------------------------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVME

YVEH--GPLDVWLRRERGH-----VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAP
|...  | |   ... ..|      |  .   ...|...|| |. ... .|  .   |||| .          ||..| |.          .    ..||
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL---TTFCGTPWYMAP

ECLPGGANSLST-AMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILR--------DLT
| |     . .. . | | .| .| | .  |. | .     . .  ...         |..  . ..||...|..||.   .|.           
EVL-----GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TYK2.AA EGFR 639-867 23 4.2e-11 32.92 In-house 31-258 (258) Show / Hide 
Range on Protein: 639-867
Range on HMM: 31-258/258
Sequence Identity: 23% (56 aa)

VVLKVL-DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCG
|  ||| . .    . .. . |  |  | | ||  . |||.      .|| |  .| |  ..|  ....     .  . | |. ..|||.. .|| .   
VAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAA

RNILLARLGLAEGTSPFIKLSDPGVG--LGALSREERVER----IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQH
||.|.            .|  | |.   | . . | ...     | |.| ||.         . | | .| |. |.   |. | .  . .|   . ..  
RNVLVKSPNH-------VKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECI--HHRCYTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGE

RLPEPS-CPQ-LATLTSQCLTYEPTQRPSFRTILRDLT
||| |  | . .  .  .|    .  || |. .   . 
RLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase TYK2.AA Src 654-741 32 6.2e-10 29.88 In-house 40-129 (255) Show / Hide 
Range on Protein: 654-741
Range on HMM: 40-129/255
Sequence Identity: 32% (30 aa)

AFYETASLMSQVSHTHLAFVHGVCVRG-PENIMVTEYVEHGPLDVWLR-RERGH-VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL
|| . | .| ...| .|   . || .. |  | |||| .|| |  .|. ...|. ...      | | |.  .||| .|..|     ||.|
AFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYI-VTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVL
Kinase TYK2.AA Ack 659-744 30 2.3e-08 24.32 In-house 53-140 (266) Show / Hide 
Range on Protein: 659-744
Range on HMM: 53-140/266
Sequence Identity: 30% (27 aa)

ASLMSQVSHTHLAFVHGVCVRGPEN-IMVTEYVEHGPLDVWLRRERG--HVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLAR
.. | .  | ||   .|| |..     ||||  . | |   ||   .  . . .     . |.|....||| |...|  .  |||||..
VAIMHSLDHPHLVRLYGV-VLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFS
Kinase TYK2.AA Syk 659-742 30 2.3e-07 21.42 In-house 56-139 (257) Show / Hide 
Range on Protein: 659-742
Range on HMM: 56-139/257
Sequence Identity: 30% (26 aa)

ASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPM-AWKMVVAQQLASALSYLENKNLVHGNVCGRNILL
|..| |  | .     |.|  ...  || | .| ||.  .|  .| ...  .   ... | |.   ||| |. ||     ||.||
AQVMCQLDHPCIVRMIGIC-HAEMMMMVMEMAELGPMHKYLQQHRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLL
Kinase TYK2.AA Pkinase 776-866 14 0.000381 15.74 Pfam 175-293 (293) Show / Hide 
Range on Protein: 776-866
Range on HMM: 175-293/293
Sequence Identity: 14% (18 aa)

IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR----SPSEKEHFYQRQHRLPEPSC------------------------PQLATLTSQ
....||| .  |..  ... | |..| .| | .. |. | ...    . .... .... .. .. ..                        . .  . . 
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CLTYEPTQRPSFRTILRD--L
||.. |..||... || .  .
CLCKDPKKRPTAEQILQHPWF
Kinase TYK2.AA Pkinase 589-732 14 0.002687 12.74 Pfam 1-131 (293) Show / Hide 
Range on Protein: 589-732
Range on HMM: 1-131/293
Sequence Identity: 14% (22 aa)

ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYE-----TASLMSQVSHTHLAFVHGVCVRGPEN
.. .. .|.|.   ||... . .|                         .|..|... . |.     ..      ...|  ..| .    .... .... 
YHIGRKIGSGSFGCVYKCHHKGTGK------------------------IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHI

IMVTEYVEHG----PLDVWLR-RERGHV--PMAWKMVVAQQLASALSYLENKNLVH
 ||.||.|.|     |  ... ...| .  ..     .. |....| |. ... .|
YMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase TYK2.AA Syk 778-860 32 0.010267 5.15 In-house 175-257 (257) Show / Hide 
Range on Protein: 778-860
Range on HMM: 175-257/257
Sequence Identity: 32% (28 aa)

WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP-SCPQ-LATLTSQCLTYEPTQRPSFR
| ||||   .    | . | |.|| |. |    |  |  . . .|   |    ||.. |  ||| .  | ..| .|..  || | 
WYAPECIYYYK--FSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase TYK2.AA Src 847-866 40 0.051173 2.59 In-house 236-255 (255) Show / Hide 
Range on Protein: 847-866
Range on HMM: 236-255/255
Sequence Identity: 40% (8 aa)

QCLTYEPTQRPSFRTILRDL
||   .| ||| | ..   |
QCWHKDPEQRPTFEYLQWFL
Kinase TYK2.AA Ack 776-866 32 0.18288 0.71 In-house 175-266 (266) Show / Hide 
Range on Protein: 776-866
Range on HMM: 175-266/266
Sequence Identity: 32% (31 aa)

IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQ-RQHRLPEPSC--PQLATLTSQCLTYEPTQRPSFRTILRDL
..| |||||  ..   | | | | || || |    || |   .....  .       ||| | |  . . ..  || . .|  ||.|  |  .|
FAWCAPECLRHRQ--FSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase TYK2.AA Jak 897-1171 40 7e-154 517.51 In-house 1-299 (299) Show / Hide 
Range on Protein: 897-1171
Range on HMM: 1-299/299
Sequence Identity: 40% (122 aa)

LKKIRDLGEGHFGKVSLYCYDPTN------DGTGE--MVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRD
||....|||||||.| ...||...      | ..|  .|.|| .. .|.|||.  ...||.|.....|.||.||.|.|..........||||...|.|.|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLP----R--HSIGL--AQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRL---VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK
||.    |  . ...  .....||.|||.|| ||....|||.|..|||.|.|....   |||..|.|........||||...|.|....|||||||...|
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

FYY--ASDVWSFG-VTLYELL-THCDSSQSPPTKFLELIG-IAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKT
||.  |.|.|||| |||.|.. ..||.|.||...||. || . |.||...|.....|.|.|||.||.|..|.|.||..||......||.| ..|..|  
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase TYK2.AA Pkinase_Tyr 897-1169 38 1e-124 423.0 Pfam 1-270 (270) Show / Hide 
Range on Protein: 897-1169
Range on HMM: 1-270/270
Sequence Identity: 38% (108 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQH--RSGWKQEIDILRTL-YHEHIIKYKGCCEDQGEK-SLQLVMEYVPLGSLRDYLPR
..... ||||.||.| .  ...  |.|.  |||| || .. ...  |    .|. |...| .|..|... |.| ||||  .. .||||.|.|.|.||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H-----SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYY-RVREDGDSPVFWYAPECLKEYKFYYASDVWS
|     .. . .|| ...||..||.||.....|||||||||.|..... |||.|||||... .  .|| |.|..|. |..|.||||....||  .|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELL-ERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPIL
|||...|..| ...              .   |.  .. |.. |.|.|.|.|..|| |.|.||| ||. ... ||||. .. .|
FGVLMWEIFTYGEQP-------------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TYK2.AA TyrKc 897-1169 35 1e-118 401.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 897-1169
Range on HMM: 1-280/280
Sequence Identity: 35% (105 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTL--YHEHIIKYKGCCEDQGE-----KSLQLVMEYVPLGSLRDY
..... ||||.||.| .  ..       ..|||| ||.|.    |    .|. |.. |   |..|..  |.| .||.     . | .||||.|.|.|.||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LPRHS--IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEG------HEYYRVRE--DGD--SPVFWYAPECLKEYK
| .|   . ...|| |. ||..||.||| ...|||||||||.|..... |||.||||.... ..      ..|||..|  .|.   |. |.||||....|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK--------CPCEVYHLMKNCWETEASFRPTFENLIPIL
|  .||||||||...|..| ...  . ...        |  |.  .. |....|.|.|.|.         || |.| .|| ||. ... ||||.... ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQ--------Q-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TYK2.AA TK 897-1169 20 5.1e-94 315.55 In-house 1-486 (486) Show / Hide 
Range on Protein: 897-1169
Range on HMM: 1-486/486
Sequence Identity: 20% (102 aa)

LKKIRDLGEGHFG---KVSLYCYDPTN---------------------DGTGEMVAVKALKADCGPQHRS----GWK------------QEIDILRT--L
.. .. ||||.||   .| .  . . |                     .|. . |||| ||.... . .      ..            .|. ...   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

YHEHIIKYKGCCEDQGEKS----------LQLVMEYVPLGS----LRDYLPRHS----------------------------------------------
 |..|..  |.| ....|.          . .||||.|.|.    ||||| ...                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IGLAQLLLFAQQICEGMAYLHAQ------HYIHRDLAARNVLLDNDRL-----------VKIGDFG---
                               . ..||| ...||..||.|||..      ...||||||||.|....             .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKAVPE-----------------------GHEYYRVREDGDSPVFWYAPECLK---------EYKFYYASDVWSFGVTLYELLTHCDSSQSPPT
     ||.....                       ...||| . .|  |. |.|||||.         . ||  .||||||||...|..|...    .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KF---------LELIGIAQ-GQMTVLR--LTELLERGERLPRP--DKCPC-------------EVYHL-MKNCWETEASFRPTFENLIPIL
            |..   . |... .|  | .  | |.|...|  . ||              |.|.. |. ||. ... ||||. |   |
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGL-N--EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TYK2.AA S_TKc 897-1169 23 3.1e-56 194.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 897-1169
Range on HMM: 1-231/231
Sequence Identity: 23% (71 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPL--GSLRDYLPRHS
 ...| .|.| |||| .         ||. ||.| .|           ..||.||.   |..|.|......|   ..| .||||..   |.|.||. .. 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

-------IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY-ASDVWS
       .   .   ...|||....|.| .. |||||   |.|||.   .||.|||||. .                 .. ||| |   .. . ..|.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGVTLYELLT----HCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI---------PIL
.|..|||.|.     .      . . ...||                           . |. .....|.. . . |||   .          | .
CGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TYK2.AA UTK 897-1097 29 5.3e-56 190.08 In-house 1-236 (296) Show / Hide 
Range on Protein: 897-1097
Range on HMM: 1-236/296
Sequence Identity: 29% (71 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGE-MVAVKALK-ADCGPQHRS---GWKQEID---ILRTLY-HEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLR
..  |.||.|.|| |..  ... ..  .|  ||||...  . ..| .     .  |     ..  .. |.....  | | ...   . .|.|| . |.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

DYLPRHSIGLA---------QLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDR-------LVKIGDFG---LAKAVPE--------GHEYYRVRED
.|| ||.  .          |.| .| .| .||.||| ....||||||||.|.. .|       ..||.|||   ....|.         . .||. ...
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GDSPVFWYAPECLKEY-KFYYASDVWSFGVTLYELLTH
.  |. |.|||.| .  .|  .||||||||...|..|.
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase TYK2.AA TKL 903-1169 22 2.9e-55 189.91 In-house 1-364 (364) Show / Hide 
Range on Protein: 903-1169
Range on HMM: 1-364/364
Sequence Identity: 22% (83 aa)

LGEGHFGKVSLYCYDPTNDGTG-----EMVAVKALKAD-CGP-------------------------QHRSGWKQEIDILRTLYHEHIIKYKGCCEDQG-
.|.|.||.|    .  ..   .     . |||| .| . .                           . |   ..|| ... | |..|....|.| . . 
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

----------EKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQH--------YIHRDLAARNVLLDND--------------RLVK
          .. | .||||.| |||..||      . |.. .|..|. ||.|||...         |||||  .|.|.|..              . .|
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IGDFGLAKAVPEGHEYYRVREDGD-------------SPV---FWYAPECLK----------------EYKFYYASDVWSFGVTLYELLTHCDSSQSPPT
|.||||.. . .  .  .   ..              ...    | |||.|.                ....  ..||.|||. |.|.|| |     |  
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----PYY

KFLELIGIAQGQMTVLRLTELLERGERLPRP------------DKCPCEVYHLMKNCWETEASFRPTFENLIPIL
.. .   |.| .   . .    ..|.|.|.|            . || ..  ||. ||..... ||.|. .. .|
DYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TYK2.AA Frk 897-1173 34 1.1e-53 184.28 In-house 1-260 (260) Show / Hide 
Range on Protein: 897-1173
Range on HMM: 1-260/260
Sequence Identity: 34% (97 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP-----
.. || || | ||.|    .. |       |||| ||.  |      . .|  |.. | |  .|.    |    |. . .. | .  ||| .||      
IQLIRRLGSGQFGEVWEGLWNNT-----TPVAVKTLKP--GTMDPNDFLREAQIMKKLRHPKLIQLYAVCTV--EEPIYIITELMRHGSLQEYLQAINDK

RHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHE-YYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVT
 ... . ||.  | |.  |||||  | ||||||||||||....  .|| |||||. .    |  |  | .   |. | |||  .  ||   |||||||. 
GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGIL

LYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVH
|.|..|.                .    ||     . ...| |.|.|  || ..|..| .||. ..  ||||| |   |.   
LTEIITYGR--------------MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase TYK2.AA Ack 897-1093 40 3.6e-52 174.29 In-house 1-203 (266) Show / Hide 
Range on Protein: 897-1093
Range on HMM: 1-203/266
Sequence Identity: 40% (83 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQH--RSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---P
..    ||.| || |     .    |.   |||| |. | ..|    .   .|  |.  | |.|...  |   ||  ..|..|.|  |.||| | |   .
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQ--PMLMMVTELAPCGSLLDCLRKHC

RHSIG-LAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDG--DSPVFWYAPECLKEYKFYYASDVWSF
| ..  .. |. |. ||..||.||.... |||||||||.||  | |.|||.||||  | ...  |||  .      |  | |||||.  .|  |||||.|
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF

GVTLYE
|||| |
GVTLWE
Kinase TYK2.AA EGFR 897-1096 38 1.3e-50 166.18 In-house 1-198 (258) Show / Hide 
Range on Protein: 897-1096
Range on HMM: 1-198/258
Sequence Identity: 38% (78 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH--S
|||.. || | ||.|    . |  .     ||.|.|.   ||.      .|  ..  . |.|...  | |  .    .|||  | |.|.| ||.  |   
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ---MQLVTQYMPYGCLLDYVRQHKDN

IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYEL
||  .||... ||  || ||  .. .||||||||||.     ||| ||||||  .   . |.. . |  |. | | ||... ..  .|||||.|||. ||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

LT
.|
MT
Kinase TYK2.AA Src 897-1097 38 4.5e-48 161.38 In-house 1-196 (255) Show / Hide 
Range on Protein: 897-1097
Range on HMM: 1-196/255
Sequence Identity: 38% (79 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP----R
.| .| ||.|.|| |    .. . .     |||| ||..    .     ||. |. .| ||....    | .  |.    | ||   ||| |||      
IKLCRKLGQGQFGEVWMGYWNGNTK-----VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQ--EEPIYIVTEYMSHGSLLDYLKKDGEG

HSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLY
... | ||. .| |. |||||| .. |||||||||||| ... ..|..|||||. . |. . |  |..   |. | |||.. . .|   |||||||. |.
RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

ELLTH
|. |.
EIVTY
Kinase TYK2.AA TK-Unique 897-1096 32 6.7e-48 163.27 In-house 1-234 (294) Show / Hide 
Range on Protein: 897-1096
Range on HMM: 1-234/294
Sequence Identity: 32% (77 aa)

LKKIRDLGEGHFGKVSLYCYDPTN--DGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLY-HEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP--
|.  . .||| || |    . ...  ..    ||||.||..  .. ..  ..|| ... |  |..|..  ||| . .  . ...|||.| |.|..||   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

-----RH--------------------SIGLAQLLLFAQQICEGMAYLHA--QHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP
     .|                    .| . .|. || ||. ||.||.   .. .||||.|||||| .|  .||.|||.|. |  ...| . .. |  |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VFWYAPECLK--EYKF-YYASDVWSFGVTLYELLT
. | ||| ||  .  . .. ||||||||...|..|
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase TYK2.AA Syk 897-1095 40 7.4e-47 159.32 In-house 1-203 (257) Show / Hide 
Range on Protein: 897-1095
Range on HMM: 1-203/257
Sequence Identity: 40% (86 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGE----MVAVKALKADCGPQHRSGWKQEI----DILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRD
| . . .| | || |    |   . | ||     ||.| |||| .     . |||.     .   | | .|..  | |  ..| .. .||| ..||.. .
LVQDNEIGCGNFGSVHKGWYM-MKSGAGEKQWIKVAIKMLKADHN---QPADKQEFMREAQVMCQLDHPCIVRMIGIC--HAE-MMMMVMEMAELGPMHK

YLPRH--SIGL-AQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVW
||  |  .|   . | | . |.  || ||  .| .||||||||||| |    || |||. ||   . .||. .  |  || ||||||   |||  .||||
YLQQHRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVW

SFGVTLYELL
|||||. | .
SFGVTMWEMF
Kinase TYK2.AA Pkinase 897-1165 25 3.4e-44 157.35 Pfam 1-287 (293) Show / Hide 
Range on Protein: 897-1165
Range on HMM: 1-287/293
Sequence Identity: 25% (77 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQ-----EIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLG----SLR
....| .|.| ||.|    |  .. |||..|||| .| .   .. . ...     || |.. | |..|.......||  .... .||||.. |    .| 
YHIGRKIGSGSFGCV----YKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF

DYLP---RHSI--GLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLD-NDRL---VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK-EYK
||.    . ..     ..  .. ||..|..|.|..  |||||   |.|.| |. .   |||.|||||| .   .  ..   .     .. ||| ..   .
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQY

FYYASDVWSFGVTLYELLTHCDSSQSPPTKFLEL----IGIAQGQMTVLRLTELLERGERLPRP---------------DKCPCEVYHLMKNCWETEASF
  ...|.||.|..|||.|.         . | .       . | || ....   |.. .  ...               .. . |  ...|.|..   . 
YGPKVDMWSCGCILYEMLCGR-------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RPTFENL
|||.| .
RPTAEQI
Kinase TYK2.AA Syk 1124-1163 40 9.1e-17 54.23 In-house 218-257 (257) Show / Hide 
Range on Protein: 1124-1163
Range on HMM: 218-257/257
Sequence Identity: 40% (16 aa)

LTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFE
.....| |.|...|..|| |.| ||. ||  ..  |||| 
VMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase TYK2.AA Src 1128-1169 46 3.5e-15 48.0 In-house 213-255 (255) Show / Hide 
Range on Protein: 1128-1169
Range on HMM: 213-255/255
Sequence Identity: 46% (20 aa)

LERGERLPRPDKCPCEVYH-LMKNCWETEASFRPTFENLIPIL
.||| |.|.|..|| |.|. .|. ||. ..  ||||| |   |
VERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TYK2.AA Ack 1126-1169 42 1.8e-14 45.25 In-house 222-266 (266) Show / Hide 
Range on Protein: 1126-1169
Range on HMM: 222-266/266
Sequence Identity: 42% (19 aa)

ELLE-RGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPIL
....  |||||||| || ..| .|..||. ..  |||| ..   |
QKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase TYK2.AA EGFR 1126-1170 46 3.1e-14 43.49 In-house 214-258 (258) Show / Hide 
Range on Protein: 1126-1170
Range on HMM: 214-258/258
Sequence Identity: 46% (21 aa)

ELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILK
.|||.||||| |. |   || .|  ||   .  ||||. |.  .|
DLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase TYK2.AA TK-Unique 1124-1169 38 4.5e-14 45.03 In-house 248-294 (294) Show / Hide 
Range on Protein: 1124-1169
Range on HMM: 248-294/294
Sequence Identity: 38% (18 aa)

LTELLERGERLPRPDKC-PCEVYHLMKNCWETEASFRPTFENLIPIL
. |....| |.|.|..| . |.| |||.||  |.. ||.|. .. .|
IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TYK2.AA UTK 1119-1169 33 8.9e-13 40.04 In-house 244-296 (296) Show / Hide 
Range on Protein: 1119-1169
Range on HMM: 244-296/296
Sequence Identity: 33% (18 aa)

MTVLRLTELLERG--ERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPIL
|.  .... ...|   |.|.|. || .|| ||. ||... ..||.|| |   .
MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM