DDB0218878e

Species: Slime mold
Alias: DDB0218878e, DdisK207
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: Dicty5

Sequence

Name Sequence Type Origin Length Description Download
DDB0218878e.AA Protein None 966 None Fasta, JSON
DDB0218878e.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of DDB0218878e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LIM DDB0218878e.AA LIM 4-55 25 5.7e-07 30.39 SMART 1-52 (52) Show / Hide
Range on Protein: 4-55
Range on HMM: 1-52/52
Sequence Identity: 25% (13 aa)

RCGVCKYIISDCERYVSDNTFYHVKCFICKICKCELPPCFRGKHASLMCGDC
.|. |.  |.. .... ..  .|..|| | .|.. | . |  |. .. | .|
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGGTFYEKDGKPYCKHC

LIM DDB0218878e.AA LIM 5-41 31 0.001429 15.52 Pfam 1-38 (60) Show / Hide
Range on Protein: 5-41
Range on HMM: 1-38/60
Sequence Identity: 31% (12 aa)

CGVCKYIISDCERY-VSDNTFYHVKCFICKICKCELPP
|. |.  |.| ..  .  |  .|..||.|  |...| |
CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTP

LIM DDB0218878e.AA LIM 63-113 34 2.6e-09 38.2 SMART 1-52 (52) Show / Hide
Range on Protein: 63-113
Range on HMM: 1-52/52
Sequence Identity: 34% (18 aa)

KCFKSHFPIHS-VSVVARNKEFHNNCFTCISCNEIIKGGFQYSDELFYCSKC
||.. . ||   . ..|..| .| .||.|  ||  . |.|   |. .|| .|
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGGTFYEKDGKPYCKHC

LIM DDB0218878e.AA LIM 70-113 32 2e-06 25.84 Pfam 7-55 (60) Show / Hide
Range on Protein: 70-113
Range on HMM: 7-55/60
Sequence Identity: 32% (16 aa)

PIHSVSVV--ARNKEFHNNCFTCISCNEIIKGG--FQYSDE-LFYCSKC
||..  .|  |.|| .| .||.|  |.. .. |  .   |. ..|| .|
PIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHC

Kinase DDB0218878e.AA Dicty5 702-956 62 2.5e-210 705.04 In-house 1-260 (260) Show / Hide
Range on Protein: 702-956
Range on HMM: 1-260/260
Sequence Identity: 62% (162 aa)

VIFGDVIAAGASGKVYKGIYKGRDVAIKVYSSEN-FCFNIDEFDREVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKEK----P
|.|.|.||.||||.||.|||||.||||||||.|| .||...||.|||||||...||||||.|.|||...|.||.|||.|....|||...|.|..|    |
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQP

LLYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDETCDVYAFGIVLWEIIARK
..||.||..|.|||..|.||||...|||||||.|.||||....|.|||||||.||...||||..||.|.|..|||.|..|...||||.|||||||...||
IAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRK

EPYENINSWSIPVMVAKGDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTLKKIS
|||.|||.|.|||||.||.|||||.|||.|.|.|||.||..||..||||||||.....|.
EPYDNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII

Kinase DDB0218878e.AA TKL 708-952 27 5.1e-96 325.31 In-house 1-364 (364) Show / Hide
Range on Protein: 708-952
Range on HMM: 1-364/364
Sequence Identity: 27% (102 aa)

IAAGASGKVYKGIYKG----------RDVAIKVYSSEN-FCFNIDE-----------------------FDREVTIMSLIDSDHPNFTRFYGANKQNKK-
|  |..|.||||...|          .|||.|...|.|  .|.. .                       | .|. ||...  .|||  .|.|. ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------YLFHVSELVKSGSLRDLLLDKEKPLLYFTQLSIASDIANAMKHLHSIG--------VIHRDLKSLNVLITEDFT--------------A
           .|. | |... |||...|.           ...| ||| .| .||| .        .||||||| |.|. |..|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVIDFGTSRNVDLAKHMTMN--------------------LGTSCYMSPELFKGN----------------GYDETCDVYAFGIVLWEIIARKEPYENIN
|. |||.||...  ..|...                     || ..|.||...|.                 |.| ||||.||||||||..|..||....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

S----------WSIPVMVAKGDRPTIP------------ADCPSEYSKLIKACWTDKPKKRPSFKEICDTL
.          . . . . || ||.||             ||| ...||.. ||  .|.|||||.|| ..|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase DDB0218878e.AA TKL-Unique 704-952 32 2.4e-82 279.87 In-house 1-290 (290) Show / Hide
Range on Protein: 704-952
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

FGDVIAAGASGKVYKGIYKGRDVAIKVYS-SENFCFN-IDEFDREVTIMSLIDSD-HPNFTRFYGANK----QNKKYLFHVSELVKSGSLRDLLL-----
|. .| .|..|.||||...| .||||. .  | . .  ..|| .||..|. .  . ||| ....|. .    ..... . |.| .  |||.|.|      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKL--HYHPNIVHYMGYCMDHQVYPPNMCI-VMEYCPGGSLYDVLHQNNNN

----DKEKPLLYFTQLSIASDIANAMKHLHSIG--VIHRDLKSLNVLITED-----FTAKVIDFGTSRNVD--LAKHMTMN--------LGTSCYMSPEL
     ....| .  ....| ||| .| .||. .  .|||||||.|.|....     . .|..|||.|.. .  ...  ...        .|.  .|.||.
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

FKG--NGYDETCDVYAFGIVLWEIIARKE------PYENINSWSIPVMVAK---GDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTL
...  . |.| .|||.||||||||. ||       ||..... ..  ||..   . ||.|| .|| ||..||..||.. | .|||| ||   |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase DDB0218878e.AA MLK 702-952 32 2.3e-70 240.05 In-house 1-291 (291) Show / Hide
Range on Protein: 702-952
Range on HMM: 1-291/291
Sequence Identity: 32% (95 aa)

VIFGDVIAAGASGKVYKGIYKGRD-----VAIKVYSSENFCFNI-----DEFDREVTIMSLIDSDHPN----FTRFYGANKQNKKYLFHVSELVKSGSLR
  |  .| .|..|||.|| ....|     ||.| . .. |.  .     ..|..|. . . .  .|||    . .|||. .|. . .. |.| .  ||| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRIL--SHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

DLLLD-KEKPL-----------LYFTQL-SIASDIANAMKHLHSIG---VIHRDLKSLNVLITE------DFTAKVIDFGTSRNVDLAKH---MTMNLGT
..| . . |.              . .. ..| ..|..|  |||     .||||||| |.||.|      . |.|. ||||||  |. ..   |. | ||
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR--DWHQMCTNMMSNAGT

SCYMSPELF---KGNGYDETCDVYAFGIVLWEIIARKEPYE-NIN-SWSIPVMVAKGDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTL
  .|.|| .   ... |.| |||. .|.||||...|..||.  .. .  .  ....| ||.|| .||   .||.| || ..|.|||||..|   |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase DDB0218878e.AA Dicty4 702-954 35 2e-68 227.34 In-house 1-277 (277) Show / Hide
Range on Protein: 702-954
Range on HMM: 1-277/277
Sequence Identity: 35% (100 aa)

VIFGDVIAAGASGKVYKGIYKGRDVAIKVY--SSENF-CFNIDEFDREVTIMSLIDSDHPNFTRFYGANK---QNKKYLFHVSELVKSGSLRDLLLD---
  ... |  |. |.||||. .| .||.|.     .||  . . || .||.||. |   |||   |.||      ..  .  |.|.. .|.|  ||.|   
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKI--RHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---KEKPLLYFTQLS---IASDIANAMKHLHS-I-GVIHRDLKSLNVLITEDFTAKVIDFGTSR----NVDLAK-HMTMNLGTSCYMSPELFKGNGYDET
   ....| . . ..   .| |.|  | .||. .  .||||||| | |. .....|| ||| |.      |.    ||.  || |.|.||   ...|.| 
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQPYNEK

CDVYAFGIVLWEIIARKEPYE--NINSWSIPVMVAK-GDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDT--LKK
 ||| ||||||||  |.|||    ..   .   |.  . || ||..||  ...||. ||   |..||||.||     |  
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase DDB0218878e.AA LISK 707-952 32 8.9e-66 212.62 In-house 1-296 (296) Show / Hide
Range on Protein: 707-952
Range on HMM: 1-296/296
Sequence Identity: 32% (97 aa)

VIAAGASGKVYKGIYK--GRDVAIKVYSSE----NFCFNIDEFDREVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKEK---PL
.|  |. |||||| ..  |...|||  ..     |   ..  ..||| .| ..  .|||  .|.|. ..|.. |. | |... | |...| |..|   ||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNL--RHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPL

LYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLIT----EDFTAKVIDFGTSRNVDLAK------------------------------------HMT
  .  ..|| ||| .|  ||| ..||||||| |.|.     .....||.|||  | .|  .                                    .||
PWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMT

MNLGTSCYMSPELFKGNGYDETCDVYAFGIVLWEIIARKEPYE------NINSWSIPVMVAKGDRPTIPAD-CPSEYSKLIKACWTDKPKKRPSFKEICD
.  ||   |.||  .|  |||.|||. ||||| |||.|... .      . .   . . ..   .. |. | ||.....|   |   .||.||||||| .
I-CGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEF---WQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQ

TL
.|
WL

Kinase DDB0218878e.AA Dicty4-Unclassified 702-952 34 4.2e-63 214.96 In-house 1-263 (263) Show / Hide
Range on Protein: 702-952
Range on HMM: 1-263/263
Sequence Identity: 34% (91 aa)

VIFGDVIAAGASGKVYKGIYKGRDVAIKVYSSENFCFN---IDEFDREVTIMSLIDSDHPNFTRFYGANKQN---KKYLFHVSELVKSGSLRDLLL----
.     |  |.  ||.||. ||.|||.|   .  | |    |..| .|| |. .|   |||  . ||.       |  .  | |.  .| |  .      
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSI--QHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

DKEKPLLYFT--QLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDETCDVYAFGIVL
....|.       . .| |||  | |||.  .||||.|| |.|.  .| .|. ||| || .|    ||   ||    |||  ..  |    ||| ....|
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMML

WEIIARKEPYENIN-SWSIPVMVA-KGDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTL
.| .   |||  |     .   |. |. || ||  |.  ..|||| || . |.|||.. .| . |
YELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL

Kinase DDB0218878e.AA LISK-DD1 707-952 34 2.7e-56 193.35 In-house 1-290 (290) Show / Hide
Range on Protein: 707-952
Range on HMM: 1-290/290
Sequence Identity: 34% (101 aa)

VIAAGASGKVYKGIYKGRDVAIKVYSSENFCFNIDEF----DREVTIMS-LIDSDHPNFTRFYGANKQ------------NKKYLFHVSELVKSGSLRDL
 |  |. |||||| | | .||||. ..    .| ...    .||. .   |..  |||  .|.|. .             |.  |. | |... | |...
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

LLD------------KEKPLLYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITED----FTAKVIDFGTSRNVDLA------KHMTMNLGTSCYMS
|..            . .|.  .  ..|| ||| ||  ||| ..||||||| | |. |      ..||.|||  | ..        .|||.  ||   |.
LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTI-CGTDNWMA

PELFKGNGYDETCDVYAFGIVLWEIIARKEPYENINSWS------IPVMVAKGDRP-TIPAD--CPSEYSKLIKACWTDKPKKRPSFKEICDTL
||.  |  ||. |||. ||.|| |.| || | ...   |      | . ..   |.  ||.|  ||.|...| . |   .|. ||||||| .||
PEVILGMSYDWSCDVFSFGMVLLELITRKKPDKRMWQRSPMNCFDIDQEEF---RQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL

Kinase DDB0218878e.AA Pkinase 702-952 25 1.6e-54 192.28 Pfam 1-293 (293) Show / Hide
Range on Protein: 702-952
Range on HMM: 1-293/293
Sequence Identity: 25% (75 aa)

VIFGDVIAAGASGKVYKGIYKGRD--VAIKVYSSENFCFNIDEFDR---EVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKSG----SLRDLLL-
  .| .| .|..|.|||.. ||    ||.|. . ..   . |. .|   |. ||  ..  |||  |.|..    |...  | |..  |    .| |..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST

DKEKPL--LYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTA----KVIDFGTSRN--VDLAKHMTMNLGTSCYMSPELFK-GNGYDETCDV
......   . .  ...  |. .....|| |.||||||. |.|| .. .     |..||| ..         ||   ||. ||.||. . |..|.  .|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YAFGIVLWEIIARKEPYENI----NSWSIPVMVAKGDRPTIPADCP-----------------------SEYSKLIKACWTDKPKKRPSFKEICDT--L
...|..|.| . .. |. .     |  .  .|...  .| .. |.|                       .|  ..|| |.. .|||||....|.    .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase DDB0218878e.AA LRRK 779-954 31 4.6e-54 185.94 In-house 135-351 (351) Show / Hide
Range on Protein: 779-954
Range on HMM: 135-351/351
Sequence Identity: 31% (68 aa)

ELVKSGSLRDLLLDKEK--------PLLYFTQLSIASDIANAMKHLHSIG--VIHRDLKSLNVLI---T---------EDFTAKVIDFGTSR--NVDLAK
|..  |.| ..| .|..         .   ..| || .|| .|..|||    .||||||| |.|.   .         .. .||..|||.||   ... .
EYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG

-HMTMNLGTSCYMSPELFKGN---GYDETCDVYAFGIVLWEIIARK-EPYENIN-------SWSIPVMVAKGDRPTIPAD-CPS-----EYSKLIKACWT
  ... .|.  .|.||  ..|    |.|  |.|.||..|||.. |.  |.....          |   . .| ||||| . ||      .|..||. ||.
VAKGC-VGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQ

DKPKKRPSFKEICDTLKK
 .|||||.| .| ..|. 
HDPKKRPHFSQIVKRLSQ

Kinase DDB0218878e.AA TyrKc 702-952 28 6.7e-53 182.98 SMART 1-280 (280) Show / Hide
Range on Protein: 702-952
Range on HMM: 1-280/280
Sequence Identity: 28% (83 aa)

VIFGDVIAAGASGKVYKGIYKGRDVAIKVYSSENFCFNIDEFDREVTIMSLI--DSDHPNFTRFYGANKQNK------KYLFHVSELVKSGSLRDLLLDK
. .|...  || |.||||..| ..||.|.  ..     . .| ||  ||. .  .  |||  |.||.  | .      . |. | |... |.|.| | ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGH--HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

EKPLLYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLA-------KHMTMNLGTSCY-------MSPELFKGNGYDET
.. |   . ||.. .||. | .||| ..|||||   |.|..|..|.|. ||| ||...         .  ..  . ..        |.|| .. . . . 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDVYAFGIVLWEIIAR-KEPYEN-----INSWSIPVMVAKGDRPTIPAD--------CPSEYSKLIKACWTDKPKKRPSFKEICDTL
 ||..||...|||  . ..||..     ..   .   | .|.|. .|..        ||.|  ...| ||  .|..||.|.||.. .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase DDB0218878e.AA TAK1 704-951 30 1.4e-52 175.94 In-house 3-284 (284) Show / Hide
Range on Protein: 704-951
Range on HMM: 3-284/284
Sequence Identity: 30% (87 aa)

FGDVIAAGASGKVYKGIYKGRDVAIKV-----YSSENFCFNIDEFDREVTIMSLIDSDHPNFTRFYG--ANKQNKKYLFHVSELVKSGSLRDLLLD-KEK
.  .. .|. | |.|  ......|.|      ||||     . .. ||..  |..  ||||  . ||  |  ... .|  | | .  ||| ..| . | |
NEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECE--QKNIEREIMQWSRV--DHPNIIKLYGMYACHRQCQCL--VMEYMDCGSLHNFLHGAKPK

PLLYFTQ-LSIASDIANAMKHLHSIG---VIHRDLKSLNVLITEDFTA-KVIDFGTSRNVDLAKHMTMNLGTSCYMSPEL--------------------
.     .  | .  .| .   |||     .||||.| .| | ..  .  |. ||||   .|.  .|| | ||  .| ||                     
WEYTHAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTF--CDMHQMMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQ

--FKGNGYDETCDVYAFGIVLWEIIARKEPYENINS----WSIPVMVAKGDR-PTIPA--DCPSEYSKLIKACWTDKPKKRPSFKEICDT
  |... |.. ||.| .||..||.|.||.||. |..      |   ...| | | .    |||   ... |.|| | | |||| .|.   
KVFRCEKYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY

Kinase DDB0218878e.AA S_TKc 702-959 26 2.5e-50 174.46 SMART 1-231 (231) Show / Hide
Range on Protein: 702-959
Range on HMM: 1-231/231
Sequence Identity: 26% (72 aa)

VIFGDVIAAGASGKVYKGIYKG--RDVAIKVYSSENFCFNIDEFDREVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKS--GSLRDLLLDKEKP-
  ....|  || |||||.. |.  | ||||. .        . . ||. |..    .|||  ..|..     ..|. | |..    |.|.|.. .. .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK---HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LLYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDE-TCDVYAFGIVLWE
    .   .  ...  |..|....|| |.||||||  |.|..|  . |..||| .| .      |   ||  ||.||..   ||.   ||....|..|.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IIARKEPYENINSWSIPVMVAKGDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICD--TLKKISESL
 .... |..      . .|  |          ..|   .|. |..  |.|||.  |.     . |. . .
MLCGYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase DDB0218878e.AA Pkinase_Tyr 702-952 30 1.6e-48 164.97 Pfam 1-270 (270) Show / Hide
Range on Protein: 702-952
Range on HMM: 1-270/270
Sequence Identity: 30% (83 aa)

VIFGDVIAAGASGKVYKGIYK------GRDVAIKVYSSENFCFN---IDEFDREVTIMSLI-DSDHPNFTRFYGANK-QNKK-YLFHVSELVKSGSLRDL
..|| .. .|| |.||||..|      . .||.|.   |.       ...| ||. ||. . .  |||  |.||.   | .  ... | |... |.|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGH--HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LLDK---EKPLLYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNV-----D-LAKHMTMNLGTSCYMSPELFKGNGYDETC
| ..   ..||   . |... .||..| .|.|.. |||||   |.|.||....|. ||| .| .        ... ..       |.|| .. . . .  
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTTKS

DVYAFGIVLWEIIA-RKEP-YENINSWSIPVMV-AKGDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTL
||..||...|||.   ..| |...    .  ..  .| |  .| .|| |  .|.| ||  .|..||.|.||   |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase DDB0218878e.AA LRRK 702-751 16 2.2e-07 22.16 In-house 82-193 (351) Show / Hide
Range on Protein: 702-751
Range on HMM: 82-193/351
Sequence Identity: 16% (18 aa)

VIFGDVIAAGASG-KVYKGIYKG----------------------------RDVAIKVYSSE---------------------------------NFCFN
....  |  |..| .||.....|                             .||||..  .                                 ..| .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IDEFDREVTIMS
  || .||.|||
FREFRHEVWIMS