Gene Nek4 (Slime mold)

Nek4

Species: Slime mold
Alias: DDB0219417, Nek4, DdisK104
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK4

Sequence

Name Sequence Type Origin Length Description Download
Nek4.AA Protein None 498 None Fasta, JSON
Nek4.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of Nek4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Nek4.AA NEK4 4-257 71 1.8e-215 722.11 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-257/257
Sequence Identity: 71% (185 aa)

YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLK--EREKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKKKNEFIS
|...|..|.||.|.|.|||...|||.|||||.|||  .|...|...||...||||||||||||.||..|||.|||.|.|..||.|||...|...||.|..
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLN-SSEFAKTMIGTPYYMSPECFGSRAYDFKSDIWSLGCCLYEMITLKH
|||...||.|||..|.|||.|...||||||||||||||||||||||||||||| ....|||||||||||||||||.|.||.||||||||||.||||||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFDAKEMPSLIFQILQGQPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
|||||.|.|||.||.||||.|..|||||||||||||.||||||||||||||||||||
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase Nek4.AA NEK 4-257 50 4.3e-158 531.52 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-286/286
Sequence Identity: 50% (144 aa)

YDIIKQIGNGSHGDVYLVRSTIDKKK-----YVMKKIFLKER--EKTKDTL-HEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCE-SGDLFTT---
|.|||.||.||.| ||.||...|.|.     ||.||| ...   ....... .||..|.||||||||.|..||. |.|..|||.| |||  |||.     
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LQKKK--NEFISEYQILDWFIQIALGLLYMHKK-----KVIHRDLKTQNIFLTKKNI----IKIGDFGISRVLNSS-EFAKT-MIGTPYYMSPECFGSRA
..|.|  .....| ||.|||||..|.| |||..     |..|||.|.|||||||.|.    .||||||||.|||.. ..|.| ..||||||||| . .. 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDFKSDIWSLGCCLYEMITL--KHAFDAK--EMPSLIFQILQG-QPLPISPN--YSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
|..|||||||||.|||| ||  ||.|.|.   ||||...| .| |. ||...  ||||||||. |.| | |..|||. .|..||.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Nek4.AA NEK1 4-257 44 3.7e-123 415.46 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-276/276
Sequence Identity: 44% (122 aa)

YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKE--REKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKK--KNEF
|..||||| || | ..||... | . ||.| | . .  .. . . . ||..|. .||||||.|.|||. . .  | |.| ||. |||.   ...  |.  
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

ISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLT--KKN---------------IIKIGDFGISRVLNSS-EFAKTMIGTPYYMSPECFGSRAYDF
.|| ||..||.|| |.| ..|..|..|||.|.||||||  |.                ..|.|||||.|.||.. |.|.| |||||| |||    . |. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCCLYEMITLKHAFDAKEMPSLIFQILQGQPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
||||||||| ||| .||||.|.|. .. |.  |.||   ||.| ||..||.|| |.. . |  |||. .| . | |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase Nek4.AA NEK8 4-257 37 1.7e-104 299.24 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

YDIIKQIGNGSHGDVYLVRSTIDK--KKYVMKKIFLKE--REKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKKKN-E
|  |  .| |. | . | | . |   .. . | | . .   .   . . |..||| | ||||..|...| .|.|. | | | |.. | |   .|. .|  
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHF-MEDNT-LMIEMEYADGGTLYQMIQHQQNKL

FISEY----------------QILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKK-NIIKIGDFGISRVLNSSEFAKT---MIGTPYYMSPECFGSRA
|  |                 .||. |.|. ... .||.. . ||||||||||.|.  ...|||||||| ..|.   . |    .|||||||||   .. 
FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKP

YDFKSDIWSLGCCLYEMITLKHAFDAKEMPSLIFQILQG-QPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
|..|||.|.||| |||| .|| ||.|   | |.  | |.    |||  || ..  || ..| . | .|||   |  || .
YNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase Nek4.AA S_TKc 4-257 30 1.1e-94 321.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKEREKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCES--GDLFTTLQKKKNEF--
|.|...|| |. | ||..| . ..... .|.|        .... |...|.. .||||| ....||    ..|...| ||.   ||||. ..|.. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--ISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLNSSEFAKTMIGTPYYMSPECFGSRAYDF-KSDIWSLGCCLYEMI
  ..| ..  .. ||...| |.|....|||||| .||.|..   |||.|||..|.|      .|..|||.||.|| .    |.. |.|.||.||.||||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TLKHAFDAKEMPSLIFQILQGQPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQ-------MPYI
. .  |.    . ..|...           |... ... ..|.| |.|||.. ...|       .|..
CGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Nek4.AA NEK-Unclassified 4-257 40 1.5e-83 276.47 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-258/258
Sequence Identity: 40% (106 aa)

YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKEREKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKK--KNEFIS
|| |  .| |  | |||||  | |.  | .   .  | | |     . .||||.|| || | .||  || . |     ||. |.|   .||.  ||| . 
YDKITTLGQGGGGAVYLVRHQISKRHLVQQ---ISKRKKKKKRQNKIIILSQLRHPHIVTYHDSF-FENAK-LFYTQDYCDGGNLDRRIQKHRKKNEPFD

EYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLNSS-EFAKTMIGTPYYMSPECFGSRAYDFKSDIWSLGCCLYEMITLKH
|  |  |.||.   . | | .|.||||||.||||||.  .. .|||||||...   . |.| .||. .||||      |. .||.||||| .||| |   
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

AFDAKEMPSLIFQILQGQP------LPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
.||.. | .. . | |.         |.|  || |||...  .|.. . .|||  .|  ..||
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase Nek4.AA Pkinase 4-257 28 5.3e-80 276.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKEREKTKDTLH----EVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESG----DLFTTLQ-K
| |...|| || | ||. .   . |....|.| ...... ||  |    |. ..  |.|||||.....|.   .. ....| ||| |    |||. .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

KKNEF-ISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNII----KIGDFGISRV--LNSSEFAKTMIGTPYYMSPECFG-SRAYDFKSDIW
... |  || .. ... ||. || |.|....|||||| .||.. ... |    ||.|||....  . ... ..|  |||.||.||    .. |. |.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGCCLYEMITLKHAFDAK------EMPSLIFQILQGQPLPISPNYS--------------------QDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
|.|| ||||.. .  |. .      ..  .|..|.....   .|. .                    .... ... .|.| |.|||.. .|.| |..
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Nek4.AA Ciliate-E2 4-257 23 1.8e-75 257.08 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YDIIKQIGNGSHGDVYLVRSTIDKK----------------------KYVMKKIF----LKEREKTKDTLHEVN----------VLSQLKHPNIVEYFES
|..||.||.|..|.||...   ..|                      |.. .||.    ... .. .. . |.|          .|.||.||||....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQIENNQFLCIIMAYCESGDLFTTLQKKKNEF---------ISEYQILDWFIQIAL---------------GLLYMHKKK-VIHRDLKTQNIFLTKKNII
|| .... . ..| ||. ||||  ....|  .         ..|..|.. . ||.                .| |.|.|. .||||.| .||..     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFGISRVLNSS--------------------------------EFAKTMIGTPYYMSPECFGSRA---------YDFKSDIWSLGCCLYEMITLKHA
|| |||.|. .. .                                . ..| .|||.||.|| ...           ||.|.||||||..||||.. |. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FDAKEMPSLIFQILQGQPLPISPN------------------YSQDLQNLVYQ----LLEKQPTKRPS-IFDIFQMPYI
|         .|. . ... ....                   ||. ..|  .    .|.|.| ||.. . .|.. |..
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Nek4.AA ULK 4-257 27 2.5e-73 249.9 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-329/329
Sequence Identity: 27% (90 aa)

YDIIKQIGNGSHGDVYLVRSTIDK----KKYVMKKIFLK-EREKTKD---------TLHEVNVLSQLK--------HPNIVEYFESFQIENNQFLCIIMA
| .....| || | ||  |  ..|    .|.. |.| .. ...| ..            |. .. .||        |||||.... |.  |.  . ||| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCESGDLFTTLQKKKN--------EFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKN------------IIKIGDFGISRVLNSS----E
||. |||.. ..|.|.         ..|| ...  |.||. |. ..||...||||.| ||| .....            ..||.||| .......    .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FAKTMI------GTPYYMSPECFGSR-----AYDFKSDIWSLGCCLYEMITLKHAFDAKEMPSLI---FQILQG-----------QPLPIS-----PNYS
 ..|.       |||.||.|. . ..      ||.|.||||||| .|||.. |  | |    ...    | |             ||| .      |. |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
.....| ...|......| |. ..|..| .
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Nek4.AA ULK 4-257 26 1.2e-72 247.7 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-324/324
Sequence Identity: 26% (86 aa)

YDIIKQIGNGSHG-DVYLVRSTID---KKKYVMKKIF---LKEREKT-------KDTLHEVNVLSQLK---HPN--IVEYFESFQIENNQFLCIIMAYCE
| .....| || |  ||  |  ..   ....  |.|    ... ..        .    |.... .||   |||  ||.... |.  |. ...||| ||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

SGDLFTTLQKKKN-------EFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKN------------IIKIGDFGISRVLNSSEFAKTMI--
 |||.. ..|.|.        ..|| ...  |.||. |. ..||...||||.| ||| .....            ..||.||| ...... .....|.  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTPYYMSPECFGSR-----AYDFKSDIWSLGCCLYEMITLKHAFDAK--EMP----SLIFQ------ILQGQPLPIS-----PNYSQDLQNL
        |||.||.|. . ..      ||.|.||||||| .|||.. |  | .   .      .|| .      . . ||...      |. |.....|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

VYQLLEKQPTKRPSIFDIFQMPYI
 ...|......| |. .||..| .
IRRMLQYDEKDRISWEEIFNHPWF
Kinase Nek4.AA CAMK 9-257 19 1.7e-72 232.7 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-257
Range on HMM: 1-425/425
Sequence Identity: 19% (81 aa)

QIGNGSHGDVYLVRSTIDK------------KKYVMKKIFLK----------------------------EREKTKDTLHEVNVLSQ-------LKHPNI
..| || | |.|.. . ..            .|. .| |  |                            . .. |  ..|......       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEYFESFQIEN-----------------NQFLCIIM---AYCESG----DLFTTLQKKKN-------------EFISEYQILDWFIQIALGLLYMHKKKV
.  .| .. ..                 .......|    ||. |    |||  ......               ..| .   .| ||. .. |.|....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKTQNIFLTKK-----------------NIIKIGDFGISRVLNSSE------------------------FAKTMIGTPYYMS-PECFGS------
.|||||  || |...                 | ||| ||| .......|                          ||. |||.||. || . .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------RAYDFKSDIWSLGCCLYEMITLKHAFDAK-------------EMPSLIFQILQGQPL-P------------------ISPN----YSQDLQN
        . |..|.|.||.|. || | . .  |...             ... |  .|..|.   |                  || .     ||. ..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVYQLLEKQPTKRPSIFDIFQMPYI
|. ..|.. |.||..| .. . | .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Nek4.AA NEK11 4-257 42 1.4e-69 237.44 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-259/259
Sequence Identity: 42% (112 aa)

YDIIKQIGNGSHGDVYLVRSTIDKKK---YVMKKIFLKE--REKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKKKN-
| . ...| || | ||||     |.     |.| |   |     |     |  .||.|.|| || .  || .| ..| |||  |||  ||   .|  |. 
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASF-MEQDNF-CIITEYCEGRDLDYRIQEYKQA

-EFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVL-NSSEFAKTMIGTPYYMSPECFGSRAYDFKSDIWSLGCCLYEM
    .| ||..||||. ||  ||| ....||||| .|||| | |..||||||.||.|  | . | |. ||| |||||      || ||||||| | ||||
GKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEM

ITLKHAFDAKEMPSLIFQILQGQPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
  . |||   .  |.. .|  |.   .   | ..|  .. ..| |.|  |||  || ..||.
CCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase Nek4.AA Pkinase_Tyr 76-198 31 3.9e-27 92.51 Pfam 82-210 (270) Show / Hide 
Range on Protein: 76-198
Range on HMM: 82-210/270
Sequence Identity: 31% (43 aa)

LCIIMAYCESGDLFTTLQKK--KNEFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLNSSEFAKTMIGTPYY-----
..|.| |.. ||| . |.|.   .. ..  ..|.. .||| |. | . |. ||||| . |. .|..|..||.||| .| .           . ||     
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---------YNDDYYYRKRG

--------MSPECFGSRAYDFKSDIWSLGCCLYEMITL
        |.|||.  . .  |||.|| | ...|..|.
GGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase Nek4.AA TyrKc 4-257 24 1.8e-26 95.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKEREKTKDTLHEVNVLSQL--KHPNIVEYFESFQIE-----NNQFLCIIMAYCESGDLFTTLQKKK
   .|..|.|  | ||. . .      |  |   ..    .| ..| .....|  .|||||  .     .       . |.|.| |.. |||   |.|..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

NEFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLNSS------EFAKTM---IGTP-----YYMSPECFGSRAYDFK
.. ..  . |.. .||| |  | |.|..||||| . |. .......||.||| || . .       .  ...    |.        |.|||.  . . .|
PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDIWSLGCCLYEMITL-KHAFDA-----KEMPSLIFQILQGQPLPISPN--------YSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI
||.|| | |..|. |. .          ..   .| .. ||  .|. ||         .... ..  |  . .| .||.  .|    ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Nek4.AA Pkinase_Tyr 47-62 47 0.230861 5.24 Pfam 51-67 (270) Show / Hide 
Range on Protein: 47-62
Range on HMM: 51-67/270
Sequence Identity: 47% (8 aa)

LHEVNVLSQL-KHPNIV
..|.....|| .|||||
MREAKIMKQLGHHPNIV