Gene ATR (Slime mold)
ATR
Sequence
Protein domains of ATR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| UME | ATR.AA | UME | 1531-1634 | 33 | 1.8e-42 | 148.32 | SMART | 1-115 (115) | Show / Hide |
Range on Protein: 1531-1634 Range on HMM: 1-115/115 Sequence Identity: 33% (38 aa) FDKFLIKEFLGSMNFFTMIMTNKQ--KSTQEKLTMMTSFHRLLG-LMGQSVDLFRPK---IMAFLRLAIKTP-MEEIAIDAWFTFIQLLKL---DS-IGP |..|| ..||| |..|.|||.... |...||.....|..... .||.....|||. |||.|. |...| ........|..||. |. .. ||| FADFLQDHFLGIMQWFNMIMHDSHGKKPYYEKKRALRSIEFMIKYMMGKHISSFRPQIIQIMACLQTALEIPELRHHCCRCWHCFIKHLNEVSCEHYIGP ILNQIVFSILPFVQS ...||.. |||.... LIDQIFAIILPYWPT |
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| UME | ATR.AA | UME | 1531-1634 | 26 | 1.5e-39 | 135.79 | Pfam | 1-112 (112) | Show / Hide |
Range on Protein: 1531-1634 Range on HMM: 1-112/112 Sequence Identity: 26% (30 aa) FDKFLIKEFLGSMNFFTMIMTN--KQKSTQEKLTMMTSFHRLLG-LMGQSVDLFRPKIMAFLRLAIKTP---MEEIAIDAWFTFIQLLKL--DSIGPILN ...|| ..||| ...| |.|.. .... .||. ...|..... ..|......||.|||.|. |.. | ........|..|||.|. ...||... MADFLQDHFLGIITRFSMVMHDFQGRQPYFEKKRCIRSIEEMIKYMCGKHISSARPQIMACLQSALEIPEEELRYHCFRCWHVFIQTLDEVPEHLGPLID QIVFSILPFVQS |....|.|. .. QTFVIIIPYWDT |
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| FAT | ATR.AA | FAT | 2247-2334 | 19 | 1.6e-08 | 28.72 | Pfam | 1-112 (408) | Show / Hide |
Range on Protein: 2247-2334 Range on HMM: 1-112/408 Sequence Identity: 19% (22 aa) GTIKIQSSWRLSHWDK--IDETLSQTH------------EPNF-----EAYLGRILYSL--VKKQEK--EFNSNLFQCRSFLAQLLNG-SALDSYQRCYP .. ...|||. || .|| .|.. | . . . . .| ..|.. |... ..|. | . . . ||.|.|| APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP YLIQAHILEEIE .. ..| |.| VMVRVQMLAELE |
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| FAT | ATR.AA | FAT | 2360-2622 | 13 | 3.6e-15 | 51.04 | Pfam | 120-408 (408) | Show / Hide |
Range on Protein: 2360-2622
Range on HMM: 120-408/408
Sequence Identity: 13% (41 aa)
GNNNNSNNNNVQKQQMLKKLLSEWDDRLKII-QPSFKLRESILSVRREILE----------IGSFSKEVIDCWMKIGKYARHDKKFELSLNAILKPTPSQ
..|.|...| ... .| .. | .||... |. . ..||..|. ... . .| ...|.| . .| ..|. ..... ..
QCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYD
QDKFY---------FIEHAKLMWNQGHSFEAINILTQELKNKWNPIINSNNNSSNNSSSNININNGSKLSLLGLPQEDLFIIS-KTHLLIARWKQQC---
.. ....|.|| .|.. ||...| . .... ....||.. | .. | .. . | .. . ... ..| ..
PSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTY---NLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEE
-----GITHHSELTEHYSSATAF--EWEK-GFFFLGRYYDSLLSNLKRVNQNSPNSPPLDSV--SYVDYTRNIISSYGQAVILGHS-YIYQTLTRIIA
. .. .| ..|. || | .|.| . ...|.. ... .. .|.. .. . . .. ..... . ... |... ..| . |..
QYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN-----YTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
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| Kinase | ATR.AA | PIKK | 2813-3074 | 37 | 2.7e-102 | 346.15 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 2813-3074 Range on HMM: 1-290/290 Sequence Identity: 37% (108 aa) LIGSFEDQIDIMPSLQGPKKINVNDRQGNRYSFLLKPNDDLRKDQRVMEFNTMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWVSNTATLRSILG | .. . . .|...| |||| | | .|.|. .|||.|||||... ..|.. |||.|.||.| ||||.||| . ..|.|||| |..||. |. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK GIYE------------------------TMD--TIGIDRFNQMVNAKKEKHYLDLFEDFNRF-FPPVLHKHFITNFPEPSAWLDARDAFARSCAIMSMVG .. |. . . .. .|.... . .|... .|....| | || | .|...| ...|| | |.||| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG SVLGLGDRHTENILLDSITGECVHIDYNCLFW-KGETFTVPERVPFRLTRNMVDVFGVLGVEGTFKTVCENTLRVLRSNKEVLLRVLENF .|||||||.|||..|..|||.||||..|.| ..... ||| ||||||||||. |. |||| | || .....|...| |. |.| | YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | ATR.AA | ATR | 2813-3074 | 42 | 1.5e-93 | 317.07 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 2813-3074 Range on HMM: 2-267/267 Sequence Identity: 42% (114 aa) LIGSFEDQIDIMPSLQGPKKINVNDRQGNRYSFLLKPNDDLRKDQRVMEFNTMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWVSNTATLRSILG | |.| ..|. ||| |||| . .| | . || |||||| | |.|| ..|.. .|| |.| ...|||.||| |....||||| ||||||.|| YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD GIYETMDTIGIDRFNQMVNAKKEKHYLDLFEDFNRFF----PPVLHKHFITNFPEPSAWLDARDAFARSCAIMSMVGSVLGLGDRHTENILLDSITGECV ... . .. || . . | |. ||. | .| ||.| | .|... || |...||| ..|||||||.|||.|.|.|||| KLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECV HIDYNCLFWKGETFTVPERVPFRLTRNMVDVFGVLGVEGTFKTVCENTLRVLRSNKEVLLRVLENF |.||||.| .||.| ||| ||||||.||| .| .. .| |. || .....| ... .. |.. | HVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | ATR.AA | PI3Kc | 2844-3146 | 28 | 1.2e-91 | 311.65 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2844-3146
Range on HMM: 1-336/336
Sequence Identity: 28% (96 aa)
SFLLKPNDDLRKDQRVMEFNTMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWVSNTATLRSILGGIYE---TMDTIGIDRFNQM-----------
....|..||||.|.|.|... ..||. .|| .||.|.|..|.| .|| ....|.||||.|..||..|. .. ....... .|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
--------------VNAKKEKHYLDLFEDFNRFFPPVLHKHFITNFPEPS-AWLDARDAFARSCAIMSMVGSVLGLGDRHTENILLDSITGECVHIDYNC
....... . .. ..|.||||...|. .||.|. .| .||| |.|||| ..||. .||.||||..||.|| ||.|.|||...
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
LFWKGETFTVP-----ERVPFRLTRNMVDVFG----VLGVEGTFKTVCENTLRVLRSNKEVLLRVLENFIYDPFLILFDKKNQNSNNNNNTHFGE-VEND
.| .|... .. ||||||||..||.| | . |..| |.| |. ..|..|....... ..| ..||| .. .... .. ... . . . .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
QAVEILKRISATLQGIPTVGLQLSIEGQVNHLIQEATNPKHL
.| . .. . .| .. |.|.. . ..... | ...
EAAQYFMQ-----T-MCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | ATR.AA | PI3_PI4_kinase | 2842-3084 | 28 | 1.3e-81 | 282.2 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2842-3084 Range on HMM: 1-300/300 Sequence Identity: 28% (86 aa) RYSFLLKPNDDLR--KDQRVMEFN-----------------------TMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWVSNTATLRSILGGIYE |.|..| .|||| .|.|.|.. ...||. ||| ..|.||. ...| .|| ....|.|||| |. |.. | . . WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEI---PRT TMDTIGIDRFNQ--MVNAKKEKHYLDL---------FEDFNRFFPPVLHKHFITNFPEP-SAWLDARDAFARSCAIMSMVGSVLGLGDRHTENILL--DS .| .... ||. ....|.......| .. . ...|.|...|. ..|.. .|..||| |.|||| |..|. .||.|||| .||.. | YMVKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDK ITGECVHIDYNCLFW--KGETFTVPERVPFRLTR------NMVDVF------GVLGVEGTFKTVCENTLRVLRSNKEVLLRVL-------ENFIYDPFLI ||...|||... | |...| .|||||||.|. .||... ...| .|.|...|. ..|.||.........| | ...|. . TTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPM LFD . . WRS |
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| Kinase | ATR.AA | ATM | 2940-3078 | 44 | 3.4e-41 | 129.14 | In-house | 106-244 (304) | Show / Hide |
Range on Protein: 2940-3078 Range on HMM: 106-244/304 Sequence Identity: 44% (62 aa) DLFEDFNRFFPPVLHKHFITNFPEPSAWLDARDAFARSCAIMSMVGSVLGLGDRHTENILLDSITGECVHIDYNCLFWKGETFTVPERVPFRLTRNMVDV . | | | || . | .| | . | |. || | |.|| .||||||| |||. | |||| | .| || ||||||| .|| EVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDG FGVLGVEGTFKTVCENTLRVLRSNKEVLLRVLENFIYDP |. |||| |. || |. |.| .| || . | .||| MGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDP |
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| Kinase | ATR.AA | FRAP | 2967-3082 | 43 | 1.1e-35 | 124.94 | In-house | 133-251 (251) | Show / Hide |
Range on Protein: 2967-3082 Range on HMM: 133-251/251 Sequence Identity: 43% (52 aa) WLDARDAFARSCAIMSMVGSVLGLGDRHTENILLDSITGECVHIDY-NCLFWKGETFTVPERVPFRLTRNMVDVFGVLGVEGTFKTVCENTLRVLRSNKE |.. | . || |.|||.| .||||||| ||.|. || ||||. | ||..|||||| .| . |.||... .|| ..|.| .|| WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE VLLRVLENFIYDPFL--IL .. ||| |.||| . .| SVMAVLEAFVYDPLFYWRL |
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| Kinase | ATR.AA | SMG1 | 2964-3026 | 53 | 9.7e-24 | 75.4 | In-house | 180-242 (242) | Show / Hide |
Range on Protein: 2964-3026 Range on HMM: 180-242/242 Sequence Identity: 53% (34 aa) PSAWLDARDAFARSCAIMSMVGSVLGLGDRHTENILLDSITGECVHIDYNCLFWKGETFTVPE | | ..||| |.||||| ..|||||| .|.|.| ||| |||||. | || ||| PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | ATR.AA | DNAPK | 2814-2911 | 37 | 3.1e-21 | 73.91 | In-house | 4-101 (301) | Show / Hide |
Range on Protein: 2814-2911 Range on HMM: 4-101/301 Sequence Identity: 37% (37 aa) IGSFEDQIDIMPSLQGPKKINVNDRQGNRYSFLLKPNDDLRKDQRVMEFNTMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWVSNTATLRSIL | |.. . .| || ||.| . |. | ||| |||. | . ||.| | |. ||| .|| | |||| || .|. || IAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL |
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| Kinase | ATR.AA | FATC | 3125-3157 | 60 | 1.5e-19 | 65.7 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 3125-3157 Range on HMM: 1-33/33 Sequence Identity: 60% (20 aa) LQLSIEGQVNHLIQEATNPKHLCNMYVGWCSWY . ||.|.||..||||||.|..|| ||.|||.|. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | ATR.AA | FRAP | 2843-2908 | 40 | 7.7e-19 | 65.94 | In-house | 2-67 (251) | Show / Hide |
Range on Protein: 2843-2908 Range on HMM: 2-67/251 Sequence Identity: 40% (27 aa) YSFLLKPNDDLRKDQRVMEFNTMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWVSNTATLR | |||| .|.| | ||| ..|.|.. .| .|.|| |. | .|| ..|.| || . ||. YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLH |
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| Kinase | ATR.AA | DNAPK | 2964-3087 | 28 | 1.6e-17 | 60.18 | In-house | 180-301 (301) | Show / Hide |
Range on Protein: 2964-3087 Range on HMM: 180-301/301 Sequence Identity: 28% (36 aa) PSAWLDARDAFARSCAIMSMVGSVLGLGDRHTENILLDSITGECVHIDYNCLFW-KGETFTVPERVPFRLTRNMVDVFGVLGVEGTFKTVCENTLRVLRS . ..| |. |.|. |. . .|| |||| .| . .|. . ||. | . ||| |||||| . ... | .. . .. .|. CETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRK NKEVLLRVLENFIYDPFLILFDKKN . .|. . || || .|| || DRNILTNFCDVFINDP---SFDWKN |
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| Kinase | ATR.AA | ATM | 2846-2900 | 41 | 3.1e-12 | 35.01 | In-house | 3-57 (304) | Show / Hide |
Range on Protein: 2846-2900 Range on HMM: 3-57/304 Sequence Identity: 41% (23 aa) LLKPNDDLRKDQRVMEFNTMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEW | | ||||.| . | | |... ||| | | || |.| ||..|| LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
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| Kinase | ATR.AA | SMG1 | 2821-2901 | 33 | 1.2e-09 | 27.99 | In-house | 1-81 (242) | Show / Hide |
Range on Protein: 2821-2901 Range on HMM: 1-81/242 Sequence Identity: 33% (27 aa) IDIMPSLQGPKKINVNDRQGNRYSFLLKPNDDLRKDQRVMEFNTMVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWV | |.| |||. | | .| | .|| | |.| | .|| . | | | | ||.| || ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV |
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