Gene MHCK-B (Slime mold)

MHCK-B

Species: Slime mold
Alias: DDB0191333, DdisK258, mhkB, MHCK-B
External Links: DictyBase Link ,
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: MHCK

Sequence

Name Sequence Type Origin Length Description Download
MHCK-B.AA Protein None 732 None Fasta, JSON
MHCK-B.kin_dom Protein Kinase Domain None 8 None Fasta, JSON

Protein domain

Protein domains of MHCK-B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Alpha_kinase MHCK-B.AA Alpha_kinase 129-320 40 2.6e-109 370.39 SMART 1-255 (255) Show / Hide 
Range on Protein: 129-320
Range on HMM: 1-255/255
Sequence Identity: 40% (103 aa)

TAQWTCTATLVKV-EPVPFAEGAFRKAYHTLDLSKS----GASGRYVSKIGKKPTPRPS----YFE--------DVKMQMIAKKWADKYNS---FKP-PK
. .|||. | ||. || |||.||.|..|.. |.|..    .   ..|.|  ||...|.     ||.        ||.|||..|.|| ..|.   ..| ||
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQHNPCPK

KIEFLQSCVLEFV-------DRTSSDLI---------------CGAEPYVEGQYRKYNNNSGFVSNDERNT------------PQSFSHFTYEHSNHQLL
||.|....|..|        ||... ..               .. ||. ||...|||||.|.|....|.|            .|.|||.|||.||||.|
KIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQML

IIDIQGV----GD--HYTDPQIHTYD--GVGFGIGNLGQKGFEKFLDTHKCNAIC
. |||||    ||  .||||||||.|  | ||| |||||.|.|||..||.||.||
VCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase MHCK-B.AA Alpha_kinase 146-320 39 1.3e-85 295.54 Pfam 1-225 (225) Show / Hide 
Range on Protein: 146-320
Range on HMM: 1-225/225
Sequence Identity: 39% (88 aa)

FAEGAFRKAYHTLDL--SKSGASGRYVSKIGKK----PTP------RPSYFEDVKMQMIAKKWADKYNSF-----KPPKKIEFLQSC-VLEFVDRTS---
||.||.|..... |.  .  .   ..| |. ||      .      .  ||.|.|||||...|..|.|.      .||..|||...| |.|. |...   
FAQGAMRWCFRMFDTWDPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHNKPDC

-----------SDLICGAEPYVEG-QYRKYNNNSGFV-SNDERNTP-----QSFSHFTYEHSNHQLLIIDIQGVG--D---HYTDPQIHTYDGVG---F-
            .  . .||| || ...|||||.|.| .|..||.|     |.||||||. ||.|... ||||||  .    .||||||| || .   | 
YQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYEMDFD

-GIGNLGQKGFEKFLD-THKCNAIC
 | |||||.|.|||.  .|||| ||
EGMGNLGQEGIEKFFQNQHKCNHIC
Kinase MHCK-B.AA Alpha 183-320 33 3.7e-55 155.32 In-house 60-215 (215) Show / Hide 
Range on Protein: 183-320
Range on HMM: 60-215/215
Sequence Identity: 33% (53 aa)

YFEDVKMQMIAKKWADKY----NSFKPPKKIEFLQSCVLEFVDRTSSDLICG-AEPYVEGQYRKYNNNSGFVS-----NDERNTPQSFSHFTYEHSNHQL
.....  .. .. |. .|    |  ||   ..|  .   |. .. ...  .  .|.| || |.|||||.|.|.     |... ..| |||.|.. ||.||
VCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYELIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQL

LIIDIQ-GVG-DHYTDPQIHT----YDGVGFGIGNLGQKGFEKFLDTH--KCNAIC
.. |.| ||| . .||||||.      |  || ||.| .|. .|  ||  .||..|
MVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGMFRFFYTHHVQCNHYC
Kinase MHCK-B.AA VWL 231-325 44 2.2e-39 115.09 In-house 107-206 (206) Show / Hide 
Range on Protein: 231-325
Range on HMM: 107-206/206
Sequence Identity: 44% (45 aa)

AEPYVEGQYRKYNNNSGFVSNDERNTP----QSFSHFTYEHSNHQLLIIDIQGVG-DHYTDPQIHTYDG-VGFGIGNLGQKGFEKFLDTHKCNAICQYLN
.| |.|| | |||||.|...  .   .    | |||||.  |  ...|.|.||..    ||||||. |    || ||||  |. .|  ||.||..|| |.
VENYIEGDYQKYNNNAGWCNQTDM-EYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKYCQKLQ

L
|
L
Kinase MHCK-B.AA Alpha-Unclassified 232-320 31 2.3e-30 96.1 In-house 111-215 (215) Show / Hide 
Range on Protein: 232-320
Range on HMM: 111-215/215
Sequence Identity: 31% (33 aa)

EPYVEGQYRKYNNNSG----FVSNDERNTP--QSFSHFTYEHSNHQLLIIDIQG-VG------DHYTDPQIHTYDGVGFG--IGNLGQKGFEKFLDTH--
|||..| ..||.||.|    ||  .   ..  . ..|.||. .||.... | || |.         ||||||| .  ...   .| | ..  ..   |  
EPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIR-QRYQGFKTNCGMRFIDYWFNNHHV

KCNAIC
.||..|
QCNHYC
Kinase MHCK-B.AA ChaK 232-320 37 1.6e-14 53.74 In-house 123-219 (219) Show / Hide 
Range on Protein: 232-320
Range on HMM: 123-219/219
Sequence Identity: 37% (36 aa)

EPYVEGQYRKYNNNSG---FVSNDERNTPQSFSHFTYEHSNHQLLIIDIQGVGDHYTDPQI-----HTYDGVGFGIGNLGQKGFEKFLDTHKCNAIC
| .. | .|||||| |      |        |||.|||     ||..|.||||.  ||| .         .. ||  |||      |   | ||. |
EKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC
Kinase MHCK-B.AA VWL 136-160 52 3e-06 14.65 In-house 2-26 (206) Show / Hide 
Range on Protein: 136-160
Range on HMM: 2-26/206
Sequence Identity: 52% (13 aa)

ATLVKVEPVPFAEGAFRKAYHTLDL
 | |..  .|||||| | |||  |.
KTKVRISNIPFAEGAMRYAYHAKDT
Kinase MHCK-B.AA Alpha 135-156 40 2.4e-05 11.02 In-house 1-22 (215) Show / Hide 
Range on Protein: 135-156
Range on HMM: 1-22/215
Sequence Identity: 40% (9 aa)

TATLVKVEPVPFAEGAFRKAYH
 .|....   ||.||| |.|.|
QCTKIQMSSYPFMEGAMRYAMH
WD40 MHCK-B.AA WD40 451-486 25 0.000109 16.11 Pfam 20-58 (39) Show / Hide 
Range on Protein: 451-486
Range on HMM: 20-58/39
Sequence Identity: 25% (10 aa)

IKLIETIKGY-HVTSHLCICDN---LLFTGCSDNSIRVYD
 |.. |. |  |  . ......   .|..|. |..||..|
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-B.AA WD40 450-486 22 0.001646 17.93 SMART 1-46 (46) Show / Hide 
Range on Protein: 450-486
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

TIKLIETIK-GYH--VTSHLCICDN--------LLFTGCSDNSIRVYD
| |.. |.|   .    ...|....        .|..|. |..||..|
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-B.AA WD40 492-528 35 1.2e-16 50.5 Pfam 1-39 (39) Show / Hide 
Range on Protein: 492-528
Range on HMM: 1-39/39
Sequence Identity: 35% (14 aa)

MECVQTLKGHEGPVESICYNDQ---YLFSGSSDHSIKVWD
 .|..|. ||...|.......    ||.||| |..|..||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-B.AA WD40 491-528 37 1.5e-12 48.96 SMART 1-46 (46) Show / Hide 
Range on Protein: 491-528
Range on HMM: 1-46/46
Sequence Identity: 37% (18 aa)

NMECVQTLKGHEG--PVESICYNDQ--------YLFSGSSDHSIKVWD
. .||.|.|||.|  .| ..|...         ||.||| |..|..||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-B.AA WD40 532-568 37 1.5e-12 38.7 Pfam 1-39 (39) Show / Hide 
Range on Protein: 532-568
Range on HMM: 1-39/39
Sequence Identity: 37% (15 aa)

LRCIFTLEGHDKPVHTVLLNDK---YLFSGSSDKTIKVWD
  |. |. || ..|  .  ..    ||.||| |.||..||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-B.AA WD40 531-568 33 1.3e-10 42.53 SMART 1-46 (46) Show / Hide 
Range on Protein: 531-568
Range on HMM: 1-46/46
Sequence Identity: 33% (16 aa)

KLRCIFTLEGHDK--PVHTVLLNDK--------YLFSGSSDKTIKVWD
. .|..|..||..  .|..|  ..         ||.||| |.||..||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-B.AA WD40 572-608 37 5.2e-13 40.06 Pfam 1-39 (39) Show / Hide 
Range on Protein: 572-608
Range on HMM: 1-39/39
Sequence Identity: 37% (15 aa)

LECKYTLESHARAVKTLCISGQ---YLFSGSNDKTIKVWD
 .||.|.  |  .|  ....     ||.||| |.||..||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-B.AA WD40 571-608 33 4.4e-10 40.73 SMART 1-46 (46) Show / Hide 
Range on Protein: 571-608
Range on HMM: 1-46/46
Sequence Identity: 33% (16 aa)

TLECKYTLESHAR--AVKTLCISGQ--------YLFSGSNDKTIKVWD
| .| .|.. |    .| ..|..          ||.||| |.||..||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-B.AA WD40 612-648 42 7.3e-13 39.64 Pfam 1-39 (39) Show / Hide 
Range on Protein: 612-648
Range on HMM: 1-39/39
Sequence Identity: 42% (17 aa)

FRCNYTLKGHTKWVTTICILGT---NLYSGSYDKTIRVWN
  | .|. |||.||| ...       | ||| |.|||.|.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-B.AA WD40 611-648 41 3.1e-10 41.27 SMART 1-46 (46) Show / Hide 
Range on Protein: 611-648
Range on HMM: 1-46/46
Sequence Identity: 41% (20 aa)

TFRCNYTLKGHTK--WVTTICILGT--------NLYSGSYDKTIRVWN
| .| .|.||||.  |||..|.  .         |.||| |.|||.|.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-B.AA WD40 652-688 35 6.1e-13 39.85 Pfam 1-39 (39) Show / Hide 
Range on Protein: 652-688
Range on HMM: 1-39/39
Sequence Identity: 35% (14 aa)

LECSATLRGHDRWVEHMVICDK---LLFTASDDNTIKIWD
 .| .|. ||  ||. . ...    .|...|.|.||.|||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-B.AA WD40 651-688 29 1.5e-09 38.99 SMART 1-46 (46) Show / Hide 
Range on Protein: 651-688
Range on HMM: 1-46/46
Sequence Identity: 29% (14 aa)

SLECSATLRGHDR--WVEHMVICDK--------LLFTASDDNTIKIWD
. .| .|..||.   || .. ...         .|...| |.||.|||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-B.AA WD40 692-730 35 2.8e-10 32.19 Pfam 1-39 (39) Show / Hide 
Range on Protein: 692-730
Range on HMM: 1-39/39
Sequence Identity: 35% (14 aa)

LRCNTTLEGHNATVQCLAVWED-KKCVISCSHDQSIRVWG
  | .|. ||...| |.|.  |  ....|.|.| .||.| 
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-B.AA WD40 691-730 29 2.4e-09 38.3 SMART 1-46 (46) Show / Hide 
Range on Protein: 691-730
Range on HMM: 1-46/46
Sequence Identity: 29% (14 aa)

TLRCNTTLEGHNA--TVQCLAVWEDK------KCVISCSHDQSIRVWG
| .|  |..||..   | |...  |       ....|.| | .||.| 
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD