Gene DDB0220138 (Slime mold)

DDB0220138

Species: Slime mold
Alias: DDB0220138, DdisK239
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
DDB0220138.AA Protein None 1248 None Fasta, JSON
DDB0220138.kin_dom Protein Kinase Domain None 291 None Fasta, JSON

Protein domain

Protein domains of DDB0220138.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_TYP DDB0220138.AA LRR_TYP 501-524 41 0.000338 21.19 SMART 1-24 (24) Show / Hide 
Range on Protein: 501-524
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LYNLKKLILDNNQITTIPIECVEP
| ||..| |.|||.|..| .  ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 DDB0220138.AA LRR_1 458-479 40 0.000644 18.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 458-479
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

HLTILDLSH-N--NLH-EICRE-LGNL
.|..||||. |  ||  .|  . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 DDB0220138.AA LRR_1 503-525 37 0.002471 15.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 503-525
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLKKLILDN-N--QIT-TIPIECVEPL
||..| |.. |  ..| .|| .|   |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP DDB0220138.AA LRR_TYP 456-478 33 0.010288 16.14 SMART 1-24 (24) Show / Hide 
Range on Protein: 456-478
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LKHLTILDLSHNNLHEICREL-GN
| .|. ||||.|.| .. ... ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 DDB0220138.AA LRR_1 481-501 33 0.013724 13.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 481-501
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

FLRELYLSN-N--SL-KKFPT--TGNL
 |..|.||. |  .| ...|     ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP DDB0220138.AA LRR_TYP 525-548 29 0.022725 13.32 SMART 1-24 (24) Show / Hide 
Range on Protein: 525-548
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LIQLQTLDLSFNKIGTITSSTTTT
| .|..||||.|.. .. . .   
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC DDB0220138.AA LRR_BAC 479-498 35 0.024144 13.57 SMART 1-20 (20) Show / Hide 
Range on Protein: 479-498
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

LSFLRELYLSNNSLKKFPTT
 ..|..|. |||.|...|  
PPHLKWLNVSNNQLTELPEL
LRR_1 DDB0220138.AA LRR_1 435-456 33 0.047751 11.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 435-456
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLEQLIMFN-N--NLS-DVPSS-IEFL
||. | . . |  ||. ..|.| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP DDB0220138.AA LRR_TYP 479-500 45 0.0531 10.3 SMART 1-24 (24) Show / Hide 
Range on Protein: 479-500
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LSFLRELYLSNNSLKKFPTT--GN
|. ||||.|||| |.  |    ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP DDB0220138.AA LRR_TYP 409-432 29 0.10394 7.91 SMART 1-24 (24) Show / Hide 
Range on Protein: 409-432
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

VQGYKIIDLSFNNIKSIPLDAFTN
    .  |||.|.....| .|| .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 DDB0220138.AA LRR_1 413-433 36 0.113259 10.1 Pfam 8-31 (26) Show / Hide 
Range on Protein: 413-433
Range on HMM: 8-31/26
Sequence Identity: 36% (9 aa)

KIIDLSF-N--NI-KSIPLDAFTNI
...|||  |  |. ..|| ..| | 
QHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 DDB0220138.AA LRR_1 527-544 45 0.14402 9.73 Pfam 1-22 (26) Show / Hide 
Range on Protein: 527-544
Range on HMM: 1-22/26
Sequence Identity: 45% (10 aa)

QLQTLDLSF-N--KI-GTITSS
.||.||||  |  .. |.| .|
NLQHLDLSGCNCCNLTGHIPPS
LRR_TYP DDB0220138.AA LRR_TYP 433-455 29 0.409554 3.03 SMART 1-24 (24) Show / Hide 
Range on Protein: 433-455
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

ISNLEQLIMFNNNLSDVPSSI-EF
 .||. |   ||.|. .|. . . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC DDB0220138.AA LRR_BAC 456-475 35 0.412569 4.16 SMART 1-20 (20) Show / Hide 
Range on Protein: 456-475
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

LKHLTILDLSHNNLHEICRE
  ||..|. |.|.| | .  
PPHLKWLNVSNNQLTELPEL
LRR_BAC DDB0220138.AA LRR_BAC 501-520 40 0.959786 1.36 SMART 1-20 (20) Show / Hide 
Range on Protein: 501-520
Range on HMM: 1-20/20
Sequence Identity: 40% (8 aa)

LYNLKKLILDNNQITTIPIE
  .||.|  .|||.|. |  
PPHLKWLNVSNNQLTELPEL
LRR_BAC DDB0220138.AA LRR_BAC 433-452 30 1.066593 1.01 SMART 1-20 (20) Show / Hide 
Range on Protein: 433-452
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

ISNLEQLIMFNNNLSDVPSS
 ..|. |   ||.|.. |  
PPHLKWLNVSNNQLTELPEL
LRR_1 DDB0220138.AA LRR_1 572-593 40 7.2e-05 21.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 572-593
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLKQLNLSH-N--ELQ-EIPSS-LRHL
||. |.||. |   |. .||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP DDB0220138.AA LRR_TYP 570-592 33 0.000681 20.18 SMART 1-24 (24) Show / Hide 
Range on Protein: 570-592
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

MKNLKQLNLSHNELQEIPSSL-RH
. ||. |.||.| |...|. . ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP DDB0220138.AA LRR_TYP 686-709 37 0.002182 18.5 SMART 1-24 (24) Show / Hide 
Range on Protein: 686-709
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LTKLVDLQLYNNQISSLPISFLKC
|..|  | | |||...||   . .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP DDB0220138.AA LRR_TYP 663-684 45 0.00324 17.93 SMART 1-24 (24) Show / Hide 
Range on Protein: 663-684
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LSNLKKLNLNNNNLKELPSNI--G
|.||..|.|.||.|..||...  |
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 DDB0220138.AA LRR_1 665-686 33 0.003794 15.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 665-686
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLKKLNLNN-N--NL-KELPSN-IGFL
||..|.|.. |  || ...|.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP DDB0220138.AA LRR_TYP 593-616 29 0.006129 17.01 SMART 1-24 (24) Show / Hide 
Range on Protein: 593-616
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LSKLHSLSIDYNQISVLPDKVVAS
|..| .|. ..||.. ||. . ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC DDB0220138.AA LRR_BAC 663-682 50 0.026995 13.2 SMART 1-20 (20) Show / Hide 
Range on Protein: 663-682
Range on HMM: 1-20/20
Sequence Identity: 50% (10 aa)

LSNLKKLNLNNNNLKELPSN
 ..||.|| .||.|.||| .
PPHLKWLNVSNNQLTELPEL
LRR_BAC DDB0220138.AA LRR_BAC 640-659 40 0.03478 12.36 SMART 1-20 (20) Show / Hide 
Range on Protein: 640-659
Range on HMM: 1-20/20
Sequence Identity: 40% (8 aa)

LSSLIELNASNNVIELLPDS
 ..| .||.||| .. ||. 
PPHLKWLNVSNNQLTELPEL
LRR_1 DDB0220138.AA LRR_1 688-709 25 0.038791 11.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 688-709
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KLVDLQLYN-N--QIS-SLPIS-FLKC
.|  | | . |  ... ..| | | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC DDB0220138.AA LRR_BAC 593-612 30 0.060404 10.53 SMART 1-20 (20) Show / Hide 
Range on Protein: 593-612
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

LSKLHSLSIDYNQISVLPDK
 ..| .| ...||.. ||. 
PPHLKWLNVSNNQLTELPEL
LRR_BAC DDB0220138.AA LRR_BAC 570-589 45 0.099362 8.88 SMART 1-20 (20) Show / Hide 
Range on Protein: 570-589
Range on HMM: 1-20/20
Sequence Identity: 45% (9 aa)

MKNLKQLNLSHNELQEIPSS
  .|| || |.|.| | |  
PPHLKWLNVSNNQLTELPEL
LRR_TYP DDB0220138.AA LRR_TYP 617-639 37 0.109026 7.74 SMART 1-24 (24) Show / Hide 
Range on Protein: 617-639
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LSRLAKLTISNNKIKQLP-FAINN
|. | .|  |||....||  | ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 DDB0220138.AA LRR_1 595-617 18 0.138516 9.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 595-617
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

KLHSLSIDY-N--QIS-VLPDKVVASL
.| .|.... |  ...  .|.    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 DDB0220138.AA LRR_1 619-640 25 0.139419 9.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 619-640
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RLAKLTISN-N--KI-KQLPFA-INNL
.| .| .|. |  .. ...|   . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 DDB0220138.AA LRR_1 642-663 25 0.166137 9.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 642-663
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLIELNASN-N--VIE-LLPDS-ICYL
.| .|. |. |   ..  .|.| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP DDB0220138.AA LRR_TYP 640-661 37 0.264954 4.58 SMART 1-24 (24) Show / Hide 
Range on Protein: 640-661
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LSSLIELNASNNVIELLPDSI--C
|..| ||. ||| .. ||. .  .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC DDB0220138.AA LRR_BAC 617-636 35 0.523557 3.37 SMART 1-20 (20) Show / Hide 
Range on Protein: 617-636
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

LSRLAKLTISNNKIKQLPFA
 ..| .| .|||... ||  
PPHLKWLNVSNNQLTELPEL
Kinase DDB0220138.AA TKL-Unique 948-1235 34 2e-140 472.78 In-house 1-290 (290) Show / Hide 
Range on Protein: 948-1235
Range on HMM: 1-290/290
Sequence Identity: 34% (111 aa)

FFNLIGQGGFSKVYHGVWRSKDVAIKQIEL---QNNKSLDDFRREVGILSKLKPHENLLAYYGACK----HANYCYIITEYLPRGSLHDLLHR-------
|.|.||.||...||.|.||...|||||...   ..|.....|..|| ...||..|.|.. |.|.|.    ......|..||.|.|||.|.||.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-EQLMKLDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNA-----LKIKIADFGLASFAKKSLTTIINNNNNTNNTATSSTTTSSANGANSI
 .. .||...|.|..||..|.|.|.|...||||.|.|||..|.||.|.     ..|||.||||. |..|......|....|.                  
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR------------------

SNNNNNGTTSVDQSRLAYAFYAAPEILNS--KHFSEKSDVFSFGTILWELVTNKI------PFDGMDPYEVKELLKS---GKRLEIPENCNEVLKNIIQD
           .|.|.......|||.|..  ...||||||.|||..|||..|.||      |..|||.....|....   ..|..||..|.. ....||.
-----------NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQ

CWNQQSEDRPTFLSIYHRL
||......||.| .|.|||
CWHHDPSQRPSFDEIIHRL
Kinase DDB0220138.AA TKL 952-1235 21 8.4e-87 294.69 In-house 1-364 (364) Show / Hide 
Range on Protein: 952-1235
Range on HMM: 1-364/364
Sequence Identity: 21% (86 aa)

IGQGGFSKVYHGVWRS----------KDVAIKQIELQNNKSLDD-------------------------FRREVGILSKLKP-HENLLAYYGACKHANY-
||.|||..||.|.||           ||||.|..  .|... ..                         |..|. |.....  |.|.. ..|.|.  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------CYIITEYLPRGSLHDLLHREQLMKLDFKQKVSFAICVALGCYHLSTYE------PPIYHTDLKTKNLLVTNALK--------------
            ..|..|| |.|||...||        . |....|. .|.|...| . .      ||| | |||.||.|| . ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

IKIADFGLASFA------------------------KKSLTT---------IINNNNNTNNTATSSTTTSSANGANSISNNNNNGTTSVDQSRLAYAFYA
.||.||||. |                         ...            ......|... .                                     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI-----------------------------------

APEILNSKHFSEKSDVFSFGTILWELVTNKIPFDGMDPYEV----------KELLKSGKRLEIP------------ENCNEVLKNIIQDCWNQQSEDRPT
.. ..... .|||.||.||| .|||..| ..|.........          .   . |.|..||            ..| . .|...||||..  |.||.
DE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPS

FLSIYHRL
|. | .||
FQEILKRL
Kinase DDB0220138.AA TK 946-1235 16 9.2e-55 181.64 In-house 1-486 (486) Show / Hide 
Range on Protein: 946-1235
Range on HMM: 1-486/486
Sequence Identity: 16% (86 aa)

IQFFNLIGQGGFS---KVYHGVWRSK---------------------------DVAIKQIELQNNKSLDDFRR--------------EVGILSKLK----
|.. . .|.| |    .|| | ||..                           .||.|.. . .. | ..|.               |. ......    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHENLLAYYGACKHA------------NYCYIITEYLPRGS----LHDLLH-------------------------------------------------
 |.|..  ||.| .               ..|..|| | |.    |.| |.                                                 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----REQLMKLDFKQKVS-------------------FAICVALGCYHLSTYEP----PIYHTDLKTKNLLVTNALK-----------IKIADFGLA--
     ..... |..|. ..                   ..  .| |. .|.         . | || . | ||.. ..           .|||||||.  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

--SFAKKSLTTIINNNNNTNNTATSSTTTSSANGANSISNNNNNGTTSVDQSRLAYAFY-----------------------------------------
                                                     || . |                                         
GSG-------------------------------------------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRW

AAPEILNSKH---------FSEKSDVFSFGTILWELVT-N-KIPFDGMDP---------YEVKELLKSG--------------KRLEIPENCN-------
 ||| ||...         |..||||.|||  .||..|   . .  ||.           || |.|..|               |.. |..|        
MAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM

-------EVLKNIIQDCWNQQSEDRPTFLSIYHRL
       |..  ..|.||. . ||||||  ....|
HPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDB0220138.AA TyrKc 946-1235 27 1.9e-51 178.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 946-1235
Range on HMM: 1-280/280
Sequence Identity: 27% (88 aa)

IQFFNLIGQGGFSKVYHGVWRSKDVAIKQIELQNNKSLDDFRREVGILSKL-KPHENLLAYYGACKHA-------NYCYIITEYLPRGSLHDLLHREQLM
|..   .| | | .||.|.|.  .||.| .       . ||.||  |..|| . |.|... ||.| .           .|..|| | |.|.| |.. .  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KLDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLASFAKKS-LTTIINNNNNTNNTATSSTTTSSANGANSISNNNNNGTT
 |  |...||.. .| |. .|.    .. | || . | ||.. . .||.||||. . .    .                                .  . 
-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------------------------------ESKDYY

SVD---QSR--LAYAFYAAPEILNSKHFSEKSDVFSFGTILWELVTN-KIPFDG-----MDPYEVKELLKSGKRLEIPEN--------CNEVLKNIIQDC
..    ...  | .    ||| .| . |..||||.|||  .||. |. . |  |     |...|| |..|.|.|...|.|        | . . .|...|
RKKEHKGGKTMLPI-RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC

WNQQSEDRPTFLSIYHRL
|. . ||||||  |....
WHEDPEDRPTFSEIHECF
Kinase DDB0220138.AA S_TKc 946-1242 20 2e-48 168.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 946-1242
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

IQFFNLIGQGGFSKVYHGVWRS--KDVAIKQIELQNNKSLDDFRREVGILSKLKPHENLLAYYGACKHANYCYIITEYLPR--GSLHDLLHREQLMK---
 .. ..||.|.|.||| .....  . ||||.|        ...|||. ||.|   |.|.  .|... . .. |...||..   |.|.|.... .  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLASFAKKSLTTIINNNNNTNNTATSSTTTSSANGANSISNNNNNGTTS
 ..  .  ...  ....  ..   .  | | |||  |.|...   |||.||||| .                                            
PFPE-HARFYMYQICCALEYC--HSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

VDQSRLAYAFYAAPEILNSKHFSE-KSDVFSFGTILWELVTNKIPFDGMDPYEVKELLKSGKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYH--R
   .     .| |||.|   ...  |.|. |.| ||.|... . ||.  ..... ....            . .|..|. |..   |.|||   . .  .
--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

LENLMKSI
. ...  .
DIKCHPWF
Kinase DDB0220138.AA Dicty4 946-1096 38 1.4e-41 136.54 In-house 1-166 (277) Show / Hide 
Range on Protein: 946-1096
Range on HMM: 1-166/277
Sequence Identity: 38% (64 aa)

IQFFNLIGQGGFSKVYHGVWRSKDVAIKQI--ELQN--NKSLDDFRREVGILSKLKPHENLLAYYGACK----HANYCYIITEYLPRGSLHDLLHR----
|.. ..||.|.|..|| | || |.||.|      ||   . | .||.|| |..|.  | |..  .|||     |   . | |||.|.|.|. |||     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIR-HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-EQLMKLDFKQKVS---FAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLASFAKK
  |  |||.    .    |. .|.|  .| .  | | | |||. ||||   ...|..||||.   ||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKK
Kinase DDB0220138.AA DRK 946-1095 36 1.3e-35 118.14 In-house 1-152 (258) Show / Hide 
Range on Protein: 946-1095
Range on HMM: 1-152/258
Sequence Identity: 36% (56 aa)

IQFFNLIGQGGFSKVYHGVWRSKDVAIKQIELQN-N--KSLDDFRREVGILSKLKPHENLLAYYGACKHANYCYIITEYLPRGSLHDLLHREQLMKLDFK
|   | || |..  |. | ||   ||.|   . | |  . | .|.||. ....|  | |   . |.|       |..||.|||||   || | . ..|  
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLR-HPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESI-EMDWP

QKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLAS-FAK
   . .. .| |   |   .| | | |||. ||||    ..|.|||||.  | |
LMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKK
Kinase DDB0220138.AA Pkinase_Tyr 946-1091 31 5.1e-34 115.84 Pfam 1-158 (270) Show / Hide 
Range on Protein: 946-1091
Range on HMM: 1-158/270
Sequence Identity: 31% (51 aa)

IQFFNLIGQGGFSKVYHGVWR------SKDVAIKQIELQNNKS---LDDFRREVGILSKLKPHENLLAYYGACK-HANY--CYIITEYLPRGSLHDLLHR
|.|   .|.| | .||.|.|.        .||.| .  .  ..   ..|| ||. |...|  |.|.. .||.|  .      ||..|| | |.|.| |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E--QLMKLDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLA
   .  .|. |....... .| |. .|.     . | || ..| |||. ...||.|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLA
Kinase DDB0220138.AA Pkinase_Tyr 1150-1235 41 5.1e-34 115.83 Pfam 182-270 (270) Show / Hide 
Range on Protein: 1150-1235
Range on HMM: 182-270/270
Sequence Identity: 41% (37 aa)

APEILNSKHFSEKSDVFSFGTILWELVT-NKIP-FDGMDPYEVKELL-KSGKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHRL
||| .| . |..|||| |||  .||..|  ..| . ||...||.|.. ..| |...|||| . . .....||... ||||||  |...|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DDB0220138.AA MLK 946-1104 29 6.1e-32 108.13 In-house 1-193 (291) Show / Hide 
Range on Protein: 946-1104
Range on HMM: 1-193/291
Sequence Identity: 29% (58 aa)

IQFFNLIGQGGFSKVYHGVWRSKD-----VAIKQIE--LQNNKSL-----DDFRREVGILSKLKPHEN----LLAYYGACKHANY-CYIITEYLPRGSLH
|||   || |.| ||. |.|| ||     ||.|...      ||      .||..|. .|..|. |.|      . ||.|.  ..  .|..||.. |||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILS-HPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

DLLHREQL------------MKLDFKQKVSFAICVALGCYHLSTYEP-PIYHTDLKTKNLLVTN------ALKIKIADFGLASFAKKSLTTIINN
..|| ..                |. .....|  .| |   |   .| || | ||| .|.|...       .. ||.|||.. . ... |.  .|
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN
Kinase DDB0220138.AA LRRK 1148-1237 32 9.2e-31 106.05 In-house 245-351 (351) Show / Hide 
Range on Protein: 1148-1237
Range on HMM: 245-351/351
Sequence Identity: 32% (35 aa)

YAAPEILN---SKHFSEKSDVFSFGTILWELVTNK-IPFDGMD-------PYEVKELLKSGKRLEIPEN-CNE-----VLKNIIQDCWNQQSEDRPTFLS
. ||||..    . ..||.|..||| |||||.| . .|||..|        ...... ..| |  ||.. |..      ... ||.||... ..||.| .
WMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQ

IYHRLEN
|  ||. 
IVKRLSQ
Kinase DDB0220138.AA Pkinase 946-1114 25 1.7e-29 105.35 Pfam 1-175 (293) Show / Hide 
Range on Protein: 946-1114
Range on HMM: 1-175/293
Sequence Identity: 25% (48 aa)

IQFFNLIGQGGFSKVYHGVWRSKD--VAIKQIELQNNKSLDD--FRR--EVGILSKLKPHENLLAYYGACKHANYCYIITEYLPRG----SLHDLLHREQ
...   ||.|.|..||......    ||.|.|.....||  |   ||  |. |. .|  |.| . .|...   ...|...||.. |    .|.|......
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

LMKL--DFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKI----KIADFGLASFAKKSLTTIINNNNNTNNTATS
  ..  . ..  ...  .. | ...  ..  | | |||  |.|. |   |    ||.||||| ...     . ||  .|  . |.
HGCFYFSEWECKFYMYQILRGLEYC--HSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTP
Kinase DDB0220138.AA TK-Unique 1150-1235 37 9.5e-28 92.83 In-house 204-294 (294) Show / Hide 
Range on Protein: 1150-1235
Range on HMM: 204-294/294
Sequence Identity: 37% (34 aa)

APEILN--SKHF-SEKSDVFSFGTILWELVTN-KIPFDGMDPYEVKELLKSGKRLEIPENC-NEVLKNIIQDCWNQQSEDRPTFLSIYHRL
|||.|    ... ..|||| ||| ..||..|. . |. ||.. .. |... |.|.. ||.| .. . |... ||.   |.||.| .| |||
APESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase DDB0220138.AA Src 946-1091 35 3.7e-27 89.27 In-house 1-144 (255) Show / Hide 
Range on Protein: 946-1091
Range on HMM: 1-144/255
Sequence Identity: 35% (52 aa)

IQFFNLIGQGGFSKVYHGVWRS-KDVAIKQIELQNNKSLDDFRREVGILSKLKPHENLLAYYGACKHANYCYIITEYLPRGSLHDLLH-REQLMKLDFKQ
|..   .||| |  |. |.|.   .||.| .   .  | ..| .|  |. ||. ||.|.. |  |      ||.|||  .||| | |. ...  .| ..|
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQ

KVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLA
 ...|  || |   |.     . | ||  .| || . .  |.||||||
LIDMAAQVAEGMAYLESMN--YIHRDLAARNVLVGENNVCKVADFGLA
Kinase DDB0220138.AA Dicty4 1148-1237 33 6.7e-27 86.89 In-house 183-277 (277) Show / Hide 
Range on Protein: 1148-1237
Range on HMM: 183-277/277
Sequence Identity: 33% (32 aa)

YAAPEILNSKHFSEKSDVFSFGTILWELVTNKIPFD--GMDPYEVKELLKS-GKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHR--LEN
. |||.. .. . ||.||.||| .|||..| ..|.   .|.. .. ..  . . |..|| .|   .|  ||.||.   . ||.|  |  |  || 
WMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase DDB0220138.AA MLK 1150-1235 36 6.3e-26 86.99 In-house 201-291 (291) Show / Hide 
Range on Protein: 1150-1235
Range on HMM: 201-291/291
Sequence Identity: 36% (33 aa)

APEIL---NSKHFSEKSDVFSFGTILWELVTNKIPFD-GMDPYEV-KELLKSGKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHRL
|||..    .  .|||.||.|.| .|||..| ..|.. ..|| ..  .    |.|. || .|.| .|. ...|||| ...||.| .|   |
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase DDB0220138.AA Dicty5 946-1089 34 6.4e-26 86.2 In-house 1-149 (260) Show / Hide 
Range on Protein: 946-1089
Range on HMM: 1-149/260
Sequence Identity: 34% (52 aa)

IQFFNLIGQGGFSKVYHGVWRSKDVAIKQIELQN--NKSLDDFRREVGILSKLK-PHENLLAYYGACKH-ANYCYIITEYLPRGSLHDLLHREQL---MK
. |   |  |   .|| |. . .|||||     |     ...| ||| |.|  .  | |.  .||| .   .| ...|||  .||| ..|          
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQP

LDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFG
. . |....|| .| .  ||      | | |||  | |.|  .|||| |||
IAYFQQLHMAIDIAQSMRHLHSMN--IIHRDLKSMNFLITENWKIKIIDFG
Kinase DDB0220138.AA LRRK 946-1094 22 4e-25 85.82 In-house 66-295 (351) Show / Hide 
Range on Protein: 946-1094
Range on HMM: 66-295/351
Sequence Identity: 22% (54 aa)

IQFFNLIGQGGFS-KVYHGVWRS----------------------------KDVAIKQIELQ-----------NN-----------------------KS
. . ..||.|||  .|| . ||.                            ..||||....            ||                       ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LDDFRREVGILSKLKPHENLLAYYGACKHANYCYIITEYLPRGSLHDLLH---REQL------MKLDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTK
.  ||.|| |.|.|. | |..  .| |   . . ...||.| |.|...||   . ..      ..  .|.|.  |. .| |  .|    ||| |.|||. 
FREFRHEVWIMSHLN-HPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKI--ALQIAKGMEYLHSHNPPIIHRDLKSP

NLLV---T---------NALKIKIADFGLAS--FA
| |.   .         .. ..||||||. .  ..
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQC
Kinase DDB0220138.AA Src 1150-1235 40 1.4e-24 80.36 In-house 168-255 (255) Show / Hide 
Range on Protein: 1150-1235
Range on HMM: 168-255/255
Sequence Identity: 40% (36 aa)

APEILNSKHFSEKSDVFSFGTILWELVT-NKIPFDGMDPYEVKELLKSGKRLEIPENCNEVLKN-IIQDCWNQQSEDRPTFLSIYHRL
||| .|  .|. |||| |||  |.|.||  ..|  ||.  || . .. | |.  |.|| . | . |.. ||... |.||||  ... |
APEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase DDB0220138.AA Dicty5 1148-1239 33 9.8e-23 75.08 In-house 169-260 (260) Show / Hide 
Range on Protein: 1148-1239
Range on HMM: 169-260/260
Sequence Identity: 33% (31 aa)

YAAPEILNSKHFSEKSDVFSFGTILWELVTNKIPFDGMDPYEVKELLKSGKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHRLENLM
. |.|. |.. . .| ||.||| .|||. | | |.| .   .   .  .| | .||  |     |.|  || |    ||.|  |   .| ..
WMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase DDB0220138.AA DRK 1150-1237 35 1.5e-21 69.83 In-house 170-258 (258) Show / Hide 
Range on Protein: 1150-1237
Range on HMM: 170-258/258
Sequence Identity: 35% (32 aa)

APEILNSKHFSEKSDVFSFGTILWELVTNKIPFDGMDPYEVKELLKS-GKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHRLEN
|||.| .  . || ||.||. .|||.|| ..|. || .  |       | |. .|..|       ..||||     ||..  .  ||| 
APEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase DDB0220138.AA TK-Unique 946-1091 24 1.5e-20 67.63 In-house 1-180 (294) Show / Hide 
Range on Protein: 946-1091
Range on HMM: 1-180/294
Sequence Identity: 24% (45 aa)

IQFFNLIGQGGFSKVYHGVWRS--------KDVAIKQIELQNNKS-LDDFRREVGILSKLKPHENLLAYYGACKHA-NYCYIITEYLPRGSLHDLLH---
. ....||.| |. |..|  ..        | ||.|. .  ...   .|| .|  ....|..|.|..  .|.|    .  .|| ||.|.|.| ..|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------------REQLMKLDFKQKVSFAICVALGCYHLST--YEPPIYHTDLKTKNLLVTNALKIKIADFGLA
                     . ..  .. |. ..||. .| |  .|.   ..  | | || ..| |.|. ...||.|||.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK--IVHRDLCARNVLLTEDKVCKICDFGMA
Kinase DDB0220138.AA Pkinase 1147-1235 18 4e-17 61.62 Pfam 176-293 (293) Show / Hide 
Range on Protein: 1147-1235
Range on HMM: 176-293/293
Sequence Identity: 18% (22 aa)

FYAAPEILN-SKHFSEKSDVFSFGTILWELVTNKIPFDGM----DPYEVKELLKSGKRLEIPENCN-----------------------EVLKNIIQDCW
.|.|||... ... . |.|..|.| ||.|... . ||.|     . .. .....  .. ......                        | .| .| .|.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

NQQSEDRPTFLSIYHR--L
..  ..|||.  | .   .
CKDPKKRPTAEQILQHPWF