Gene Nek3 (Slime mold)

Nek3

Species: Slime mold
Alias: DdisK103, DDB0220003, Nek3
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK1

Sequence

Name Sequence Type Origin Length Description Download
Nek3.AA Protein None 1123 None Fasta, JSON
Nek3.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of Nek3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Nek3.AA NEK1 4-264 55 1.8e-189 635.71 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-276/276
Sequence Identity: 55% (154 aa)

YEEIKTIGKGSFGRAILVKRKSDGLLLVLKEINVMEMQPKERSDAMNEVNLLSMLDHENIIGYYDSFILNGC--LYIIMEYANAGDINLEIKKRTLQNKT
|..||.||.||||.|.|||.|.|| ..|.||||||.||.|||...||||..|....|.||..|..||..|||  |||.|||...||....|.......|.
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FSEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGDY--------------FIKLGDFGIAKILNSETSLASTVLGTPYYLSPELIQNEKGYD
|||..|..||.|||.||..|..|.|||||.|.|||||.|.....              ..||||||||..||.....|.|..|||||||||..|| |.|.
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQN-KPYN

HKSDIWSLGCVLYELTTLKHAFNAANLPALVLKILKGTYPPIPSHYSNDLRNLISSMLQIDPKNRPSVNDILELPFI
.||||||||||||||.||||.|.|.|...|||||..|||||||.|||..|..|.|.|....|..|||||.||| |||
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase Nek3.AA NEK 4-264 53 3.6e-167 561.67 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-286/286
Sequence Identity: 53% (154 aa)

YEEIKTIGKGSFGRAILVKRKSDGLL-----LVLKEINVMEMQPKERSDAM-NEVNLLSMLDHENIIGYYDSFILNG--CLYIIMEYAN-AGDINLE---
||.||.||.||||.. .|.|||||       .|.|.||...|..||. .|. |||..|..|.|.||..|||||| ..  ||.|.|||..  ||       
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKKRTLQNKTFSEFEILSWFSQICKALQYISSR-----NILHRDLKTQNIFLSIVNGDY-FIKLGDFGIAKILNSETSLAST-VLGTPYYLSPELIQNEK
|||.. ..| |.| .|. || |.|.||.|. .|     .|||||.|.|||||.  | || ..|.|||||.|.||..|..|.| . |||||.|||..| .|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQ-NK

GYDHKSDIWSLGCVLYELTTL--KHAFNAA--NLPALVLKILKG-TYPPIPSH--YSNDLRNLISSMLQIDPKNRPSVNDILELPFI
.|..|||||||||||||. ||  ||.|.|   |.|.|..|| || .|||||||  ||.||.||||.||| ||..|||.|.|||.|||
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Nek3.AA NEK8 4-264 45 2e-146 421.12 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-278/278
Sequence Identity: 45% (129 aa)

YEEIKTIGKGSFGRAILVKRKSDG--LLLVLKEINVMEMQPKERSDAMNEVNLLSMLDHENIIGYYDSFILNGCLYIIMEYANAGDINLEIKKRTLQNKT
|| | ..|.|.|| ..|  ||.|.   | ..|.||. .| .||| .|.||...||||.| |||.|||.|. .. | | ||||. |     | ..  ||| 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQ--QNKL

FSEFE-----------------ILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGD-YFIKLGDFGIAKILNSETSLA-S-TVLGTPYYLSPELIQ
|.| .                 ||  | |.| |. .. . |||||||||||||.   . .  ..|.|||||.||.|.... . . ||.|||||.|||. .
FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFM---TRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCE

NEKGYDHKSDIWSLGCVLYELTTLKHAFNAANLPALVLKILKG-TYPPIPSHYSNDLRNLISSMLQIDPKNRPSVNDILELPFI
  | |. |||.|.|||||||. .|| || |.||||||.||  . .| ||..||||..| |... || || .|||.  |.  | .
G-KPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase Nek3.AA NEK4 4-264 46 1.4e-106 360.43 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-257/257
Sequence Identity: 46% (121 aa)

YEEIKTIGKGSFGRAILVKRKSDGLLLVLKEINVMEMQPKERSDAMNEVNLLSMLDHENIIGYYDSF-ILNG-CLYIIMEYANAGDINLEIKKRTLQNKT
|. .| .||||.|   ||. . |.   |.| ..  .   .|| .|  |..||| | | ||. | .|. | ||  |||.| . . ||     |..   |. 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQ--KNQF

FSEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGDYFIKLGDFGIAKILNSETSLASTVLGTPYYLSPELIQNEKGYDHKSDIWSLGCVLYE
 .|  .. || ||  ||||.  ..|||||||||||||   |    ||.|||||...||    .|.|..|||||.|||.  | . ||.||||||||| .||
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKN---IIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGN-RPYDYKSDIWSLGCCVYE

LTTLKHAFNAANLPALVLKILKGTYPPIPSHYSNDLRNLISSMLQIDPKNRPSVNDILELPFI
. ||||||.| ... |. .|..|  ||.|  || || ||.  ||.  |..|||. ||.  |.|
MITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase Nek3.AA NEK2 4-264 38 2.6e-90 304.31 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-319/319
Sequence Identity: 38% (123 aa)

YEEIKTIGKGSFGRAILVKRKSDGLLLVLKEINVMEMQPKERSDAMNEVNLLSMLDHENIIGYYDSFI--LNGCLYIIMEYANAGDINLEIKKRTLQNKT
||  .|||.|||||   |.||||| .|| |||.  .|| ||.    .|.|.|. | |.||. |||  |   |  |||.|||   ||    ||| . . . 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FSEFEILSWFSQICKALQYISS------------------RN---ILHRDLKTQNIFLSIVNGDYF----------------------------------
. |  |.  . |.| ||| .                     .   |||||.|  ||||.    ||                                   
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKLGDFGIAKILNSETSLASTVLGTPYYLSPELIQNEKGYDHKSDIWSLGCVLYELTTLKHAFNAANLPALVLKILKGTYPPIPSHYSNDLRNLISSM
  .|||||| |..|| .|| | |  ||||| |||...  | |. ||||||.||..||. .|.  | | |  .|  || .| . .||. || .|  .|..|
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQK-YNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

LQIDPKNRPSVNDILELPFI
. .|.. |||.. ||. |.|
INVDHYHRPSIEEILQHPQI
Kinase Nek3.AA S_TKc 4-264 31 2.7e-87 297.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YEEIKTIGKGSFGRAILVKRKSDGLLLVLKEINVMEMQPKERSDAMNEVNLLSMLDHENIIGYYDSFILNGCLYIIMEYANA--GDINLEIKKRTLQN--
|| ...||||.||.  ... |..| .  .|.|.          ....|...|.. .|.||. .||.|   ..||..|||..   ||    ||||  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KTFSEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGDYFIKLGDFGIAKILNSETSLASTVLGTPYYLSPELIQNEKGYDH-KSDIWSLGCV
. |.| .. ... |||.||.|. |..|.||||| .||.|.       ||..|||.|..|       .|. |||.|..||..    ||.. |.|.||.||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

LYELTTLKHAFNAANLPALVLKILKGTYPPIPSHYSNDLRNLISSMLQIDPKNRPSVNDILE-------LPFI
|||. . .  |     .....|...          | .....|. .|| ||..||.. ..|.        |..
LYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Nek3.AA CAMK 9-264 21 2.6e-76 245.2 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

TIGKGSFGRAILVKRKSDG------------LLLVLKEINVMEMQ--------------------------PKERSDAMNEVNLLSM-------LDHENI
|.|.||||   |...|...                 | |.   ..                          || |   ..|......       |||.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IGYYDSFI------------LNGC--------LYIIM---EYANAG----DINLEIKKR------------TLQNKTFSEFEILSWFSQICKALQYISSR
|  |. .                .        .|..|   ||.  |    |.   |...              ... |.| |   .| ||| |..|. |.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

NILHRDLKTQNIFLSIVNGD--------------YFIKLGDFGIAKILNS-----------------------ETSLASTVLGTPYYLS-PELIQN----
|| |||||  || |.  |.|              . ||. ||| |.....                       |. . .|. |||.| . ||...     
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------EKGYDHKSDIWSLGCVLYELTTLKHAFNAA-------------NLPALVLKILKGTYPPIPSHYSN-----------------------DL
         ...|. |.|.||.|..|| . . .  |..              |.. |  ||.|| |  .|.. |.                       . 
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

RNLISSMLQIDPKNRPSVNDILELPFI
..||..||| ||..|... ..|. |..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Nek3.AA Pkinase 4-264 26 4.4e-76 263.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

YEEIKTIGKGSFGRAILVKRKSDGLLLVLKEINVMEMQPKERSDAMN--EVNLLSMLDHENIIGYYDSFILNGCLYIIMEYANAG----DINLEIKKRTL
|. ...||.||||.  . ..|..| . ..|.|.. .  ....  . .  |. .. .|.|.||. .||.|  .. .|..|||.. |    |       . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-----DYI

Q---NKTF--SEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLS--IVNGDYFIKLGDFGIAKIL-NSETSLASTVLGTPYYLSPELIQNEKGYDHK
.   ...|  || |. ... ||...|.|. |..|.||||| .||...   .... ..|..|||.|| . .   | ..|. |||.|..||.|.  ..|..|
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDIWSLGCVLYELTTLKHAFNAA------NLPALVLKILK-GTYPPIPSHYS-------------------NDLRNLISSMLQIDPKNRPSVNDILELPF
.|.||.||.|||. . .  |  .      .  ... .|..  .  ..|  .|                    ... .|...|. ||| ||.  .||. |.
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

I
.
F
Kinase Nek3.AA STE 4-264 25 4.1e-75 255.85 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-359/359
Sequence Identity: 25% (92 aa)

YEEIKTIGKGSFGRAILVKRKS---------------DGLLLVLKEINVMEMQP---------------KERSDAMNEVNLLSMLD--HENIIGYYDSFI
.| |. ||||.||   . ...                 | .   |..|. . ..               .|. . ..|..... ..  |.||. ||....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LNG-------CLYIIMEYANAGDINLEIK-KRTLQN---------KTFSEFEILSWFSQICKA-LQYISSRNILHRDLKTQNIFLSIVNGDYFIKLGDFG
 .|        |.|.||| ..| .   || |   ..         ..|.| .|     ||.|. |.|. | .| |||.| .||.|        .|| |||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

IAKILNSE--------------TSL--ASTVLGTPYYLSPELIQN-----EKGYDHKSDIWSLGCVLYELTTLKHAFNA-ANLPALVLKILK--------
....|...              |.     |. ||| . .|| ||.     .|||| |.|||||||.. |. | |. .    .. |. ... .        
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------GTYPPIPS-------------------HYSNDLRNLISSMLQIDPKNRPSVNDILE--LPFI
      |. ||.|.                   ..| .... |.  ||.||..||.... |.   |||
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Nek3.AA Ciliate-E2 4-264 24 3.6e-70 239.43 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-365/365
Sequence Identity: 24% (92 aa)

YEEIKTIGKGSFG-----RAILVKR------------------KSDGLLLVLKEINVMEMQPKER-SDAMNEVN----------LLSMLDHENIIGYYDS
|. || ||.|.||     . ..|..                  | .. .  .| ..  . . ...  . |.|.|          .|. |.| ||| .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FI--LNGCLYIIMEYANAGDINLEIKKRTLQN-------KTFSEFEILSWFSQICK---------------ALQYISSRN-ILHRDLKTQNIFLSIVNGD
|.   . ..|..|||.. ||    ||.. ..        | |.|.||.  . ||..               ||.|. |.| |.|||.| .||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

YFIKLGDFGIAKILNSETS-------------------------------LASTVLGTPYYLSPELIQN--------EKGYDHKSDIWSLGCVLYELTTL
  ||. |||..|... .                                 .. |..|||.|..|| ...        .||||.|.||||||..|||. . 
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KHAFNAANLPALVLKILKGTYP-P----------------IPSHYSNDLRNLISS----MLQIDPKNRPS-VNDILELPFI
|. |          .|... .  |                .. . |..  .||.     ||| ||..|..  ..||. |..
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Nek3.AA NEK6 4-255 40 3e-69 227.01 In-house 1-252 (252) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-252/252
Sequence Identity: 40% (104 aa)

YEEIKTIGKGSFGRAILVKRKSDGLLLVLKEINVMEM-QPKERSDAMNEVNLLSMLDHENIIGYYDSFILNGCLYIIMEYANAGDINLEIKKRTLQNKTF
..  | |||| |      .   |..   || . . ||   | | | . |..||  |.|.|.| ||.||| |  | |..| |.|||.   ||    | .  
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLI

SEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGDYFIKLGDFGIAKILNSETSLASTVLGTPYYLSPELIQNEKGYDHKSDIWSLGCVLYEL
 |  |  .| |.|.||. . |. ..|||.|  |.|   . ..  .|||| |. .   |.|  |  . |||||.||| |. |.||  |||||||||.|||.
PERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVF---ITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEM

TTLKHAF--NAANLPALVLKILKGTYPPIPS-HYSNDLRNLISSMLQIDPKNRPSV
  |.  |     || .|  || .  |||.|. |||..||.|.. ... ||. || .
AALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase Nek3.AA ULK 4-264 28 2.9e-67 229.8 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-329/329
Sequence Identity: 28% (93 aa)

YEEIKTIGKGSFG---RAILVKRKSDGLLLVLKEINVME---MQPKERSDA--------MNEVNLLSMLD--------HENIIGYYDSFILN--GCLYII
|. .. .||||||   ... .|.| |    ..  . ...   |. |.  .         .||. .. .|.        |.||. .|| |      ..|||
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MEYANAGDINLEIKKRTL------QNKTFSEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGD---------YFIKLGDFGIAKILNSE---
||| | ||    |||.         .|..|| |... | ||. ..... ..|| |||.| ||| ..  ..          . .|..||| || ....   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

TSLASTVL------GTPYYLSPELIQ----NEKGYDHKSDIWSLGCVLYELTTLKHAFNAANLPALVLKILKGT---YPPIP----------------SH
  .. | .      |||.| .|...|    ... ||.|.|||||||..||. . |  |.|     ..|.|..     .||.|                 .
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

YSNDLRNLISSMLQIDPKNRPSVNDILELPFI
 |.....||. |||.|.| | |  .... |..
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Nek3.AA Pkinase_Tyr 4-205 25 2.4e-21 72.89 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-205
Range on HMM: 1-210/270
Sequence Identity: 25% (54 aa)

YEEIKTIGKGSFG---RAILV-KRKSDGLLLVLKEINVMEMQPKE--RSDAMNEVNLLSML-DHENIIGYYDSFI-LNGC--LYIIMEYANAGDINLEIK
 . .|..|.|.||   ....  . .....    | .      ...  | | |.|..... | .|.||. .|   .   .   .||.|||.  ||     .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KRTLQNKTFSEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGDYFIKLGDFGIAKIL-NSETS-LASTVLGTPY-YLSPELIQNEKGYDHKS
|.  ... ..  ..|..  ||.|...| .|.|. |||| . |. ..    . ..| .||| |. . | ..   ...    |   ..|| |.. | . .||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKS

DIWSLGCVLYELTTL
|.|| | ...|. |.
DVWSFGVLMWEIFTY
Kinase Nek3.AA TyrKc 4-262 21 4.4e-17 53.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YEEIKTIGKGSFG---RAILVKRKSDGLLLVL-KEINVMEMQPKERSDAMNEVNLLSML--DHENIIGYYDSFILN-------GCLYIIMEYANAGDINL
 . .|..| | ||   ....        . |  | ..        | | |.| .....|  .|.||.  |   .         . |.|.|||.  || . 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

EIKKRTLQNKTFSEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGDYFIKLGDFGIAKILNSE-------TSLASTV--LGTP----YYLSP
 ..|.  .   ..  . ||.  ||..  .|..|.|. |||| . |.    |. .. .| .||| .. . ..           ..    |        ..|
YLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL---VGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ELIQNEKGYDHKSDIWSLGCVLYELTTLKHAFNAA------NLPALVLKILKGTYPPIPSH--------YSNDLRNLISSMLQIDPKNRPSVNDILELP
| | |.. . .|||.|| | ...|. |.             .   .. .. .| ..|.| .         . .. .....  . ||..||. ..| |. 
ECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF