Gene MHCK-A (Slime mold)
MHCK-A
Sequence
Protein domains of MHCK-A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Alpha_kinase | MHCK-A.AA | Alpha_kinase | 569-800 | 34 | 3.8e-106 | 359.86 | SMART | 1-255 (255) | Show / Hide |
Range on Protein: 569-800
Range on HMM: 1-255/255
Sequence Identity: 34% (99 aa)
INKWIRLSMKLKV-ERKPFAEGALREAYHTVSLGVGTDENYPLGTTTKLFPPIEMISPISKNNEAMTQLKNGTKFVLKLYKKEAEQQASRELYFE-----
.|||. .. .|. |.||||.||.|..|.. . . .... ..|...|.|..|||.... ..| ||.
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCF-----------------------------CHGWECVAKYFKKEYKRTWDEERYFHETLHL
---DVKMQMVCRDWGNKFNQ---KKP-PKKIEFLMSWVVELI-------DRSPSSNGQPIL-----------CSIEPLLVGEFKKNNSNYGAVLTN-RST
||.|||.|. |.|.||| ..| ||||.|....|.... ||... . .... ...||.. |||.| |.|.| | . |.|
CLRDVEMQMMCKHWANEFNQEAQHNPCPKKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWT
------------PQAFSHFTYELSNKQMIVVDIQGV----DD--LYTDPQIHTPD--GKGFGLGNLGKAGINKFITTHKCNAVC
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TTSQRRTEMFEYCQAFSHWTYEWSNHQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
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| Kinase | MHCK-A.AA | Alpha_kinase | 586-800 | 34 | 2.8e-82 | 284.44 | Pfam | 1-225 (225) | Show / Hide |
Range on Protein: 586-800 Range on HMM: 1-225/225 Sequence Identity: 34% (89 aa) FAEGALREAYHTVSLGVGTDENYPLGTTTKLFPPIEMISPISKNNEAMTQLKNGTKFVLKLYKK----EAE--QQASRELYFEDVKMQMVCRDWGNKFNQ ||.||.|...... .. .....|....|.|.||| . .......||.|.||||.|. | .|||| FAQGAMRWCFRMFDTW-------------------------------DPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQ K-----KPPKKIEFLMSW-VVELIDRSP-----------SSNGQPILCSIEPLLVG-EFKKNNSNYGAV--LTNRSTP-----QAFSHFTYELSNKQMIV | .||..|||. .. |.||.|... . .......|| . | ||.| |.||| | ...|..| ||||||||. ||.||.| KLQEHNNPPPPIEFYDCCIVYELEDHNKPDCYQGFFSYRT-DWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMV VDIQGVD--D---LYTDPQIHTPDGKG---F--GLGNLGKAGINKFIT-THKCNAVC .|||||. . ..|||||||.||.. | |.||||. ||.||. .|||| .| CDIQGVGYNNKCYYLTDPQIHTKDGNYEMDFDEGMGNLGQEGIEKFFQNQHKCNHIC |
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| Kinase | MHCK-A.AA | Alpha | 641-800 | 32 | 8.8e-50 | 139.75 | In-house | 31-215 (215) | Show / Hide |
Range on Protein: 641-800 Range on HMM: 31-215/215 Sequence Identity: 32% (61 aa) KFVLKLYKKEAEQQ-ASRELYFEDVKMQMVCRDWGNKFNQKKPPKKI-------------EFLMSWVVELIDRSPSSNGQPI--LCSIEPLLVGEFKKNN | |.|..|| .. . . . .||. |||| . . |||. .. .| . .|||.. . .. . |.|. . ||. | | KMVKKQHKKQWKSFKYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYELIHC-----HNHNIKYYSVENYMEGEYQKYN SNYGAVL------TNRSTPQAFSHFTYELSNKQMIVVDIQ-GVD-DLYTDPQIHT----PDGKGFGLGNLGKAGINKFITTH--KCNAVC .| | | . . ..|||||.|.. || | .|||.| ||. ...||||||. |. || ||.|..|. .|. || .||. | NNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGMFRFFYTHHVQCNHYC |
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| Kinase | MHCK-A.AA | VWL | 738-805 | 48 | 6.6e-33 | 95.48 | In-house | 137-206 (206) | Show / Hide |
Range on Protein: 738-805 Range on HMM: 137-206/206 Sequence Identity: 48% (34 aa) QAFSHFTYELSNKQMIVVDIQGVD-DLYTDPQIHTPDG-KGFGLGNLGKAGINKFITTHKCNAVCALLDL |||||||. .| . .||.||.. . ||||||. | . || |||| |. .| ||.||. |. | | QAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKYCQKLQL |
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| Kinase | MHCK-A.AA | Alpha-Unclassified | 709-800 | 31 | 9.7e-28 | 87.41 | In-house | 107-215 (215) | Show / Hide |
Range on Protein: 709-800 Range on HMM: 107-215/215 Sequence Identity: 31% (35 aa) LCSIEPLLVGEFKKNNSNYG-----AVLTNRSTP--QAFSHFTYELSNKQMIVVDIQG-VD------DLYTDPQIHTPDGKGFG--LGNLGKAGINKFIT . |.|| |.||| | ..| | ... ....|.||. .| . ||.| || || ||||||| . .... .| |...| ... CISVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIR-QRYQGFKTNCGMRFIDYWFN TH--KCNAVC | .||. | NHHVQCNHYC |
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| Kinase | MHCK-A.AA | ChaK | 711-800 | 38 | 2e-14 | 53.36 | In-house | 121-219 (219) | Show / Hide |
Range on Protein: 711-800 Range on HMM: 121-219/219 Sequence Identity: 38% (38 aa) SIEPLLVGEFKKNNSNYGAVLTNRSTPQ----AFSHFTYELSNKQMIVVDIQGVDDLYTDPQIHTPDGKG-----FGLGNLGKAGINKFITTHKCNAVC .|| . |||.| | | | .. | ||||.||| ..|.|.||| . ||| . |. | || ||| | |. | ||. | TIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC |
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| Kinase | MHCK-A.AA | VWL | 575-596 | 50 | 3e-06 | 14.9 | In-house | 1-22 (206) | Show / Hide |
Range on Protein: 575-596 Range on HMM: 1-22/206 Sequence Identity: 50% (11 aa) LSMKLKVERKPFAEGALREAYH . |... . |||||| | ||| IKTKVRISNIPFAEGAMRYAYH |
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| Kinase | MHCK-A.AA | Alpha | 575-600 | 34 | 2e-05 | 11.23 | In-house | 1-26 (215) | Show / Hide |
Range on Protein: 575-600 Range on HMM: 1-26/215 Sequence Identity: 34% (9 aa) LSMKLKVERKPFAEGALREAYHTVSL . |... ..||.|||.| |.| ... QCTKIQMSSYPFMEGAMRYAMHAWDC |
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| Kinase | MHCK-A.AA | VWL | 641-680 | 35 | 0.004925 | 4.99 | In-house | 31-72 (206) | Show / Hide |
Range on Protein: 641-680 Range on HMM: 31-72/206 Sequence Identity: 35% (15 aa) KFVLKLYKKEAEQQ--ASRELYFEDVKMQMVCRDWGNKFNQK | | |.||| |. ..| |. |.||. |.|| . KMVAKQYKKQHKQNPKINKEDMIKDIESQFVCQHIVNCFNDR |
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| WD40 | MHCK-A.AA | WD40 | 858-897 | 25 | 3.5e-07 | 31.12 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 858-897 Range on HMM: 1-46/46 Sequence Identity: 25% (12 aa) DLKCVSTIQSFRE--RVNSIAFFDNQ------KLLCAGYGDGTYRVFD . |||.|.. . .|..... .. ..|..| ||| |..| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 859-897 | 30 | 7e-06 | 19.49 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 859-897 Range on HMM: 1-39/39 Sequence Identity: 30% (12 aa) LKCVSTIQSFRERVNSIAFFDN-QKLLCAGYGDGTYRVFD ||..|. |...|. .. ...|. | ||| |..| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 902-936 | 31 | 1.4e-09 | 30.16 | Pfam | 1-37 (39) | Show / Hide |
Range on Protein: 902-936 Range on HMM: 1-37/39 Sequence Identity: 31% (12 aa) WKCLYTVNGHRKSIESIACNSN---YIFTSSPDNTIKV |||..| || ......|.. . |....| |.||.. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRI |
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| WD40 | MHCK-A.AA | WD40 | 901-938 | 20 | 4e-06 | 27.78 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 901-938 Range on HMM: 1-46/46 Sequence Identity: 20% (10 aa) NWKCLYTVNGHRK--SIESIACNSN--------YIFTSSPDNTIKVHI . ||..| .||.. .. ... ... |....| |.||.. T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 944-980 | 42 | 1.6e-14 | 44.39 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 944-980 Range on HMM: 1-39/39 Sequence Identity: 42% (17 aa) TKCIETLVGHTGEVNCVVANEK---YLFSCSYDKTIKVWD ||. |. |||. |.|. . ||.|.| |.||..|| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 943-980 | 39 | 2.7e-11 | 44.79 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 943-980 Range on HMM: 1-46/46 Sequence Identity: 39% (19 aa) NTKCIETLVGHTG--EVNCVVANEK--------YLFSCSYDKTIKVWD . ||. |. |||| .|.|| . ||.|.| |.||..|| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 983-1021 | 26 | 2e-06 | 28.88 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 983-1021 Range on HMM: 1-46/46 Sequence Identity: 26% (13 aa) TFKEIKSFEGVHTK--YIKTLALSGR--------YLFSGGNDQIIYVWD | | ...|. ||. .. ... . ||.||. | |..|| T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 985-1021 | 30 | 3e-06 | 20.63 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 985-1021 Range on HMM: 1-39/39 Sequence Identity: 30% (12 aa) KEIKSFEGVHTKYIKTLALSGR---YLFSGGNDQIIYVWD .. |. ||. . .| . ||.||. | | .|| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 1025-1061 | 32 | 9.2e-09 | 27.83 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 1025-1061 Range on HMM: 1-39/39 Sequence Identity: 32% (13 aa) LSMLFNMQGHEDWVLSLHCTAS---YLFSTSKDNVIKIWD . ||..|| .. . . ||.| | |. |.||| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 1024-1061 | 29 | 1.7e-07 | 32.15 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1024-1061 Range on HMM: 1-46/46 Sequence Identity: 29% (14 aa) TLSMLFNMQGHED--WVLSLHCTAS--------YLFSTSKDNVIKIWD | . .. ..||.. ||... . ||.| | |. |.||| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 1065-1101 | 37 | 8.2e-11 | 33.74 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 1065-1101 Range on HMM: 1-39/39 Sequence Identity: 37% (15 aa) FSCIDTLKGHWNSVSSCVVKDR---YLYSGSEDNSIKVWD |. |. || ..|..| . . || |||.|..|..|| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 1064-1101 | 33 | 2e-06 | 28.38 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1064-1101 Range on HMM: 1-46/46 Sequence Identity: 33% (16 aa) NFSCIDTLKGHWN--SVSSC-VVKD-------RYLYSGSEDNSIKVWD . .|. |.||| . .|... . | .||.||| |..|..|| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 1104-1142 | 24 | 2e-06 | 28.31 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1104-1142 Range on HMM: 1-46/46 Sequence Identity: 24% (12 aa) TLECVYTIPKSHSL--GVKCLMVFNN--------QIISAAFDGSIKVWE | .||.|.. |. .| |. . . ...|. ||.|..|. T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-A.AA | WD40 | 1105-1142 | 24 | 3e-06 | 20.78 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 1105-1142 Range on HMM: 1-39/39 Sequence Identity: 24% (10 aa) LECVYTIPKSHSLGVKCLMVFNN---QIISAAFDGSIKVWE .|..|. |. .| |. . . ..|. ||.|..|. WKCKHTF--GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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