Gene ARCK-1 (Slime mold)

ARCK-1

Species: Slime mold
Alias: DdisK183, ARCK-1, ArkA, DDB0229363
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: ARK

Sequence

Name Sequence Type Origin Length Description Download
ARCK-1.AA Protein None 1460 None Fasta, JSON
ARCK-1.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of ARCK-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1 ARCK-1.AA C1 500-551 19 1.5e-09 38.95 SMART 1-61 (61) Show / Hide 
Range on Protein: 500-551
Range on HMM: 1-61/61
Sequence Identity: 19% (12 aa)

HDFSSEYSSNPGGKCAICRKPLWSFPIS---DKSRRCRDCSLVVHRACVPLAT--------EC
|...       . .|..|||..|...     ....||..| ...|  |.. ..         |
HHWHWWRF--KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 ARCK-1.AA C1_1 500-554 15 4e-06 26.33 Pfam 1-55 (55) Show / Hide 
Range on Protein: 500-554
Range on HMM: 1-55/55
Sequence Identity: 15% (9 aa)

HDFSSEYSSNPGGKCAICRKPLWSFP-ISDKSRRCRDCSLVVHRACVP-LATECPSA
|..   .. .  ..|. |....  .. ..    .|..| ...|  |.. ...||.  
HHWVHHWNFKQPTFCCHCGEFC--WGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
GRAM ARCK-1.AA GRAM 653-724 20 1.8e-11 45.33 SMART 1-80 (80) Show / Hide 
Range on Protein: 653-724
Range on HMM: 1-80/80
Sequence Identity: 20% (17 aa)

RDFHFIFRGCGIPLDEFPLDS------YVCGLYS---YFAHGRLYLTESYVCFYDGFVFDRTKER--TKIIKVSNIASIEKRS
..|. .|.   .| .|. ...      |.| |     ....|..|......||.     . |..   . .|. . | .||| .
EKFRQHFK---LPPNEKLINDCKKEVTYSCYLWRTYDIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT
GRAM ARCK-1.AA GRAM 653-724 24 1.1e-09 37.69 Pfam 1-78 (78) Show / Hide 
Range on Protein: 653-724
Range on HMM: 1-78/78
Sequence Identity: 24% (20 aa)

RDFHFIFRGCGIPLDEFPLDS----YVCGLYS----YFAHGRLYLTESYVCFYD---GFVFDRTKERTKIIKVSNIASIEKRS
..|. .|.   .| .|. ...    | | |      ....||.|.|...||||    |  .     .. .|. . | ..|| .
EKFRKHFKD-PLPPNEKLIMDCNVTYSCCLWRPFTKIPVQGRMYITNHHVCFYSDKFGWET----YYKMVIPWNDITRVEKMQ
Ank ARCK-1.AA Ank 819-846 25 2.16246 5.67 Pfam 6-33 (33) Show / Hide 
Range on Protein: 819-846
Range on HMM: 6-33/33
Sequence Identity: 25% (7 aa)

LMSAIKNNNLDMVVTLLNYYCQVNSDEI
|. |........|  ||.. . ||    
LHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ARCK-1.AA Ank 852-876 32 2.148699 5.68 Pfam 1-24 (33) Show / Hide 
Range on Protein: 852-876
Range on HMM: 1-24/33
Sequence Identity: 32% (8 aa)

KGYTPLHNAVFSECSDQIFMHLLNQ
 |.|||| |...  . ..   ||..
DGFTPLHLACRCG-HTEVVKMLLQH
Ank ARCK-1.AA Ank 959-991 45 2.5e-08 34.27 Pfam 1-33 (33) Show / Hide 
Range on Protein: 959-991
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

AGESPLHYAVRLGRLDVAKMLLAAGADPTIISL
 |..|||.|.| |...|.|||| .|||. .   
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ARCK-1.AA Ank 887-923 32 1.8e-07 31.19 Pfam 1-33 (33) Show / Hide 
Range on Protein: 887-923
Range on HMM: 1-33/33
Sequence Identity: 32% (12 aa)

DGNTPLHYFCQKFKSPECQRIVQAMIEKGANINEQNY
||.||||. |..     . ..|.  ...||..| |. 
DGFTPLHLACRCG----HTEVVKMLLQHGADVNAQDD
Ank ARCK-1.AA Ank 924-958 34 9.1e-07 28.66 Pfam 1-33 (33) Show / Hide 
Range on Protein: 924-958
Range on HMM: 1-33/33
Sequence Identity: 34% (12 aa)

NGETPLHKAIFNHSVRLLMVYILLKNNANVNIVNN
.|.|||| |...   .. .|  ||...|.||....
DGFTPLHLACRCG--HTEVVKMLLQHGADVNAQDD
Kinase ARCK-1.AA ARK 1112-1372 53 2.8e-195 655.01 In-house 1-280 (280) Show / Hide 
Range on Protein: 1112-1372
Range on HMM: 1-280/280
Sequence Identity: 53% (151 aa)

LEYTEKIGSGASGKVFKGIYRGRVVAIKVLKS-ADDEMTREDFLKEFGVLASLESHTIVGLYGVVLEP-----KICLVMEYCSNGSIYHSIRKNPP--SW
||||.|||||.|.||.||.|||..|||||||| ..|.|..|.|.|||....|..|...|..||...||     |.|.||||||.||.||....|..  .|
LEYTCKIGSGSSCKVYKGKYRGKEVAIKVLKSIMTDSMQIEEFKKEFQIMSSIRSPHVVYFYGACIEPEPQKQKLCMVMEYCSRGSLYHIMNNNKMDFGW

ERFFSFVQQMLAGINALHQSTPQVLHRDIKTLNFLVNHNNKVKVADFGLSRFNTESNQETLNKTRGTSVYCAPEVFE-----------GKEYNERSDMYS
.|||....||..|||.||..|||..|||.|.||.|||.|...||.|||||||||.||||||.|.|||..||||||..           ||.|...||.||
DRFFKWMMQMVRGINCLHNWTPQIVHRDLKSLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDVYS

MGIVMWEIVYCVVYGCYMIPYQEYNKMFNAFQVALLVNSSKRVLRPTIPIGVPQVLKDLIYCLWDHDVSSRPTATEAMTA
|||.|||.||....||||.||.||....|||....|...||..||||||...|..||.||.|.||.|...||...|.|..
MGIIMWEMVYRCINGCYMRPYSEYKHIKNAFDFQILIQTSKNNLRPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE
Kinase ARCK-1.AA TKL 1118-1373 25 5.9e-85 288.54 In-house 1-364 (364) Show / Hide 
Range on Protein: 1118-1373
Range on HMM: 1-364/364
Sequence Identity: 25% (96 aa)

IGSGASGKVFKGIYRG----------RVVAIKVLKS-------------------------ADDEMTREDFLKEFG-VLASLESHTIVGLYGVVLEPK--
||||..|.|.||..||          ..||.|..||                         ... .  ..|..|   .. .|    || ..|....|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------ICLVMEYCSNGSIYHSIRKNPPSWERFFSFVQQMLAGINALHQST------PQVLHRDIKTLNFLVNHNNK--------------VKV
            .|.|||||..|| .| .      |..........  |.| ||...      |...|||.|. | ||. |..              .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADFGLSRFNTESNQ------------------ETLNKTRGTSVYCAPEVFEGK----------------EYNERSDMYSMGIVMWEIVYCVVYGCYMIPY
.|||||||...|..                  .|... .||  ..||||..|.                ||.|..|.||.|||.|||. . .      ||
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PY

QEYNKMFNAFQV---ALLVNSSKRVLRPTIP------------IGVPQVLKDLIYCLWDHDVSSRPTATEAMTAL
..|. |   ||    . ..  ... |||.||              .|. .|.|. . |||| ..||...| .  |
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ARCK-1.AA TKL-Unique 1114-1373 31 3.2e-64 219.66 In-house 1-290 (290) Show / Hide 
Range on Protein: 1114-1373
Range on HMM: 1-290/290
Sequence Identity: 31% (94 aa)

YTEKIGSGASGKVFKGIYRGRVVAIKVLK-SADDEMT-REDFLKEFGVLASLE-SHTIVGLYGVVL-----EPKICLVMEYCSNGSIYHSIR--------
  .|||.|..|.|.||..||  ||||...  .| . . ...| .|  ..  |. .  || ..|.       .|. |.|||||. || |  .         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---KNPPSWERFFSFVQQMLAGINALHQSTPQVLHRDIKTLNFLVNHN-----NKVKVADFGLSRFNTESNQETLN--------KTRGTSVYCAPEVFEG
   ......... ......  | . || . | ..|||.|..||||. |     ...|..|||||.||. .|..|.|           |.  . ||||...
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--KEYNERSDMYSMGIVMWEIVYCVVYGCYMIPYQEYNKMFNAFQVALLVNSSKRVLRPTIPIGVPQVLKDLIYCLWDHDVSSRPTATEAMTAL
  . |.| || || |||.|||.   .   |  |||...      |.. .| . .. .||.||   |. ..|||   |.|| | ||. .|  . |
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQE----QWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase ARCK-1.AA Pkinase 1112-1373 23 7.2e-52 183.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1112-1373
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

LEYTEKIGSGASGKVFKGIYRGRV--VAIKVLKSADDEM--TREDFL-KEFGVLASLESHTIVGLYGVVL-EPKICLVMEYCSNG----SIYHSIR---K
..  .|||||..|.|.|.. .|    ||.|..|  ....   .....  |  ....| .  || ||...  ...|..||||| .|    . .. |.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NPP--SWERFFSFVQQMLAGINALHQSTPQVLHRDIKTLNFLVNHNNKV----KVADFGLSR-FNTESNQETLNKTRGTSVYCAPEVFE-GKEYNERSDM
..   |..   ... |.| |.. .|.    ..|||.|  |.|...|. .    |..||||.. |. . |.. ..   ||. |.||||   |..|  ..||
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSMGIVMWEIVYCVVYGCYMIPYQEY------NKMFNAFQVAL-LVNSSKRVLRP-------------TIPIGVPQVLKDLIYCLWDHDVSSRPTATEAM
.|.|....| .     |    |...       ..|.  ...    . ..   ...             |  . ... .||.|..... | ..||||....
WSCGCILYEMLC----GR--PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

TA--L
    .
QHPWF
Kinase ARCK-1.AA Dicty4 1112-1365 32 6.4e-51 168.15 In-house 1-265 (277) Show / Hide 
Range on Protein: 1112-1365
Range on HMM: 1-265/277
Sequence Identity: 32% (89 aa)

LEYTEKIGSGASGKVFKGIYRGRVVAIKVL---KSADDEMTREDFLKEFGVLASLESHTIVGLYGVVL----EP-KICLVMEYCSNGSIYHSIRK-----
.  ...||.|. |.|.||. ||  ||.|.|   .  .|| . ..|.||   ....    |. ..|  .    .| |.| |.||.. |. |  ...     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

---NPPSWERFFS---FVQQMLAGINALHQSTPQVLHRDIKTLNFLVNHNNKVKVADFGLSR-FNTESNQET-LNKTRGTSVYCAPEVFEGKEYNERSDM
    ...|... .          |.| || ..| ..|||.|. | ||  |..|||.|||||. . ..... . .  . ||  . ||||  ...||| .| 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSMGIVMWEIVYCVVYGCYMIPYQ-EYNKMFNAFQVALLVNSSKRVLRPTIPIGVPQVLKDLIYCLWDHDVSSRPT
|| ||| |||. .       .||| ..    . .|.. .| . |  ||| ||  .|  .|.||   |||| ..||.
YSFGIVLWEILTR------QEPYQKHHM---PYMQFVRAVCNKK--LRPPIPDWCPPSWKHLIQWCWDHDPQHRPS
Kinase ARCK-1.AA MLK 1112-1373 28 8.2e-48 163.94 In-house 1-291 (291) Show / Hide 
Range on Protein: 1112-1373
Range on HMM: 1-291/291
Sequence Identity: 28% (88 aa)

LEYTEKIGSGASGKVFKGIYRGRV-----VAIKVLK-----SADDEMTREDFLKEFGVLASLESHT----IVGLYGVVLEP-K-ICLVMEYCSNGSIYHS
..  |.||||..|||.|| .|..      ||.|  .     ..| .  ..|| .|.  |. |        |. .||| |.| .  |.|||||..|| |. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IRKNPPSWE---------------RFFSFVQQMLAGINALHQSTP-QVLHRDIKTLNFLVNH------NNKVKVADFGLSRFNTESNQETLNKTRGTSVY
.. ... |.                ....  |.  |.. ||.  | .. |||.|  | |. .      . ..|..|||.||. ...  ..  ...||  .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

CAPEVF---EGKEYNERSDMYSMGIVMWEIVYCVVYGCYMIPYQ-EYNKMFNAFQVALLVNSSKRVLRPTIPIGVPQVLKDLIYCLWDHDVSSRPTATEA
 ||||.   ..  |.| .|..| |.|.||.. . |      ||. .|. |. |..||.        |||.||.. |  .| |. . |. | ..||.  . 
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV------PYKQHYDPMAIAWWVAY------NGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQI

MTAL
.. |
VQHL
Kinase ARCK-1.AA S_TKc 1112-1375 24 4.1e-47 163.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 1112-1375
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

LEYTEKIGSGASGKVFKGIYRG--RVVAIKVLKSADDEMTREDFLKEFGVLASLESHTIVGLYGVVLEPKICLVMEYCSN--GSIYHSIRKNPP------
 |  .|||.|| |||.|.. ..  |.||||..|        |....|  .| .     || ||.|  . ....|||||..  |. .. |.|...      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

-SWERFFSFVQQMLAGINALHQSTPQVLHRDIKTLNFLVNHNNKVKVADFGLSRFNTESNQETLNKTRGTSVYCAPEVFEGKEYNE-RSDMYSMGIVMWE
 .  .  ....|.. ... .|.   ...|||.|  | |...   .|..||||.|.         .   ||  |.||||.    |.  ..|..| |....|
FPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IVY-CVVYGCYMIPYQEYNKMFNAFQVALLVNSSKRVLRPTIPIGVPQVLKDLIYCLWDHDVSSRPTATEAMT-------ALAV
 .. .  .        ....||.                       .. .||.|  ... | . |||| ||..          .
MLCGYPPFP-------QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ARCK-1.AA TK 1112-1373 16 1.4e-44 146.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 1112-1373
Range on HMM: 1-486/486
Sequence Identity: 16% (82 aa)

LEYTEKIGSGASG---KVFKGIYRGR---------------------------VVAIKVLK--SADDEMTRED-----------FLKEFGVLASLES---
... .|.|.|. |   .|.||..|||                            ||.|.||  .|.... ..|           ||.|  ... . .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HT-IVGLYGVVLEPK-------------ICLVMEYCSNGS----IYHSIRKN-----------------------------------------------
 |  || ||||.....             ...||||...|.      .  ||.                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------PPSWERFFS-------------------FVQQMLAGINALHQSTP----QVLHRDIKTLNFLVNHNNK-----------VKVADFG----
          | .   . .                   . .|  .|   ||.       .. |||. . | ||..||.           .|.||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSRFNTESNQETLNKTRGTSV-------------------------YCAPEVFEGKE---------YNERSDMYSMGIVMWEIV-YC-VVYGCYMI
    |.|   ..   .  ...||..                         ..|||......         . . ||..| |..||||. |. . |. .| 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

PYQEYNKMFNAFQVALLVNSS-----------KRVLRPTIPIGVP--------------QVLKDLIYCLWDHDVSSRPTATEAMTAL
  .  .      .|  .. .             . .|.  | . |              ... ||. . |..| . ||| ..   .|
NQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ARCK-1.AA STE 1112-1301 22 8e-40 138.31 In-house 1-262 (359) Show / Hide 
Range on Protein: 1112-1301
Range on HMM: 1-262/359
Sequence Identity: 22% (61 aa)

LEYTEKIGSGASGKVFKGIYR-----------------GRVVAIKVLKSADDE----------------MTREDFLKEFGVLASLE--SHTIVGLYGVVL
.|  ||||.||.|.|.|....                 |...|||...  ...                . ....|||  ..  .   .  ||  ||  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

--------EPKICLVMEYCSNGSIYHSIR------KNPPSW--------ERFF-SFVQQMLAG-INALHQSTPQVLHRDIKTLNFLVNHNNKVKVADFGL
        . .....|||...||.   |.      |. ..         |     ...| | |  . ||.    . |||||  | |.     || .|||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

SRFNTE---------------SNQETLNKTRGTSVYCAPEVFEG------KEYNERSDMYSMGIVMWEIV
.   |.               ..|.  |   ||  . |||| ..      |.|....|..| |....| .
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase ARCK-1.AA Pkinase_Tyr 1112-1301 31 1.7e-37 127.61 Pfam 1-208 (270) Show / Hide 
Range on Protein: 1112-1301
Range on HMM: 1-208/270
Sequence Identity: 31% (67 aa)

LEYTEKIGSGASGKVFKGIYR------GRVVAIKVLKSADDEMT--REDFLKEFGVLASL-ESHTIVGLYGVVL---EP-KICLVMEYCSNGSIYHSIRK
..  .|.|.|| |.|.||...      .  ||.|.||   ..    ||||..|  .. .|   . || ||||..   || .|..||||. .|. ..  ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N-----PPSWERFFSFVQQMLAGINALHQSTPQVLHRDIKTLNFLVNHNNKVKVADFGLSRFNTESNQETLNKTRGTSV---YCAPEVFEGKEYNERSDM
.     |.. ..  .. .|  .| . |..      |||. . | ||..||.||..||||.|  ..  .  . |. |. .    .|||..  ..... || 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSMGIVMWEIV
.| |..||||.
WSFGVLMWEIF
Kinase ARCK-1.AA CAMK 1117-1297 17 2.3e-37 117.46 In-house 1-324 (425) Show / Hide 
Range on Protein: 1117-1297
Range on HMM: 1-324/425
Sequence Identity: 17% (57 aa)

KIGSGASGKVFKGIYR-G-------------RVVAIKVLKSAD---------------------------DEMTREDFLKEFGVLASLE------SHT-I
..|.|. |||...| .               . ||||...                              .. .|. ...|  .. .|       .|  |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGLYGVVL--------------------EPKICLVM---EYCSNG----SIYHSIRKNPPSWERF----------F------SFVQQMLAGINALHQSTP
. || |                      . ....||   ||||.|     ..  |.....  | |          |       ...|.. ... .|.   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

QVLHRDIKTLNFLVNHN-----------------NKVKVADFGLSRFNTESN----------------------QETLNKTRGTSVYCA-PEVFEGKE--
 . |||.|  | |...|                 |..|..|||.... ....                       . ..   ||  |.| |||..||   
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YNERSDMYSMGIVM
            |.. .|| |.|...
NMQNATDEEKPYYGPKCDMWSCGVIL
Kinase ARCK-1.AA TyrKc 1112-1373 27 3.6e-36 127.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 1112-1373
Range on HMM: 1-280/280
Sequence Identity: 27% (81 aa)

LEYTEKIGSGASGKVFKGIYRGRVVAIKVLKSADDEMTREDFLKEFGVLASL--ESHTIVGLYGVVLE--------PKICLVMEYCSNGSIYHSIRKNP-
..  .|.|.|| |.|.||... . ||.|.||.      ||||..|  .. .|  .   || ||||...        . ...||||...|.  . .||.  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-PSWERFFSFVQQMLAGINALHQSTPQVLHRDIKTLNFLVNHNNKVKVADFGLSRFNTES-----NQETLNK-----TR--GTSVYCAPEVFEGKEYNER
  ... . ||  |  .| . ||.   .. |||. . | ||..|. ||..||||||. ..      ....  |     ..       .|||..  ..... 
KLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDMYSMGIVMWEIV-YCVVYGCYMIPYQEYNKMFNAFQVALLVNSSKRVLRPTI--PI---GVPQVLKDLIYCLWDHDVSSRPTATEAMTAL
|| .| |..||||  |.      ||       | ....|  .| . .|  .|    |.   . |. . ... . |..| ..||| .|    .
SDVWSFGVCMWEIFTYGQQPYPGMIQQ-----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ARCK-1.AA LRRK 1112-1301 22 2.6e-32 111.59 In-house 66-341 (351) Show / Hide 
Range on Protein: 1112-1301
Range on HMM: 66-341/351
Sequence Identity: 22% (63 aa)

LEYTEKIGSGASG-KVFKGIYRG----------------------------RVVAIKVLKS--------------------------------ADDEMTR
|.. |.||.|..| .|.....||                              ||||...                                 ..| .. 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-EDFLKEFGVLASLESHTIVGLYGVVLEPKICLVMEYCSNGSIYHSIR---KNP-----PS--WERFFSFVQQMLAGINALHQSTPQVLHRDIKTLNFLV
   | .|  .. .|.   || |.|. ..| .|.|||| ..|. || ..   ...     ..  |  .   . |   |.. || ..| ..||| |. | |.
FREFRHEVWIMSHLNHPNIVSLKGFCIHP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

-NHNN-----------KVKVADFGLSR-FNTESNQET-LNKTRGTSVYCAPEVFEG---KEYNERSDMYSMGIVMWEIV
  ...           ..|.||||.|| |   . ... ...  |. ...|||.  .   .||.| .|.|| |...||..
WSSPQNHSPNYPNAHVCAKIADFGISRMF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELL
Kinase ARCK-1.AA Shk 1216-1300 43 2.6e-25 87.7 In-house 113-199 (269) Show / Hide 
Range on Protein: 1216-1300
Range on HMM: 113-199/269
Sequence Identity: 43% (38 aa)

GINALHQSTPQVLHRDIKTLNFLVNHNNKVKVADFGLSRFNTESN--QETLNKTRGTSVYCAPEVFEGKEYNERSDMYSMGIVMWEI
|.| || | .  .|||.|| | ||  |  |||.|||.|    .    .  .    ||  . ||||  ...||| .| || ||. |||
GMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEI
Kinase ARCK-1.AA Shk 1112-1142 41 3.3e-08 25.86 In-house 1-31 (269) Show / Hide 
Range on Protein: 1112-1142
Range on HMM: 1-31/269
Sequence Identity: 41% (13 aa)

LEYTEKIGSGASGKVFKGIYRGRVVAIKVLK
   ....|.|. ||| ||. ||. ||.||..
INREDFLGQGSFGKVYKGRCRGKEVAVKVMH
Kinase ARCK-1.AA Shk 1336-1364 48 0.001774 8.75 In-house 225-253 (269) Show / Hide 
Range on Protein: 1336-1364
Range on HMM: 225-253/269
Sequence Identity: 48% (14 aa)

LRPTIPIGVPQVLKDLIYCLWDHDVSSRP
.|| ||   |  ||.||   |||. ..||
ERPPIPDDCPKSLKHLIQKCWDHNPQRRP
Kinase ARCK-1.AA LRRK 1336-1375 34 0.015713 4.75 In-house 306-351 (351) Show / Hide 
Range on Protein: 1336-1375
Range on HMM: 306-351/351
Sequence Identity: 34% (16 aa)

LRPTIP--IGVPQ-----VLKDLIYCLWDHDVSSRPTATEAMTALAV
||||||  .  |.      ..|||   |.||  .||....    |  
LRPTIPQHY-CPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ