DDB0229335

Species: Slime mold
Alias: DdisK082, DDB0229335
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: Dicty7

Sequence

Name Sequence Type Origin Length Description Download
DDB0229335.AA Protein None 663 None Fasta, JSON
DDB0229335.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of DDB0229335.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0229335.AA Dicty7 318-585 66 6.7e-224 750.12 In-house 1-271 (271) Show / Hide
Range on Protein: 318-585
Range on HMM: 1-271/271
Sequence Identity: 66% (179 aa)

LGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSKLVEVYKELAIHQKINGICGPKLFGCVKLNVGFGIIIERFDCSLHDYIQNNNIDFDLFFEL
.||||..||...|.|.|..|||||.|||||||..|.|..|.|..|||..|||||.|||.||||||||||.||.|||||.||.||.|||.|.|.|||||.|
IGRGGFSTVHKAVYKNIQNQGNEIIIPVAIKIFKQYYDDKFVRIYKEVSIHQKIQGICIPKLFGCVKLNFGFSIIIERCDCDLHNYIQCNQINFDLFFIL

ALKMVITIRNLHKCHLN---EIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELNDNILYNEKSDIYSLGVSFMMLLY
...||.|||..|.||.|   .|.||||||||||.||..|..||..|||||||||.||||.|||.||||.|.||||..||.||||.|||||.|.|||||.|
STQMVNTIRQVHNCHPNAEINIYHRDIKPHNWLIKKIDDNHVVFISDFGLSRENTETNECTLQQYRGTNVHIPPECYDNFLYNEQSDIYSVGISFMMLAY

KVVYGKMENPFYEFKISKMEYFKTVVALENFLVPIVPTFLPDSFKEFLFSTMNRIYTCRPNSEECVERLIT
|||||||..|..|..||.|.|||.....||||.||.|.||||.||.||||.|||.|.||||..||.| .  
KVVYGKMVHPYHEYQISDMPYFKNIIQNENFLIPIIPPFLPDRFKRFLFSMMNRMYECRPNIKECIEEIQK

Kinase DDB0229335.AA ARK 399-531 34 6.3e-22 76.57 In-house 86-228 (280) Show / Hide
Range on Protein: 399-531
Range on HMM: 86-228/280
Sequence Identity: 34% (50 aa)

SLHDYIQNNNIDF--DLFFELALKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELND----
||.  . || .||  |.|| ..  ||  |. ||.     | |||.|  | ||    .   . ..|||||| | ..|. || | |||...  ||. .    
SLYHIMNNNKMDFGWDRFFKWMMQMVRGINCLHNWTP-QIVHRDLKSLNLLV---NENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDI

-------NILYNEKSDIYSLGVSFMMLLYKVVYGKMENPFYEF-KIS
        ..|..|||.||.|. .  . | ...|. . |. |. .|.
DDDYVSNGKHYTTKSDVYSMGIIMWEMVYRCINGCYMRPYSEYKHIK

Kinase DDB0229335.AA TKL 399-583 19 2.3e-20 70.07 In-house 124-364 (364) Show / Hide
Range on Protein: 399-583
Range on HMM: 124-364/364
Sequence Identity: 19% (48 aa)

SLHDYIQNNNIDFDLFFELALKMVITIRNLHKCHL-----NEIFHRDIKPHNWLVKK-TK----------DELVVVLSDFGLSRENSETNENTLQKY---
||..|..     ..... .|| .   .  || ..        | |||.|..| ||..  .          .. .. ..||||||..|...... ...   
SLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMM

---------------RGTSVFIPPELNDNI----------------LYNEKSDIYSLGVSFMMLLYKVVYGKMENPFYEFKISKME------YFKTVVAL
               .||  . .||. ..                  |.||.|.|| |. .  .|   .      |.|... . |.       .  .|..
ESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDYPYMPMIFQDPFEEMFMMVCD

ENFLVPIV-----------PTFLPDSFKEFLFSTMNRIYTCRPNSEECVERL
..   ||            ..  |.|.|. .   ..   . ||. .|...||
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase DDB0229335.AA MSK 419-512 30 1.2e-16 52.83 In-house 108-204 (277) Show / Hide
Range on Protein: 419-512
Range on HMM: 108-204/277
Sequence Identity: 30% (30 aa)

LKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELND----NIL-YNEKSDIYSLGV-SFMML
.. |. .. .|. .   | |||.|| | |    .|.  |.|.|||..|.. . .|  .. ...|  . .||. .    .   |.|  |..|||| ...||
RELVMAVDHMHQKG---IIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTML





Pkinase DDB0229335.AA Pkinase 312-515 19 2e-16 59.13 Pfam 1-208 (293) Show / Hide
Range on Protein: 312-515
Range on HMM: 1-208/293
Sequence Identity: 19% (44 aa)

IERRNELGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSKLVEVYK----ELAIHQKINGICGPKLFGCVKLNVGFGIIIERFDC-----SLHD
...   .|.|. |.|| .. |            ||.||     ... .....    |..|....|  .  .|....  .    .. |  ..     .|.|
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

YIQ---NNNI--DFDLFFELALKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKTKDEL--VVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELND-NI
||.   ....  . .     .. ..  .  .|..    | |||.|| | |..  ....   | ..||||..  . .  |... . ||. ...||.   . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIRGGQ

LYNEKSDIYSLGVSFMMLLYK
 |  |.|..|.|. .  .| .
YYGPKVDMWSCGCILYEMLCG

Kinase DDB0229335.AA C8 428-509 29 1.8e-15 50.28 In-house 136-226 (226) Show / Hide
Range on Protein: 428-509
Range on HMM: 136-226/226
Sequence Identity: 29% (27 aa)

LHKCHLNEIFHRDIKPHNWLVKKTKDEL-VVVLSDFGLSRENSETNENTLQKYR---GTSVFIPPELNDN-----ILYNEKSDIYSLGVSF
.   |. .| |||||||| ||.  . ..  . |.|||..   |.  .  ..|     ||  .. ||           |. .||..|.|.  
VNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL

S_TKc DDB0229335.AA S_TKc 312-584 19 2.9e-15 46.94 SMART 1-231 (231) Show / Hide
Range on Protein: 312-584
Range on HMM: 1-231/231
Sequence Identity: 19% (58 aa)

IERRNELGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSKLVEVYKELAIHQKINGICGPKLFGCVKLNVGFGIIIERFDC---SLHDYIQNNN
 |  ...|.|. |.|| .. |.           |||||           ...|..|..| .     ||...      . .. |  |    .|.|||....
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

ID-----FDLFFELALKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELNDNILYNE-KSDI
       |.   . .  |  ... |  || . | |||.|| | |. .     .. ..||||.|.           . ||  ...||.     |.  |.|.
RHGLRFPFPE--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDW

YSLGVSFMMLLY-KVVYGKMENPFYEFKISKMEYFKTVVALENFLVPIVPTFLPDSFKEFLFSTMNRIYTCRPNSEECVE--------RLI
.|.|. .  .|. .  .    ...  ||. .                      ....|.|.   ...  . ||   |. .          .
WSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase DDB0229335.AA Ciliate-E2 431-507 25 5.8e-15 47.78 In-house 176-284 (365) Show / Hide
Range on Protein: 431-507
Range on HMM: 176-284/365
Sequence Identity: 25% (30 aa)

CHLNE-IFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTL----QK--------------------------YRGTSVFIPPELNDNIL----
.| .  |.|||||| | |.        . ..|||||..... |.|..    .|                          . ||  . .||   .      
LHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ

-----YNEKSDIYSLGV
     |..|.||.||||
QKQKGYDYKCDIWSLGV

Kinase DDB0229335.AA CAMK 431-507 19 8.3e-15 43.44 In-house 195-322 (425) Show / Hide
Range on Protein: 431-507
Range on HMM: 195-322/425
Sequence Identity: 19% (25 aa)

CHLNEIFHRDIKPHNWLVKKTKDE--------------LVVVLSDFGLSRENSETNENT----------------------LQKYRGTSVFIP-PELNDN
|| . | |||.|| | |. . .|.                . ..|||....  . ..|.                      .. . ||  ... ||.   
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

IL--------------YNEKSDIYSLGV
                |..|.|. |.||
KGHCNMQNATDEEKPYYGPKCDMWSCGV

Kinase DDB0229335.AA TKL-Unique 399-507 28 9.5e-15 48.6 In-house 86-216 (290) Show / Hide
Range on Protein: 399-507
Range on HMM: 86-216/290
Sequence Identity: 28% (37 aa)

SLHDYIQ-----------NNNIDFDLFFELALKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKT--KDELVVVLSDFGLSRENSETNENTLQ--------
||.|...           |..... ..  .|....    .|| |    | |||.|. | ||       |. . ..|||||. ||  |..|.         
SLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQ

KYRGTSVFIPPELNDN--ILYNEKSDIYSLGV
   |.   ..||.  .   .|.||||.|| |.
TRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGI

Kinase DDB0229335.AA Ciliate-C8 432-509 25 1.6e-14 48.73 In-house 136-238 (238) Show / Hide
Range on Protein: 432-509
Range on HMM: 136-238/238
Sequence Identity: 25% (26 aa)

HLNEIFHRDIKPHNWLVKKT-KDELVVVLSD------FGLSRENSETNE-------NTLQKY-----RGTSVFIPPELNDN------ILYNEKSDIYSLG
| ..| |||||||| ||    .. . . |.|      ||...  .   .       .. . |      |.  ...||. ..       ..  |||.||.|
HCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVG

VSF
. .
LVL

Kinase DDB0229335.AA STE 432-506 28 9.2e-14 45.08 In-house 169-255 (359) Show / Hide
Range on Protein: 432-506
Range on HMM: 169-255/359
Sequence Identity: 28% (27 aa)

HLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSE---------------TNENTLQKYRGTSVFIPPELNDN------ILYNEKSDIYSLG
| . | |||||| | |.        | |.|||..   ..               |.    .   ||  .  ||  ..        |..|.||.|||
HSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLG

Kinase DDB0229335.AA TyrKc 312-583 17 2.3e-08 -87.35 SMART 1-280 (280) Show / Hide
Range on Protein: 312-583
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)

IERRNELGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSKLVEVYKELAIHQKI--NGICGPKLFGCVKLN-------VGFGIIIE--RFDCSL
|.   .||.|  |.|| |..|          |.||.|         . . ..|. |  |.  .  .  .|.|..              |. |      .|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDL

HDYIQNNNIDFDLFFELALKMVITIRNLHKC-----------HLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSET------NENTLQKY--RG
.||....  .            .. . |..            | . . |||.   | ||.. .   .|  |||||||.  .        .   .|    |
KDYLRKHRPK------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

TSVF----IPPELNDNILYNEKSDIYSLGV------SFMMLLYKV----------VYGKMENPFYEFKISK---MEYFKTVVALENFLVPIVPTFLPDSF
 ...     .||  .   ...|||..| ||      .. .  |            |. . .. ..  .      |           |     ..  .. .
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------F-----VCCPDEMY

KEFLFSTMNRIYTCRPNSEECVERL
.    .  ..   .||. .|..|..
Q-IMKQCWHEDPEDRPTFSEIHECF

Kinase DDB0229335.AA STE 312-372 19 2e-06 19.27 In-house 1-86 (359) Show / Hide
Range on Protein: 312-372
Range on HMM: 1-86/359
Sequence Identity: 19% (17 aa)

IERRNELGRGGNGTVYSGVLKE---IDSQGNEI------SIPVAIK-IPTQFYK----------------SKLVEVYKELAIHQKIN
 |.  ..|.|. |||| .. ..   |. . .|.         .||| .. .  .                ... .. ||. |..| |
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCN

Pkinase_Tyr DDB0229335.AA Pkinase_Tyr 312-367 27 7e-06 20.45 Pfam 1-56 (270) Show / Hide
Range on Protein: 312-367
Range on HMM: 1-56/270
Sequence Identity: 27% (16 aa)

IERRNELGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSK---LVEVYKELAI
|.   .||.|  |.|| |..|    .. .  ||||.|.  . . ..   . .  .|..|
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI

Kinase DDB0229335.AA CAMK 317-374 22 6.6e-05 10.96 In-house 1-91 (425) Show / Hide
Range on Protein: 317-374
Range on HMM: 1-91/425
Sequence Identity: 22% (21 aa)

ELGRGGNGTVYSGVLKEIDSQGNEIS------IPVAIKI----------PTQFYKS--------------------KLVEVYKELAIHQKINGI
.||||. |.|. .. |.   . .. .        |||||          . |.| |                    .. .|..|..|..|..||
TLGRGSFGKVKLCIHKNTTGKERV-HHIYTNGQKVAIKIIDKKKLKDKQN-QDY-SNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGI

Kinase DDB0229335.AA TKL 318-349 28 0.005486 6.61 In-house 1-33 (364) Show / Hide
Range on Protein: 318-349
Range on HMM: 1-33/364
Sequence Identity: 28% (11 aa)

LGRGGNGTVYSGVLKEIDSQGNEISIP------VAIKI
.|.|| |.|| |... .....     |      ||.|.
IGSGGFGEVYKGKWRGWGGKC-----PSDTGKDVAVKK

Kinase DDB0229335.AA Ciliate-E2 312-327 31 0.227238 0.44 In-house 1-16 (365) Show / Hide
Range on Protein: 312-327
Range on HMM: 1-16/365
Sequence Identity: 31% (5 aa)

IERRNELGRGGNGTVY
..  . .|.|. |.||
YKFIKKIGQGNFGSVY

Kinase DDB0229335.AA Pkinase_Tyr 453-507 27 1.613575 2.38 Pfam 146-202 (270) Show / Hide
Range on Protein: 453-507
Range on HMM: 146-202/270
Sequence Identity: 27% (16 aa)

DELVVVLSDFGLSRENSETNEN-TLQKYRGTSVF-IPPE-LNDNILYNEKSDIYSLGV
...||  .||||.|   .. .  . ..     ..  .|| .|... ...|||..| ||
ENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGV