Gene PakF (Slime mold)

PakF

Species: Slime mold
Alias: PakF, DDB0229410, DdisK170
External Links: DictyBase Link ,
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKL

Sequence

Name Sequence Type Origin Length Description Download
PakF.AA Protein None 1176 None Fasta, JSON
PakF.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of PakF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PakF.AA PBD 369-385 50 0.000308 17.72 Pfam 1-18 (60) Show / Hide 
Range on Protein: 369-385
Range on HMM: 1-18/60
Sequence Identity: 50% (9 aa)

EISVP-YNVIHKMHVDFD
.|| | .|. |.||| .|
MISTPLTNFKHTMHVGWD
Kinase PakF.AA PAKL 394-646 68 1.8e-220 738.75 In-house 1-256 (256) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-256/256
Sequence Identity: 68% (176 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKES-ESVSLQNEINILKNCKSPNIVSYFGSLQTE-SHIWILLDFCALGSIRDIIESTEKTLNEAQI
|...||||.|.||||||..|||..|.|||||||.||| |......||.|||.||.|||||||||.|.. .|.|||.|.|.||||.|..||..|||||.||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

SFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALD-QSKEMIGTPLWMAPEVILKKNYDYKADIWSLGITIIEMADGLPPHI
|.....|||||.||||.||||||.||||.||.|.|.|||||||||..|....| |...|||||.|||||.|.|.||..|.||||||||.||||||.|||.
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHY

DLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
|.||||||.|.||||||||..||.|||..|||||.|.|||||||.||||||||||.
DMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase PakF.AA STE20 394-646 45 1.5e-149 503.17 In-house 1-288 (288) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-288/288
Sequence Identity: 45% (130 aa)

FILDEKLGDGAYGSVYKGTHKDLGFT----LAIKVIEMKES----ESV-SLQNEINILKNCKSPNIVSYFGSLQTE----SHIWILLDFCALGSIRDIIE
. | ||.| |.||.|||..||. |       |||......     ... ..|.||.|.|.||.||||.|.|| . .    ...||. ..|. ||..||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---STEK-----TLNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNG----ALD-QSKEMIGTPLWMAPEVILK----
   ...|     ..||.||... ...|.|| ||||..|||||.||.|.||.|  .||.|||||. .|.     . . . . ..||| |||||||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KNYDYKADIWSLGITIIEMADGLPPHIDLPPMRAMKMVP--NWPPPTFAE--PKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
 |.||||.||||||||.||||.| ||. |..||||| |.|  . ||||. .  |.|||| ..||...||.||||||... .|| |||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PakF.AA STE 394-646 33 3.5e-127 428.81 In-house 1-359 (359) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-359/359
Sequence Identity: 33% (123 aa)

FILDEKLGDGAYGSVYKGTHKD---------------LGFTLAIKVIEMKE------------------SESVSLQNEINILKNCK--SPNIVSYFGSLQ
. . ||.| ||.|.|||. ...                |.  |||......                  .|  ....||.|.|.|.  .|||| |.|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TE-------SHIWILLDFCALGSIRDIIE---STEKTLN----------EAQISFVVKNTLKG-LIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSE
 |       ...|| . ... ||..|||.   .. |.||          | ||..... .||| | ||||..|||||.|.||.||     ||..||||. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLNGALD----------------QSKEMIGTPLWMAPEVILK------KNYDYKADIWSLGITIIEMADGLPPHIDLPPMRAMKMVP--N----------
.|.  ..                ... ..||| |||||||..      | ||.|.||||||.||||||.| ||. |..||||| | |  .          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---WPPPTFAE-----------------PKKWSPLLNDFLARCLVKDPEKRASPIDLLC--HPFL
    |||.. .                 |.|||| ..||...||.|||.||... .||   |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PakF.AA MST 394-646 50 7.4e-126 402.05 In-house 1-254 (254) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-254/254
Sequence Identity: 50% (129 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVSLQNEINILKNCKSPNIVSYFGSLQ--TESHIWILLDFCALGSIRDIIESTEKTLNEAQI
| . |||| |.|||||| .||  |  .|||..   ..   .. .||.|...|||..|| |.||     ..|.||   .|. ||. ||.  | .||||.||
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV-NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQI

SFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNG--ALDQSKEMIGTPLWMAPEVILKKNYDYKADIWSLGITIIEMADGLPPH
. . ..||.|| |||.  .|||| ||.| ||..    | ||||||  |    |  ..   |||| ||||||| .  ||.||||||||||.|||| | || 
ACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNT--VIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPY

IDLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
 |. |||||.| |  ||||| .| .||. .|||...||.|.||.|..  .|| ||| 
SDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PakF.AA YSK 394-646 43 7.4e-107 322.82 In-house 1-257 (257) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-257/257
Sequence Identity: 43% (111 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESES--VSLQNEINILKNCKSPNIVSYFGSLQTESHIWILLDFCALGSIRDIIES-TEKTLNEAQ
|   |. | | .| ||||  .  . . |||.|.  ..|     .| ||..|  |.||.|  |.||    . .||   .|. ||..| . .     . | .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

ISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALDQSKEMIGTPLWMAPEVILK--KNYDYKADIWSLGITIIEMADGLPP
|... .  |||| ||||.. ||||.|||||||||  |||..||||. ...        ..||| ||||||| .    ||.|||||||||| .||| |.||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

HIDLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
. |. |||.|  .|  .||.    ...|  . .| . ||.||||.| |  .|| | | 
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PakF.AA PAKA 394-646 40 2.6e-95 322.97 In-house 1-260 (260) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-260/260
Sequence Identity: 40% (106 aa)

FILDEKLGDGAYGSVYKGTHKDLGFT--LAIKVIEMKESESV-SLQNEINILKNCKSPNIVSYFGSLQTESHIWILLDFCALGSIRDIIESTEK----TL
.   ||.| || |.||..| .  . .   |||...||.  .   . ||| ..|.|| .||| |  |   .. .|. ... . |.  |.|. ...    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

NEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALDQSKEMIGTPLWMAPEVILKKNYDYKADIWSLGITIIEMADGL
.|.||..|.. .|.|| ..||...||||.|  |.||    .|||.|||    |.    . . | ||| |||||||..|.||.| ||||||| .|||..| 
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPHIDLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
||... || |||  . .   | . .| |||. ..|||..|| .|...|||  .|| ||||
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PakF.AA S_TKc 394-646 32 1.3e-93 318.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVSLQNEINILKNCKSPNIVSYFGSLQTESHIWILLDFCAL--GSIRDIIESTEK-----TL
. . .|.| ||.|.|||..||. |   |||.|        ....||.|||. . |||| .... |. .|... ...|    |. .|.|..  .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALDQSKEMIGTPLWMAPEVILKKNYDY-KADIWSLGITIIEMADG
.| .. |... ....| |.||..|||||.| .|.||.|   .||.|||.. .|       . ..||| .|||||.    |.. |.|.||.|....||. |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

LPPHIDLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLC-------HPFL
 ||     ... .|..              || . ||. .||.|||||| .  ..|        ||..
YPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PakF.AA SLK 395-646 43 1.3e-87 295.65 In-house 3-259 (259) Show / Hide 
Range on Protein: 395-646
Range on HMM: 3-259/259
Sequence Identity: 43% (113 aa)

ILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVS-LQNEINILKNCKSPNIVSYFGSLQTESHIWILLDFCALGSIRDIIESTEKTLNEAQISF
|. | |||||.| |||  ||. .   | |.||.|. | ..    ||.|| .|| ||||  ...   . ..|....||. | .  |.   |..| | || .
IIGE-LGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

VVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALDQSKEMIGTPLWMAPEVIL-----KKNYDYKADIWSLGITIIEMADGLPP
| | .. .| .|||...||||.|| |.|.    ||..|||||| |.   ...    |||| ||||||..      . |||||||||||||.||||.. ||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

HIDLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
| .. ||| .  .    ||| ..| .||   .||| .||||||..| .  .|. |...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase PakF.AA KHS 394-646 42 2.7e-85 286.82 In-house 1-258 (258) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-258/258
Sequence Identity: 42% (111 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVS-LQNEINILKNCKSPNIVSYFGSLQTESHIWILLDFCALGSIRDIIESTEKTLNEAQIS
. |  ..| | || |||  ..  .   |.||| |  .. .. .| || ..|.|. ||||.||||   . ..|| ...|  ||. || . | . |.| ||.
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGP-LSELQIA

FVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALDQSKEMIGTPLWMAPEVI---LKKNYDYKADIWSLGITIIEMADGLPPH
.| ..||.|| ||||.  .|||.| ||.||..  |||.|||||| ..  .. . |  |||| ||||||     |  |.   |||..||| ||.|.  || 
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

IDLPPMRAMKMVP--NWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
 || ||||. ..   |. ||.  . .|||.   .|.  .|.|.| || ..  || |||.
FDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PakF.AA Pkinase 394-646 29 1.4e-81 282.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVSLQN-----EINILKNCKSPNIVSYFGSLQTESHIWILLDFCALG----SIRDIIE-STE
. . .|.| |..|.|||..||. | . |.|.|. .. .|  .|.     || |.|....|||| .... ....||.. ...|  |    .  |.|. . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KTL--NEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDV----KIADFGVSEKL-NGALDQSKEMIGTPLWMAPEVIL-KKNYDYKADIWSL
...   | .. |... .|.|| |.||..|||||.| .|.|... ...    ||.|||..... .      .   ||| .||||||.  . |..|.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GITIIEMADGLPPHIDL----PPMRAMKMVPNWPPPTFAEPKKWS---------------------PLLNDFLARCLVKDPEKRASPIDLLCHPFL
|....||. | ||  .     . .. |.|. .  .| . ..  |.                     . . ||. .|| |||.|| .. ..|.||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PakF.AA MSN 394-646 40 3.4e-80 264.49 In-house 1-265 (265) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-265/265
Sequence Identity: 40% (109 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVSLQNEINIL-KNCKSPNIVSYFGSL------QTESHIWILLDFCALGSIRDIIEST-EKT
| |.| .| |.|| |||| |.  |   ||||....| |   .. |||.| |     ||..|.|          .  .|. ..||. ||. |.. .| ...
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

LNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGALDQSKEMIGTPLWMAPEVIL-----KKNYDYKADIWSLGITII
| |  | .. .. |.|| .||.. .||||.|  |||| .  .||. ||||| .|.         |||| |||||||      .  |||..|.||.||| |
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

EMADGLPPHIDLPPMRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
|||.| ||  |. ||||. ..|  |||.    ||||   ..|. .||.|. ..| .  ..| |||.
EMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase PakF.AA STE11 394-646 34 1.3e-77 264.15 In-house 1-303 (303) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-303/303
Sequence Identity: 34% (105 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESV---------S------LQNEINILKNCKSPNIVSYFG-SLQ--TESHIWILLDFCALGSI
. . |..| ||.|.|||.  .| |  .|.| || . ...          |      .| ||...|. . .||| |.| .|.   ..|. | . .|. ||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

RDIIESTEKT--LNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLL-SEGCDVKIADFGVSEKLNGALDQSKE----------MIGTPL--------
......   .  ..|. |.. .|  |.|| ||||..|||||.|.||.|| |.|. .|.|||| . .|.. . ....          | |||         
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVILKKN---YDYKADIWSLGITIIEMADGLPPHIDLP--PMRAMKMVPNWPPPTFAEPKKWS------PLLNDFLARCLVKDPEKRASPIDLLCH
||||||| .     |. |||||||| |.|||| | ||  ..   .| ||  .     |.   | . |      . ..||| .|...||.||..  .|| |
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase PakF.AA Pkinase_Tyr 394-601 27 4.2e-34 116.12 Pfam 1-228 (270) Show / Hide 
Range on Protein: 394-601
Range on HMM: 1-228/270
Sequence Identity: 27% (63 aa)

FILDEKLGDGAYGSVYKGTHK----DLGFTLAIKVI--EMKESE--SVSLQNEINILKNC-KSPNIVSYFGSLQ-TESH--IWILLDFCALGSIRDIIES
 ....||| ||.|.||||| |    . . . |.|..     ...  . .. .|..|.|.  . ||||.. |     . .  |.| . ....|. .|   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T---EKTLNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKL-NGALD-QSKEMIGTPL-WMAPEVILKKNYDYKADIWSL
    .. |.  ..        ||. ||.|.|.||||. | |.|..|.  |||.||| .  . |     ....    |  |||||.|  . .  | |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GITIIEMAD-GLPP-HIDLPPMRAMKMV
|... |.   |  |   .... . ....
GVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase PakF.AA TyrKc 394-646 25 1.2e-21 79.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 394-646
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

FILDEKLGDGAYGSVYKGTHKDLGFTLAIKVIEMKESESVSLQNEINILKNC--KSPNIVSYFGSLQTE-------SHIWILLDFCALGSIRDIIESTEK
  |..||| ||.| ||||| |    . |.|..         . .|..|...   . ||||  .|   ..         ..|.. ....|. .| . ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TLNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGVSEKLNGA--------LDQSKEMIGTP--L---WMAPEVILKKNYDYKAD
.|. ..         .|  ||||.|.||||  | |.|..|.  |||.||| | ..              .||  |.   |   |||||.| .. .  | |
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

IWSLGITIIEMA-DGLPPHID-----LPPMRAMKMVPNW----PPPT-----FAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFL
.|| |... |.  .| .|. .     ... .... | .     .||      |  .   . . .    .|   |||.| .  ..  | ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF