Gene DDB0229344 (Slime mold)

DDB0229344

Species: Slime mold
Alias: DdisK085, DDB0229344
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: Dicty8

Sequence

Name Sequence Type Origin Length Description Download
DDB0229344.AA Protein None 737 None Fasta, JSON
DDB0229344.kin_dom Protein Kinase Domain None 158 None Fasta, JSON

Protein domain

Protein domains of DDB0229344.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0229344.AA Dicty8 320-482 67 1.4e-128 433.43 In-house 455-618 (618) Show / Hide 
Range on Protein: 320-482
Range on HMM: 455-618/618
Sequence Identity: 67% (110 aa)

LIEQTQLIEWLLDLSYGVQALHRASMIHRDLKSENIFISGSNKLKIGDFGLAIQSAHHTGSIHSETVGTYCYSSPEILN-STYDKTTDIFSLGCIFYELI
.|.|.|..||.....||||..||..||||||||||||||.|.|.||||||||.|..|||||||||.||||||||||||| ..||..||||||||||||..
KIPQKQFYEWIYQICYGVQSIHRNHMIHRDLKSENIFISESQKIKIGDFGLAKQYEHHTGSIHSEVVGTYCYSSPEILNNKNYDRPTDIFSLGCIFYEMY

TLKLLSHNRIYLGEDMLNDRFDSMQFLSTFPEKYEKLAPLVLSMISKNPTFRPSIESIIETLQK
||.||.|||.|.|.||.|||||.|||...|..||||.|.|.|.||.||..|||.|.|||     
TLNLLPHNRRYFGQDMINDRFDRMQFKQEFDDKYEKIADLILDMINKNQNFRPTIDSIIQNKLF
Kinase DDB0229344.AA TKL 50-480 11 1.6e-33 117.72 In-house 74-364 (364) Show / Hide 
Range on Protein: 50-480
Range on HMM: 74-364/364
Sequence Identity: 11% (60 aa)

KEAMSLARIVHPNTVRFEDAIMTQIG--DQIE-------ITIMMEFCEMGDLLDFLIELSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSS
.|.|.. |. ||| |.|  . .   .    ..       . | ||.|. |.||..|.                                           
EEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------------------------------------

TNFEAALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPPITTTTPNNRHSISTPTLAGTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRK
                                                                                                    
----------------------------------------------------------------------------------------------------

SSKSERKKKCSLKERKCIVKMTVDLTKKIFKKDNSNHTTAATTTTTTNTTHSSSSSSNLNIEEHVIHSNEIKKGVDSIYLIEQTQLIEWLLDLSYGVQAL
                                                                                    |.. | || . |.. |
----------------------------------------------------------------------------------WHQRCRWALDIARGMNYL

HRAS--------MIHRDLKSENIFISGSNK--------------LKIGDFGLAIQSAHHTGSIHSE------------------TVGTYCYSSPEILN--
|           .|||||||.||..   ..              .||.||||.    ..... ...                   .||... .||.|.  
HSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQ

---------------STYDKTTDIFSLGCIFYELITLKLLSHNRIYLGEDMLNDRFDSMQFLST------------------FPEKYE--KLAPLVLSMI
               ..|.. .|..| | ...|..| ..  ..  |  ...  . |. |. .                     |...    .. |     
MNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCW

SKNPTFRPSIESIIETL
. .|. ||| . |...|
DHDPEKRPSFQEILKRL
Kinase DDB0229344.AA ULK 60-419 13 2.7e-33 113.63 In-house 77-251 (329) Show / Hide 
Range on Protein: 60-419
Range on HMM: 77-251/329
Sequence Identity: 13% (53 aa)

HPNTVRFEDAIMTQIGDQI-EITIMMEFCEMGDLLDFLI---ELSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNN
|||.|.. |  .|.   .   | |.||.|. ||| ...    .|.|..                                                    
HPNIVKLYDWFETS---NHNNIYIIMEYCNGGDLEQYIKKNKKLPEDT-E--------------------------------------------------

TIQHSHSSSSLVNGTTSPTNATTPPITTTTPNNRHSISTPTLAGTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKCSLKER
                                                                                                    
----------------------------------------------------------------------------------------------------

KCIVKMTVDLTKKIFKKDNSNHTTAATTTTTTNTTHSSSSSSNLNIEEHVIHSNEIKKGVDSIYLIEQTQLIEWLLDLSYGVQALHRASMIHRDLKSENI
                                                                 ... . |. . ..  | ..||    ||||.| .||
-------------------------------------------------------------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNI

FISGSNK------------LKIGDFGLAIQSAHH--TGSIHSETV------GTYCYSSPEILNST-----YD-KTTDIFSLGCIFYELIT
 |.  .             |||.|||.| .         .   .|      ||  | .|.||..      |. ...||.||||||||...
LIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase DDB0229344.AA Ciliate-E2 8-422 12 9.6e-32 106.23 In-house 1-294 (365) Show / Hide 
Range on Protein: 8-422
Range on HMM: 1-294/365
Sequence Identity: 12% (63 aa)

YKLIKDLRSGGEG---KAILYEKDG---------------------VKYVGKKRL----FDNLKDANQGLKEAM----------SLARIVHPNTVRFEDA
||.|| . .|. |   |.  ....                      .|.. .|..      ..|  .. ..|             | .. ||| ... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IMTQIGDQIEITIMMEFCEMGDLLDFLI-----ELSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNNTIQHSHSSS
  ..  |.  | . ||.|. |||.|...     ...|..                                                             
FQEK--DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE-------------------------------------------------------------

SLVNGTTSPTNATTPPITTTTPNNRHSISTPTLAGTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKCSLKERKCIVKMTVD
                                                                                                    
----------------------------------------------------------------------------------------------------

LTKKIFKKDNSNHTTAATTTTTTNTTHSSSSSSNLNIEEHVIHSNEIKKGVDSIYLIEQTQ-LIEWLLD--LSY----------GVQALHRAS-MIHRDL
                                                |     . ... . ... .|.  .            ... ||     ||||.
------------------------------------------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDI

KSENIFISGSNKLKIGDFGLAIQSA----------------------HHTG--------SIHSETVGTYCYSSPEILNST----------YDKTTDIFSL
| |||..     .|| ||||. .                         ..|         ..  ..||. | .|||||.           ||.  ||.||
KPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GCIFYELITLKL
|.|.||... |.
GVILYEMLFGKP
Kinase DDB0229344.AA ULK 55-419 13 2.4e-31 108.52 In-house 64-247 (324) Show / Hide 
Range on Protein: 55-419
Range on HMM: 64-247/324
Sequence Identity: 13% (53 aa)

LARIV---HPN--TVRFEDAIMTQIGDQI-EITIMMEFCEMGDLLDFLI---ELSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEA
.  .    |||  .|.. |  .|.   .   | |.||.|. ||| ...    .|.| .                                          
MKKLKELKHPNHHIVKLYDWFETS---NHNNIYIIMEYCNGGDLEQYIKKNKKLPE-T-E----------------------------------------

ALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPPITTTTPNNRHSISTPTLAGTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSE
                                                                                                    
----------------------------------------------------------------------------------------------------

RKKKCSLKERKCIVKMTVDLTKKIFKKDNSNHTTAATTTTTTNTTHSSSSSSNLNIEEHVIHSNEIKKGVDSIYLIEQTQLIEWLLDLSYGVQALHRASM
                                                                           ... . |. . ..  | ..||    
-----------------------------------------------------------------------EKKRLSEQEAIQFFKQICNGFKELHKHNI

IHRDLKSENIFISGSNK------------LKIGDFGLAIQSAH--HTGSIHSETV------GTYCYSSPEILNST-----YD-KTTDIFSLGCIFYELIT
||||.| .|| |.  .             |||.|||.| .         .  ..|      ||  | .|.||..      |. . .||.||||||||...
IHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase DDB0229344.AA Ciliate-E2-Unclassified 8-419 12 2.5e-29 98.87 In-house 1-265 (352) Show / Hide 
Range on Protein: 8-419
Range on HMM: 1-265/352
Sequence Identity: 12% (59 aa)

YKLIKDLRSGGEGKAILYEKDGVKYV------GKKRLFDNLKDAN--------QGLKEAM-------------SLARIVHPNTVRFEDAIMTQIGDQIEI
||.|| . .|| ||  . ...  |..       |.. .. ..  |        . ... .             .|  . ||. |.....      |.  |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF----QDKQNI

TIMMEFCEMGDLLDFLIELSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPP
 | ||.|| |||.... . .  .                                                                             
YIVMEYCEGGDLWQYIKKRKKQK-----------------------------------------------------------------------------

ITTTTPNNRHSISTPTLAGTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKCSLKERKCIVKMTVDLTKKIFKKDNSNHTTA
                                                                                                    
----------------------------------------------------------------------------------------------------

ATTTTTTNTTHSSSSSSNLNIEEHVIHSNEIKKGVDSIYLIEQTQLI-----EWLLDLSYGVQALHRAS-MIHRDLKSENIFISGSN---KLKIGDFGLA
                      .  .  |.. .   .   ..  | .      ..  .  | . ||.    ||||.| |||... ..   ..|| |||..
----------------------Q--K-GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

I------QSAHHTG---------SIHSETVGTYCYS----SPEILNS-TYDKT----TDIFSLGCIFYELIT
.      ..  ...          . . ..||..|     .||.| .  ||..     ||.|||.|.||...
KKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase DDB0229344.AA Pkinase 336-480 24 3.2e-29 104.39 Pfam 120-293 (293) Show / Hide 
Range on Protein: 336-480
Range on HMM: 120-293/293
Sequence Identity: 24% (43 aa)

GVQALHRASMIHRDLKSENIFISGSNKL----KIGDFGLAIQ-SAHHTGSIHSETVGTYCYSSPEILN--STYDKTTDIFSLGCIFYELITLKLLSHNR-
|.. .|. . ||||||.|||.|.  . .    ||.||||| | . .  .|  .  .||. | .||...  . |..  |..|.|||.||... ...  .. 
GLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC

---IYLGEDMLNDRFDSMQFLSTFPEKY--------------------EKLAPLVLSMISKNPTFRPSIESIIET--L
     . .. . .|  . .. . .|...                    | .  .. ... |.|. ||..| | .   .
WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDB0229344.AA NEK 8-421 15 1e-28 98.45 In-house 1-223 (286) Show / Hide 
Range on Protein: 8-421
Range on HMM: 1-223/286
Sequence Identity: 15% (69 aa)

YKLIKDLRSGGEGKAILYEK--DGVK-----YVGKKRLFDNL--KDANQGL-KEAMSLARIVHPNTVRFEDAIMTQIGDQIEITIMMEFCE-MGDLLDF-
|..|| . .|  ||. ....  || .     || ||  ..|.  |.  . . .|.  |... ||| |.. |... . ...  . | ||.||  ||| .. 
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNC--LCIVMEYCEGGGDLYQKI

--LIELSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPPITTTTPNNRHSIS
  . .  .                                                                                            
KSIKKQKQ--------------------------------------------------------------------------------------------

TPTLAGTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKCSLKERKCIVKMTVDLTKKIFKKDNSNHTTAATTTTTTNTTHSS
                                                                                                    
----------------------------------------------------------------------------------------------------

SSSSNLNIEEHVIHSNEIKKGVDSIYLIEQTQLIEWLLDLSYGVQALHRA-----SMIHRDLKSENIFISGSNK----LKIGDFGLAIQSAHHTGSIHSE
                       .  ..|  |  .|.  .. ... .|         .|||.|. |||.. .|.    .||||||.. .  | |   .. 
-----------------------KGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTT

TVGTYCYSSPEIL-NSTYDKTTDIFSLGCIFYELITL--K
 ||| .| |||.. |  |.   || ||||. ||. ||  |
QVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPK
Kinase DDB0229344.AA Ciliate-B1 336-423 41 3.9e-24 81.47 In-house 130-228 (290) Show / Hide 
Range on Protein: 336-423
Range on HMM: 130-228/290
Sequence Identity: 41% (42 aa)

GVQALHRASMIHRDLKSENIFIS------------GSNKLKIGDFGLAIQSAHHTGSIHSETVGTYCYSSPEILN-ST-YDKTTDIFSLGCIFYELITLK
|.|.||    .||||| |||.|.            ..  .||.|||.  ..     . .| .|||  | .||||| .  |||. || |.||| ||.|| .
GIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEY--MMQS-CVGTINYMAPEILNFNQQYDKKVDIWSFGCIMYEIITNE

LL
.|
QL
Kinase DDB0229344.AA PEK 115-418 11 6.8e-23 75.95 In-house 410-588 (655) Show / Hide 
Range on Protein: 115-418
Range on HMM: 410-588/655
Sequence Identity: 11% (42 aa)

SSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPPITTTTPNNRHSISTPTLAGTTTATTASPSSPSSP
|. |  ...  .                                                                                        
SM-NM-RQW-DE----------------------------------------------------------------------------------------

SSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKCSLKERKCIVKMTVDLTKKIFKKDNSNHTTAATTTTTTNTTHSSSSSSNLNIEEHVIHSNEIKKG
                                                                                                    
----------------------------------------------------------------------------------------------------

VDSIYLIEQTQLIEWLLDLSYGVQALHRASMIHRDLKSENIFISGSNK-----LKIGDFGLAIQ---------------------------SAHHTGSIH
 .    .. .|. ... ..  |.. .|   |||||||  |||.. ...     .||||||||..                            .. | .  
-NNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQN

SET-----------------------------VGTYCYSSPEILNST------YDKTTDIFSLGCIFYELI
|.|                             |||. |.||| |. .      |.. .|..||| || |..
SPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMW
Kinase DDB0229344.AA NEK4 320-421 40 1.6e-21 74.14 In-house 98-199 (257) Show / Hide 
Range on Protein: 320-421
Range on HMM: 98-199/257
Sequence Identity: 40% (42 aa)

LIEQTQLIEWLLDLSYGVQALHRASMIHRDLKSENIFISGSNKLKIGDFGLAIQSAHHTGSIHSETVGTYCYSSPEILNS-TYDKTTDIFSLGCIFYELI
..|  | .||      . | .|.   .|||||  |||.   | .||||||..     | . . .  .||  | |||.  .  ||   || ||||  ||.|
FLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNH-CDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMI

TLK
|||
TLK
Kinase DDB0229344.AA Dicty8 8-96 43 5.4e-18 62.46 In-house 1-91 (618) Show / Hide 
Range on Protein: 8-96
Range on HMM: 1-91/618
Sequence Identity: 43% (40 aa)

YKLIKDLRSGGEGKAILYEK--DGVKYVGKKRLFDNLKDANQGLKEAMSLARIVHPNTVRFEDAIMTQIGDQIEITIMMEFCEMGDLLDFL
|  .| .  ||| ||.|  .      || |.|.|  | .|| || ||||||.|  |  ||||.  .        . |.||.|| |||.| |
YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNL
Kinase DDB0229344.AA Pkinase_Tyr 84-371 8 2.8e-14 49.0 Pfam 86-158 (270) Show / Hide 
Range on Protein: 84-371
Range on HMM: 86-158/270
Sequence Identity: 8% (25 aa)

MEFCEMGDLLDFLIELSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPPITT
||... |||||.| . .                                                                                   
MEYMPHGDLLDYLRKHR-----------------------------------------------------------------------------------

TTPNNRHSISTPTLAGTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKCSLKERKCIVKMTVDLTKKIFKKDNSNHTTAATT
                                                                                                    
----------------------------------------------------------------------------------------------------

TTTTNTTHSSSSSSNLNIEEHVIHSNEIKKGVDSIYLIEQTQLIEWLLDLSYGVQALHRASMIHRDLKSENIFISGSNKLKIGDFGLA
                                ..   .   .|... .. . | . |..  .|||||   |. .. .|. ||.|||||
--------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase DDB0229344.AA S_TKc 8-487 9 3.7e-14 30.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-487
Range on HMM: 1-231/231
Sequence Identity: 9% (49 aa)

YKLIKDLRSGGEGKAILYEK--DGVKYVGKKRLFDNLKDANQGLKEAMSLARIVHPNTVRFEDAIMTQIGDQIEITIMMEFCEMGDLLDFLIELSEPQHH
|.... . .|. ||  .  .  .| ..  |.                                                                     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

HTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPPITTTTPNNRHSISTPTLAGTTTATT
                                                                                                    
----------------------------------------------------------------------------------------------------

ASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKCSLKERKCIVKMTVDLTKKIFKKDNSNHTTAATTTTTTNTTHSSSSSSNLNIEEHV
                                                        ..    .| || .  .      .  .        ..   . |..
-------------------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYC

IHS-NEIKKGVDSIYL------IEQTQLIEWLLDLSYGVQALHRASMIHRDLKSENIFISGSNKLKIGDFGLAIQSAHHTGSIHSETVGTYCYSSPEILN
 ..  . ..  ..         .   .   ..  .  ... .|.   |||||| |||...    .||.||||| |         .  .||  | .||.| 
DGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-

STYDK-TTDIFSLGCIFYELITLKLLSHNRIYLGEDMLNDRFDSMQFLSTFPEKYEKLAPLVLSMISKNPTFRPSIESIIE--TLQKMDTSL
  |.|   |. |.|||.||... . . .         ..  |. .          . .  ..  .  |.|. ||..  . .   . |..  .
-GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0229344.AA TyrKc 11-480 10 8.3e-13 -15.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-480
Range on HMM: 1-280/280
Sequence Identity: 10% (53 aa)

IKDLRSGGEG------KAILYEKDGVKYVGKKRLFDNLKDANQGLKEAMSLARI--VHPNTVRFEDAIMTQIGDQI----EITIMMEFCEMGDLLDFLIE
|. ..  |||      |....    ..   |.   |        ..||  . ..   ||| ||.  ....| .        . | ||... |||.|.| .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK

LSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPPITTTTPNNRHSISTPTLA
  .                                                                                                 
HRPK------------------------------------------------------------------------------------------------

GTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKCSLKERKCIVKMTVDLTKKIFKKDNSNHTTAATTTTTTNTTHSSSSSSN
                                                                                                    
----------------------------------------------------------------------------------------------------

LNIEEHVIHSNEIKKGVDSIYLIEQTQLIEWLLDLSYGVQALHRASMIHRDLKSENIFISGSNKLKIGDFGLAIQSAHH--------TGSI----HSETV
                      .   .|... .. . | . ||.   |||||   |. ..  .  ||.||||.    ..        . .     .. |.
----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

GTYCYSSPEIL-NSTYDKTTDIFSLGCIFYELITLKLLSHNRI----YLGEDMLNDRFDSMQFLSTFPE--------KYEKLAPLVLSMISKNPTFRPSI
  .   .|| .  ...   .|..| |   .|. |.    .  .       ..... . ..   .   |.          ...  . ..    .|  ||. 
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIE-YVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

ESIIETL
. |.| .
SEIHECF
Kinase DDB0229344.AA NEK4 8-92 29 1.8e-05 15.8 In-house 1-87 (257) Show / Hide 
Range on Protein: 8-92
Range on HMM: 1-87/257
Sequence Identity: 29% (26 aa)

YKLIKDLRSGGEGKAIL--YEKDGVKYVGKKRLFD--NLKDANQGLKEAMSLARIVHPNTVRFEDAIMTQIGDQIEITIMMEFCEMGDL
|  .|    |  |   |    .|. .|| ||        ..    ..||  | .  ||| | . .    .|..     | | ||| |||
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESW--EIENGQFLYIVMGFCEGGDL
Kinase DDB0229344.AA PEK 443-482 31 0.000121 11.25 In-house 615-655 (655) Show / Hide 
Range on Protein: 443-482
Range on HMM: 615-655/655
Sequence Identity: 31% (13 aa)

QFL-STFPEKYEKLAPLVLSMISKNPTFRPSIESIIETLQK
.|  . |  || |.| ... |.|..|. |||.. | ...  
DFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase DDB0229344.AA NEK 449-482 32 0.000685 10.04 In-house 250-286 (286) Show / Hide 
Range on Protein: 449-482
Range on HMM: 250-286/286
Sequence Identity: 32% (12 aa)

PEK--Y-EKLAPLVLSMISKNPTFRPSIESIIETLQK
|..  | ..|  |. .|. |.|. |||...|.|. . 
PSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase DDB0229344.AA Ciliate-B1 82-96 53 0.00113 8.87 In-house 94-108 (290) Show / Hide 
Range on Protein: 82-96
Range on HMM: 94-108/290
Sequence Identity: 53% (8 aa)

IMMEFCEMGDLLDFL
| ||.|| |||....
IIMEYCEQGDLYNYI
Kinase DDB0229344.AA NEK4 455-477 52 0.003464 7.51 In-house 230-252 (257) Show / Hide 
Range on Protein: 455-477
Range on HMM: 230-252/257
Sequence Identity: 52% (12 aa)

LAPLVLSMISKNPTFRPSIESII
|. ||  |..| || |||| .|.
LQNLVYQMLEKQPTKRPSIFDIF
Kinase DDB0229344.AA Pkinase 8-263 10 0.005645 11.6 Pfam 1-118 (293) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-118/293
Sequence Identity: 10% (28 aa)

YKLIKDLRSGGEGKAILYEKDGVK--YVGKK-RLFDNLKDANQGLK---EAMSLARIVHPNTVRFEDAIMTQIGDQIEITIMMEFCEMG----DLLDFLI
|.... . ||. |.  .  . |    .. |. .. .. .. .| .    |.  ..|. ||| ||. |. ..      .| . ||.||.|    || |.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

ELSEPQHHHTVTLGSELSSLNLGSEYTGSDIDSTTSRTSSSSSTNFEAALLLENNNNNTIQHSHSSSSLVNGTTSPTNATTPPITTTTPNNRHSISTPTL
                                                                                                    
T---------------------------------------------------------------------------------------------------

AGTTTATTASPSSPSSPSSPSSPSSPSSPLSPQQHPVTSPQRKSSKSERKKKC--SLKERKCIVKMTV
                                               .|...   | .| |.... ..
-----------------------------------------------WRHGCFYFSEWECKFYMYQIL
Kinase DDB0229344.AA Pkinase_Tyr 465-480 37 5.301997 0.63 Pfam 255-270 (270) Show / Hide 
Range on Protein: 465-480
Range on HMM: 255-270/270
Sequence Identity: 37% (6 aa)

KNPTFRPSIESIIETL
..|  ||. . |.| |
YDPEDRPTFSEIHEQL
Acetyltransf_1 DDB0229344.AA Acetyltransf_1 615-710 14 1.6e-11 36.12 Pfam 1-78 (78) Show / Hide 
Range on Protein: 615-710
Range on HMM: 1-78/78
Sequence Identity: 14% (14 aa)

MRFDDNILSMAQNNNNNPNTSTSNLQTFKGSSSSSSSSCNHWFLAYCCTSEIFRGNGIGSHMIENVLNWADH----NGVETRTVVFENNSIEFFQHHGFE
.. |..|. ... . ...                      |...  .. .. .||.|||..... .. || .    ..... . .    .|.|....||.
AEEDGEIVGFIMCYPDWH----------------------HAYIHDIYVHPDYRGQGIGTRLMQHAIEWAREERGCHRIYLWVREHNHPAIRFYEKCGFK