Gene PakD (Slime mold)

PakD

Species: Slime mold
Alias: PakD, DdisK168, DDB0229968
External Links: DictyBase Link ,
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
PakD.AA Protein None 1678 None Fasta, JSON
PakD.kin_dom Protein Kinase Domain None 272 None Fasta, JSON

Protein domain

Protein domains of PakD.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CH PakD.AA CH 85-154 19 0.000108 20.1 Pfam 1-79 (119) Show / Hide 
Range on Protein: 85-154
Range on HMM: 1-79/119
Sequence Identity: 19% (16 aa)

ENDIKKWIGEKCSSSLS--DDFLE--KDLMESLCTGTILCVLINMIKQGT-I--QKIHLQP-NY---LQRVENIRNYLRAC
|... .|. ...       .   .  .........| .|| ||. .. |. |   |.  .| .     ...|||.. | .|
EKAFLRWCNRHLEKY-GHWGVPITPVNFFFTDWRDGVALCALIHKYCPGLLIDWKKV-FPPRMRKMPFHCMENINYALDFC
C1 PakD.AA C1 1142-1197 29 2.1e-11 45.13 SMART 1-61 (61) Show / Hide 
Range on Protein: 1142-1197
Range on HMM: 1-61/61
Sequence Identity: 29% (18 aa)

HSFVLKSFRIISECNYCRQYIWGVRGIVA-REAFECVGCKYKTHKKCLKEASEKT-----FC
|... ..|   . |..||..|||..  .. .....|  |||| ||||.. .....      |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PakD.AA C1_1 1142-1198 20 2e-06 27.18 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1142-1198
Range on HMM: 1-55/55
Sequence Identity: 20% (12 aa)

HSFVLK-SFRIISECNYCRQYIWGVRGIVAREAFECVGCKYKTHKKCLKEASEKTFCS
| .| . .|. .  |..|.. .   .|. .. .. |  |.|. |..| . .. .  |.
HHWVHHWNFKQPTFCCHCGEFC---WGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
PBD PakD.AA PBD 1201-1254 33 8.5e-09 33.52 Pfam 1-60 (60) Show / Hide 
Range on Protein: 1201-1254
Range on HMM: 1-60/60
Sequence Identity: 33% (20 aa)

NVGAP-FNVKHEMHVGLAI--Q---GLPSGWRTLLLQSGFQDYEIQQHQEDVLDVLEFHH
 ...| .|.|| ||||     .   |.|  |  || .|| .  | ... . |.||. |. 
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PakD.AA PBD 1202-1232 34 6.7e-05 23.52 SMART 1-38 (38) Show / Hide 
Range on Protein: 1202-1232
Range on HMM: 1-38/38
Sequence Identity: 34% (13 aa)

VGAPF-NVKHEMHVG------LAIQGLPSGWRTLLLQS
...|. |.|| .|||         .|||. |..||  .
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PakD.AA PAKA 1376-1647 52 7.1e-175 587.26 In-house 1-260 (260) Show / Hide 
Range on Protein: 1376-1647
Range on HMM: 1-260/260
Sequence Identity: 52% (146 aa)

YKVREVVGGGSTGKVYVGENSITGEK--VAIKKMKVDNNNIK-NIINEISTMKNSKHKNVIKYVSSHLVINH-IWLIMEYMSYGSLTDLISNCINIQCNG
||..| .| |..|.|||..|. |...  ||||.|...|.. | .|||||..||..||||...|..|.|| .. .|..||||..|.|||.|..|.||||| 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLV-DDELWVVMEYMEGGCLTDVITQCCNIQCN-

NNQQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTRKKLQRNSVVGTPYFMAPELIRGNQYNHKV
              |. |..|||.|...|||...||. ||.||||||||||||.||||||.||||.|.||.....||..|||||.||||.||..||..||
--------------YMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKV

DIWSLGILARELSEGEPPYAKYPPVRALFLLTLEGVPDFKEPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
|||||||.|.|. |||||| ..||.||..|.. .|.||.|.|.|||..| .|...||..|..||..|..||.||||
DIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PakD.AA STE20 1376-1647 43 1.5e-143 483.19 In-house 1-288 (288) Show / Hide 
Range on Protein: 1376-1647
Range on HMM: 1-288/288
Sequence Identity: 43% (130 aa)

YKVREVVGGGSTGKVYVGENSITGEK----VAIKKMKVDN-----NNIKNIINEISTMKNSKHKNVIKYVSSHLVI----NHIWLIMEYMSYGSLTDLIS
|.  |..| ||.||||.. .  |||.    ||||||....     . ...|..||| ||..||.|..||  |.|.     ...|..|||...|||||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

NCINIQCNGNNQQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTR-----KKLQRNSVVGTPYFM
.|.....|  .. .        . . |..|||||..|||| ||.|. |. |||||.|||||..||.||.||||. | ||.     .. .||..|||||.|
HCMKCGKN--HK-G--------HPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWM

APELIRG-----NQYNHKVDIWSLGILARELSEGEPPYAKYPPVRALFLLT--LEGVPDFKE--PNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
|||.|..     ..|..|.||||||| | |. ||||||....|.||.|. .   .. |..|.  |.|||..| .||..||. | . || |  ||.|||.
APEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PakD.AA STE 1376-1647 30 2.7e-118 399.28 In-house 1-359 (359) Show / Hide 
Range on Protein: 1376-1647
Range on HMM: 1-359/359
Sequence Identity: 30% (114 aa)

YKVREVVGGGSTGKVYVGENS------ITGEK---------VAIKKMKVDNNN------------------IKNIINEISTMKNSK--HKNVIKYVSSHL
..  |..| |..|.|| . |        |||.         .|||.|...|.|                  ...|..||..||...  |.|..||  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VI-------NHIWLIMEYMSYGSLTDLISNCINIQCNGNNQQQQQQQQQQQTYFIESHIAYICQQVLQG-MDYIHKGHRTHRDIKSDNILLGKDGSVKIA
.        ...|..||||..|||.|.| ..  .... |...|     . |..| || |||||.|.|.| ..|.|. |. |||||..||||     ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ-----H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLC

DFGFVANLTRK----------------KLQRNSVVGTPYFMAPELIRG------NQYNHKVDIWSLGILARELSEGEPPYAKYPPVRALFLLTLE-----
|||. ..|| .                . .||..|||| .|||| |..      ..|. |.||||||... |. .|.||.....| ||.|. . .     
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ

----------GVPDFKE-----------------PNKWSSDFIEFVNLCLNLDDKRRPDAHYLLR--HPFL
          . | ...                 | |||..|..|.|.||. | . ||.|. ||.  |||.
QFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PakD.AA S_TKc 1376-1647 27 2.2e-79 270.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 1376-1647
Range on HMM: 1-231/231
Sequence Identity: 27% (78 aa)

YKVREVVGGGSTGKVYVGENSITGEKVAIKKMKVDNNNIKNIINEISTMKNSKHKNVIKYVSSHLVINHIWLIMEYMSY--GSLTDLISNCINIQCNGNN
|.. ...| |. |||| . .  ||..||||..|      ..|..||. .|. .|.|..|.  .    .|....|||..   |.| |.| ..     .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR---

QQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTRKKLQRNSVVGTPYFMAPELIRGNQYNH-KVD
            .| | |......|......|.|. .  |||.| .|||| .   .||.|||. . |       ....|||..||||..   .|.. |.|
-----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCD

IWSLGILARELSEGEPPYAKYPPVRALFLLTLEGVPDFKEPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLR-------HPFL
.||.|..  |.  |.||.     . ..| . .            |.....|.. ||. | ..|| |  .|.       ||..
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PakD.AA FRAY 1376-1647 36 2.1e-77 239.88 In-house 1-277 (277) Show / Hide 
Range on Protein: 1376-1647
Range on HMM: 1-277/277
Sequence Identity: 36% (104 aa)

YKVREVVGGGSTGKVYVGENSITGEKVAIKKMKVDNNN---IKNIINEISTMKNSKHKNVIKYVSSHLVINHIWLIMEYMSYGSLTDLISNCINIQCNGN
|. .||.| | |. |.        |..|||    .  .   .. .| ||  |   .| ||..|  | .| . .||.| | . ||. |..   ..      
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEP--

NQQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTR-KKLQRN----SVVGTPYFMAPELIRGNQ-
          .|  | |  || |   ||.|..| ||  . |||||..|||.| ||.. |||||  | |     | |.      ||||  |||| .   . 
---------HKQGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCWMAPEVMEQVHG

YNHKVDIWSLGILARELSEGEPPYAKYPPVRALFLLT------LEGVPDFK-EPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
|. |.||||.||.| ||  | .||.||||   | |.       ||.  | |    |..  | . .  ||  | ..|| |  ||.| | 
YDFKADIWSFGITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase PakD.AA Pkinase 1376-1647 26 5.7e-74 256.85 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1376-1647
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

YKVREVVGGGSTGKVYVGENSITGEKVAIKKMKVDNNNIKNIIN-----EISTMKNSKHKNVIKYVSSHLVINHIWLIMEYMSYG----SLTDLISNCIN
|.. ...| || |.|| . .  ||..||.|..|..... .  ..     ||. ||. .|.|....  .    .||...|||.  |    .| |.||    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

IQCNGNNQQQQQQQQQQQTYF--IESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSV----KIADFGFVANL-TRKKLQRNSVVGTPYFMAP
               .... |   | ..  .. |.|.|..|.|.    |||.|..|||. ..| .    ||.|||. . . . ..   ....|||..|||
---------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP

ELIR-GNQYNHKVDIWSLGILARELSEGEPPYAKY----PPVRALFLLTLEGVPDFKEPNKWS---------------------SDFIEFVNLCLNLDDK
|.|| |. | .|||.||.|..  |.  |.||.       . .. .... . . |.....  |.                     .....|.. ||..| |
EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

RRPDAHYLLRHPFL
.|| |. .| ||..
KRPTAEQILQHPWF
Kinase PakD.AA MST 1487-1647 47 2.9e-71 225.76 In-house 94-254 (254) Show / Hide 
Range on Protein: 1487-1647
Range on HMM: 94-254/254
Sequence Identity: 47% (76 aa)

FIESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTRKKLQRNSVVGTPYFMAPELIRGNQYNHKVDIWSLGILARELSEG
. |  || |....||| .| |. .. |||||. |||| ..|  | ||||  . ||     ||.|.||||.|||| |  . |. |.||||||| | |. ||
LNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEG

EPPYAKYPPVRALFLLTLEGVPDFKEPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
.|||.   |.||.|.      | ||.| .||..|. ||  || ..   |. |  || ||| 
MPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PakD.AA YSK 1489-1647 45 8.7e-71 212.25 In-house 98-257 (257) Show / Hide 
Range on Protein: 1489-1647
Range on HMM: 98-257/257
Sequence Identity: 45% (74 aa)

ESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTRKKLQRNSVVGTPYFMAPELIRG--NQYNHKVDIWSLGILARELSEG
|..|| |   .|.| ||.|.    |||||. |.|| ..| ||..|||  . .|   . ||  |||||.||||.|     .|. |.||||||| | |.  |
EKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKG

EPPYAKYPPVRALFLLTLEGVPDFKEPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
||||..| | |..||.  .  |  .  ...|  |.|||..||| | . || |  || | | 
EPPYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PakD.AA PAKB 1489-1647 47 1.6e-53 184.09 In-house 94-252 (252) Show / Hide 
Range on Protein: 1489-1647
Range on HMM: 94-252/252
Sequence Identity: 47% (76 aa)

ESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTRKKLQRNSVVGTPYFMAPELIRGNQYNHKVDIWSLGILARELSEGEP
|  ||..|.|||| ..| |     ||||||| ||| .|| ||  |||| | . .   .| | ||||| ||||.|    |  .||||||||.  |. .|||
EEQIATVCRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEP

PYAKYPPVRALFLLTLEGVPDFKEPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
||   ||..|.  .  .  | .|.  | |.   ||.. .|  | ..|  |. |||||||
PYFNEPPLQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PakD.AA KHS 1489-1647 46 1.4e-52 175.15 In-house 95-258 (258) Show / Hide 
Range on Protein: 1489-1647
Range on HMM: 95-258/258
Sequence Identity: 46% (77 aa)

ESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTRKKLQRNSVVGTPYFMAPELI---RGNQYNHKVDIWSLGILARELSE
|  |||.|...|||..|.|   . |||||  |||| ..| ||.||||  |..|    .| | .||||.||||     |   ||.  |||..|| | ||.|
ELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAE

GEPPYAKYPPVRALFLLTLEGV--PDFKEPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
  ||     |.|||||.|  .   |  |. .|||. | .|| ..|  . |.|| |. ||.|||.
LQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PakD.AA MSN 1489-1647 42 2.3e-52 171.12 In-house 103-265 (265) Show / Hide 
Range on Protein: 1489-1647
Range on HMM: 103-265/265
Sequence Identity: 42% (69 aa)

ESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTRKKLQRNSVVGTPYFMAPELIRGNQ-----YNHKVDIWSLGILAREL
|  |||||  .|.|. ..|. .  |||||  |.|| ..  ||. |||  | | |    ||. .||||.|||| |         | .. |.||.|| | |.
EDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAIEM

SEGEPPYAKYPPVRALFLLTLEGVPDFKEPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
 ||.||  .  |.|||||.  .  |  |   |||  | .|.. ||  . . ||... .|.|||.
AEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase PakD.AA MKC 1487-1647 38 3.7e-50 172.95 In-house 99-260 (260) Show / Hide 
Range on Protein: 1487-1647
Range on HMM: 99-260/260
Sequence Identity: 38% (64 aa)

FIESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTR-KKLQRNSVVGTPYFMAPELIRGNQYNHKVDIWSLGILARELSE
| || |||.|  .||| .| |. .  |||.|| ||    || .|. |||. ....  |....   .| |..|.|| |...|.   .||||.|| . |.  
FCESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHEKEEIH--MCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMAN

GEPPYAKYPPVRALFLLTLEGVPD---FKEPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL
|.||. |  .. | |.   .|. .   |. | .|| .|  | ..||  |   || |  ||.|||.
GRPPHHK-SRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase PakD.AA TyrKc 1376-1647 20 3.9e-26 94.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 1376-1647
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YKVREVVGGGSTGKVYVGENSITGEKVAIKKMKVDNNNIKNIINEISTMKNS--KHKNVIKYVSSHLVI-------NHIWLIMEYMSYGSLTDLISNCIN
 .  .. | |  |.|| |. .   ..||.|..| |   .. ...|.. |..   .|.|... .   .           ....||||..|.| | . .. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

IQCNGNNQQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFGFVANLTRK-------KLQRNSV--VGT---P
                    .  ..  ..| |. .||.|.|. .  |||.   |.|.|... |||.|||   ... .       .  | .    |    |
K-------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

YF-MAPELIRGNQYNHKVDIWSLGILAREL-SEGEPPYAK-----YPPVRALFLLTLEGVPDFKEPNK------WSSDFIEFVNLCLNLDDKRRPDAHYL
.  |||| |. . ...| |.|| |..  |. . |..||        .. ... ..   . ..  . .        ...  .    | . | . ||    .
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

LRHPFL
  | ..
--HECF
Kinase PakD.AA MST 1376-1461 39 3.8e-20 60.67 In-house 1-87 (254) Show / Hide 
Range on Protein: 1376-1461
Range on HMM: 1-87/254
Sequence Identity: 39% (35 aa)

YKVREVVGGGSTGKVYVGENSITGEKVAIKKMKVDNNNIKNIINEISTMKNSKHKNVIKYVSSHL--VINHIWLIMEYMSYGSLTDLI
. . |  | || |.||   .  ||. ||||...| |. . .||.|||.|.. | |.. ||  | .    ||.|..|||   ||. |..
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV-NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIM
Kinase PakD.AA Pkinase_Tyr 1376-1535 22 1.4e-18 63.6 Pfam 93-248 (270) Show / Hide 
Range on Protein: 1376-1535
Range on HMM: 93-248/270
Sequence Identity: 22% (40 aa)

YKVREVVGGGSTGKVYVGENS----ITGEKVAIKKM--KVDNNN--IKNIINEISTMKNS-KHKNVIKYVSSHLVI-----NHIWLIMEYMSYGSLTDLI
 .  .. | |. |.|| |.       |. .||.|..  . .  .  ..  ..|...||.  .|.|.....    ..     |.|...|||| .|.| |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY--GVCTDQGEPNQIYIVMEYMPHGDLLDYL

SNCINIQCNGNNQQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIHKGHRTHRDIKSDNILLGKDGSVKIADFG
 .                   ..  .  ...  .|.|. .||.| .  .  |||.   |.|..... |||.|||
RKHR----------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase PakD.AA KHS 1376-1460 33 4e-17 54.03 In-house 1-86 (258) Show / Hide 
Range on Protein: 1376-1460
Range on HMM: 1-86/258
Sequence Identity: 33% (29 aa)

YKVREVVGGGSTGKVYVGENSITGEKVAIKKMKVD-NNNIKNIINEISTMKNSKHKNVIKYVSSHLVINHIWLIMEYMSYGSLTDL
| .   ||.|  | ||   .  ..| .|.| .|.. ..... |  ||  ||. .| |.. |  | |  ...|..|||   ||| |.
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDI
Kinase PakD.AA PAKB 1373-1462 35 1.1e-14 49.75 In-house 1-88 (252) Show / Hide 
Range on Protein: 1373-1462
Range on HMM: 1-88/252
Sequence Identity: 35% (32 aa)

IDLYKVREVVGGGSTGKVYVGENSITGEKVAIKKMKVDNNNIKNII-NEISTMKNSKHKNVIKYVSSHLVINHIWLIMEYMSYGSLTDLIS
 | |.    .| |||| | .  .  ||  ||.|||            ||.. | . .|.|...  ||.|| .  | .||.|  |.||| ..
LDNYV---KIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVT
Kinase PakD.AA MSN 1376-1463 33 1.4e-14 44.28 In-house 1-95 (265) Show / Hide 
Range on Protein: 1376-1463
Range on HMM: 1-95/265
Sequence Identity: 33% (32 aa)

YKVREVVGGGSTGKVYVGENSITGEKVAIKKMKVDNNNIKNIINEISTM-KNSKHKNVIKYVSSHLVIN------HIWLIMEYMSYGSLTDLISN
... |||| |  |.|| |    ||. .||| |.| ...  .|  ||  . | | |.|.. |    .  .       .|..||. . ||.|||. .
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKM
Kinase PakD.AA YSK 1376-1461 34 8.6e-14 37.55 In-house 1-88 (257) Show / Hide 
Range on Protein: 1376-1461
Range on HMM: 1-88/257
Sequence Identity: 34% (30 aa)

YKVREVVGGGSTGKVYVGENSITGEKVAIK--KMKVDNNNIKNIINEISTMKNSKHKNVIKYVSSHLVINHIWLIMEYMSYGSLTDLI
..  |..| || | || | .  |.. ||||      .   |  |  ||      .  .. ||  | |    .| ||||   ||. ||.
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLM
Kinase PakD.AA MKC 1376-1463 34 6.2e-11 37.4 In-house 1-95 (260) Show / Hide 
Range on Protein: 1376-1463
Range on HMM: 1-95/260
Sequence Identity: 34% (33 aa)

YKVREVVGGGSTGKVYVGEN-----SITGEKVAIKKMK-VDNNNIKNIINEISTMKNSKHKNVIKYVSSHLVIN-HIWLIMEYMSYGSLTDLISN
|| .. || |  |.||   .           ||||||  |     .|  |||.  .  .| | .||  ||.. .  || .||.|. | |.. ..|
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQN
Kinase PakD.AA Pkinase_Tyr 1557-1579 47 0.000203 15.59 Pfam 181-203 (270) Show / Hide 
Range on Protein: 1557-1579
Range on HMM: 181-203/270
Sequence Identity: 47% (11 aa)

MAPELIRGNQYNHKVDIWSLGIL
|||| |. . ...| |.|| |.|
MAPECINYGKFTTKSDVWSFGVL