MkcF

Species: Slime mold
Alias: DdisK162, DDB0229970, MkcF
External Links: DictyBase Link ,
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MKC

Sequence

Name Sequence Type Origin Length Description Download
MkcF.AA Protein None 677 None Fasta, JSON
MkcF.kin_dom Protein Kinase Domain None 246 None Fasta, JSON

Protein domain

Protein domains of MkcF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MkcF.AA SH3 2-57 34 2.9e-13 51.33 SMART 1-58 (58) Show / Hide
Range on Protein: 2-57
Range on HMM: 1-58/58
Sequence Identity: 34% (20 aa)

LYLVATGDYKGPSENHLSFTKGQRIEFLERTENGFIKGKLD--GKVGIFPSSLITIET
 | .|  ||.. ....|||.||. |. ||....|  ||...  |..|.|||. ... .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID

SH3_2 MkcF.AA SH3_2 3-56 20 4e-10 38.33 Pfam 1-68 (68) Show / Hide
Range on Protein: 3-56
Range on HMM: 1-68/68
Sequence Identity: 20% (14 aa)

YLVATGDYKG-PSENH-----LSFTKGQRIEFL---ERTENGFIKG-KL--DGKV--GIFPSSLITIE
| ... ||.. ...|.     |.|.||. |. .   ..  ......     .|..  | |||. . . 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC

SH3_1 MkcF.AA SH3_1 5-50 36 1e-06 25.48 Pfam 1-49 (49) Show / Hide
Range on Protein: 5-50
Range on HMM: 1-49/49
Sequence Identity: 36% (18 aa)

VATGDYKGPSENHLSFTKGQRIEFLERTEN-GFIKGKLD--GKVGIFPS
||  ||.. ....|||.||  |. .|.... .  ||...  |..|.|||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS

Kinase MkcF.AA MKC 401-646 49 3.5e-191 641.44 In-house 1-260 (260) Show / Hide
Range on Protein: 401-646
Range on HMM: 1-260/260
Sequence Identity: 49% (129 aa)

IKFTHMVGRGQYGKVYDALY-------DKKRVCVKVVNYSTPKEQHNVLQEIGFLTQCDHPNILKYNCSVLYGS-DLFIVSEFIQGGTLEQASASSHVFK
.||.|.||.|..|.||.|.|       ||.||..|.....|.|.|.|.|.|||||..|.||||.||.||..... ....|.||.||||||.||..||.|.
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFC

ETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEK-GGSQHMVGSPYYMSPEMIRGEECSYPSDIWSFGICILELLFKKPP
|........|.|....||||....|||.|.||.|..||||.||||||||..|.. ....||.|||..||||||.....|||.||||||||.||.....||
ESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHEKEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRPP

HRDSRMKAMFYNAINGIDFP-----KIRCSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF
|..|||||||..|.||..||     ....|....|.||||....|.||.|...|..|||.
HHKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI

Kinase MkcF.AA STE20 401-646 34 3.6e-108 365.68 In-house 1-288 (288) Show / Hide
Range on Protein: 401-646
Range on HMM: 1-288/288
Sequence Identity: 34% (99 aa)

IKFTHMVGRGQYGKVYDALYDK---KR----VCVKVVNYSTP----KEQHNVLQEIGFLTQCDHPNILKYNCSVLYG----SDLFIVSEFIQGGTLEQAS
 .... .|.| ||||| | |.|   .     |..|..|....    .|......|| .. ||.|||| || .| |..    ..|.|| |. .||.| .. 
YELLEKIGQGSYGKVYKA-YHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

ASS---------HVFKETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEK-------GGSQHMVGSPYYMSPEMIRG---
  .         |...| |. .|  |.|.. .|||... |||||||.|.....||||||.|||.||...|       .  ...||.||.|.||.|..   
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--EECSYPSDIWSFGICILELLFKKPPHRD-SRMKAMFYNAINGIDFP------KIRCSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF
   .  | .||||.||...|..  .||..| ..|.|||. . |. ..|      . ..| ...|....| . .|||| |...|..|||.
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI

Kinase MkcF.AA STE 401-646 23 2.4e-91 309.76 In-house 1-359 (359) Show / Hide
Range on Protein: 401-646
Range on HMM: 1-359/359
Sequence Identity: 23% (86 aa)

IKFTHMVGRGQYGKVYDALYD-----------------KKRVCVKVVNYSTP-----------------KEQHNVLQEIGFLTQCD--HPNILKYNCSVL
 ..  ..|.| .|.|| |..                  .... .|..|...                  .|. ..|.|| .. .|.  |||| || .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YG-------SDLFIVSEFIQGGTLEQASASS--------------HVFKETQVGFIGLELLKA-ISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCA
..       ..|.|. |.. ||.|..   .               |.|.|.|...|  ..||.  .|||... ||||||.||...     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

SVEK------------------GGSQHMVGSPYYMSPEMIRGEE------CSYPSDIWSFGICILELLFKKPPHRD-SRMKAMFYNAING----------
....                  . ....||.| .|.||.|....      ... .||||.|..|.|..  |||. | . |.|||. ..|.          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---IDFPKI---------------------RCSIDLKDMLWQCFESNPEKRSTVDKLMR--HPFF
    . |..                     ..| ..|| . .|.. .|.|| |...|..  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase MkcF.AA S_TKc 401-646 26 5.2e-73 249.79 SMART 1-231 (231) Show / Hide
Range on Protein: 401-646
Range on HMM: 1-231/231
Sequence Identity: 26% (69 aa)

IKFTHMVGRGQYGKVYDALYDK--KRVCVKVVNYSTPKEQHNVLQEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQG--GTLEQASASSHV------
 ..   .|.| .|||| .   |  ..| .|...        ....||  | . .|||| |.  .    ..|..| |.. |  |.| .   .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FKETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKGGSQHMVGSPYYMSPEMIRGEECSY-PSDIWSFGICILELLFKK
| | .. |.  ....|. |.|... ||||.| .|.....  ..|..||||.. .      ...|.|.||.||..     .. ..|.||.|... |.|  .
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

PPHRDSRMKAMFYNAINGIDFPKIRCSIDLKDMLWQCFESNPEKRSTVDKLMR-------HPFF
|| .   |..|| .            | ..||.. .|.. .|||| |. ....       ||.|
PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase MkcF.AA Pkinase 401-646 23 2e-63 221.85 Pfam 1-293 (293) Show / Hide
Range on Protein: 401-646
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

IKFTHMVGRGQYGKVYDALYDKKR--VCVKVVNYSTPKE---QHNVL-QEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQGG----TLEQASA--SS
...   .|.| .|.|| .   . .  |.||...... |.   |.... .||  .  ..||||... ... ..... .| |. .||     |       ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HVF--KETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEV----KLIDFGLCA---SVEKGGSQHMVGSPYYMSPEMIR-GEECSYPSDIWSF
 .|   | .. |. ...|... |.|... ||||.| .|.... .|..    |..||||..      ..  .. .|.|.||.|| || |.. ....|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GICILELLFKKPPHRDS------RMKAMFYNAIN---GIDFPKIRC------------------SIDLKDMLWQCFESNPEKRSTVDKLMRHPFF
|. . |.|...|| ...      ....|...        |.|. ..                  | ..|| .  |.. .|.|| | . .. ||.|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase MkcF.AA Ciliate-E2 401-646 21 2e-55 188.71 In-house 1-365 (365) Show / Hide
Range on Protein: 401-646
Range on HMM: 1-365/365
Sequence Identity: 21% (83 aa)

IKFTHMVGRGQYGKVYDA-------LY------------------DKKRVCVKVVNYSTPKEQHN---VLQEIG----------FLTQCDHPNILKYNCS
.||  . |.|..|.|| .       ..                  ..| . .|... .  ... .   ...||            | | .||||.|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VL--YGSDLFIVSEFIQGGTLEQ-----ASASSHV------FKETQVGFIGLELLK---------------AISYLHEKK-LIHRDIKAANVMVSTDGEV
      . ...| |..|||.|..        . |       |.| ....|  ..|.               |. |||.|.  ||||||  |...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLIDFGLCASVEKG------GSQHM---------------------------VGSPYYMSPEMIRGEE---------CSYPSDIWSFGICILELLFKKPP
|.|||||.  . .       ..|.                            .|.|.||.||...|..          .| .||||.|... |.||.|||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

HRDSRMKAMFYNAING--IDFP-----------------KIRCSIDLKDMLWQ----CFESNPEKRST-VDKLMRHPFF
          .. |    ||||                 .  .| . ||.. .    ... .|||| |  .... ||.|
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase MkcF.AA YSK 402-646 34 3.8e-54 161.25 In-house 2-257 (257) Show / Hide
Range on Protein: 402-646
Range on HMM: 2-257/257
Sequence Identity: 34% (89 aa)

KFTHMVGRGQYGKVYDALYDK--KRVCVKVVNYSTPKEQ-HNVLQEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQGGTLEQASASS--HVFKETQV
. .  .|||..| || .   .  . | .|...     .    . ||| || ||| |.| ||  | | .. | |. |.  || . .   ..    | |...
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYI

GFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVE--KGGSQHMVGSPYYMSPEMIRGEECSYPS--DIWSFGICILELLFKKPPH
..|  |.||. .|||. . |||||||||| .| .|.||| |||  . .       . .||.||.| || |  |  .| .  |||| ||  .|..   ||.
AIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPY

RDSR-MKAMFYNAINGIDFPKIRC---SIDLKDMLWQCFESNPEKRSTVDKLMRHPFF
 |   |..||   |     ||      |  .|.    | . .||.| . . |  | | 
CDYHPMRVMF--LIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI

Kinase MkcF.AA PAKA 402-646 32 1.2e-51 177.9 In-house 2-260 (260) Show / Hide
Range on Protein: 402-646
Range on HMM: 2-260/260
Sequence Identity: 32% (85 aa)

KFTHMVGRGQYGKVYDALYDKKR----VCVKVVNYSTPKEQHNVLQEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQGGTL----EQASASSHV-FK
||.  .| |  |.|| |   |      | .|. | ...    ... ||. . .| |.|| .|  | |. ..|..| |. .|| |    .|   .  . ..
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

ETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKGGSQH--MVGSPYYMSPEMIRGEECSYPSDIWSFGICILELLFKKP
| |....  | |......|.|. ||||||  |. . .||.||. ||| ||  ..  ..   ||| ||.|.|| ||. . ..  |||| || ..|..   |
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PH-RDSRMKAMFYNAINGIDFPKIR----CSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF
|. ..   .||.. | ||.  |.|.     | ...| | .| . ....| ....|..|||.
PYLNEPPLRAMYLIATNGK--PDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL

Kinase MkcF.AA CAMK 406-646 16 1.2e-51 164.25 In-house 1-425 (425) Show / Hide
Range on Protein: 406-646
Range on HMM: 1-425/425
Sequence Identity: 16% (70 aa)

MVGRGQYGKVYDALY--DK------------KRVCVKVVNYS----------------------------TPKEQHNVLQEIGFLTQC-------DHPNI
  |||..|||. .    ..            ..| .|... .                            .|| ..||..||  . ..       |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKYNCSVL-----------------YGS---DLFIVS---EFIQGG----TLEQASASS---------------HVFKETQVGFIGLELLKAISYLHEKK
.|                       . .   ....|    |...||     | .   .                . |.| .. ..   .. |. |.|...
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LIHRDIKAANVMVSTD-----------------GEVKLIDFGLCASVEKGGSQH-------------------------MVGSPYYMS-PEMIRG-----
 .|||.|  |......                 . .|.||||. . ...| ...                         ..|.|.||. ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EECSYPSDIWSFGICILELLFKKPPHRDS-------------RMKAMFYNAINGI-DFPKIR-----------------------CSIDLK
         . .....|.|| |.    .|  .|| ...              .. .| . ..|  |||                          .| . |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DMLWQCFESNPEKRSTVDKLMRHPFF
|.. .. . .|||| |..  ..||..
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase MkcF.AA Ciliate-E2-Unclassified 401-646 22 1.3e-50 173.81 In-house 1-352 (352) Show / Hide
Range on Protein: 401-646
Range on HMM: 1-352/352
Sequence Identity: 22% (79 aa)

IKFTHMVGRGQYGKVYDALYDKKRVCV--------------KVVNYS--------TPKEQH--------NVLQEIGFLTQCDHPNILKYNCSVLYGSDLF
 |. .  |.|..|||| .  .|.   .              | ....        . ...           .|.   | ...||.|.|.         ..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQ--ILLNHPHPFIVKMFYCFQDKQNIY

IVSEFIQGGTLEQASASS-----------------HVFKETQVG-----FIGLELLKAISYLHEKK-LIHRDIKAANVMVSTDG---EVKLIDFGLCASV
|| |...||.|.|   ..                 . | | |.      |.  ..|....|||.|.  ||||||  |.... .|   ..|.||||..   
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

E-----KGG-------------SQHMVGSPYYM----SPEMIRGEECS----YPSDIWSFGICILELLFKKPPHRDSRMKA---------------MFYN
.     . .             .....|.|.||    .||...|.. .    | .||||.|... |.|| ..|  |   .                ..|.
QQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

AING--IDFPK-------IRCSIDLKDMLW----QCFESNPEKRSTVDKLMRHPFF
 |.   |.|||        . |   ||..     .... ||.|| | .... ||.|
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase MkcF.AA SLK 402-646 30 4.2e-47 156.88 In-house 2-259 (259) Show / Hide
Range on Protein: 402-646
Range on HMM: 2-259/259
Sequence Identity: 30% (79 aa)

KFTHMVGRGQYGKVYDALYDKKRV--CVKVVNYSTPKEQHNVLQEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQGGTLEQASAS-SHVFKETQVGF
.    .| | .|||| |    ..|    |...     |  . . ||  |..|.||||.|   .  |  .|... || .|| ...      |. .| |. .
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

IGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKGGSQH--MVGSPYYMSPEMIRGEECS-----YPSDIWSFGICILELLFKKPP
.. ... |. .||..|.||||.|| |...  ||.|.| |||  |  ..   ..   .| ||.| ||..  |        | .||||.|| ..|.    ||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

HRD-SRMKAMFYNAINGIDFPKI----RCSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF
| . . |. ..   |.  . |..    . | . ||.| .| . .|..| | ..||.|...
HHEMNPMRVLL--KIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV

Kinase MkcF.AA TKL 407-644 18 3.3e-45 156.53 In-house 1-364 (364) Show / Hide
Range on Protein: 407-644
Range on HMM: 1-364/364
Sequence Identity: 18% (69 aa)

VGRGQYGKVYDALYDK----------KRVCVKVVNYS------------------------TPKEQHNVLQEIGFLTQ---CDHPNILKYNCSVLYGSD-
.|.| .|.|| . .            | | ||. .                           |. ...  .|.  . .   ..||||...  ....... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFIVSEFIQGGT-LEQASASSHVFKETQVGFIGLELLKAISYLHE--------KKLIHRDIKAANVMVSTDGE--------------V
            |.|| |...||. |..           |   . |.  ....|||         ...||||.| .|..|  ...              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLIDFGLCASVEKGGSQHM---------------------VGSPYYMSPEMIRGE----------------ECSYPSDIWSFGICILELLFKKPPHRDSR
|. ||||. .... |.. .                     .|.|..|.||..||.                | |  .|..||||.. |.|  ..| .|  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

MK---------AMFYNAINGIDFPKIR--------------CSIDLKDMLWQCFESNPEKRSTVDKLMRHP
.          .||. ...    | |               |  ..|. . .| ...|||| . .... . 
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase MkcF.AA TyrKc 401-646 21 1.9e-17 59.48 SMART 1-280 (280) Show / Hide
Range on Protein: 401-646
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

IKFTHMVGRGQYGKVYDALYDKKRVCVKVVNYSTPKEQHNVLQEIGFLTQC--DHPNILKYNCSVLYG-------SDLFIVSEFIQGGTLEQA-SASSHV
|.. .. |.|..|.|| . ..   | ||... ..   .   ..|.  ...   .||||..    .. .         |.|| |.  .| | .   .. . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FKETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKG------GSQHMV----GSP-----YYMSPEMIRGEECSYPSDI
..  .   . .   .  .|||.|..||||. | |..|. .. ||  ||||.  .. .      ..  ..    |.        |.|| |.  ...  ||.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGICILELL-FKKPPHRD-----SRMKAMFYNAING--IDFPKI-------RCSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF
||||.|. |.. . ..|. .        . .. .  .|   . |.        .|. .. ..  || . .||.| |   .  | .|
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase MkcF.AA Pkinase_Tyr 505-586 34 5.6e-13 44.58 Pfam 122-208 (270) Show / Hide
Range on Protein: 505-586
Range on HMM: 122-208/270
Sequence Identity: 34% (30 aa)

KAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKGGSQ-HMVG---SPY-YMSPEMIRGEECSYPSDIWSFGICILELL
|. .||..|..||||. | |..|. .. ||  ||||.  ... .   .. |    |   |.|| |.  ...  ||.||||... |..
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF

Kinase MkcF.AA Pkinase_Tyr 401-481 24 6.9e-13 44.28 Pfam 1-94 (270) Show / Hide
Range on Protein: 401-481
Range on HMM: 1-94/270
Sequence Identity: 24% (23 aa)

IKFTHMVGRGQYGKVYDALYD------KKRVCVKVV-NYSTPKE--QHNVLQEIGFLTQC-DHPNILKYNCSVL-YGSD--LFIVSEFIQGGTL
|.| .. |.|..|.|| . ..      |  | ||.. .......  .   ..|.  ..|  .||||...   ..  |    ..|| |. ..| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL