Gene DDB0229432 (Slime mold)

DDB0229432

Species: Slime mold
Alias: DDB0229432, DdisK121
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK

Sequence

Name Sequence Type Origin Length Description Download
DDB0229432.AA Protein None 1078 None Fasta, JSON
DDB0229432.kin_dom Protein Kinase Domain None 650 None Fasta, JSON

Protein domain

Protein domains of DDB0229432.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0229432.AA PEK 379-1029 41 0.0 1313.52 In-house 1-758 (758) Show / Hide 
Range on Protein: 379-1029
Range on HMM: 1-758/758
Sequence Identity: 41% (313 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALAKLDHINILRYHNAWLELD---PKNNKPRSSSFSSVEGSLG
|..|..||.||||.|.......|...||||...|..||||||||..|..|||.|||..||.|||.||.||.|||||..   |.|||.||.|||.|.|...
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

TGNNDNDESDDSFFED----QDEDEDEDEDEDDVSNSNFSDSIKFKGGFKKSSCSNNSISSNLKKKRNDKKYPFKRNLSISFSLNDSVTNTNSQ-----E
..|||||.....||.|    |||||||.|.|||.....|...|..|...|...|.||.||.|.|||....|||||....|||..|...|..|.|     .
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENEDDNPCNRFVNKIPKKWQEKMDKCWNNNISNNWKKKLHQLKYPFKMDDDISFIRNMDQTMQNDQSRYKMQ

YSISEYFEKFN--------LTNNSESDESEIEESDSDEIYSE-------------SESEESESEESESDESEESESDSDNIDFENENIKEMIKALTISKS
||....|.|||        ..|.|.|.||.....||..|||.             |||....||.|..|..|.|..||.|....|...|.|.|.....|.
YSHDPFFKKFNKQIIIREPMRNSSFSKESYCDQDDSNDIYSNEVDFFFTPKKCYFSESQFMPSEFSGTDDEEQSWMDSNNDTMYNAQQKCMTKCFGHHKH

MIPFVKPIKKKKGKIYNPSSGSGASSGSG--NSSSIGDSDSSEGNKPKGLTLSTKQLSNSQLIG---------INNLNNNN----NNRNNNNNNNNRNND
|..|.|..|........||..|...|||.  |||.|....|.|.||||....||||....|...         ......||    ...||||||||.||.
MMDFSKDNKEEHTFFDCPSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNN

KNSNSNNLRLKYTVYIQTQYCEGKTLRDLLENP-DFKNNSKTTILSLFKQIITGVNYIHSMGMIHRDLKPANLFLSSG----------------------
||............|||.|.|...||.|...|. ..........|..|.||..|||||||.|||||||||.|.|.|..                      
KNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDG

---VIKIGDFGLVKDITATTPSTTPLTNNTPSTTPIDTTPTSSANTIPISTPP------------------------------TSTITPTISVSPSKPLS
   .|||||||||.|.|..||..||..|||||||||.|..|.....|.|...|                              | ||| |||||||||.|
GHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQT-TIT-TISVSPSKPSS

SSLSSTAATTHLNSSLGCTISSSSSTTTATATTSTTPFMFYNSISVNTVGVGTLTYASPEQLSNKGVFGGGGYTN-----TWYTNKTDIYSCGIILFEMI
.|........|......|.|...|.|.........||.|...|....||.|||..|.||||.....|||.|.|||     |||..|.||||.|.|.||.|
ISTPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELI

VGGFETQFERTTHIKNLKNGILPSWFTSKHPEESNLILRMIDINPDNRPTSDQILSELLP
..||.||.||......|.||..|.|||.|.|.|...|..|...|||.|||.|||..... 
HPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF
Kinase DDB0229432.AA PEK 379-1029 26 3.4e-229 767.72 In-house 1-655 (655) Show / Hide 
Range on Protein: 379-1029
Range on HMM: 1-655/655
Sequence Identity: 26% (193 aa)

FKEISKLGSGGF-GSVYLSEYVLDGHKYAIKKVNFSISNNQSPT--------NASSKIEKVVREVVALAKLDHINILRYHNAWLELDPKNNKPRSSSFSS
|.||..||.||| |.||   . |||. ||||.... ......|.        ......||| ||| .||.|.|.|| ||||||.| ..............
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

VEGSLGTGNNDNDESDDSFFEDQDEDEDEDEDEDDVSNSNFSDSI--KFKGGFKKSSCSNNSISSNLKKKRNDKKYPFKRNLSISFSLNDSVTNTNSQEY
 . |....|... .|.|..|. ..|.|. |. |........|. .  ....|.||.....|| ||. .............. | ||..            
LDSSTDWPNGKH-KSKDYNFH-PFEKEW-DD-EEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPN------------

SISEYFEKFNLTNNSESDESEIEESDSDEIYSESESEESESEESESDESEESESDSDNIDFENENIKEMIKALTISKSMIPFVKPIKKKKGKIYNPSSGS
 |...|. .|. ......||.|....|....|.|......|..|.|..|.....|.|...|..............||...|| ..........|..|...
-IENQFS-INF-GTENENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQD

GASSGSGNSSSIGDSDSSEGNKPKGLTLSTKQLSNSQLIGINNLNNNNNNRNNNNNNNNRNNDKNSNSNNL--RLKYTVYIQTQYCEGKTLRDLLENP--
.  ......|.. ||......|....| ...| .|.. ..... ...........||.|.|..|... .|   . ....|||..|||.|||||...|   
DEHEQNDCQSKQCDSKNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGC

----------------------------------------DFKNNSKTTILSLFKQIITGVNYIHSMGMIHRDLKPANLFL-SSGV-----IKIGDFGLV
                                        ......|......|.||..|.|||||.|||||||||.| || ..|      .|||||||.
PVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLA

KDIT--------------------ATTPSTTPLTNNTPSTTPIDTTPTSSANTIPISTPPTSTITPTISVSPSKPLSSSLSSTAATTHLNSSLGCTISSS
....                    |. ..... ||...| |..||... |.| ..| .|                                         
TNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMW-SNN-YHI-QP-----------------------------------------

SSTTTATATTSTTPFMFYNSISVNTVGVGTLTYASPEQLSNKGVFGGGGYTNTWYTNKTDIYSCGIILFEMIVGGFETQFERTTHIKNLKN------GIL
            |. |||.... .| ||||..|.||||||..      .|....|..|.|.||.|||.|||... | |..||......|..      |..
------------TS-MFYCEHCHHTGGVGTCLYMSPEQLSGQ------HYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDF

P-SWFTSKHPEESNLILRMIDINPDNRPTSDQILSELLP
| .||..|.|.....|..|....|..||...|||. .. 
PPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase DDB0229432.AA S_TKc 379-1031 10 2.3e-40 141.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 379-1031
Range on HMM: 1-231/231
Sequence Identity: 10% (71 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALAKLDHINILRYHNAWLELDPKNNKPRSSSFSSVEGSLGTGN
.. . |.|.|.||.||.   . .|...|||...                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

NDNDESDDSFFEDQDEDEDEDEDEDDVSNSNFSDSIKFKGGFKKSSCSNNSISSNLKKKRNDKKYPFKRNLSISFSLNDSVTNTNSQEYSISEYFEKFNL
                                                                                                    
----------------------------------------------------------------------------------------------------

TNNSESDESEIEESDSDEIYSESESEESESEESESDESEESESDSDNIDFENENIKEMIKALTISKSMIPFVKPIKKKKGKIYNPSSGSGASSGSGNSSS
                                                                                                    
----------------------------------------------------------------------------------------------------

IGDSDSSEGNKPKGLTLSTKQLSNSQLIGINNLNNNNNNRNNNNNNNNRNNDKNSNSNNLRLKYTVYIQTQYCEG--KTLRDLLENPDFKNN----SKTT
                       .. .  |. | .       .  |  .  |   .         .|. . ||.|   .|.|....   . .    .  .
-----------------------EHIRREIQILKK-------HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

ILSLFKQIITGVNYIHSMGMIHRDLKPANLFLSSGVIKIGDFGLVKDITATTPSTTPLTNNTPSTTPIDTTPTSSANTIPISTPPTSTITPTISVSPSKP
. ....||. ...|.||.| |||||||.|..|.. .|||.|||| . .                                                    
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----------------------------------------------------

LSSSLSSTAATTHLNSSLGCTISSSSSTTTATATTSTTPFMFYNSISVNTVGVGTLTYASPEQLSNKGVFGGGGYTNTWYTN-KTDIYSCGIILFEMIVG
                                                 |  .||. | .|| |               |.  | |..|||.||.||..|
-------------------------------------------------TTFCGTPWYMAPEVL--------------GYGKCKCDWWSCGCILYEMLCG

GF--ETQFERTTHIKNLKNGILPSWFTSKHPEESNLILRMIDINPDNRPTSDQILS-----ELLPIL
    . | ... ..                ||  ..| .. . .|..|||  ..|       . | .
YPPFP-QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0229432.AA Ciliate-E2 379-1024 11 4.9e-37 124.68 In-house 1-360 (365) Show / Hide 
Range on Protein: 379-1024
Range on HMM: 1-360/365
Sequence Identity: 11% (83 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIK-------------KVN---FSISNN-QSPTNASSKIEKVVREVVALAKLDHINILRYHNAWLELDPKNNK
.| | |.|.|.|||||. .  ......|||             ||.   . . .. ..  .. ...... ||.                           
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-F-----------------------

PRSSSFSSVEGSLGTGNNDNDESDDSFFEDQDEDEDEDEDEDDVSNSNFSDSIKFKGGFKKSSCSNNSISSNLKKKRNDKKYPFKRNLSISFSLNDSVTN
                                                                                                    
----------------------------------------------------------------------------------------------------

TNSQEYSISEYFEKFNLTNNSESDESEIEESDSDEIYSESESEESESEESESDESEESESDSDNIDFENENIKEMIKALTISKSMIPFVKPIKKKKGKIY
                                                                                                    
----------------------------------------------------------------------------------------------------

NPSSGSGASSGSGNSSSIGDSDSSEGNKPKGLTLSTKQLSNSQLIGINNLNNNNNNRNNNNNNNNRNNDK----------NSNSNNLRLKYTV-------
                                                                     |          ... | ......        
-------------------------------------------------------------------Y-KKINEKNILEQLNHPNIIKMYECFQEKDDNN

-YIQTQYCEGKTLRDLLENPDFKNNSK---------TTILSLFKQIIT---------------GVNYIHSMG-MIHRDLKPANLFLSSGVIKIGDFGLVK
 |. . ||.|..|.|...| . | |..           |. ..|||.                ...|.|| .  ||||.|| |...    ||| |||| |
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSK

DIT---------------------ATTPSTTPLTNNTPSTTPIDTTPTSSANTIPISTPPTSTITPTISVSPSKPLSSSLSSTAATTHLNSSLGCTISSS
...                      .||.   .                                                                   
KYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQ-------------------------------------------------------------------

SSTTTATATTSTTPFMFYNSISVNTV--GVGTLTYASPEQLSNKGVFGGGGYTNTWYTNKTDIYSCGIILFEMIVGGFETQFERTTHIKNLKNGILPSWF
                    |. |..   .||. | .|| |..|.  .    . . |. | ||.|.|.||.||. | .         ... |.. .   .
-------------------IIQQNMFNTICGTPGYMAPEILNGKKYDNQ--QKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPC

T---------------SKHPEES--NLILR----MIDINPDNRPT-SDQIL
                 |. ...  .|| .    |.. .|..|.|  .|||
PEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase DDB0229432.AA STE 379-971 10 1.7e-36 126.37 In-house 1-264 (359) Show / Hide 
Range on Protein: 379-971
Range on HMM: 1-264/359
Sequence Identity: 10% (68 aa)

FKEISKLGSGGFGSVYLSEYVL---------------DGHKYAIKKVNFSISNNQSPT---------NASSKIEKVVREVVALAKLD--HINILRYHNAW
.. |.|.|.|.||.||.  ..                 |  .|||..|.. .|| . .           ....... .|.  . |..  | || .|. . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

LELDPKNNKPRSSSFSSVEGSLGTGNNDNDESDDSFFEDQDEDEDEDEDEDDVSNSNFSDSIKFKGGFKKSSCSNNSISSNLKKKRNDKKYPFKRNLSIS
.  ...                                                                                              
FKEGHN----------------------------------------------------------------------------------------------

FSLNDSVTNTNSQEYSISEYFEKFNLTNNSESDESEIEESDSDEIYSESESEESESEESESDESEESESDSDNIDFENENIKEMIKALTISKSMIPFVKP
                                                                                                    
----------------------------------------------------------------------------------------------------

IKKKKGKIYNPSSGSGASSGSGNSSSIGDSDSSEGNKPKGLTLSTKQLSNSQLIGINNLNNNNNNRNNNNNNNNRNNDKNSNSNNLRLKY--TVYIQTQY
                                                                                        |   ...|   |
---------------------------------------------------------------------------------------HKNDDELWICMEY

CEGKTLRDLLEN--PDFKNNS----------KTTILSLFKQIITG-VNYIHSMGMIHRDLKPANLFLSSGVIKIGDFGLVKDITATTPSTTPLTNNTPST
..| .|.|....    .|...           . |    .||. |  .|.||.. ||||.|||| .|    .|. |||. . .| . ..    .      
MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQLTDSMANI-Q-S------

TPIDTTPTSSANTIPISTPPTSTITPTISVSPSKPLSSSLSSTAATTHLNSSLGCTISSSSSTTTATATTSTTPFMFYNSISVNTVG------VGTLTYA
          .| | |                                                              . |  .| .      |||  . 
----------NN-I-I--------------------------------------------------------------DCI--ETMQQKRNTFVGTP-WM

SPEQLSN----KGVFGGGGYTNTWYTNKTDIYSCGIILFEMIVG
.|| ...    .         .  |. | ||.| |. . ||. |
APEVIQQNGQGR---------DKGYDTKCDIWSLGCTIIEMATG
Kinase DDB0229432.AA GCN2 580-818 19 4.2e-24 80.99 In-house 96-356 (511) Show / Hide 
Range on Protein: 580-818
Range on HMM: 96-356/511
Sequence Identity: 19% (63 aa)

NNSESDESEIEESDSDEIYSESESEESESEESESDESEESE-----------------------------------------------------------
..||. .. .|...|..  .|. ..|...|.|.|.|...|.                                                           
DESECFSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWD

-----------SDSDNIDFENENIKEMIKALTISKSMIPFVKPIKKKKGKIYNPSSGSGASSGSGNSSSIGDSDSSEGNKPKGLTLSTKQLSNSQLIGIN
           .|... . ...|    .|  . .                                                           .| .   
IESNNVRDMESDDNEWEQEQQNNQSFQPKQEDHQ-----------------------------------------------------------NQYYDQE

NLNN-----------NNNNRNNNNNNNNRNNDKNSNSNNLRLKYTVYIQTQYCEGKTLRDLLENPDFKNNSKTTILSLFKQIITGVNYIHSMGMIHRDLK
 |||           ..   ...| ..|  ..| .|..  .   ..|||  ||||||||....|  . . ..  . ..| ||. |.|||||.||||||||
DLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD-ELWRYFRQILEGLNYIHSQGMIHRDLK

PANLFL-SSGVIKIGDFGLVK
|.| || ..| .|||||||..
PSNIFLDCCGNVKIGDFGLAT
Kinase DDB0229432.AA WEE 743-821 29 2.9e-22 71.56 In-house 79-183 (297) Show / Hide 
Range on Protein: 743-821
Range on HMM: 79-183/297
Sequence Identity: 29% (31 aa)

TVYIQTQYCEG--KTLRDLLENPDFKNN--SKTTILSLFKQIITGVNYIHSM-GMIHRDLKPANLFLSSG---------------------VIKIGDFGL
. |||. ||.|  . | .... .  .|.  .   |  .. .|..|...|||. ||.| |.||.|.|.|.                      ..||||||.
HMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGH

VKDIT
|.|..
VTDMN
Kinase DDB0229432.AA GCN2 922-1028 32 1.5e-21 71.92 In-house 411-511 (511) Show / Hide 
Range on Protein: 922-1028
Range on HMM: 411-511/511
Sequence Identity: 32% (37 aa)

TVGVGTLTYASPEQLSNKGVFGGGGYTNTWYTNKTDIYSC-GIILFEMIVGGFETQFERTTHIKNLKNGILPSWFTS----KHPEESNLILRMIDINPDN
| .|||  | .|||.               |. | |.||  |||.|||. . | || ||   .|.|..  .|. | .    .|...  .| ......|..
TGKVGTPFYMCPEQQ------------KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQK

RPTSDQIL-SELL
||. .|.| .|.|
RPSAQQLLQHEFL
Kinase DDB0229432.AA Pkinase 741-839 35 3.7e-21 75.88 Pfam 72-171 (293) Show / Hide 
Range on Protein: 741-839
Range on HMM: 72-171/293
Sequence Identity: 35% (39 aa)

KYTVYIQTQYCEGK----TLRDLLE---NPDFKNNSKTTILSLFKQIITGVNYIHSMGMIHRDLKPANLFLS-SGVI----KIGDFGLVKDITATTPSTT
|  .|. . ||||      | |...   .  |   |  .. . ..||. |..|.|||| |||||||.|....  |.|    ||.|||| | .        
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------

PLTNNTPSTTP
 . ||.  ||.
-Y-NNS-MTTF
Kinase DDB0229432.AA PKR 744-817 49 4.5e-21 72.12 In-house 96-170 (272) Show / Hide 
Range on Protein: 744-817
Range on HMM: 96-170/272
Sequence Identity: 49% (37 aa)

VYIQTQYCEGKTLRDLLENPDFKNNSKTTILSLFKQIITGVNYIHSMGMIHRDLKPANLFL-SSGVIKIGDFGLV
..||  .|.  ||   ..|   .   |  || |. ||..||.|||| ..|||||||.|.||     |||||||||
LFIQMEFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLV
Kinase DDB0229432.AA PEK-Unclassified 922-1027 37 2.9e-20 66.94 In-house 731-835 (835) Show / Hide 
Range on Protein: 922-1027
Range on HMM: 731-835/835
Sequence Identity: 37% (40 aa)

TVGVGTLTYASPEQLSNKGVFGGGGYTNTWYTNKTDIYSCGIILFEMIVGGFETQFERTTHIKNLKNGILPSWFTSKHPEESNLILRMIDINPDNRPTSD
|  .|| ||.|.||.| | |     .    |  .||||| |||.|.|.   . |  || . | |.| | ||  |  | |    .|   .   |  ||   
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFH-QMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLS

QILSEL
.|   |
KIEQTL
Kinase DDB0229432.AA HRI 379-454 39 3.3e-18 60.19 In-house 1-69 (613) Show / Hide 
Range on Protein: 379-454
Range on HMM: 1-69/613
Sequence Identity: 39% (30 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALAKLDHINILRYHNAWLE
| .   .| ||.| ||     ||.  |||||.             .  . |. |||  || |.| || ||| ||.|
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIK-------KRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase DDB0229432.AA GCN2 379-510 17 3.7e-18 59.81 In-house 1-221 (511) Show / Hide 
Range on Protein: 379-510
Range on HMM: 1-221/511
Sequence Identity: 17% (39 aa)

FKEISKLGSGGFGSVYL-SEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALAKLDHINILRYHNAWLE-------------------LDPK
|.||  || ||||.|.  .   .||  ||||| .  ... . |     .. |  |||  |..| |... ||..||.|                   ... 
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLP-----CKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSD

NNKPRSSSFSSVEGSLGTGNNDNDESDDS------------------FFEDQD-----------------------------------------------
.... .|. .... |.. . .  .... .                  ||.. |                                               
DESECFSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWD

---------EDEDEDEDEDDVSNSNF
         | .|.... ... |..|
IESNNVRDMESDDNEWEQEQQNNQSF
Kinase DDB0229432.AA PKR 379-452 45 1.2e-17 59.61 In-house 1-61 (272) Show / Hide 
Range on Protein: 379-452
Range on HMM: 1-61/272
Sequence Identity: 45% (34 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALAKLDHINILRYHNAW
||.| ..|||||| |.     .|| .|.||.| .   ||          ||  .|| |||||||.|| .||  |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKY---NN----------EKAEHEVQALAKLDHVNIVHYHSCW
Kinase DDB0229432.AA PEK-Unclassified 778-820 52 1.3e-16 53.83 In-house 620-665 (835) Show / Hide 
Range on Protein: 778-820
Range on HMM: 620-665/835
Sequence Identity: 52% (24 aa)

KQIITGVNYIHSMG-MIHRDLKPANLFLSSG--VIKIGDFGLVKDI
.||| .  .||. . |.|||.|| | |.      |||||||||| |
RQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKKI
Kinase DDB0229432.AA TKL 748-839 22 2e-16 55.67 In-house 117-237 (364) Show / Hide 
Range on Protein: 748-839
Range on HMM: 117-237/364
Sequence Identity: 22% (29 aa)

TQYCEGKTLRDLLENPDFKNNSKTTILSLFKQIITGVNYIHSMG--------MIHRDLKPANLFLSS-GV--------------IKIGDFGLVKDITATT
..||.| .|...|            .... ..|  |.|| |||.        .||||||..|... . .               .||.|||| .... ..
MEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSG

PSTTPL--------------TNNTPSTTP
 ..                 |..|.  ||
NMNDTMTTMMESAEHQNNRKTTMTQCGTP
Kinase DDB0229432.AA WEE 379-454 36 1.7e-15 48.5 In-house 1-76 (297) Show / Hide 
Range on Protein: 379-454
Range on HMM: 1-76/297
Sequence Identity: 36% (30 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALAKLD-------HINILRYHNAWLE
|.|..|.|.| ||.||     .|| .|||||         .| . .|  .  .||| |...|        |..|.||..|| |
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKS-------KQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEE
Kinase DDB0229432.AA HRI 776-816 50 7.9e-15 48.0 In-house 438-483 (613) Show / Hide 
Range on Protein: 776-816
Range on HMM: 438-483/613
Sequence Identity: 50% (23 aa)

LFKQIITGVNYIHSMGMIHRDLKPANLFLSSG-----VIKIGDFGL
.| ||. |..||| |. .|||.|| | ||.        .|||||||
IFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGL
Kinase DDB0229432.AA PEK-Unclassified 379-460 32 3.5e-14 45.08 In-house 686-765 (835) Show / Hide 
Range on Protein: 379-460
Range on HMM: 686-765/835
Sequence Identity: 32% (27 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALAKLDHINILRYHNAWLELDPKNN
| .. |.| |||..||     .|   ||.|..   |   .         || ..|| ..|.. | || ||   | | . | |
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIK--EDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEIKKN
Kinase DDB0229432.AA HRI 922-1028 36 8.4e-13 40.7 In-house 518-613 (613) Show / Hide 
Range on Protein: 922-1028
Range on HMM: 518-613/613
Sequence Identity: 36% (39 aa)

TVGVGTLTYASPEQLSNKGVFGGGGYTNTWYTNKTDIYSCGIILFEMIVGGFETQFERTTHIKNLKNGILPSWFTSKHPEESNLILRMIDINPDNRPTSD
| .||| ||||||||             . | || | || |.||||.    | |  || . .  .. | .|     . |     |  .   |   ||   
TSRVGTCTYASPEQLD-----------GSQYDNKSDMYSMGVILFELFQ-PFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKYIQHLTRRNASQRPSAI

QIL-SELL
|.| ||| 
QLLQSELF
Kinase DDB0229432.AA TKL 941-1027 18 6.1e-12 39.3 In-house 244-364 (364) Show / Hide 
Range on Protein: 941-1027
Range on HMM: 244-364/364
Sequence Identity: 18% (22 aa)

VFGGGGYTNT-----------WYTNKTDIYSCGIILFEMIVGG--FETQFERTTH---------IKNLKNGILPSWF------------TSKHPEESNLI
|. | ....             |. |.|.|| ||.|.|.. .   .. . ...           ... ..|  |               ..  |. ..|.
VLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLM

LRMIDINPDNRPTSDQILSEL
 .  | .|..||. ..||..|
QDCWDHDPEKRPSFQEILKRL
Kinase DDB0229432.AA Pkinase 914-1027 22 3.7e-11 40.53 Pfam 162-293 (293) Show / Hide 
Range on Protein: 914-1027
Range on HMM: 162-293/293
Sequence Identity: 22% (33 aa)

F-YNSISVNTVGVGTLTYASPEQLSNKGVFGGGGYTNTWYTNKTDIYSCGIILFEMIVG-----------GFETQFERTTHIKNLKNGILPSWFTSKH--
| | . | .|. .||. |..|| .           ... |. | |..|||.||.||. |           .  .| ..   |.  ..    .|  |.   
FDY-NNS-MTTFCGTPWYMAPEVIR----------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYF

---------------PEESNLILRMIDINPDNRPTSDQILSE--L
               .|   .| .... .|  ||| .|||    .
FFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDB0229432.AA Pkinase 379-454 25 4.4e-10 36.74 Pfam 1-71 (293) Show / Hide 
Range on Protein: 379-454
Range on HMM: 1-71/293
Sequence Identity: 25% (20 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVR--EVVALAKLDHINILRYHNAWLE
.. ..|.|||.||.||.   . .|...|.|...        ... |.| .  .|  |.  ...|.| ||.|.. .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK-------KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED
Kinase DDB0229432.AA TyrKc 379-1027 7 9.2e-09 -80.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 379-1027
Range on HMM: 1-280/280
Sequence Identity: 7% (54 aa)

FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALAKL--DHINILRYHNAWLEL-------DP------------
 . . |||.| || ||. ..     . |.|... .             .|   ||   . ||  .| ||.| . . ..        .|            
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

-----KNNKPRSSSFSSVEGSLGTGNNDNDESDDSFFEDQDEDEDEDEDEDDVSNSNFSDSIKFKGGFKKSSCSNNSISSNLKKKRNDKKYPFKRNLSIS
     ....|.                                                                                         
LKDYLRKHRPK-----------------------------------------------------------------------------------------

FSLNDSVTNTNSQEYSISEYFEKFNLTNNSESDESEIEESDSDEIYSESESEESESEESESDESEESESDSDNIDFENENIKEMIKALTISKSMIPFVKP
                                                                                                    
----------------------------------------------------------------------------------------------------

IKKKKGKIYNPSSGSGASSGSGNSSSIGDSDSSEGNKPKGLTLSTKQLSNSQLIGINNLNNNNNNRNNNNNNNNRNNDKNSNSNNLRLKYTVYIQTQYCE
                                                                                                    
----------------------------------------------------------------------------------------------------

GKTLRDLLENPDFKNNSKTTILSLFKQIITGVNYIHSMGMIHRDLKPANLFLSSGV-IKIGDFGLVKDITAT------TPSTTP----LTN---------
                .  . ||   ||  | .|.||.. |||||   |  ....  .||.|||| .||.        .   ..     ..         
---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

-----NT--------------------------PS-----TTPIDTTPTSSANTIPISTPPTSTITPTISVSPSKPLSSSLSSTAATTHLNSSLGCTISS
                                 |       ....      .   .   |      | .|                              
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MS------------------------------

SSSTTTATATTSTTPFMFYNSISVNTVGVGTLTYASPEQLSNKGVFGGGGYTNTWYTNKTDIYSCGIILFEMIVGGFETQFERTTHIKNLKNGILPSWFT
                                                                                                  | 
--------------------------------------------------------------------------------------------------FV

SKHPEESNLILRMIDINPDNRPTSDQILSEL
  ..|  .....  . .|..|||  .| ...
CCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DDB0229432.AA PKR 926-1027 31 2.5e-08 25.79 In-house 185-272 (272) Show / Hide 
Range on Protein: 926-1027
Range on HMM: 185-272/272
Sequence Identity: 31% (32 aa)

GTLTYASPEQLSNKGVFGGGGYTNTWYTNKTDIYSCGIILFEMIVGGFETQFERTTHIKNLKNGILP-SWFTSKHPEESNLILRMIDINPDNRPTSDQIL
||| | ||||.. .            |    |||  |.|| |..   | |.||.    ..|..|..    |  |   |  |. ...   |. ||    ||
GTLQYMSPEQIFSQH-----------YGKEVDIYALGLILAELLHVCF-TEFEKIKFFEDLRDGDFSNDIFDNK---EKTLLQKLLSKKPKDRPNTSEIL

SEL
  |
RTL
Kinase DDB0229432.AA TKL 385-448 21 9.6e-07 20.33 In-house 50-139 (364) Show / Hide 
Range on Protein: 385-448
Range on HMM: 50-139/364
Sequence Identity: 21% (19 aa)

LGSGGFGSVYLSEYV--------LDGHKYAIKKVNF--SISNNQSPTN----------------ASSKIEKVVREVVALAKLDHINILRY
.|||||| ||  ..         ..|   |.|| .   . ... .  .                ||   .. ..|.. . .|.| ||...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQF
Kinase DDB0229432.AA Pkinase_Tyr 461-829 6 0.000744 13.68 Pfam 100-177 (270) Show / Hide 
Range on Protein: 461-829
Range on HMM: 100-177/270
Sequence Identity: 6% (25 aa)

KPRSSSFSSVEGSLGTGNNDNDESDDSFFEDQDEDEDEDEDEDDVSNSNFSDSIKFKGGFKKSSCSNNSISSNLKKKRNDKKYPFKRNLSISFSLNDSVT
|.|                                                                                                 
KHR-------------------------------------------------------------------------------------------------

NTNSQEYSISEYFEKFNLTNNSESDESEIEESDSDEIYSESESEESESEESESDESEESESDSDNIDFENENIKEMIKALTISKSMIPFVKPIKKKKGKI
                                                                                                    
----------------------------------------------------------------------------------------------------

YNPSSGSGASSGSGNSSSIGDSDSSEGNKPKGLTLSTKQLSNSQLIGINNLNNNNNNRNNNNNNNNRNNDKNSNSNNLRLKYTVYIQTQYCEGKTLRDLL
                                                                                                    
----------------------------------------------------------------------------------------------------

ENPDFKNNSKTTILSLFKQIITGVNYIHSMGMIHRDLKPANLFLS-SGVIKIGDFGLVKDI-------TATTPSTTP
  .| .. .  ..|.   ||  | .| .|...|||||   |  .. ..|.||.|||| .||       .... .  |
--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLP
Kinase DDB0229432.AA Pkinase_Tyr 379-449 23 0.000937 13.34 Pfam 1-70 (270) Show / Hide 
Range on Protein: 379-449
Range on HMM: 1-70/270
Sequence Identity: 23% (18 aa)

FKEISKLGSGGFGSVYLSEYV----LDGHKYAIKKVNFSISNNQSPTNASSK--IEKVVREVVALAKL-DHINILRYH
 . . |||.| ||.||. ..      .. . |.|...        ..  ..   .|.  ||.  . .| .| ||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase DDB0229432.AA WEE 1004-1031 39 0.008895 5.23 In-house 272-297 (297) Show / Hide 
Range on Protein: 1004-1031
Range on HMM: 272-297/297
Sequence Identity: 39% (11 aa)

NLILRMIDINPDNRPTSDQILSELLPIL
.||  |.. .|..|||. |.|.   |.|
QLIKWMMHPDPEQRPTCQQLLQ--HPVL