Gene pk4 (Slime mold)

pk4

Species: Slime mold
Alias: pkgD, DdisK018, DDB0218566, pk4
External Links: DictyBase Link ,
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
pk4.AA Protein None 992 None Fasta, JSON
pk4.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of pk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Med15 pk4.AA Med15 1-204 10 0.00237 10.83 Pfam 435-466 (945) Show / Hide 
Range on Protein: 1-204
Range on HMM: 435-466/945
Sequence Identity: 10% (22 aa)

QQQQQQQQQQQQQQQQQHQKTSPSTSFVDYNNINNSNGNNINGTTSTCNSTSSSKSNSKEIYNENNNNNNNNNNNSFTNVHNNNNNNNNNRKRRNSHISY
|||||||.|.|.||||| |                                                                                 
QQQQQQQHQAQHQQQQQQQ---------------------------------------------------------------------------------

DTPDSNNIDNNIESNDTESGFRKNSKKSTDNNNNNNNNNNNNNNNNNNNNNNNNNNNSCNINGNINNGNSNNINNNNCSNIDSTLADVSKHQYTNQHQQQ
                                                                                           |   |||||
-------------------------------------------------------------------------------------------QQQQQHQQQ

QNIQ
.. |
MMQQ
Med15 pk4.AA Med15 246-509 11 0.049525 6.2 Pfam 426-470 (945) Show / Hide 
Range on Protein: 246-509
Range on HMM: 426-470/945
Sequence Identity: 11% (30 aa)

QQQHQQQNSQQQQNNQHQQQLQQQQYQQKHYNNNNNNNNNNQPQTSNQNIQHSQGLNYNQNQNQNQNQEAPIVVNSLILRSIGMMTSKISKDFEELTTFM
..| |||. ||||  |||.|.|||| ||                                                                        
CDQQQQQQQQQQQQQQHQAQHQQQQQQQ------------------------------------------------------------------------

KSSCPMLLRFSGVENSYHILEKLNNIITQSLEGLPKTPQCSQPPFNQLIPLSNTTTLTPNNYNNNNNNSNNNNNSNNNNNNNSNNNNSNNNNSNNSNNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NNSNNNNSNNNNSNNNNSNNNNNNSNNNNSNNNNSSNNNNNYSGFNDQQQQQQQQQQQQQQQQQ
                                               |||||.|||. || ||.
-----------------------------------------------QQQQQHQQQMMQQMQQG
Kinase pk4.AA PKA 679-934 52 7.29999999999e-178 597.19 In-house 1-263 (263) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-263/263
Sequence Identity: 52% (139 aa)

FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIV-KLYSTFKDDRYLYFLQEFIPGGELFDYIRANGSLSLY
|.....||.|||..|.||.| .|.. ..||.|....|.||.|. ||.|||..|.....|||| |.|.||.||||||...|..||||.|.|.|..|..| .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

VTQIYAA-EIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRITENTKSMCGTPEYIAPEILSGH-GHGKSADWWSLGILIYEMLVGVPPFV
....||| .|||||||||.|.||||||||||.|||..||||.|||||||.....|...||||||.||||.... ||||| |||.|||||||||.|.||| 
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFY

SEG-SQNDIFRLIREARIQVPPEVDQVA---RDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF
 .. ....|.. |....|. |...|. |   .|||.||...|..||.|....|..|||||..|
DHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase pk4.AA AGC 679-934 30 6.4e-175 456.82 In-house 1-395 (395) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-395/395
Sequence Identity: 30% (120 aa)

FKLFDLLGSGSFAKVRLCQHI------PSERLFCMKILNQNK-IIRLR--QEVHVCNE------------KQVLMLTD----------NPFIVK-LYSTF
|..  ..| ||| ||.|...        ..... ||.|.  . |....  .. |. .|            ...|.. .          .||||| |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDDRY--LYFLQEFIP---------GG-ELFDYIR---ANGSLSLYVTQIYAAE-------IVLALEYLHN-QDIIYRD-LKPENLLIDQYGHIKLTDFG
.|...  |||. |..|         || ||| ...    .|...  ....||||       |||||||||. ..||.|| |||||.|.|. |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKRIT-----------------------------------------------------ENTKSMCG--TPEYIAPEILSGHGHGKSADWWS--LGILIY
..|..                                                      . |...||  ||||.|||||    .||..||||  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGVPPFVSEG---------SQNDIFRLIR------EARIQVP----------PEVDQVARDLIEKLVVTDVEKRLGSLEG-----GIEDIKNHPFF
|||.| ||| ..          .....| .|.      . ... |          ..... |.|||.|| . | |||||....     |.|.|||||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase pk4.AA Akt 679-934 41 1.7e-114 367.45 In-house 1-264 (264) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

FKLFDLLGSGSFAKVRLCQHIPSERLF-CMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIRANGSLSLY
| . ..||.|||.|| |..   .....  ||.|  ..||  .|  |.  |. .|  ...||||.|.  | .  .|||  ....||||| ...  .  |  
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

VTQIYAAEIVLALEYLHNQDIIYRD-LKPENLLIDQYGHIKLTDFGFAK-R-ITE--NTKSMCGTPEYIAPEILSGHGHGKSADWWS-LGILIYEMLVGV
 .  |.|||.||.|.||...||||| |||||.|.|. |||.||||| .|   |..   ||..||||||.|||||.|.||.|..|||. ||...|||. | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFVSEGSQNDIFRLIREARIQVP--PEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF
||| ..  .   | .| .. .. |  . ... ..|||..|   | .||||. ......||.||.|
PPFYNQD-HHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase pk4.AA AktR 679-934 42 2.3e-113 382.92 In-house 1-268 (268) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-268/268
Sequence Identity: 42% (113 aa)

FKLFDLLGSGSFAKVRLCQHI-PSERLFCMKILNQNKIIRLRQEVHVCNEKQVLM-LTDNPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIRANGSLSL
|..  .||.| |.|| |.|.   . ... ||..   |||...|. |. .|....  . ..||||||. .|.....|.|..|..||||||.... .. .| 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

YVTQIYAAEIVLALEYLHNQ-DIIYRDLKPENLLIDQYGHIKLTDFGFAK----R-ITENTKSMCGTPEYIAPEILSG-HGHGKSADWWSLGILIYEMLV
 ....|.|.|.|||||||.. .||||||||||.|.|. ||.|.|||| .|    .  .| ..| ||||||.|||..    ||.||.|||..||.||||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GVPPFVSEGSQNDIFRLIREAR-IQVPPE--VDQVARDLIE-KLVVTDVEKRLGSLEGGIEDIKNHPFF
| ||| .. .||..| .|.. . ...|.   . . ..|||. ||   . .||||.   |.|.||.||.|
GCPPFYHK-NQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase pk4.AA SGK 679-934 38 1.5e-109 339.52 In-house 1-283 (283) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-283/283
Sequence Identity: 38% (110 aa)

FKLFDLLGSGSFAKVRLCQHIPS------------------ERLFCMKILNQNKII-------RLRQEVHVCNEK-QVLMLTDNPFIVKLYSTFKDDRYL
|..  ..| ||| || . .|                     . .. ||.|... ||       .  ...|.  |.  .| .   ||||.|   |  . .|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFLQEFIPGGELFDYIRANGSLSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAK---RITENTKSMCGTPEYIAPEILSGH
||  ... |||.| ...  ....  .  .||||||.|||||| ||||||||||||.| |  ||..||||| .|     .. |.. |||||| |||.| ..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHGKSADWWSLGILIYEMLVGVPPFVSEGSQNDIFRLIREARIQVPPEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF
.|... |||.||.. |||..| ||| |    .  .  |.   .| || .   |.|||. |   |..||||. ....| |||||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSR-NKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFME-IKNHPFF
Kinase pk4.AA S_TKc 679-934 37 2e-103 350.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-231/231
Sequence Identity: 37% (100 aa)

FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPG--GELFDYIRANGS---
... ...|.|.|.||..|.|. . |.. .||..           |...| |.|.  . |.||||| .| |  .||.  |...|  |.|||||. .|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRITENTKSMCGTPEYIAPEILSGHGHGK-SADWWSLGILIYEMLV
   ..  ... |...|..||||.|.. ||.|||||||.|.|.  |||..|||.|...    ...||||.|.|||.|   |.|| ..||||.|...||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GVPPFVSEGSQNDIFRLIREARIQVPPEVDQVARDLIEKLVVTDVEKRLGSLEGGI--EDIKNHPFF
| |||     .. .|..|.          .. |.|.|.|. . | |||..  |     .|||.||.|
GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase pk4.AA RSK 681-934 39 3.9e-101 342.31 In-house 1-278 (278) Show / Hide 
Range on Protein: 681-934
Range on HMM: 1-278/278
Sequence Identity: 39% (110 aa)

LFDL--LGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQ-EVHVCNEKQVLMLTD-NPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIRANGS---
| .|  .| |..  .| |.|  ..... ||.|...||..      |.  | ..|...   ||||.|. .|... .||   |...|||||. ..  ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQ---YGHIKLTDFGFAKR-ITE---NTKSMCGTPEYIAPEILS----GHGHGKSADWWSLGI
.|    ..|.||||||.|.|| |.||.||||||| | |.    ||||||||||.|    .    |.. |.| ||.|||.|     . ||.|..||||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMLVGVPPFVSEGSQ---NDIFRLIREAR--IQVP--PEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF
|.||||.| ||| . . .   ..|.. |....     |  ... | |.||| |.   | .||||.  ...|.||.||.|
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase pk4.AA Ciliate-E2 679-934 26 5.2e-95 321.96 In-house 1-365 (365) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-365/365
Sequence Identity: 26% (103 aa)

FKLFDLLGSGSFAKVRLCQHIPSER-----------------------LFCMKILNQNKIIRLRQEVHVC----------NEKQVLMLTDNPFIVKLYST
.|.  ..|.|.|..|..|...   .                       .. |||...|.|. . || |..          |||..| . ..|.|.|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DDRYLYFLQEFIPGGELFDYIR-------------------ANGSLSLYVTQ-------IYAAEIVLALEYLHNQD-IIYRDLKPENLLIDQYGHI
|.  || ..|.  |.. ||.|||||.                     . .. ...|        |.|.|.|||||||..  ||.||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGFAKRITEN----------------------------------TKSMCGTPEYIAPEILS---------GHGHGKSADWWSLGILIYEMLVGVPP
|..|||..|.....                                  ... ||||.| |||||.         ..|.....|.||||...|||| | ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FVSEGSQNDIFRLIREARIQVPPE------------------VDQVARDLIEK----LVVTDVEKRLGSLEGGIEDIKNHPFF
|         .. | .  |. |..                  ..| . ||| |    . . | |||..    |.|.|.|||.|
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase pk4.AA RSK-Unclassified 679-934 36 1.1e-94 297.82 In-house 1-283 (283) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-283/283
Sequence Identity: 36% (104 aa)

FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIR--ANGSLSL
|    |.| |.| || | .   ..... ||.|. .|.|| .    |  |. .. .|. ||||.||  |    |||   |. .||..|          .. 
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

YVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRI------------------------TENTKSMCGTPEYIAPEILSGHGHG
   ..||.|...|||||| .|.|||||||.| . .| ||..||||.  .                             |.| ||| ||.|||.. . ||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KSADWWSLGILIYEMLVGVPPFVSEGSQNDIFRLIREARIQVP--PEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF
|  ||| |||..||||.|.||.  .  .| .|  |  . ...|   .. . .|||| ||      ||||.  |  .||| ||||
KAVDWWTLGIVMYEMLFGCPPYYGN-NKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase pk4.AA PKG 679-934 41 3.4e-84 286.01 In-house 1-260 (260) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-260/260
Sequence Identity: 41% (108 aa)

FKLFDLLGSGSFAKVRLCQHIPSE-RLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIRANGSLSLY
.|  . || | |  | | |    . | | .|...   |.  ||. |. .||...| ....|||.|| ||.|..|.|.| |   ||||   .|  |.   .
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

VTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRITENTKS--MCGTPEYIAPEILSGHGHGKSADWWSLGILIYEMLVGVPPFV
 |. |.| .| |..|||.. |||||||||||. |. | .|| ||||||.| .. |    ||||||.||||    ||  |.|.|.||||..| |.| ||| 
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFS

SEGSQNDIFRLIRE--ARIQVPPEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF
.   .  .. .|      .. | ..   | ..| ||       |||.. .||.||| |  |
GS-DPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase pk4.AA Pkinase 679-934 29 3.9e-83 287.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 679-934
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVC-NEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPGG----ELFDYIR--AN
...   .|||||..|..|.|. .......||..  ..    .. |.  .| |..   . |.||.|| .| |....|. .|. .||    .|||||.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSL--SLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHI----KLTDFGFA----KRITENTKSMCGTPEYIAPEILS-GHGHGKSADWWSL
|..  |  . . |. .|. .|||.|.. ||.|||||||.|||. |||    |..|||.|        . ... ||||.|.|||..  | ..|...|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILIYEMLVGVPPFVSE----GSQNDIFRLIREARIQVPPEVD-----------------------QVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPF
|...|||| | ||| ..    .  ...... |  . ... . .                       . ..|.|...   | .||..     .|.|..||.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase pk4.AA MAST 679-825 38 3.3e-53 160.57 In-house 203-352 (337) Show / Hide 
Range on Protein: 679-825
Range on HMM: 203-352/337
Sequence Identity: 38% (57 aa)

FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKD--DRYLYFLQEFIPGGELFDYIRANG-SLS
|.   ... | . .| | .|. .  .| ||..| . .|.  |  .|  |. .|  ..|||.||....|    ..||..  |.  ||  .  .|. | .. 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

LYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAK
   ...| ||.||.|||||...|. |||||.|.|||  |||||||||..|
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSK
Kinase pk4.AA MAST 832-934 44 1.5e-47 142.93 In-house 226-337 (337) Show / Hide 
Range on Protein: 832-934
Range on HMM: 226-337/337
Sequence Identity: 44% (51 aa)

KSMCGTPEYIAPEILSGHG-HGKSADWWSLGILIYEMLVGVPPFVSEGSQND-IFRLIRE--ARIQVPPE--------VDQVARDLIEKLVVTDVEKRLG
|. ||||.|||||.. | | .||..||||.|| .|| |||.|||. . ...  ||  |     .|  |.|        .  .|.|||.||   .  ||||
KQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGD-TPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

SLEGGIEDIKNHPFF
.   | ..||.||||
AN--GADEIKQHPFF
Kinase pk4.AA TyrKc 679-928 20 1.7e-12 -20.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 679-928
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLT--DNPFIVKLYSTFKDD-------RYLYFLQEFIPGGELFDYIR
 .| . ||.| | .|.... .   .    | |. ..      .   ..| ....    ..| ||.||    ..         |. . |. |.| | ||.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ANGS-LSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRITEN--------TKSM----CGTP----EYIAPEILSGHGHG
...  |..     ..  |    |||| . .| |||   | |..  ...| .||| .. |..         ....    .|         ||| .  .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSADWWSLGILIYEML-VGVPPFVSE----GSQNDIFRLIREA-RIQVPPE--------VDQVARDLIEKLVVTDVEKRLGSLEGGIEDI
   | || |....|..  | .|   .     |  ........  |   ||.          .   .....    | |.|    |  .|..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase pk4.AA Pkinase_Tyr 679-838 22 0.000444 14.44 Pfam 1-175 (270) Show / Hide 
Range on Protein: 679-838
Range on HMM: 1-175/270
Sequence Identity: 22% (40 aa)

FKLFDLLGSGSFAKVRLCQHI----PSERLFCMKILNQNKIIRL--RQEVHVCNEKQVLMLT-DNPFIVKLYSTFK-DDRY--LYFLQEFIPGGELFDYI
 ..   ||.|.| .|...         .     |.|...   .   |..    .| ....   ..| ||.||     ...   .|   |. |.| | || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCRED--FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RA----NGSLSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRI--TENT-KSMCGTP
|.    ...|..     ....|  ..|||... .| |||   | |..  ...| .||| |. |  ...  ..  |..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK