SMG1

Species: Slime mold
Alias: DDB0229297, DdisK280, SMG1
External Links: DictyBase Link ,
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: SMG1

Sequence

Name Sequence Type Origin Length Description Download
SMG1.AA Protein None 2344 None Fasta, JSON
SMG1.kin_dom Protein Kinase Domain None 8 None Fasta, JSON

Protein domain

Protein domains of SMG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Herpes_gp2 SMG1.AA Herpes_gp2 111-554 6 5.1e-05 16.39 Pfam 204-288 (889) Show / Hide
Range on Protein: 111-554
Range on HMM: 204-288/889
Sequence Identity: 6% (30 aa)

TTTTATATAITPTPITTSQSTSSSMLNLPLKVGKESIETLFRNRFHPKNNIRETVLSSLQSILIPDLSDTINNTKENIEYFYNMIIDENNYILKLLLLNI
||| || || | |  ||   |...                                                                            
TTTAATTTAATTTAATTTAATTTAA---------------------------------------------------------------------------

INDTKRNLVVYNYNQQHQLPIQNTSSPNTPSSTTTTTTTSTKPSKRGDKERERGRRNKDKINEKQLQQQQLQQLQLQQQLDHEGSSLYLPFSSLLSFIKP
                                                                                                    
----------------------------------------------------------------------------------------------------

DKQQQPQQSQQSQLNEIDQMVRPKSLPKDDNDSDNFNIRVLEYNLKLLIKIYFKVSMYQDSIKTHIFDLYIQINQAISEQQRQLQEKEKESKTSKPIPQP
                                                                                                    
----------------------------------------------------------------------------------------------------

IISLVIPTVLVSIGDIIKYKYATPSPPNLTPTTTTKMEEEERIINTILINEFKKTDVSIIESNLYLFECILSISVSNEPTIVVPNTTTATTATTATTSNT
                                                                                     || |||    ||  |
-------------------------------------------------------------------------------------TTAATTTAATTTAAT

STAAAATTTTPT-LSTSSSSLSPPASTQSSLSLSSSSSAVIAPTT
 |||  |  |.|  |  .. .. . .   .    . ..   | ||
TTAATTTAATTTESSEAATTTAATTADTTADTTADTTADTTADTT

HEAT SMG1.AA HEAT 605-635 22 2.705776 4.88 Pfam 1-31 (31) Show / Hide
Range on Protein: 605-635
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

LLNITLFKLSDPSEQVKLSYLTLLSKMVSYF
.|.. |  |.||...|... .  |.......
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT SMG1.AA HEAT 1508-1538 25 0.008711 13.51 Pfam 1-31 (31) Show / Hide
Range on Protein: 1508-1538
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

IIPQLFARLSHPDTFVQKYVVEILNRIGRDN
|.| |.  |..||  |.. ... | .. .  
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

Kinase SMG1.AA PIKK 1804-2144 30 5.9e-102 345.03 In-house 1-290 (290) Show / Hide
Range on Protein: 1804-2144
Range on HMM: 1-290/290
Sequence Identity: 30% (104 aa)

TIQLIKPTIYLLPTKTKPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYK
 |. . . .  ...|.||||. ..|.||  | ||.||.|||..|.|.|||. ..  .| .|.  . . |  | |||||.|| .|||.||...|.|. |||
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

NWYKNDQ-VYKQQQQQQQQLQQQQQQQQQQQQQQPQPQQQPQQQPQQQPQQQPQPQQNSTTTSNIVNKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEW
.|..  .  . |  | ..|. ...   .|                                                        .   ..  .  .. |
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS-----------------------------------------------------YYKHQMQQQCMMYQHW

PKEILIQVLNELMQETPKWILQRELWFSSSSSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFE-KGAELKIPERVPFR
| .   .|..|.|| ||  ......| ..... . . ....| ||.|.|.. || .||||||..||..|  ||||||||.. ||| ..  |. || ||||
PLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFR

MTQIFEYALGLTGVQGTFRETSIQIMHLLRKNKDILLNLLETF
.|. .. |.| .|| | || . ...|...|.....|....|.|
LTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase SMG1.AA PI3_PI4_kinase 1833-2154 18 3.9e-61 214.2 Pfam 1-300 (300) Show / Hide
Range on Protein: 1833-2154
Range on HMM: 1-300/300
Sequence Identity: 18% (70 aa)

LYYYLLKGREDLH--LDERIMQLL-----------------------NVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYKNWYK
 | ...|| .||.   |.|.||..                       .... ....|.    . .  . |..||..  .|.|.||. ....  | .....
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

NDQVYKQQQQQQQQLQQQQQQQQQQQQQQPQPQQQPQQQPQQQPQQQPQPQQNSTTTSNIVNKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEWPKEIL
..    ....  . .....   .                                                                         ... 
KCKHKHFNKEHKMWMKMWPDWWHLM-----------------------------------------------------------------------RMQK

IQVLNELMQETPKWILQRELWFSSSSS-SELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILL--DLKTGEIVHIDYNICFE--KGAELKIPERVPFRM
 .| .. .  ||| .| ...| .. .   |..   . . ||.| |.|..|..|.||||.|||..  | .||...|||...||.  |.  .. ||||||| 
VEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRW

TQ------IFEYAL------GLTGVQGTFRETSIQIMHLLRKNKDILLNLL-------ETFIYDPLFDWKH
|.       . .|.      . .|  |.||..  ... .||.......|||       |....|.|..|. 
THWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS

Kinase SMG1.AA SMG1 1969-2096 52 5.6e-52 170.42 In-house 115-242 (242) Show / Hide
Range on Protein: 1969-2096
Range on HMM: 115-242/242
Sequence Identity: 52% (67 aa)

NKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEWPKEILIQVLNELMQETPKWILQRELWFSSSSSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNI
|  |. || ...|.|| | |   ||     | .||  ..  || |||  ||  .| .||| |     | .  |||| || | ||..||.||||||||||.
NPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNV

LLDLKTGEIVHIDYNICFEKGAELKIPE
|.|. |||.|||||.||||||  |..||
LIDMTTGEVVHIDYPICFEKGKKLNVPE

Kinase SMG1.AA PI3Kc 1835-2201 20 8.4e-45 156.07 SMART 1-336 (336) Show / Hide
Range on Protein: 1835-2201
Range on HMM: 1-336/336
Sequence Identity: 20% (80 aa)

YYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYKNWYKNDQVYKQQQQQQQQLQ--QQQQQQQQQ
  ..|...||. |.|.||...... ....||      |. | |..||... .|.|.||  ...| .| |. .|.. ...  .| ..      . |    .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM

QQQQPQPQQQPQQQPQQQPQQQPQPQQNSTTTSNIVNKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEWPKEILIQVLNELMQETPKWILQRELWFSSS
    .  ||. . ..  |.  . . ..  . . . ...|...   | |. . .                                               
Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLY---DWFWEHFPDPN--------------------------------------------

SSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAELKIP------ERVPFRMTQIFEYALG----LTGVQGTFRET
   . .     . ||.| .....|. |.||||.|||.|| |||...|||.. .|..| ..|..      |||||| |. . |. |     .|. | ||..
--EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTC

SIQIMHLLRKNKDILLNLLETFIYDPL-FDWKHS-NKQTNNNNNNNNN-NNMNQAAGEQ------ESIEKK-QSSNNSSNPIISTPTKL
  ... ..||... ..||.|...|||. ..|. . ..  . ..  . .  . ..||         . ||.  .| ..  . .. . ...
CCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase SMG1.AA FRAP 2023-2154 43 2.5e-41 143.64 In-house 119-251 (251) Show / Hide
Range on Protein: 2023-2154
Range on HMM: 119-251/251
Sequence Identity: 43% (58 aa)

LQRELWFSSSSSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAEL-KIPERVPFRMTQIFEYALGLTGVQGTFRE
|.. ||  | .|   | .   | |||| ||..||..||||||. ||.|.  || |||||.  |||      |.||..|||.| .   |.  .|..|..| 
LKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRN

TSIQIMHLLRKNKDILLNLLETFIYDPLFDWKH
|.  .|  .| .|. ..  || |.||||| |. 
TCELVMKVIREHKESVMAVLEAFVYDPLFYWRL

Kinase SMG1.AA ATR 2042-2144 41 2.7e-40 134.77 In-house 165-267 (267) Show / Hide
Range on Protein: 2042-2144
Range on HMM: 165-267/267
Sequence Identity: 41% (43 aa)

QSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAELKIPERVPFRMTQIFEYALGLTGVQGTFRETSIQIMHLLRKNKDILLNLL
. | || | ....||.||||||| ||||.|  .||.||.|||. | .| ....|| ||||.|.  ....|  . .| ||   . || ..|...| .. ..
ENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVW

ETF
..|
DCF

Kinase SMG1.AA SMG1 1812-1937 50 1.1e-38 125.68 In-house 1-116 (242) Show / Hide
Range on Protein: 1812-1937
Range on HMM: 1-116/242
Sequence Identity: 50% (63 aa)

IYLLPTKTKPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYKNWYKNDQV
| .|||||||||.  |||||  | || || ||||||||||| | .|. .     .        | ||| ||   |||||||.|| ||| .|| |      
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRW------

YKQQQQQQQQLQQQQQQQQQQQQQQP
    ||    || |. |   |  | |
----QQREAALQAQKAQDSYQTPQNP

Kinase SMG1.AA ATM 2038-2152 46 2.9e-37 116.35 In-house 134-248 (304) Show / Hide
Range on Protein: 2038-2152
Range on HMM: 134-248/304
Sequence Identity: 46% (53 aa)

FLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAELKIPERVPFRMTQIFEYALGLTGVQGTFRETSIQIMHLLRKNKDIL
| |   | || |  |..||..||||||  |||.  .  |.||||  . ||.|  |  || ||||.|      .|.||| | ||    . |  .|  .. |
FEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETL

LNLLETFIYDPLFDW
| . |  .|||||||
LTIVEVLLYDPLFDW

Kinase SMG1.AA DNAPK 2032-2154 32 3.5e-25 88.46 In-house 177-301 (301) Show / Hide
Range on Protein: 2032-2154
Range on HMM: 177-301/301
Sequence Identity: 32% (41 aa)

SSSSELFLKTQS-YSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFE-KGAELKIPERVPFRMTQIFEYALGLTGVQGTFRETSIQIMHL
|.. | .|  .. . |. |.  . ..  | |||||.| .    .|.|. ||.   |   .  | .||  |||.|  |   .   .. | ..   |  |  
STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA

LRKNKDILLNLLETFIYDPLFDWKH
.|| . ||.|  . || ||.|||| 
FRKDRNILTNFCDVFINDPSFDWKN

Kinase SMG1.AA FRAP 1834-1893 48 3.1e-20 71.13 In-house 2-61 (251) Show / Hide
Range on Protein: 1834-1893
Range on HMM: 2-61/251
Sequence Identity: 48% (29 aa)

YYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVE
|..||||.||.  |||.|||   . .|| |. .   | |  . ||.||||  .||| ||.
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVH

Kinase SMG1.AA ATR 1803-1934 26 1.3e-18 59.7 In-house 1-132 (267) Show / Hide
Range on Protein: 1803-1934
Range on HMM: 1-132/267
Sequence Identity: 26% (35 aa)

VTIQLIKPTIYLLPTKTKPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIY
  |  .   . .| .  ||||... |||| .|  . | ..||  | | |.  ........ | .  .. .  | |.|||| . ...| ||.  . | .| 
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

KNWYKNDQVYKQQQQQQQQLQQQQQQQQQQQQ
.  .|  ..| | .| .|  ... ... ..|.
DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQK

Kinase SMG1.AA DNAPK 1820-1898 35 1.6e-10 34.35 In-house 19-97 (301) Show / Hide
Range on Protein: 1820-1898
Range on HMM: 19-97/301
Sequence Identity: 35% (28 aa)

KPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPL
.||.. . | |     .. || ||| .| || ||  |    .  |     . |  | |..||.    ||| ||.  | |
RPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL

Kinase SMG1.AA ATM 1836-1897 35 3.2e-09 25.18 In-house 2-63 (304) Show / Hide
Range on Protein: 1836-1897
Range on HMM: 2-63/304
Sequence Identity: 35% (22 aa)

YLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVP
 | |||.||  |  . |   .   ||        . |    | |.|||| || . |  | .|
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIP

FATC SMG1.AA FATC 2312-2344 42 3.3e-13 45.35 Pfam 1-33 (33) Show / Hide
Range on Protein: 2312-2344
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

KKLSIPDQIDLIIRESMNVENLSSTYEGWSPWV
..||...|.|  |.| ...|||.  | ||.||.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW