DhkL

Species: Slime mold
Alias: DDB0191389, DhkL, DdisK274
External Links: DictyBase Link ,
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
DhkL.AA Protein None 1709 None Fasta, JSON
DhkL.kin_dom Protein Kinase Domain None 8 None Fasta, JSON

Protein domain

Protein domains of DhkL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DhkL.AA Dicty3 113-222 36 2.9e-07 19.83 In-house 197-258 (351) Show / Hide
Range on Protein: 113-222
Range on HMM: 197-258/351
Sequence Identity: 36% (40 aa)

NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNSSNDIYMNSPSSTLSSPGNAGNNLPIGCTKPNVPKSPYSPSPPHLYKSNSTSYLKSSFFSGNGS
|||.||||||||||||||||||||||||||||||||  ..|  |                                                  .|.  .
NNNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNNNVKIINNN------------------------------------------------IYSNKQY

SSSSSSTTTT
.... | . |
KQKCYSICGT

Response_reg DhkL.AA Response_reg 641-679 30 0.001034 15.86 Pfam 77-115 (115) Show / Hide
Range on Protein: 641-679
Range on HMM: 77-115/115
Sequence Identity: 30% (12 aa)

VIVLTESTDPSEFCQYIDAGATDYIPQPISPILLDLRLT
.|..|   |..   ....||| |||. |..|  |  .. 
IIMCTAHGDEDDAVEALQAGANDYITKPFDPDELHAAIR

PAS DhkL.AA PAS 702-810 24 2.7e-09 33.64 Pfam 1-120 (120) Show / Hide
Range on Protein: 702-810
Range on HMM: 1-120/120
Sequence Identity: 24% (30 aa)

RKMVTCIEN-SPDCVEIWDPSGHIQYLNLAFSEMTGFARWELLGKEFSNLIDNT------EIIPNMWATLTDKKTWNGFIRTRHN-----NNTLIYFEAS
. ... ||| .|| . .|| .| | |.| |. .|.|..| |..|| .. || ..      |    .|  . ..   ..| .|.       ... ...|  
EHYRRIIENNLPDPIFVWDEDGWILYWNRAAERMFGWSREEVMGKMLYDLIHHDDHRCCLEFHDQLWQCMQQGEE-RMFEITFRTPGQHRDGRPRWCEVR

ISPVLDQFQQILYYNCTKRDV
 .|..|  ..|... |. .|.
WCPYRDPGGEIHGFCCFMHDI

PAS_4 DhkL.AA PAS_4 708-815 19 8.5e-07 27.84 Pfam 1-123 (123) Show / Hide
Range on Protein: 708-815
Range on HMM: 1-123/123
Sequence Identity: 19% (24 aa)

IENSPDCVEIW-DPSGHIQYLNLA----FSE-MTGFARWELLGKEFS----NLI----DNTEIIPNMWATLTDKKTWNGFIRTRHNNNTLIYFEASI-SP
 ..||||. .. || |...|.| |    . | . |... |..|. .     ..     .  .. ... . |  ....   . . |.|    ..| .. .|
FDHSPDCIAVCKDPDGRYRYANPACSNWYREWWFGWPPEEWIGRTWWGEMWPPELEDPHQQRFHRQWRRVLEGEEPIFFHHHHHHPNGEERWWEWRYQHP

VLDQFQQILYYNCTKRDVTQKRI
..|   ... . .. ||.|. | 
LRDPDGEVIGVIWICRDITERRR

PAS DhkL.AA PAS 702-769 26 2.4e-05 25.01 SMART 1-68 (68) Show / Hide
Range on Protein: 702-769
Range on HMM: 1-68/68
Sequence Identity: 26% (18 aa)

RKMVTCIENSPDCVEIWDPSGHIQYLNLAFSEMTGFARWELLGKEFSNLIDNTEI-IPNMWATLTDKKT
... . .||.|| . .||. | | | | |. .|.|. . ||.|. ...||.  .  .. . . . .   
ERYRAILENMPDGIWVWDHDGRITYWNPAACQMFGYSPEELIGQSWWDLIHPEDRNLERFQE-HQRLQQ

PAC DhkL.AA PAC 771-813 25 0.000676 20.19 SMART 1-43 (43) Show / Hide
Range on Protein: 771-813
Range on HMM: 1-43/43
Sequence Identity: 25% (11 aa)

NGFIRTRHNNNTLIYFEASISPVLDQFQQILYYNCTKRDVTQK
.. .| .. . ..|. ..|..|. |.  |..|. |. ||.|..
TWEYRFYRKDGSWIWVQVSWTPIRDWQGQPQYWICVHRDITER

HisKA DhkL.AA HisKA 831-895 33 9.3e-22 79.53 SMART 1-89 (89) Show / Hide
Range on Protein: 831-895
Range on HMM: 1-89/89
Sequence Identity: 33% (30 aa)

SRLR-LSMMSHDIRTPMSNIIGMADLLLD----------TSLSQHQ-------------HHYLEIIKNSSNTLLTIINDILDISKIEAG
.. . |..|||..|||.. |.|.|.||.|          | |.  |             . |||.|..... .. .|||.||.|.||||
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG

HisKA DhkL.AA HisKA 831-895 43 1.2e-21 78.46 Pfam 1-69 (69) Show / Hide
Range on Protein: 831-895
Range on HMM: 1-69/69
Sequence Identity: 43% (30 aa)

SRLR-LSMMSHDIRTPMSNIIGMADLLLD-TSLSQHQ--HHYLEIIKNSSNTLLTIINDILDISKIEAG
.. . |..|||..|||.. |.|.|.||.| | |.  |  . |||.|..... .. .|||.||.|.||||
AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG

HATPase_c DhkL.AA HATPase_c 942-1058 33 2.6e-34 121.63 Pfam 1-120 (120) Show / Hide
Range on Protein: 942-1058
Range on HMM: 1-120/120
Sequence Identity: 33% (43 aa)

GPSSRLNQILTNLLGNSLKFTDK-GEISICCLLNDETDSEYEIKVDVRDTGIGIKK------EALPLLFKAFTQAEG-TITRQYGG--SGLGLAICKELV
|   || |...||..|..|.| . |.|.. .   |      .. . |.|.|.|| .      | .| .| .| ....    |.|||  .||||.||...|
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-----DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIV

HLAFNGEISVESQYGHGSTFTCILKFK
 . ..|.|.|||. |.|.|||. |...
EQ-HGGTIWVESEPGGGTTFTFTLPLE

HATPase_c DhkL.AA HATPase_c 942-1059 28 1.2e-30 109.11 SMART 1-130 (130) Show / Hide
Range on Protein: 942-1059
Range on HMM: 1-130/130
Sequence Identity: 28% (42 aa)

GPSSRLNQILTNLLGNSLKFTDK--------------GEISICCLLNDETDSEYEIKVDVRDTGIGIKK------EALPLLFKAFTQAEG--------TI
|   || |.|.|||.|..|.|..              |.|..               . |.|.|.|| .      | .| .| .| ....          
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-----------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSR

TRQYGG--SGLGLAICKELVHLAFNGEISVESQYGHGSTFTCILKFKK
.|.|||  .||||.|||..| . ..|.|.||      .|||  |. ..
SRKYGGGLTGLGLSICKRIVEQ-HGGTIWVE------TTFTFTLPLER

Kinase DhkL.AA HisK 944-1057 28 5.5e-30 104.77 In-house 3-164 (164) Show / Hide
Range on Protein: 944-1057
Range on HMM: 3-164/164
Sequence Identity: 28% (46 aa)

SSRLNQILTNLLGNSLKFTDKG------EISICCLLNDETDS----------------------EYEIKVDVRDTGIGIKKEALPLLFKAFTQAEG----
 .|. ||| ||..|.||||.||       |.|   . .....                      .. |...| |||.|...| .  .||.| .  .    
PNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQHQM

---TITRQYG-----GSGLGLAICKELV-HLA------FNGEISVESQYGHGSTFT-CILKF
   |   | .     | ||||.||. |.  |        |..|.|.|..|.||||. .|...
IKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN

REC DhkL.AA REC 1311-1488 13 5.5e-05 14.25 SMART 1-150 (150) Show / Hide
Range on Protein: 1311-1488
Range on HMM: 1-150/150
Sequence Identity: 13% (29 aa)

AKMLFIERN----DTSRGNLF------KQLLAWNIQ--------LELVEDGE-------SGFRKWKQSIESN--------SPYSIIIMDLNTP-------
 . | .. .     . |  |       . |  ....         . . |||        .......   ..        .|. .||||.. |       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

GVDGASLPMRIKKELELMQQHLQQQQEQEQQQQQEQQQSELQKQPDVENKNSSQNNDNNNNNNKSNSSGGNQCIYRSPIIMLMPIQFLNSQLEDNLKDAG
|.||  |  ||.                                                                 |||||    . . ..     .||
GMDGIELCRRIR-----------------------------------------------------------------PIIMLT--AHDDEEDRVRALEAG

VCAILSKPIRMSQLADVF
. . ..||... .| .. 
ADDYITKPFDPEELLARI

Response_reg DhkL.AA Response_reg 1326-1374 28 0.352173 6.79 Pfam 13-59 (115) Show / Hide
Range on Protein: 1326-1374
Range on HMM: 13-59/115
Sequence Identity: 28% (15 aa)

LFKQLLA--WNI-QLELVEDGESGFRKWKQSIESNSPYSIIIMDLNTPGVDG
...|.|   . .   ....|||.. ..|..       . .||||.| ||.||
GLRQILEQKEGYEVVAEADDGEEALEWWQEHH-----PDLIIMDINMPGMDG

REC DhkL.AA REC 1569-1688 24 1.9e-36 128.3 SMART 1-150 (150) Show / Hide
Range on Protein: 1569-1688
Range on HMM: 1-150/150
Sequence Identity: 24% (40 aa)

GKVLVVDDN----HINIQILS------KMLQTVGCE--------VDSVLSGA-------DALAKINQSSGDS----------YDAIFLDIQMP-------
 ..|.|||.    ... ..|.      ..|.  |.|        ||.. .|.       .||..... ...           .| |..||.||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

DMDGFQVSRKIREREKKFSLPRVAIIATTANVFKEDQLKCFDAGMDDFISKPIKRAEIKEII
.|||... |.||            ||. ||.   ||  ....||.||.|.||... |. . |
GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI

Response_reg DhkL.AA Response_reg 1571-1689 30 1.4e-31 115.7 Pfam 1-115 (115) Show / Hide
Range on Protein: 1571-1689
Range on HMM: 1-115/115
Sequence Identity: 30% (37 aa)

VLVVDDNHINIQILSKMLQ-TVGC-EVDSVLSGADALAKINQSSGDSYDAIFLDIQMPDMDGFQVSRKI-RERE-KKFSLPRVAIIATTANVFKEDQLKC
||.|||.... ..| ..|.   |. .|... .|..||... .     .| |..||.||.|||... |.| |...  .     . ||. ||.  ..| ...
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH---PDLIIMDINMPGMDGLELCRRIRRQHPHPQ-----TPIIMCTAHGDEDDAVEA

FDAGMDDFISKPIKRAEIKEIIK
..||..|.|.||....|....|.
LQAGANDYITKPFDPDELHAAIR