Gene MHCK-D (Slime mold)
MHCK-D
Sequence
Protein domains of MHCK-D.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Alpha_kinase | MHCK-D.AA | Alpha_kinase | 342-574 | 33 | 5.3e-101 | 342.76 | SMART | 1-255 (255) | Show / Hide |
Range on Protein: 342-574
Range on HMM: 1-255/255
Sequence Identity: 33% (95 aa)
DDEWTKALIIVEI-DAKPFAKGALRNAYQLKIRSNAMQCFNHFATPIHEKYMEGKKLNLSQIPKLNQNLSLDTLYVAKDSKTSVNFNRYFE--------D
|..||.. ..|.| . |||||||.|..|... |. |.|| ... .. |..|..|......|||. |
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCF-------------------------CHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRD
VKMQMVCKSYGERYNS---NHP-PKKIEFLSAWVIEIQGTTNYRVGNRNSSNN---TL-----------YGLELFMKGEFKKQNSNFGTVFTE-RNT---
|.|||.|| .....|. .| ||||.|. ..|... .. .... .||.. . .. ...| ||.|||.| |.|.| | .. |.|
VEMQMMCKHWANEFNQEAQHNPCPKKIDFIPCYVFHFPRR-IPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTS
---------PQSFSHFTYECTTHEMVVVDIQGV----DD--IYTDPQVHTKD--GKGYGEGNLGQKGIEKFLISHKCSPIC
.|.|||.|||.. |.|.|.||||| .| .|||||.||.| |.|.|.|||||.|||||...|.| .||
QRRTEMFEYCQAFSHWTYEWSNHQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
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| Kinase | MHCK-D.AA | Alpha_kinase | 359-574 | 30 | 6.6e-74 | 256.64 | Pfam | 1-225 (225) | Show / Hide |
Range on Protein: 359-574
Range on HMM: 1-225/225
Sequence Identity: 30% (78 aa)
FAKGALRNAYQLKIRSNAMQCFNHFATPIHEKYMEGKKLNLSQIPKLNQNLSLDTLYVAKDSKT----SVN------FNRYFEDVKMQMVCKSYGERYNS
||.||.|... .. . ..|..... .|||. |. ... . ||.|.||||.|... |..|.
FAQGAMRWCFRMFDTW-------------------------------DPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQ
N-----HPPKKIEFLSAW-VIEIQGTTNYRVG------NRNSSNNTLYGLELFMKG-EFKKQNSNFGTV--FTERNTP-----QSFSHFTYECTTHEMVV
.||..|||. .. |.|.. ...... .. ... ... .| ...| ||.| |.|.| | ..||.| |.||||||. . ..|.|
KLQEHNNPPPPIEFYDCCIVYELEDHNKPDCYQGFFSYRT-DWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMV
VDIQGVD--D---IYTDPQVHTKDGKG---Y--GEGNLGQKGIEKFLI-SHKCSPIC
.|||||. . ..||||.|||||.. . | |||||.|||||.. .|||..||
CDIQGVGYNNKCYYLTDPQIHTKDGNYEMDFDEGMGNLGQEGIEKFFQNQHKCNHIC
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| Kinase | MHCK-D.AA | Alpha | 405-574 | 24 | 1.3e-44 | 124.75 | In-house | 28-215 (215) | Show / Hide |
Range on Protein: 405-574 Range on HMM: 28-215/215 Sequence Identity: 24% (47 aa) LNQNLSLDTLYVAKDSKTSVNFNRYFEDVKMQMVCKSYGERYNSNHPPKKIEFLS-----AWVIEIQGTTNYRVGNRNSSNNTLYGLELFMKGEFKKQNS |.|.... ... .. .. . ... .||. ||||. . |. .. . ... . | . .. ..| .| .| .|.||. | |. LHQKMVK-KQHKKQWKSFKYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYELIHCHNHNIKYYSVENYMEGEYQKYNN NFGTVF------TERNTPQSFSHFTYECTTHEMVVVDIQ-GVD-DIYTDPQVHT----KDGKGYGEGNLGQKGIEKFLISH--KCSPIC | | | ... ..| |||.|.. . .. .|||.| ||. ...||||.|. . |. .| ||.| .|. .| .| .| .| NAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGMFRFFYTHHVQCNHYC |
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| Kinase | MHCK-D.AA | VWL | 484-579 | 33 | 8.6e-30 | 86.05 | In-house | 105-206 (206) | Show / Hide |
Range on Protein: 484-579 Range on HMM: 105-206/206 Sequence Identity: 33% (34 aa) YGLELFMKGEFKKQNSNFGTVFTERNTP----QSFSHFTYECTTHEMVVVDIQGVD-DIYTDPQVHTKDG-KGYGEGNLGQKGIEKFLISHKCSPICLQF | | ...|.. | | | | . . . | |||||. . .||.||.. . ||||.|..| . .|.|||| |. .| .|.| .| .. YFVENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKYCQKL GL | QL |
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| Kinase | MHCK-D.AA | Alpha-Unclassified | 486-574 | 28 | 2.9e-22 | 69.27 | In-house | 110-215 (215) | Show / Hide |
Range on Protein: 486-574 Range on HMM: 110-215/215 Sequence Identity: 28% (31 aa) LELFMKGEFKKQNSNFG-------TVFTERNTPQSFSHFTYECTTHEMVVVDIQG-VD-----DIY-TDPQVHTKDGKGYG--EGNLGQKGIEKFLISH- .| . ||| | ..| | . . ..|.||. | | .|.| || || .. ||||.||.. ..|. .| | ..| .. .| VEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIR-QRYQGFKTNCGMRFIDYWFNNHH -KCSPIC .| .| VQCNHYC |
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| Kinase | MHCK-D.AA | ChaK | 479-574 | 38 | 7.2e-14 | 51.18 | In-house | 115-219 (219) | Show / Hide |
Range on Protein: 479-574 Range on HMM: 115-219/219 Sequence Identity: 38% (40 aa) SNNTLYGLELFMKGEFKKQNSNFGTVFTERNTPQ----SFSHFTYECTTHEMVVVDIQGVDDIYTDPQVHTKDGKG-----YGEGNLGQKGIEKFLISHK | | . .| .| |||.| | | | . || |||.||| | |..|.|.||| . ||| | . | .| ||| | | | SANQWFTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHH CSPIC | | CNSCC |
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| Kinase | MHCK-D.AA | Alpha | 348-371 | 25 | 0.001422 | 5.87 | In-house | 1-24 (215) | Show / Hide |
Range on Protein: 348-371 Range on HMM: 1-24/215 Sequence Identity: 25% (6 aa) ALIIVEIDAKPFAKGALRNAYQLK .... .||..||.| |.. . QCTKIQMSSYPFMEGAMRYAMHAW |
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| WD40 | MHCK-D.AA | WD40 | 627-665 | 27 | 2.4e-10 | 32.41 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 627-665 Range on HMM: 1-39/39 Sequence Identity: 27% (11 aa) LTSIVHLSGHDERVCSLLINQD-KTKLYSASADGYVKIWN . . . || |... ...| . | |.|.|| ..||. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 626-665 | 22 | 2.5e-08 | 34.93 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 626-665 Range on HMM: 1-46/46 Sequence Identity: 22% (11 aa) ELTSIVHLSGHDE--RVCSLLINQDK------TKLYSASADGYVKIWN . . . ..||. .|... ...| . |.|.| || ..||. T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 675-711 | 27 | 5.1e-08 | 25.7 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 675-711 Range on HMM: 1-39/39 Sequence Identity: 27% (11 aa) IQMIDSFRAHRRSIEKMLLNEK---YLFTASSDGTIKIWS . . .| .| ... . . ||...| ||||.||. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 674-711 | 22 | 1.1e-05 | 26.13 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 674-711 Range on HMM: 1-46/46 Sequence Identity: 22% (11 aa) KIQMIDSFRAHRR--SIEKMLLNEK--------YLFTASSDGTIKIWS . . . .|..|. .. . . ||...| ||||.||. T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 733-771 | 27 | 2.7e-11 | 35.12 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 733-771 Range on HMM: 1-39/39 Sequence Identity: 27% (11 aa) YECIGKLEDHTAEVNDMCIDIE-NNFLVSCSFDKQIKIYD .|. .. ||. |...... . ..|.|.| |. |.|.| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 732-771 | 27 | 2.2e-10 | 41.71 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 732-771 Range on HMM: 1-46/46 Sequence Identity: 27% (13 aa) SYECIGKLEDHTA--EVNDMCIDIEN------NFLVSCSFDKQIKIYD . .|. ... ||. .|...|.. . |.|.|.| |..|.|.| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 775-811 | 30 | 1e-09 | 30.56 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 775-811 Range on HMM: 1-39/39 Sequence Identity: 30% (12 aa) FKCIKSLNAHGKSIKSIYMSGK---YLFSSSNDQSIKIWD ||.... .| ... .. . ||.|.| | .|.||| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 774-811 | 27 | 2.8e-08 | 34.75 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 774-811 Range on HMM: 1-46/46 Sequence Identity: 27% (13 aa) TFKCIKSLNAHGK--SIKSIYMSGK--------YLFSSSNDQSIKIWD | ||......| . .. .. . ||.|.| | .|.||| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 816-852 | 22 | 0.013726 | 10.07 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 816-852 Range on HMM: 1-39/39 Sequence Identity: 22% (9 aa) MCVYGMNDAHDAPITSLRMFGN---RLFSASKDGEIKDWN .. .| ...|... . .|.|.| || |. |. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 812-852 | 19 | 0.015745 | 11.74 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 812-852 Range on HMM: 1-46/46 Sequence Identity: 19% (10 aa) LEMCMCVYGMNDAHDA--PITSLRMFGN--------RLFSASKDGEIKDWN | ... .|.. ..|... . .|.|.| || |. |. T-KCVHTFK---GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 855-893 | 29 | 3.7e-07 | 31.03 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 855-893 Range on HMM: 1-46/46 Sequence Identity: 29% (14 aa) TFQPTTTLDQHNM--AITDILVTSNG-------YLFVSSDDSTIRIID | ... |.. |. ..|.. . ..| ||...| |.|||| | T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 856-893 | 30 | 4.6e-07 | 22.96 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 856-893 Range on HMM: 1-39/39 Sequence Identity: 30% (12 aa) FQPTTTLDQHNMAITDILVTSN--GYLFVSSDDSTIRIID ....|. |. ..|.. . . ||. .|.|.|||| | WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 901-937 | 22 | 5.1e-09 | 28.58 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 901-937 Range on HMM: 1-39/39 Sequence Identity: 22% (9 aa) IKIISSTKAHRSGVNSLATDGK---RIFSGGCDNLIKVWN | .... .| ..|...| . ...||..|. |..|. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MHCK-D.AA | WD40 | 897-937 | 17 | 4e-06 | 27.59 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 897-937 Range on HMM: 1-46/46 Sequence Identity: 17% (9 aa) QNEPIKIISSTKAHRS--GVNSLA--TDG------KRIFSGGCDNLIKVWN . ....... .|.. .|.... || ....||. |. |..|. T-KCVHTFK---GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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