Gene DhkD (Slime mold)
DhkD
Sequence
Protein domains of DhkD.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PAS | DhkD.AA | PAS | 65-131 | 17 | 0.00037 | 21.06 | SMART | 1-68 (68) | Show / Hide |
Range on Protein: 65-131 Range on HMM: 1-68/68 Sequence Identity: 17% (12 aa) KNARIMLDEMYQFVALLDVNGNLLDVNEPALQGGGMIRSSIQGIPFWDCRWWATS--QENIDNVREAVH . | .|. | .. ..| .|. ...|. |.| | . ..| ..|| ... .. . ...... ERYRAILENMPDGIWVWDHDGRITYWNPAACQMFGYSPEELIGQSWWDLIHPEDRNLERFQE-HQRLQQ |
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| HisKA | DhkD.AA | HisKA | 211-277 | 44 | 8e-20 | 72.06 | Pfam | 1-69 (69) | Show / Hide |
Range on Protein: 211-277 Range on HMM: 1-69/69 Sequence Identity: 44% (31 aa) LKTQFFANVSHELRTPLALIVGPTDKLLKDENVDINV--RKDLEIVARNARGLLKIVNNLLDISRLEAG |.||.||.||||||||. | | .. |..... | |. ||.. | |. .....|.|||.||.||| AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG |
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| HisKA | DhkD.AA | HisKA | 211-277 | 34 | 1.7e-19 | 72.01 | SMART | 1-89 (89) | Show / Hide |
Range on Protein: 211-277 Range on HMM: 1-89/89 Sequence Identity: 34% (31 aa) LKTQFFANVSHELRTPLALIVGPTDKLLK--------------DENV--------DINVRKDLEIVARNARGLLKIVNNLLDISRLEAG |.||.||.||||||||. | | .. |.. .| . ....|. ||.. | |. .....|.|||.||.||| AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG |
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| HATPase_c | DhkD.AA | HATPase_c | 323-440 | 32 | 9.4e-43 | 149.27 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 323-440 Range on HMM: 1-130/130 Sequence Identity: 32% (48 aa) IDADKMQRVITNLISNAFKFTPS-------------GGAVKCILEKFDLSPNKPGFQIVVSDTGPGIPD------NLHEIIFERFRQVDG--------SS .|.| ...|..||..||.|.||. || .. .. .|.|.|.|||||. . . |||.| ..|. |. GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-----------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSR TRKHGG--TGLGLSIVKEFVTLHGGTVTIHNISTGGAQFTLRLPLTP .||.|| |||||||.|..| .||||... . ||..|||.. SRKYGGGLTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER |
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| HATPase_c | DhkD.AA | HATPase_c | 323-439 | 38 | 1.6e-40 | 143.23 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 323-439 Range on HMM: 1-120/120 Sequence Identity: 38% (49 aa) IDADKMQRVITNLISNAFKFTPSGGAVKCILEKFDLSPNKPGFQIVVSDTGPGIPD------NLHEIIFERFRQVDG-SSTRKHGG--TGLGLSIVKEFV |.| ...|..||..|| |.||.|| .. ... | . .|.|.|.|||||. . . |||.| ..|. |. ||.|| |||||.|....| GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-----DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIV TLHGGTVTIHNISTGGAQFTLRLPLT .||||..... ||. ||..|||. EQHGGTIWVESEPGGGTTFTFTLPLE |
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| Kinase | DhkD.AA | HisK | 331-415 | 26 | 8e-15 | 50.1 | In-house | 9-132 (164) | Show / Hide |
Range on Protein: 331-415 Range on HMM: 9-132/164 Sequence Identity: 26% (33 aa) VITNLISNAFKFTPSGG-----AVKCILEKFDLSPN----------------------KPGFQIVVSDTGPGIPDNLHEIIFERFRQVDG-------SST .. |||||| ||| || .| ..|... .| | .|| |.||| |.|... . ||. | ..|. . ILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQHQMIKKTFN RKHG-----GTGLGLSIVKEFVTL ... | ||||.| . .... HQNKKNNQHGCGLGLTICNNLAKG |
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| REC | DhkD.AA | REC | 570-682 | 28 | 3.3e-40 | 140.8 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 570-682 Range on HMM: 1-150/150 Sequence Identity: 28% (45 aa) PIVLVVEDN----PEMNRFIA------ELLSKYYF---------VVTAFDGV-------EGIEKTRAI-------------TPDLIVTDCMMP------- . .|.|.|. |.. . .. .||.| . |..| || |..|. .. ||||..|.||| MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG RMSGDEMVEQLRSDEQFDNIPILLLTAKADENLRIKLLQNGVSDYVNKPFSSEELVARV .|.| |.....| ||..|||..|| .|.. |. |. ||. |||. |||.||. GMDGIELCRRIR--------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI |
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| Response_reg | DhkD.AA | Response_reg | 572-683 | 37 | 1.8e-30 | 111.72 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 572-683 Range on HMM: 1-115/115 Sequence Identity: 37% (43 aa) VLVVEDNPEMNRFIAELLS-KYYF-VVT-AFDGVEGIEKTRAITPDLIVTDCMMPRMSGDEMVEQL-RSDEQFDNIPILLLTAKADENLRIKLLQNGVSD ||.|.|.| | . ....| |. . ||. | || |..|. .. .||||..|..||.|.| | ... | .. ....||...||..||..... || | | VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHHPDLIIMDINMPGMDGLELCRRIRRQHP-HPQTPIIMCTAHGDEDDAVEALQAGAND YVNKPFSSEELVARVV |. |||. .||.|.. YITKPFDPDELHAAIR |
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| HisKA | DhkD.AA | HisKA | 740-820 | 39 | 6.8e-15 | 54.88 | Pfam | 1-69 (69) | Show / Hide |
Range on Protein: 740-820 Range on HMM: 1-69/69 Sequence Identity: 39% (32 aa) SKDEFFMNLSHELRTPLNGILGWCQLLLYDIDSGGSSGGGSGSISGDDST-VRTGLETIERCASSQNQLINDLLDMSLIIGD .| .|. |.||||||||..|.| ..||. . |. . .| ||||.|.| . ..|||||||.| | AKRQFLANMSHELRTPLTAIRGYAELLQD-------------YTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG |
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| HisKA | DhkD.AA | HisKA | 740-820 | 31 | 4.4e-13 | 50.72 | SMART | 1-89 (89) | Show / Hide |
Range on Protein: 740-820 Range on HMM: 1-89/89 Sequence Identity: 31% (31 aa) SKDEFFMNLSHELRTPLNGILGWCQLLLY----------DIDSGGS-------SGGGSGSISGDDSTVRTGLETIERCASSQNQLINDLLDMSLIIGD .|..|. |.||||||||..|.| ..||. . . . . .| ||||.|.| . ..|||||||.| | AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRRE---------FNCEYREYLETIQREADRMQRLINDLLDLSRIEAG |
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| HATPase_c | DhkD.AA | HATPase_c | 873-1010 | 27 | 2.4e-35 | 124.64 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 873-1010 Range on HMM: 1-130/130 Sequence Identity: 27% (46 aa) GDKARLQQVIWNLLSNSIKFTKE-------------KGRIHLNLKVVNQIPSREVLGFCSNPMFNTINRHGDRWILFTITDNGKGIPK------QFLPSV || ||.||.||||.|.||.|.| |||.. .. .|..|||.|||. . .| . GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH------------------------------RITVEDNGPGIPPEMHKSIEDIPRI FDRFKQADC--------SSTRSYGG--LGIGLSITQNIIHLHKGAVYANSEGENKGSQFTVVLPIIK |..| ..| |..|.||| |.|||| ..|. .| | . .. . ||. ||. . FEPFYRTDDSPSRMCPDSRSRKYGGGLTGLGLSICKRIVEQHGGTIWVE-------TTFTFTLPLER |
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| HATPase_c | DhkD.AA | HATPase_c | 873-1009 | 31 | 1.3e-34 | 122.72 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 873-1009 Range on HMM: 1-120/120 Sequence Identity: 31% (46 aa) GDKARLQQVIWNLLSNSIKFTKEKGRIHLNLKVVNQIPSREVLGFCSNPMFNTINRHGDRWILFTITDNGKGIPK------QFLPSVFDRFKQADC-SST || ||.||.|||..|.||.|.| |.|.. .. . .. .|..|||.|||. . .| .|..| ..| |. GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD------------------------DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR- RSYGG--LGIGLSITQNIIHLHKGAVYANSEGENKGSQFTVVLPII |.||| |.||.| . |. .| | . ..|| ..|. ||. || RKYGGGLTGLGLYICRRIVEQHGGTIWVESEP-GGGTTFTFTLPLE |
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| Kinase | DhkD.AA | HisK | 873-982 | 18 | 1.2e-13 | 45.83 | In-house | 1-130 (164) | Show / Hide |
Range on Protein: 873-982 Range on HMM: 1-130/164 Sequence Identity: 18% (27 aa) GDKARLQQVIWNLLSNSIKFTKE-----KGRIHLNLK-------------VVNQIPSREVLGFCSNPMFNTINRHGDR-------WILFTITDNGKGIPK |. |..|.. ||.||..|||.. .| | .... ...|... . . | ... | | |.|. SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQEN-------------M-V---QEQLQQKNLIQISVQDTGCGMPE QFLPSVFDRFKQAD-----------CSSTRS-YGGLGIGLSITQNII . . |. | . | .. . | |.||.| .|.. EQQKKIFKMFGNIDDQHQMIKKTFNHQNKKNNQHGCGLGLTICNNLA |
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| REC | DhkD.AA | REC | 1358-1479 | 21 | 1.1e-21 | 79.27 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 1358-1479 Range on HMM: 1-150/150 Sequence Identity: 21% (35 aa) IQIMLVDDL----EETTHLFS------SMLYKLGAK-------RIDTFQRVS-------DAYAFLCDSSK----------PQPDIILSDLTMP------- . |..||| .. .. . .| |.| .|.. .| . | .. ..||.|. |. || MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG FEDGYSMVRKLRDREKINTQNKKTPIIALTASVSSSDKEKVLKSGFDLHCSKPVNFLELSNSI ||. ..|..| |||.||| . .|... |..| | .||.. || | GMDGIELCRRIR------------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI |
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| Response_reg | DhkD.AA | Response_reg | 1360-1480 | 25 | 4.1e-14 | 53.13 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 1360-1480 Range on HMM: 1-115/115 Sequence Identity: 25% (31 aa) IMLVDDLEETTHLFSSMLY-KLGAKRIDTFQRVSDAYAFLCDSSKPQPDIILSDLTMPFEDGYSMVRKL-RDREKINTQNKKTPIIALTASVSSSDKEKV ...||| . .. .| | | ...... .| . .. ||.|. |. || ||. |.. | .. . ||||..|| . .|.... VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH---PDLIIMDINMPGMDGLELCRRIRRQHP-HPQ----TPIIMCTAHGDEDDAVEA LKSGFDLHCSKPVNFLELSNSIL |. | . . .||... || . | LQAGANDYITKPFDPDELHAAIR |
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