FNIPK-E

Species: Slime mold
Alias: DDB0229870, fnkE, DdisK151, FNIPK-E
External Links: DictyBase Link ,
Annotation: Secondary Group: STE, Secondary Family: Dicty3, Secondary Subfamily: FNIPK

Classification

Group: STE
Family: Dicty3
Subfamily: FNIPK

Sequence

Name Sequence Type Origin Length Description Download
FNIPK-E.AA Protein None 1321 None Fasta, JSON
FNIPK-E.kin_dom Protein Kinase Domain None 217 None Fasta, JSON
FNIPK-E.kin_dom2 Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of FNIPK-E.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FNIP FNIPK-E.AA FNIP 67-99 27 0.00489 14.16 Pfam 1-36 (46) Show / Hide
Range on Protein: 67-99
Range on HMM: 1-36/46
Sequence Identity: 27% (10 aa)

YGQL-LTLGTLPKYVMSLDL-SSYNQLFT-PGRLPI
. |  |. |.||. . .| . ...|| .. .. ||.
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPN

FNIP FNIPK-E.AA FNIP 150-191 34 4.8e-14 52.77 Pfam 1-46 (46) Show / Hide
Range on Protein: 150-191
Range on HMM: 1-46/46
Sequence Identity: 34% (16 aa)

YNQP-LTPGTLPNKVKYLVL-SSYNQLLT-PGTLPNNVKYVDL-SS
.||| |..|.||| .|.|.. ...|| .. .. |||..|.  . ..
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC

FNIP FNIPK-E.AA FNIP 192-233 26 1.7e-09 36.79 Pfam 1-46 (46) Show / Hide
Range on Protein: 192-233
Range on HMM: 1-46/46
Sequence Identity: 26% (12 aa)

YNKL-LTPETLPNKVKYLVL-SSYDQLLT-PGTLPNNVKCVDL-SS
.|.  |....||| .|.|.. ....| .. .. |||..|   . ..
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC

FNIP FNIPK-E.AA FNIP 108-149 26 3.6e-09 35.65 Pfam 1-46 (46) Show / Hide
Range on Protein: 108-149
Range on HMM: 1-46/46
Sequence Identity: 26% (12 aa)

YNQL-FTPGRLPDTVDYLKL-SSYNQLFT-PGTLPNHMVYLNL-SS
.||  ...| ||. . .|.. ...|| .. .. |||.  .| . ..
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC

FNIP FNIPK-E.AA FNIP 234-249 35 0.084538 9.82 Pfam 1-17 (46) Show / Hide
Range on Protein: 234-249
Range on HMM: 1-17/46
Sequence Identity: 35% (6 aa)

YDKL-LTPGTLPNNVKY
...  |..|.|||..|.
FNQPFLEKGCLPNSIKH

FNIP FNIPK-E.AA FNIP 255-296 28 4.7e-10 38.75 Pfam 1-46 (46) Show / Hide
Range on Protein: 255-296
Range on HMM: 1-46/46
Sequence Identity: 28% (13 aa)

YNKL-LTPRTLPNNVECLVL-SSYNQLLT-PGILPNYVKYLDI-SS
.|.  |.. .|||... |.. ...|| .. .. ||| .|.| . ..
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC

FNIP FNIPK-E.AA FNIP 297-332 30 7.7e-07 27.49 Pfam 1-39 (46) Show / Hide
Range on Protein: 297-332
Range on HMM: 1-39/46
Sequence Identity: 30% (12 aa)

YNQL-LTPGTLSNNVEYLDL-SSYNQVLA-PKTIPNNVK
.||  |..|.| |....| . ...|| .  .  .||..|
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLK

Kinase FNIPK-E.AA FNIPK 373-586 28 1.7e-122 412.77 In-house 34-425 (425) Show / Hide
Range on Protein: 373-586
Range on HMM: 34-425/425
Sequence Identity: 28% (112 aa)

PQKNISENKVYYTTKHKNAKIIDVLNICK---------CSLKLYGYVKDR-NNEFNIYFEYIDKAIPLSR-----LLEKLN-----KKEQFIVATEIIKS
..|.|.....||..|.....|...|..||         |..|.|||..|. ...|.||.||||..||.|.     ||.|..     ............||
IIKIIKKKDKYYYFKWNEIEIHIKLRDCKEILEKIKHICIMKYYGYCCDEIDHNFYIYMEYIDGYIPISYVKTNNLLKKHPHNQFPEDIISRCMCDLVKS

IKSIHEMG--IIHFDIKCQNILILYDE-------------------------------------------------------------------------
...|||.|  |||.||||.||.|..||                                                                         
LNCIHENGRHIIHRDIKCDNIMIVNDEFHSCDFDYNCSKDISYYSKDNNNNFFTEDCVCNVNGSGTDENCKSCKLKSKPIREIQGSCESCGSNNNNNNNN

--------------------------NEKMLPTDFIKIIGFDHSTLDSEVNSNIIGV------------------------TETHMAPEIKLKNGKLGY-
                          |.|....||......|||..||...|....|                        |||||.|||||.|||... 
NNNNNNNNNNNNNNNNCNANNCNYNTNNKWKFIDFGLSKSCDHSNDDSKCYSQCGEVSITSTISTILSGSSSSQLSTPSTSTETHMPPEIKLQNGKCCRI

-----------------KSDIWSLGCTLIEIVGGNLK--LLDINGI-------------PLIPDHLSNLFKNTIQHCLQINPNARFNANELY
                 |||||.||||.||.|||||.  ..||.||             |.|||||||..||.|||||||.||.|...|.|.
APEIRNQQKITSKGLSKKSDIWCLGCTMIEMVGGNLCHTENDIHGISFNNNNNKPNIWIPKIPDHLSNFCKNFIQHCLQIDPNHRWDINNLI

Kinase FNIPK-E.AA Dicty3 367-586 29 2.9e-103 341.87 In-house 19-351 (351) Show / Hide
Range on Protein: 367-586
Range on HMM: 19-351/351
Sequence Identity: 29% (98 aa)

NWEIIKPQKNISENKVYYTT------KHKNAKIIDVLNICKCSLKLYG--YVKDRNN-EFNIYFEYIDKAIPLSR-----LLEKLNKK---EQFI--VAT
| .| .....|...|.....      .....|||.......|..| ||  |..|.|| ...||.|||...||.|.     .|.|....   |..|  ...
NCIINIKMVDICHIKIINKCDFNEVNNWRHEKIINKKMRHPCIVKYYGACYCCDNNNDNHYIYMEYIEGEIPISFVKTNNMLKKHKNNRFNEHEISKIIC

EIIKSIKSIHEMG-IIHFDIKCQNILILYDE-------NEKMLP-----------TDFIKIIGFDHST-LDSEV--------------------------
...|....||... |||.||||.||.. .||       |.||..           ....|.|.|..|. .....                          
DLVKTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDIQCYYSNEINWKLIDFGLSKNISYYSNNNNNNNYNNNNNNNNNNNNNNNNNN

--------------------------------NSNIIGVTETHMAPEIKLKNGK-LGYKSDIWSLGCTLIEIVGGNLK--LLDIN-------------GI
                                ....|..|...|||||||.|.. ...||||||||||..|.|||||.  ..|||             .|
NNNNNNNNNNNNTNNNVKIINNNIYSNKQYKQKCYSICGTIHYMAPEIKLNNQCCACRKSDIWSLGCTVWEMVGGNLCHCEQDINEMAFMVNDNKQNIWI

PLIPDHLSNLFKNTIQHCLQINPNARFNANELY
|.||||.||..||.||||.||.||.|....||.
PQIPDHVSNFCKNFIQHCWQIDPNHRWDMHELI

Kinase FNIPK-E.AA STE 394-591 20 3.1e-39 136.2 In-house 79-359 (359) Show / Hide
Range on Protein: 394-591
Range on HMM: 79-359/359
Sequence Identity: 20% (61 aa)

IDVLNICKC-S---LKLYGYVKDR------NNEFNIYFEYIDKAIPLSRLLEKLNKK--------------EQFI--VATEIIKS-IKSIHEMGIIHFDI
|.... |.. .    | ||.  .       ..| .|. ||.|     . . .|  ..              |. |  .. .|.|   . .|...||| ||
IKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDI

KCQNILILYDENEKMLPTDFIKIIGFDHST-LDSEV-----------------NSNIIGVTETHMAPEIKLK-----NGKLGYKSDIWSLGCTLIEIVGG
|..|||.             .|.. | ... |....                 ..| .  |  .||||. ..     ... ..|.||||||||.|| . |
KPANILL-------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG

NLKL---LDI-----------------------NGIPLIPD-------------------HLSNLFKNTIQHCLQINPNARFNANELYN--YVIK
.  .    .                        ...| .||                   ..|  ||. |..|||..|| | .|..| .      
KPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase FNIPK-E.AA NZAK 503-586 31 7.8e-23 73.08 In-house 229-329 (329) Show / Hide
Range on Protein: 503-586
Range on HMM: 229-329/329
Sequence Identity: 31% (32 aa)

SNIIGVTETHMAPEIKLKNGKLGYKSDIWSLGCTLIEIVGGNLK--------------LLDINGIPLIPDHLSNLFKNTIQHCLQINPNAR----FNANE
. .|| | . |||| | .| .   |||.||.||| ....|.|..                 .|.|| ||.|... .|. |..|. |.|. |        |
KFAIGGTHHYMAPENK-NNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIE

LY
. 
KL

Kinase FNIPK-E.AA Ciliate-E2 446-587 22 9.6e-20 64.43 In-house 166-361 (365) Show / Hide
Range on Protein: 446-587
Range on HMM: 166-361/365
Sequence Identity: 22% (46 aa)

ATEIIKSIKSIHEMG-IIHFDIKCQNILILYDENEKMLPTDFIKIIGFDHSTLDSEVNSNIIG---------------------------------VTET
...||. ....|. . ||| ||| .|||.             |||| |  |.  .. | |...                                  |  
IACIILALEYLHSKNNIIHRDIKPENILF-------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPG

HMAPEIKLKNGKLG--------YKSDIWSLGCTLIEIVGGNL--KLLDINGIPLIP------------------DHLSNLFKNTIQH----CLQINPNAR
 |||||  . .  .        ||.||||||..| | . |..      ...   .|                  ...|.  |. |.     .|| .|. |
YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKR

FN-ANELYN
.. .... |
ITGWEQILN

Kinase FNIPK-E.AA Pkinase 404-589 19 8.6e-19 67.53 Pfam 63-293 (293) Show / Hide
Range on Protein: 404-589
Range on HMM: 63-293/293
Sequence Identity: 19% (46 aa)

LKLYGYVKDRNNEFNIYFEYIDKA---IPLSRLLE-----KL--NKKEQFIVATEIIKSIKSIHEMGIIHFDIKCQNILILYDENEKMLPTDFIKIIGFD
..||... | ...  . .|| ..    . |.....     ..    .|   ....|.. .. .|.||||| |.| .||||  . . .     ..||. | 
VRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----CVKICDFG

HST---LDSEVNSNIIGVTETHMAPEIKLK-NGKLGYKSDIWSLGCTLIEIVGGNLKLLDI------NGIPLIPDHLS----------------------
 .    . . .  . . .|   ||||. .. . . |.|.|.||.||.|.| . |..   .       . . .|   ..                      
LAKQFDY-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH

---------NLFKNTIQHCLQINPNARFNANELYNY--V
           .|  |  ||. .|. | .| .. .   .
FHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase FNIPK-E.AA CAMK 404-587 15 3.2e-16 48.1 In-house 101-421 (425) Show / Hide
Range on Protein: 404-587
Range on HMM: 101-421/425
Sequence Identity: 15% (49 aa)

LKLYGYVKDRNN------------------EFNIYF---EYIDKAIPLSRLLEKLNKKEQ---------------F------IVATEIIKSIKSIHEMGI
.||| .  |...                  .. . .   ||..    . .|.... ....               |       .   |.  .. .|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHFDIKCQNILILYDENEKM---------LPTDFIKIIGFDHST-LDSEVNSN-------------------------IIGVTETHMA-PEIKLK-----
.| |.|. |||. ......          . .  |||| |  .. .|.  |..                           | |   || ||. ..     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG-TPEYMAAPEVLNGKGHCN

--------NGKLGYKSDIWSLGCTLIEIVGG-----------------------NLKLLDINGIPL-IPDHLSN-----------------------LFK
        .   |.|.|.||.|. |   . |                       .|.   ..|    .|...|.                         |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NTIQHCLQINPNARFNANELYN
. |...|| .|. |... .  |
DLIRKMLQVDPEKRMTIEQCLN

Kinase FNIPK-E.AA S_TKc 368-595 22 6.6e-13 12.4 SMART 1-231 (231) Show / Hide
Range on Protein: 368-595
Range on HMM: 1-231/231
Sequence Identity: 22% (59 aa)

WEIIKPQKNISENKVYYTTKHKNAKI-------------IDVLN-ICKCSLKLYGYVKDRNNEFNIYFEYIDK-AIPLSRLLEK---------LNKKEQF
.||...    .  |||  ...|  .|             |..|   ..   |||..  |  ... . .||.|  .  | ....|         ..  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

IVATEIIKSIKSIHEMGIIHFDIKCQNILILYDENEKMLPTDFIKIIGFDHSTLDSEVNSNIIGVTETHMAPEIKLKNGKLGY-KSDIWSLGCTLIEIVG
 .. .|.. .. .|..|||| |.| .|||.             |||. |  ...      . . .|   ||||.     . |. |.|.||.||.|.| . 
FYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC

GNL------KLLDINGIPLIPDHLSNLFKNTIQHCLQINPNARFNANELYN---YVIKDSIM
|        ..... |        |  .|. |..||| .|. |  | |. .    . ..  .
GYPPFPQMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase FNIPK-E.AA TKL 446-589 17 2.6e-11 37.02 In-house 138-364 (364) Show / Hide
Range on Protein: 446-589
Range on HMM: 138-364/364
Sequence Identity: 17% (40 aa)

ATEIIKSIKSIHEMG--------IIHFDIKCQNILILYDENE------KMLPTDFIKIIGFDHSTLDSEVNS--------------------NIIGV-TE
| .| . .   | |.        ||| |.| .|||.  . .       .   ....||  |  |.  |. ..                    ..  . | 
ALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTP

THMAPEI---------------KLKNGKLGYKSDIWSLGCTLIEIVGGNLKLLDINGI---------------------PLIP------------DHLSN
 .||||.               ..|...   |.|..| |  | ||. . .   |.. .                     |.||            ..   
RWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPP

LFKNTIQHCLQINPNARFNANELYNYV
 .|. .|.| . .|..| ...|.  . 
SMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase FNIPK-E.AA Ciliate-E2-Unclassified 446-537 26 1.6e-08 25.69 In-house 149-260 (352) Show / Hide
Range on Protein: 446-537
Range on HMM: 149-260/352
Sequence Identity: 26% (32 aa)

ATEIIKSIKSIHEMG-IIHFDIKCQNILILYDENEKMLPTDF-IKIIGFDHSTLDSEVNSNIIGV------------------TETHM----APEIKLKN
. .|.. ....|. . ||| |||..|||.  . .       . ||||.|  |    . | .  .                   |   |    |||.  ..
FAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK------NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQ

GKLG---YKSDIWSLGCTL
.  .   ||.||||||. |
NYDHSKAYKCDIWSLGVIL

Kinase FNIPK-E.AA STE20 513-585 30 5.9e-07 21.77 In-house 189-282 (288) Show / Hide
Range on Protein: 513-585
Range on HMM: 189-282/288
Sequence Identity: 30% (29 aa)

MAPEIKLKN----GKLGYKSDIWSLGCTLIEIVGGNLKLLD-------------INGIP--LI--PDHLSNLFKNTIQHCLQINPNARFNANEL
||||. ...    .. .||.|||||| |.|| . |.  ..|              |. |      |.. |  |.. . .|||..|. |  | .|
MAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQL

Kinase FNIPK-E.AA ULK 513-591 27 1e-06 19.29 In-house 218-329 (329) Show / Hide
Range on Protein: 513-591
Range on HMM: 218-329/329
Sequence Identity: 27% (31 aa)

MAPEIKLKNG---KLG-YKSDIWSLGCTLIEIVGGN----------L-----KLLD--------INGIPLI-P-----DHLSNLFKNTIQHCLQINPNAR
|||.|  ..|   . . ||.||||||| . |.. |                 ||..        |. .||  |     ...|. .|. |. .||.... |
MAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDR

FNANELYNYVIK
..  ||.|  . 
ISWEELFNHPWF

Kinase FNIPK-E.AA ULK 449-473 56 5.7e-05 13.38 In-house 139-163 (329) Show / Hide
Range on Protein: 449-473
Range on HMM: 139-163/329
Sequence Identity: 56% (14 aa)

IIKSIKSIHEMGIIHFDIKCQNILI
|.   | .|...||| ||| |||||
ILNGFKELHKHNIIHRDIKPQNILI

Kinase FNIPK-E.AA Ciliate-E2-Unclassified 556-587 33 0.010268 5.27 In-house 313-348 (352) Show / Hide
Range on Protein: 556-587
Range on HMM: 313-348/352
Sequence Identity: 33% (12 aa)

IPDHLSNLFKNTIQ----HCLQINPNARFNANELYN
||.|.|.  |. |.     .|. ||| | ..... |
IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN

Kinase FNIPK-E.AA STE20 456-473 55 0.010733 6.03 In-house 133-150 (288) Show / Hide
Range on Protein: 456-473
Range on HMM: 133-150/288
Sequence Identity: 55% (10 aa)

IHEMGIIHFDIKCQNILI
.|...||| ||| .|||.
LHSNHIIHRDIKADNILL

Kinase FNIPK-E.AA Pkinase_Tyr 513-541 48 0.035113 8.01 Pfam 181-208 (270) Show / Hide
Range on Protein: 513-541
Range on HMM: 181-208/270
Sequence Identity: 48% (14 aa)

MAPEIKLKNGKLGYKSDIWSLGCTLIEIV
||||  ...||   |||.|| | .. ||.
MAPEC-INYGKFTTKSDVWSFGVLMWEIF

Kinase FNIPK-E.AA NZAK 419-486 21 0.097119 1.04 In-house 79-149 (329) Show / Hide
Range on Protein: 419-486
Range on HMM: 79-149/329
Sequence Identity: 21% (16 aa)

IYFEYID-----KAIPLSRLLEKLNKKEQFIVATEIIKSIKSIHEMGIIHFDIKCQNILILYDENEKMLPTDF
|| |...     . .   .   . .  .   . . | . .   |  .||| |||  |..   | | .... ||
IYMEWMEGGNLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVIL--DFNKNLKLIDF

FNIP FNIPK-E.AA FNIP 654-696 41 6e-14 52.41 Pfam 1-46 (46) Show / Hide
Range on Protein: 654-696
Range on HMM: 1-46/46
Sequence Identity: 41% (19 aa)

FNHP-LGPGILPESIKYLKL-PSFNHPLK-EGSIPRSVIHLVFNKF
||.| | .|.||.|||.|..  .||.|..  ...| |. || | ..
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC

FNIP FNIPK-E.AA FNIP 624-653 27 0.016156 12.34 Pfam 14-46 (46) Show / Hide
Range on Protein: 624-653
Range on HMM: 14-46/46
Sequence Identity: 27% (9 aa)

GIKYLEL-QAYNQPID-SIFIFNGVEYLIL-QS
.||.|..   .||||.  ... | ...|..  .
SIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC

FNIP FNIPK-E.AA FNIP 741-783 30 2.5e-11 43.24 Pfam 1-46 (46) Show / Hide
Range on Protein: 741-783
Range on HMM: 1-46/46
Sequence Identity: 30% (14 aa)

FNQP-INQRYIPSSVTDLQL-YNYNLKIL-PHSIPRSIIMLTLGSN
|||| . .  .|.|.. |.. .|.| .|. ....| |.  |..|..
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC

FNIP FNIPK-E.AA FNIP 793-829 26 0.316448 7.81 Pfam 11-46 (46) Show / Hide
Range on Protein: 793-829
Range on HMM: 11-46/46
Sequence Identity: 26% (10 aa)

LPSSIINLTFGFKNNFKIAEL-KKYIPSHITSININGK
||.||..|.||  .||.   . .  .|...... .  .
LPNSIKHLIFG--DNFNQPIEDINVLPNSLKHLEFGYC

Kinase FNIPK-E.AA FNIPK 860-1110 33 1.4e-159 536.43 In-house 1-425 (425) Show / Hide
Range on Protein: 860-1110
Range on HMM: 1-425/425
Sequence Identity: 33% (144 aa)

WEIISTLGSGNFGKVFKARKINGIINGSKVSLCAIKKIEKKDKLKIKLSTEVEILNKLKDNE---------HSMKYYGYGYDE-DDNLFIYTEYIEGSTS
|||||||.|||||.|.||.|||...||..|..|.||.|.||||.......|.||..||.|..         ..||||||..|| |.|..||.|||.|...
WEIISTLKSGNFGRVCKAKKINCQFNGNRVNFCIIKIIKKKDKYYYFKWNEIEIHIKLRDCKEILEKIKHICIMKYYGYCCDEIDHNFYIYMEYIDGYIP

ISD-----LIKKKPNNRFEEEEIKSLMIKIVKALSKIHESG--VIHRDIKSDHIILAQDK----------------------------------------
||.     |.||.|.|.|.|..|...|...||.|..|||.|  .||||||.|.|....|.                                        
ISYVKTNNLLKKHPHNQFPEDIISRCMCDLVKSLNCIHENGRHIIHRDIKCDNIMIVNDEFHSCDFDYNCSKDISYYSKDNNNNFFTEDCVCNVNGSGTD

------------------------------------------NN---------------ETIVKFIDFGLSKQIE---KNSKYYSFVG------------
                                          ||               ....|||||||||...   ..||.||..|            
ENCKSCKLKSKPIREIQGSCESCGSNNNNNNNNNNNNNNNNNNNNNNNNCNANNCNYNTNNKWKFIDFGLSKSCDHSNDDSKCYSQCGEVSITSTISTIL

--------------TDSHMAPEVKLQNGKAGS------------------KSDIFCIGCTMIEMAGLNLCHSERDDKGI-------------PSIPTHLS
              |..||.||.||||||...                  ||||.|.|||||||.|.||||.|.|..||             |.||.|||
SGSSSSQLSTPSTSTETHMPPEIKLQNGKCCRIAPEIRNQQKITSKGLSKKSDIWCLGCTMIEMVGGNLCHTENDIHGISFNNNNNKPNIWIPKIPDHLS

NSFKNIIQNCLKFDTNARHSVESLI
|..||.||.||..|.|.|.....||
NFCKNFIQHCLQIDPNHRWDINNLI

Kinase FNIPK-E.AA Dicty3 863-1110 35 7.79999999999e-136 451.15 In-house 1-351 (351) Show / Hide
Range on Protein: 863-1110
Range on HMM: 1-351/351
Sequence Identity: 35% (123 aa)

ISTLGSGNFGKVFKARKINGIINGSKVSLCAIKKIEKKDKLKIKLSTEVEILNKLKDNEHSMKYYG--YGYDE-DDNLFIYTEYIEGSTSISD-----LI
.|..|.||||.|.|..|.|.|||...|..|.||.|.|.|...........|.||........||||  |..|. .||..||.|||||...||.     ..
WSIGGCGNFGRVKKCHKNNCIINIKMVDICHIKIINKCDFNEVNNWRHEKIINKKMRHPCIVKYYGACYCCDNNNDNHYIYMEYIEGEIPISFVKTNNML

KKKPNNRFEEEEIKSLMIKIVKALSKIHESG-VIHRDIKSDHIILAQDK-------NN---------------ETIVKFIDFGLSKQIEKNS--------
||..||||.|.||.......||.|..||... .||||||.|.|.|..|.       ||               |...|.|||||||.|...|        
KKHKNNRFNEHEISKIICDLVKTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDIQCYYSNEINWKLIDFGLSKNISYYSNNNNNNNY

--------------------------------------------------KYYSFVGTDSHMAPEVKLQNGK-AGSKSDIFCIGCTMIEMAGLNLCHSER
                                                  |.||..||...||||.||.|.. |..||||...|||..||.|.||||.|.
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNNNVKIINNNIYSNKQYKQKCYSICGTIHYMAPEIKLNNQCCACRKSDIWSLGCTVWEMVGGNLCHCEQ

DDK-------------GIPSIPTHLSNSFKNIIQNCLKFDTNARHSVESLI
|..             .||.||.|.||..||.||.|...|.|.|.....||
DINEMAFMVNDNKQNIWIPQIPDHVSNFCKNFIQHCWQIDPNHRWDMHELI

Kinase FNIPK-E.AA STE 860-1110 25 2.5e-74 253.22 In-house 1-352 (359) Show / Hide
Range on Protein: 860-1110
Range on HMM: 1-352/359
Sequence Identity: 25% (93 aa)

WEIISTLGSGNFGKVFKARKI-NGIIN--------GSKVSLCAIKKIEKKD------------------KLKIKLSTEVEILNKLKD-NEHSMKYYGYGY
||.|. .|.|.||.|.||... |..|.        |... ..|||......                  . . ..  |..|..|...  ..  ||||. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE------DDNLFIYTEYIEGSTSISDLIK-----KKPNN-------RFEEEEIKSLMIKIVKA-LSKIHESGVIHRDIKSDHIILAQDKNNETIVKFID
.|      ||.|.|. ||..|  |..|.||     .||.|       ||.|..|.     |.|. |. .|. ..||||||...| |         || .|
KEGHNHKNDDELWICMEYMDG-GSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD

FGLSKQIEKN-----------------SKYYSFVGTDSHMAPEVKLQ-----NGKAGSKSDIFCIGCTMIEMAGLNLCHSERDDK---------------
||...|....                 .| ..||||  .||||| .|     ... . |.|| ..|||.||||  .  ...  .                
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

---------GIPSIPT-------------------HLSNSFKNIIQNCLKFDTNARHSVESLI
         ..|..|.                   ..| .||. |..||. | | | ... |.
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLL

Kinase FNIPK-E.AA S_TKc 860-1118 27 1.3e-42 148.84 SMART 1-231 (231) Show / Hide
Range on Protein: 860-1118
Range on HMM: 1-231/231
Sequence Identity: 27% (74 aa)

WEIISTLGSGNFGKVFKARKINGIINGSKVSLCAIKKIEKKDKLKIKLSTEVEILNKLKDNEHSMKYYGYGYDEDDNLFIYTEYIEGS-TSISDLIKKKP
.||. ..|.| ||||.|.|...         ..|||.|       ...  |..|| |  . ..  |.|.. .|  |.|.. .||..|.  .  |.|||..
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG

NNR----FEEEEIKSLMIKIVKALSKIHESGVIHRDIKSDHIILAQDKNNETIVKFIDFGLSKQIEKNSKYYSFVGTDSHMAPEVKLQNGKAGS-KSDIF
 ..    | | .....|  |..||  .|. |.||||.| . | | .       .| .||||..|.      ..|.||   |||||     . |  |.|. 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWW

CIGCTMIEMAG-LNLCHSERDDKGIPSIPTHLSNSFKNIIQNCLKFDTNARHSVESLII----TLSNIQI
 .||...||.    . .   ... .  |    | ..|..|..||..| . | ..  .        .   .
SCGCILYEMLCGYPPFP--QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase FNIPK-E.AA Pkinase 860-1063 30 2.1e-40 143.95 Pfam 1-206 (293) Show / Hide
Range on Protein: 860-1063
Range on HMM: 1-206/293
Sequence Identity: 30% (66 aa)

WEIISTLGSGNFGKVFKARKINGIINGSKVSLCAIKKIEKKDKLKIKLST-----EVEILNKLKDNEHSMKYYGYGYDEDDNLFIYTEYIEGS---TSIS
..|....|||.||.|.|.....  .      . |.|.|.|... . |. |     |..|...| . ..  ..|.. .| .|.. . .|| ||     . .
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLF

DLIKKKPNNRF--EEEEIKSLMIKIVKALSKIHESGVIHRDIKSDHIILAQDKNNETIVKFIDFGLSKQ--IEKNSKYYSFVGTDSHMAPEVKLQ-NGKA
|.|. . ...|  .|.|.|. |  |...|  .|. |.||||.|.. | . .. .....|| .||||.||  . .|| ...|.||   ||||| .. . . 
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-IRGGQYY

GSKSDIFCIGCTMIEMA
|.|.|.. .||...||.
GPKVDMWSCGCILYEML

Kinase FNIPK-E.AA CAMK 865-1059 18 8.1e-35 109.09 In-house 1-324 (425) Show / Hide
Range on Protein: 865-1059
Range on HMM: 1-324/425
Sequence Identity: 18% (60 aa)

TLGSGNFGKVFKARKI-NG-IINGSKV------SLCAIKKIEKK-----------------------------DKLKIKLSTEVEILNKLK------DNE
|||.|.||||.... . ..  ...           .||| |.||                             .| . ..  |.||..||.      | .
TLGRGSFGKVKLCIHKNTTGKERV--HHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHP

HSMKYYG-------------------YGYDEDDNLFIYT---EYIEGS---TSISDLIKKKPN-------------NRFEEEEIKSLMIKIVKALSKIHE
.  | |                    .  . |..... .   ||..|      . | |.....              ||.|.| . ..  |. |.  .|.
NIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

SGVIHRDIKSDHIILAQDKNNE-------------TIVKFIDFGLSKQIEK------------------------NSKYYSFVGTDSHMA-PEVKLQ---
 ...|||.| . | | ......               .| ||||.......                        . |.. |.|| . || ||| ..   
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------NGKAGSKSDIFCIGCTM
          .   | |.|.  .|. .
CNMQNATDEEKPYYGPKCDMWSCGVIL

Kinase FNIPK-E.AA Ciliate-E2-Unclassified 860-1062 23 1.5e-34 117.3 In-house 1-263 (352) Show / Hide
Range on Protein: 860-1062
Range on HMM: 1-263/352
Sequence Identity: 23% (63 aa)

WEIISTLGSGNFGKVFKARKING-----IINGSKVSLCAIKKIEKKDKLKIKLSTEVEILN-------------KLKDNEHSMKYYGYGYDEDD-NLFIY
 .|| ..|.|.||||.|.....      .   .|.  .. |.|..||  ..   .|.....              |... |  ... . ...|. |..| 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEYIEGSTSISDLIKKKPN---------------NRFEEEEIK-----SLMIKIVKALSKIHESG-VIHRDIKSDHIILAQDKNNETIVKFIDFGLSKQI
.||.|| .  .. |||...               ..|.|...|      ..  |...|...|... .|||||| . |.. ....    .| ||||.||..
MEYCEGGD-LWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKY

EKN----------------SKYYSFVGTDSHM----APEVKLQNGKAGS---KSDIFCIGCTMIEM
..|                 ....|.|| . |    ||||  ...  .|   |.||.. |. . ||
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM

Kinase FNIPK-E.AA STE20 860-1063 31 3.8e-31 109.8 In-house 1-221 (288) Show / Hide
Range on Protein: 860-1063
Range on HMM: 1-221/288
Sequence Identity: 31% (73 aa)

WEIISTLGSGNFGKVFKARK-INGII-NGSKVSLCAIKKIEKKDK----LKI-KLSTEVEILNKLKDNEHSMKYYGYGYDE---DDNLFIYTEYIEGSTS
.|..  .|.|..|||.||..  .| . |    . .||||.. ...     ..  . .|. |....| ...  ||||  . .   ||.|.|  || .|  |
YELLEKIGQGSYGKVYKAYHKPTGEYCN----QRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGG-S

ISDLIK---KKPNN----RFEEEEIKSLMIKIVKALSKIHESGVIHRDIKSDHIILAQDKNNETIVKFIDFGLSKQIEK-----NS-KYYSFVGTDSHMA
..|..|   |. .|    ...||.|   .  ....|. .|. ..||||||.|.| |    . .  || .|||.. |..|     .. |  .||||   ||
LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILL----TEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMA

PEVKLQN----GKAGSKSDIFCIGCTMIEMA
||| ...    .. ..|.||   | | ||||
PEVIQCMEGPDKGYDYKCDIWSLGITAIEMA

Kinase FNIPK-E.AA Ciliate-E2 860-1059 20 5.2e-31 103.67 In-house 1-286 (365) Show / Hide
Range on Protein: 860-1059
Range on HMM: 1-286/365
Sequence Identity: 20% (61 aa)

WEIISTLGSGNFGKVFKARK-INGIIN----------------GSKVSLCAIKKIEKKDKLKIKLSTEVEILNKLK---------------DNEHSMKYY
 ..|  .|.||||.|.|...  ..                   . |... |.| ..|...  ||   |  |.....               .. . .|.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQ--EIHIMREINCFYKKINEKNILEQLNHPNIIKMY

GYGYD-EDDNLFIYTEYIEGSTSISDLIKKKPNNRFEE---------EEIKSLMIKIVK---------------ALSKIHESG-VIHRDIKSDHIILAQD
 . ..  |.|... .||..| .   |.||... .|..|         .||| .| .|..               ||  .|. . .|||||| . |..   
ECFQEKDDNNIYLVMEYCQGGD-LFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

KNNETIVKFIDFGLSKQIEKN--------------------------------SKYYSFVGTDSHMAPEVKLQNGKAG--------SKSDIFCIGCTM
      .| |||||||.. ..                                  .....||   ||||.    .  .         |.||...|...
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

Kinase FNIPK-E.AA ULK 860-1103 21 1.1e-30 104.39 In-house 1-317 (329) Show / Hide
Range on Protein: 860-1103
Range on HMM: 1-317/329
Sequence Identity: 21% (68 aa)

WEIISTLGSGNFGKVFKAR-KINGIINGSKVSLCAIKKIEKKDKLKIK-----------LSTEVEILNKLK-------DNEHSMKYYGYGYDEDD-NLFI
....  ||.| ||||.|.| |...     .. ..|.|.|.|. . ...           |  |..|. |||        ...  |.| . .. .. |..|
YCLNHCLGKGSFGKVYKGRNKKTK--D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

YTEYIEGSTSISDLIKKKPN--------NRFEEEEIKSLMIKIVKALSKIHESGVIHRDIKSDHIILAQDK---------NNETIVKFIDFGLSKQIEKN
 .|| .| .  ...|||. .        .|..|.|... .. |. ..  .|. ..|||||| . | .  ..           . ..|  |||..|.....
IMEYCNGGD-LEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDND

----SKYYSFV------GTDSHMAPEVKLQNG---KAG-SKSDIFCIGCTMIEMAGLNLC-----HSER-----DDKGI------------PSIP-----
      ....|      ||   |||..  ..|   . . .|.||. .|| . ||            ..      . . .            . .|     
NMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

THLSNSFKNIIQNCLKFDTNAR
 ..|. .|..|. .|..| . |
PQISPECKDLIRRMLQYDEKDR

Kinase FNIPK-E.AA TKL 866-1113 15 7.9e-30 104.59 In-house 1-364 (364) Show / Hide
Range on Protein: 866-1113
Range on HMM: 1-364/364
Sequence Identity: 15% (60 aa)

LGSGNFGKVFKA--RKINGIINGSKV----SLCAIKKIEKKDKLK--------------------------IKLSTEVEILNKLK-DNEHSMKYYGYGYD
.||| ||.|.|.  | ..|              |.||. ...  .                          ..   |.||. ... . ..  ...||  .
IGSGGFGEVYKGKWRGWGG-KC---PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCC

EDD------------NLFIYTEYIEGSTSISDLIKKKPNNRFEEEEIKSLMIKIVKALSKIHESG--------VIHRDIKSDHIILAQDKN---------
...            .|.| .||..| .  ..|.          . . .... | ....  | ..        .||||.||. | . .. .         
PPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

-NETIVKFIDFGLSKQIEKNS--------------------KYYSFVGTDSHMAPEV---------------KLQNGKAGSKSDIFCIGCTMIEMAG---
 ..  .|  |||||. .....                    . .. .||  .|||||               .......  |.|..  |  . |..    
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

LNLCHSERDDKGI----------------PSIP------------THLSNSFKNIIQNCLKFDTNARHSVESLIITL
   .. ... ..                 | ||            ..   |.|...| | . | ..| | . .. .|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase FNIPK-E.AA NZAK 860-1016 34 1.6e-22 71.99 In-house 1-152 (329) Show / Hide
Range on Protein: 860-1016
Range on HMM: 1-152/329
Sequence Identity: 34% (56 aa)

WEIISTLGSGN-FGKVFKARKINGIINGSKVSLCAIKKIEKKDKLKIKLSTEVEILNKLKDNEHSMKYYG--YGYDEDD-NLFIYTEYIEGSTSISDLI-
|| ||..|... |..| | || |. |   .|   ..| | |.|  .     |. || |.       .||     ..||| . .|| |..||   ..... 
WEEISFIGGCQFFSRVKKCRKKNTEIANEQVDKVHCKIITKCDFFY----HETDILEKIRHFNI-PRYYSACIKHAEDDNYHCIYMEWMEGGN-LTQFLM

KKKPNNRFEEEEIKSLMIKIVKALSKIHESGVIHRDIKSDHIILAQDKNNETIVKFIDFGLS
..|   || | .| ...  |.. .|  |  ..|||||||  .||  |.| .  .| |||| |
NDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVIL--DFNKN--LKLIDFGSS

Kinase FNIPK-E.AA NZAK 1030-1109 31 5.3e-17 53.16 In-house 234-329 (329) Show / Hide
Range on Protein: 1030-1109
Range on HMM: 234-329/329
Sequence Identity: 31% (31 aa)

GTDSHMAPEVKLQNGKAGSKSDIFCIGCTMIEMAGLNLC------------HSERDDKGIPSIPTHLSNSFKNIIQNCLKFDTNAR-----HSVESL
||   ||||.| .| ..  |||.. .||| ..|.| |.              |..   .|| || |... .|..|. |.  | . |     | .| |
GTHHYMAPENK-NNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL

Kinase FNIPK-E.AA TyrKc 860-1113 18 3.4e-13 -9.33 SMART 1-280 (280) Show / Hide
Range on Protein: 860-1113
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

WEIISTLGSGNFGKVFKARKINGIINGSKVSLCAIKKIEKKDKLKIKLSTEVEILNKL-KDNEHSMKYYGYGYDE------DDNLFIYTEYIEGSTSISD
 . . .||.|.||.|.|.. .           .|.|.. .    .  .  | .|. || .....  . ||.  ..      .. |.| .|| ..  .  |
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKD

LIKKKPNNRFEEEEIKSLMIKIVKALSKIHESGVIHRDIKSDHIILAQDKNNETIVKFIDFGLSKQIEKN------SKYYSFVG-TDSH-------MAPE
 ..|. .. .  ..  | .. | .  . .|. ..||||.    . .. ..    .||  |||||. |.        ..||.  .  ...       ||||
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VKLQNGKAGSKSDIFCIGCTMIEMAGLNLCHSERDD-----------------KGIPSIPTH--------LSNSFKNIIQNCLKFDTNARHSVESLIITL
. .. ||  .|||..  | .| |.  . .. .   .                  . . .| .         .    .|.. | ..| . | . . ..  .
C-INYGKFTTKSDVWSFGVCMWEI--FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF





Kinase FNIPK-E.AA Pkinase_Tyr 860-991 18 7.3e-07 23.86 Pfam 1-137 (270) Show / Hide
Range on Protein: 860-991
Range on HMM: 1-137/270
Sequence Identity: 18% (26 aa)

WEIISTLGSGNFGKVFKARKINGIINGSKVSLCAIKKI--EKKDKL--KIKLSTEVEILNKLKDNEHSMKYYGYGYDEDDN--LFIYTEYIEGSTSISDL
 ... .||.|.||.|.|..       ...   .|.|..     ..   . ..  |..|. .| ....  ..||  .|...   ..| .|| ..  .  | 
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-DLLDY

IKKK--PNNRFEEEEIKSLMIKIVKALSKIHESGVIHRDI
 .|.  .....  ... .  . | |...  .. . ||||.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase FNIPK-E.AA STE20 1081-1109 27 0.047844 3.63 In-house 254-282 (288) Show / Hide
Range on Protein: 1081-1109
Range on HMM: 254-282/288
Sequence Identity: 27% (8 aa)

PTHLSNSFKNIIQNCLKFDTNARHSVESL
|.. | .|.. . .||  | . | ... |
PHKWSPEFHDFVDKCLQKDPEKRPTASQL

FNIP FNIPK-E.AA FNIP 1160-1202 34 2.2e-09 36.41 Pfam 1-46 (46) Show / Hide
Range on Protein: 1160-1202
Range on HMM: 1-46/46
Sequence Identity: 34% (16 aa)

YNQM-ITPGALPPSVQYLLF-NKLNQYLE-CDSIPESVKYLDLGNE
.||  ...| ||.|. .| | .  || .|  ...| |.|.| .|. 
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC

FNIP FNIPK-E.AA FNIP 1224-1268 29 3e-06 25.5 Pfam 1-46 (46) Show / Hide
Range on Protein: 1224-1268
Range on HMM: 1-46/46
Sequence Identity: 29% (14 aa)

FNFTQP-VSQRLLPYSVTDLQL-YNYNINLK-RNSIPTLVTSLTLGSN
||  ||   .  || |.. |.. .|.|  ..  |..|  ...|..|..
FN--QPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC