Gene Pdk1A (Slime mold)
Pdk1A
Sequence
Protein domains of Pdk1A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Pdk1A.AA | PDK1 | 69-449 | 43 | 1.9e-220 | 682.79 | In-house | 1-307 (307) | Show / Hide |
Range on Protein: 69-449
Range on HMM: 1-307/307
Sequence Identity: 43% (175 aa)
FIIGKVLGEGSYGAVVLGTEKET----QQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSN-----HPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIK
||.||..|||||..|.|..|||| ...|||||.||..||.|.|.|||..||||.|..| ||.||||.|||..|||||.|||.|..|||||..|
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK
K--VGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTG---KILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNL
| .||||...|..|.||||..||||||.||.||||||||||...| |..||||||. ||||..||.||.|.|||.|
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQ---------------------
SVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEY
|.|.... ..|..| ||..||||||||
---------QHNKGMD-----------------------------------------------------------------KPEEDKQTRCKSFVGTAEY
VSPELISNKETSTDSDLWALGCIIYQMASGRVPFRGK-----TEFLTFQKVSNRELVYPIN--MNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHP
|||||...||.....|.||||||||||..|..||||. .|..||||........|.| ..|..||||.||||..|.|||.|....||....||||
VSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQIKAHP
FF
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FF
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| Kinase | Pdk1A.AA | AGC | 69-449 | 24 | 8.10000000001e-148 | 385.12 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 69-449
Range on HMM: 1-395/395
Sequence Identity: 24% (119 aa)
FIIGKVLGEGSYGAVVLGTEK------ETQQQYAIKILEKKQ---IIKENKIKYVQIE------------KEIFCKSN----------HPNIVK-LFFTF
| . ||.|.||.| | | .| |...||.|.|.|| |.|.|.......| ..|. | | ||.||| |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF
RSEQC--LYYVLELCS--------QGD-LLHQIK----KVGSFDYRSCQYYVAE-------IISGLEHLHS-LGIVHRD-LKPENILMSSDLHVKITDFG
... || |.|... |. |.... | |.|| ...| || |...||.||| .||.||| |||||||. .| |.|.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG
TGKILPPPQSSQQQQQQ------------------QQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNN
|... .. .|| .| . . . .... |.|. .|
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDT-N-----------------------K-CNPNNWQRNN-MS------------------------
NNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNN------SFVG--TAEYVSPELISNKETSTDSDLWA--LGCIIYQMASG
. | .. || . .|.| |.||..|| . . | |. |||..|.| .|
-----------------------------------------Q-E-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTG
RVPFRGKT----------EFLTFQKVSNR------ELVYP----------INMNPVIKDLVEKLLVIKPTDRLGS-SSTPG--GFDNLKAHPFF
. ||.|.. .. .|||. |. .. .| .. | |||..|||. |..|||. .. | |.. .|.||.|
YPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
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| Kinase | Pdk1A.AA | S_TKc | 69-449 | 22 | 8.7e-91 | 308.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 69-449
Range on HMM: 1-231/231
Sequence Identity: 22% (89 aa)
FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQ--GDLLHQIKKVGS---
. |....|.|..| | ....|.|....||||. . .. | .| | .|||||||. .|.. ..|| |.|.|.. |||.. ||| |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL
---FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDL
|. ...|...|...||..||.||.||||||||||... |.||.||| ..|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------
TQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEYVSPELI
..|.|| .|..||..
-------------------------------------------------------------------------------------TTFCGTPWYMAPEVL
SNKETST-DSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRELVYPINMNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPFF
.. .| |..|||.| |..|. ||. .....|.|. | ||...|.|. |..|.. . |.||.|
---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Pdk1A.AA | Ciliate-E2 | 69-449 | 18 | 7.6e-84 | 284.87 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 69-449
Range on HMM: 1-365/365
Sequence Identity: 18% (92 aa)
FIIGKVLGEGSYGAVVLGTEKETQQQ-----------------------YAIKILEKKQIIKENKIKYVQ----------IEKEIFCKSNHPNIVKLFFT
... |..|.|..| | ... ...|.| ||.||..|.||. ...... .||.| . |||||.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
FR--SEQCLYYVLELCSQGDLLH-------------------QIKKVGSFDYRSCQ-------YYVAEIISGLEHLHSLG-IVHRDLKPENILMSSDLHV
| .....|.|.|.|..|||.. .|... . . .| .|.|.||..||.||| . |.|||.||||||. .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I
KITDFGTGKILPPPQSSQQQQQQQQQ----------------QQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTT
||.|||. |.. ... ... ||.. |
KIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQ---------------------------------------------------------
TTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEYVSPELISNKE---------TSTDSDLWALGCIIYQM
| . |...||..|..|| ...|. .. .|.|.||.|.|.|
------------------------------------------------IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
ASGRVPFRGKTEFLTFQKVSNRELVYP------------------INMNPVIKDLVEK----LLVIKPTDRLGSSSTPGGFDNLKAHPFF
.|. || .|. . .. .| . . ||| | .|. .| |.. |.. .. ||.|
LFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT------GWEQILNHPWF
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| Kinase | Pdk1A.AA | RSK | 72-449 | 23 | 1.2e-79 | 270.89 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 72-449
Range on HMM: 1-278/278
Sequence Identity: 23% (94 aa)
GKVLGEGSYGAVVLGTEK---ETQQQYAIKILEKKQIIKENK-IKYVQIEKEIFCKSN-HPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGS---
||||.|.||.| | .. |.|.|| |.|.|. |.. .| .... | .| .. ||.||.|. .|. |. || ..|.|. |.|. ..| ..
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC
FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSS---DLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDL
|. . ...| |||.. .||||..||.|||||||||| . . |.|.|||| |..
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------
TQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPK-LTRNNSFVGTAEYVSPEL
.. . ..|..|.||. ||.
------------------------------------------------------------------------------RCDHNQWTMTFCYTIEYMAPEM
IS----NKETSTDSDLWALGCIIYQMASGRVPFRG---KTEFLTFQKVSNRE--LVYP--INMNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPF
. .. . |.| ||...| | .|..||.| .. ..... . . | | .. . |||. |.| | .|||. |.. . .|.||.
LKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCG--PQDAEEIKQHPW
F
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F
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| Kinase | Pdk1A.AA | AktR | 69-449 | 26 | 1.5e-76 | 260.62 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 69-449
Range on HMM: 1-268/268
Sequence Identity: 26% (104 aa)
FIIGKVLGEGSYGAVVLGTEK-ETQQQYAIKILEKKQIIKENKIKYVQIEKEIFC-KSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDY
| . |.||.| .| |.| ..| ..|.|||.|.. || ||..|...... |. | ..||| ||||...| .. .|....| | |.|.. .|| . |.
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE
RSCQYYVAEIISGLEHLHSL-GIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQ
. | |.|. .||.||. |. |||||||||. .| |||||||| |
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------
NRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIP--KLTRNNSFVGTAEYVSPELISN-
.. . ...||.|| ||..|| | .
-----------------------------------------------------------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKK
KETSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRE-LVYPINMNP--VIKDLVE-KLLVIKPTDRLGSSSTPGGFDNLKAHPFF
| .|.||.|. || | .| || | ||| . . . |..... |||.. ||| |. |||... |.. .| ||.|
KGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCN--GWEEIKSHPWF
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| Kinase | Pdk1A.AA | Ciliate-E2-Unclassified | 69-449 | 20 | 5.8e-75 | 255.36 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 69-449
Range on HMM: 1-352/352
Sequence Identity: 20% (94 aa)
FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYV----QIEKEIFCK------------------SNHPNIVKLFFTFRSEQCLYYVL
..|.|..|.|..| | . .|...|.||.|.. |.||.| ..|... ...||...| ..||.|||.|..|...|..| |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM
ELCSQGDLLHQIKKVGS-----------------FDYRSCQ-----YYVAEIISGLEHLHSLG-IVHRDLKPENILMSSDL---HVKITDFGTGKILPPP
|.| .|||. ||| .. |. . .. .| |.|..|||.||. . |.|||.||||||.... ..||.||| | . .
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN
QSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTN
. .. .|
NNCD-TNQ--------------------------------------------------------------------------------------------
TNINTNINANINNIKTTEIPKLTRNNSFVGTAEYV----SPELISNKETSTD----SDLWALGCIIYQMASGRVPFRGKTEFL----------------T
. |.| . ..|.|| .| .||.. ... .. .| |.||.|.|.| |. || ....
-------------QQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL
FQKVSNRELVYP--------INMNPVIKDLVE----KLLVIKPTDRLGSSSTPGGFDNLKAHPFF
.|. .... .| . .| ||... |.|. .| |. .|. .. ||.|
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-------TFEQILNHPWF
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| Kinase | Pdk1A.AA | CAMK | 74-431 | 17 | 7.1e-74 | 237.24 | In-house | 1-414 (425) | Show / Hide |
Range on Protein: 74-431
Range on HMM: 1-414/425
Sequence Identity: 17% (92 aa)
VLGEGSYGAVVLGTEKETQ------------QQYAIKILEKKQIIK-------------------------ENKIKYVQIEKEIFCKSN-------HPNI
.||.||.| | |...|.|. |..||||..||.. . ... | |. | || | . ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VKLFFTFRS-------------------EQCLYYVL---ELCSQG----DLLHQIKKVGS---------------FDYRSCQYYVAEIISGLEHLHSLGI
.||. .. . ....| |. |.|| | ||. |.. |. |. | ...|. |.|.....||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
VHRDLKPENILMSSD-----------------LHVKITDFGTGKILPPPQSSQ----QQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNR
|||||||||||.... .||.||| ....| ... ... . . .|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQW-------------------------------
TSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNS--------FVGTAEYVS-PE
. . |.|| ||.. ||
-----------------------------------------------------------------------------TTPTEGQKMKTFCGTPEYMAAPE
LISNKE--------------TSTDSDLWALGCIIYQMASGRVPFRGK-------------TEFLTFQKVSNRELVYPINMNPV-----------------
... | . .| |..|.| | | .|. ||.|. .. .|.|. . . .| . .
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF
-------IKDLVEKLLVIKPTDRL
|||. |.|. |..|.
HHFVSQECKDLIRKMLQVDPEKRM
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| Kinase | Pdk1A.AA | MAST | 69-449 | 26 | 5e-72 | 231.4 | In-house | 1-334 (334) | Show / Hide |
Range on Protein: 69-449
Range on HMM: 1-334/334
Sequence Identity: 26% (109 aa)
FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYRS
| . |... | ||.| | |.| . .|.|.. | . |. | .. ||.|. |. . | .||.| .| ... |. |.| . ||. . .. .|.|| .
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM
CQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKI-----------------LPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNV
. |.||.. .|| ||| |||||||||.|.| .|. |.|.|||| |. .
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI----------------------------------
NNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTA--AGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFV
|| . |.|.... .. | |.|||.| |.... . . . .|.. .
----------------------------------------FNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQ-IQQQQEQPQCQQQNMRPHNIHQNKQCC
GTAEYVSPELISNKE-TSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRE---LVYP--------INMNPVIKDLVEKLLVIKPTDRLGSSSTP
|| .| .||.| .. . .| |..| |.|. | .|| ..| ..||.. ||. .| . | |. .||.|||| | .|||...
GTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANN--
GGFDNLKAHPFF
| | | ||||
-GADEVKQHPFF
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| Kinase | Pdk1A.AA | Ciliate-E2b | 69-217 | 37 | 5.1e-54 | 162.59 | In-house | 1-152 (272) | Show / Hide |
Range on Protein: 69-217
Range on HMM: 1-152/272
Sequence Identity: 37% (57 aa)
FIIGKVLGEGSYGAVVLGTE-KETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVG--SFD
.|. | || | .| | |. . |.|.|.||.| .| |||..| |. ..||.. | |||.|.|.. .|...|..| ..|.|. ..|. | .| .
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS
YRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKIL
| |.|.|. .|| ||...|..||.|||||. .. ..|. |.|| |..
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHM
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| Kinase | Pdk1A.AA | PKC | 69-212 | 38 | 2e-46 | 148.39 | In-house | 1-145 (262) | Show / Hide |
Range on Protein: 69-212
Range on HMM: 1-145/262
Sequence Identity: 38% (56 aa)
FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCK-SNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYR
| |||| ||.| |.|. |.|.. ||||.| | ||. . ...|| .. ..|| ..|. .| .. |..|.| . ||| ..| ... |. .
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE
SCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG
| ||||..| ||. ||. |||| .|.|. .. |.||.|||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFG
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| Kinase | Pdk1A.AA | Pkinase | 69-212 | 37 | 1.8e-45 | 161.85 | Pfam | 1-157 (293) | Show / Hide |
Range on Protein: 69-212 Range on HMM: 1-157/293 Sequence Identity: 37% (59 aa) FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQ-IEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQG----DLLHQIK--KV . ||...|.||.| | ....| |....|.||..|. . .. .. . | .| . ||||||.|. .|.... .| |.|.| | || . |. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GSF--DYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHV----KITDFG |.| ... |. |. .|..|||..|| ||.||||||||||.... |. ||.||| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG |
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| Kinase | Pdk1A.AA | Pkinase | 343-449 | 21 | 1.5e-24 | 87.85 | Pfam | 167-293 (293) | Show / Hide |
Range on Protein: 343-449 Range on HMM: 167-293/293 Sequence Identity: 21% (29 aa) TRNNSFVGTAEYVSPELIS-NKETSTDSDLWALGCIIYQMASGRVPFRGK------TEFLTFQKVSNRELVYPI---------------------NMNPV . ...|.|| .|..||.| ... .. .| |..|||.|.|..|| ||.|. .. .... ..| ... |... S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE IKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPFF ||.....| .|..|.. .. .. ||.| CKDFIKWCLCKDPKKRPT-------AEQILQHPWF |
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| Kinase | Pdk1A.AA | PKC | 346-449 | 29 | 4e-24 | 74.96 | In-house | 158-262 (262) | Show / Hide |
Range on Protein: 346-449 Range on HMM: 158-262/262 Sequence Identity: 29% (31 aa) NSFVGTAEYVSPELISNKETSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRELVYPINMNPVIKDLVEKLLVIKPTDRLGSSSTP-GGFDNLK ..| || .|..|| .. .| . | ||.| |.| |. || |..| || . ... .||. . .... .... .|..|||. .. .|... . STFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIR AHPFF .|||| EHPFF |
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| Kinase | Pdk1A.AA | Ciliate-E2b | 342-449 | 26 | 4.9e-22 | 63.9 | In-house | 159-272 (272) | Show / Hide |
Range on Protein: 342-449 Range on HMM: 159-272/272 Sequence Identity: 26% (31 aa) LTRNNSFVGTAEYVSPELIS-----NKETSTDSDLWALGCIIYQMASGRVPFRGKTE--FLTFQKVSNR--ELVYPINMNPVIK--DLVEKLLVIKPTDR .||. . .|| .| ||.|. .| .. .|.|..| . | . .|.||. . . |.. . |. .| . ... .|....| | .| MTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVR LGSSSTPGGFDNLKAHPFF || | .. ||.||.| LG-----GSYSWLKSHPWF |
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| Kinase | Pdk1A.AA | Pkinase_Tyr | 69-212 | 31 | 2.7e-17 | 59.18 | Pfam | 1-156 (270) | Show / Hide |
Range on Protein: 69-212 Range on HMM: 1-156/270 Sequence Identity: 31% (50 aa) FIIGKVLGEGSYGAVVLGTEK----ETQQQYAIKILEKKQIIKEN--KIKYVQIEKEIFCKS-NHPNIVKLFFTFR-SEQC--LYYVLELCSQGDLLHQI ..||.||||..| |..|| | .|... |.|.| | . .|. . . . | .| .. .|||||.| .. .| |.|.. ||||. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL KK----VGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG .| .... . ..| .|.|.|.| ...|||| |.| .....|||.||| RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG |
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| Kinase | Pdk1A.AA | TyrKc | 69-260 | 20 | 3.3e-11 | -41.44 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 69-260
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)
FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKS--NHPNIVKLFFTFRSE-------QCLYYVLELCSQGDLLHQIK
||.|||| .| |..|| | .| |.| | . .. | .| || .|||||.|. ... . |. |.|... |||.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR
KVGS-FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG------------------------TGK-------------------
| . . . .. | .| |.||| ...|||| |.| .....|||.||| ||
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT
-------------------ILPPPQ------SSQQ--QQQQQQQQQQLPTN--------SSGNLSSLLNNVNNL---------SVSTDL
|.| | |. .. .| | | . . .. . . ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| PDK1_PH | Pdk1A.AA | PDK1_PH | 584-681 | 40 | 4.1e-41 | 142.91 | In-house | 1-112 (112) | Show / Hide |
Range on Protein: 584-681 Range on HMM: 1-112/112 Sequence Identity: 40% (45 aa) SKW---LN-NGENVIYQGLVWKRKGFSI----KKRQLILTDTPRLIYIDPKKMELKGEIPWS-DSIKPKLK-----SNNNFVIKTPKRKYLLEDVAHNPQ ..| | .||.....| | ||||.. |.|||||||.|||.|.||..|..||||||| .......| . | |.||.|.| .||. .... TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN KWVDSIKSVILS ||.. | |. KWCEAIEKVCKR |
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| PH | Pdk1A.AA | PH | 593-682 | 27 | 2.2e-05 | 25.11 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 593-682 Range on HMM: 1-82/82 Sequence Identity: 27% (25 aa) VIYQGLVWKRKGFSIKKRQLILTDTPRLIYIDPKKMELKGEIPWSDSIKPKLKSNNNFVIKTPKRKYLLEDV-AHNPQKWVDSIKSVILSS ||..| . |... . ||| ..|.. .|.| ..| ..||.|| || . . | |.. .| |.. . |.|...|...| .. VIKEGWLYKKSK-RWKKRWFVLFN-DCLYYYKDK--KPKGSIPLSDC-TVRE-P--CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN |
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