Gene DDB0229847 (Slime mold)

DDB0229847

Species: Slime mold
Alias: DDB0229847, DdisK185
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: ARK

Sequence

Name Sequence Type Origin Length Description Download
DDB0229847.AA Protein None 2230 None Fasta, JSON
DDB0229847.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of DDB0229847.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Med15 DDB0229847.AA Med15 1462-1868 8 7.8e-08 26.55 Pfam 396-462 (945) Show / Hide 
Range on Protein: 1462-1868
Range on HMM: 396-462/945
Sequence Identity: 8% (36 aa)

MASGALSPSTLNQQQHQILQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQHQQFQPNPSPSPPLTPSSNSIIQPSQQQQPQQIVNTLINSSSDNTLV
|  |  .. ..  .| | . |.|. . .|...||||||||||||||.|.|||| || |                                          
MVQGQHMQQQVMSAQQQQNKQMQAMNMRQHCDQQQQQQQQQQQQQQHQAQHQQQQQQQ------------------------------------------

LPTIPNITNTPPSPTQTLPLPSSSSSSLVIPNSNINSSPTSPSLSYNNNSNSNSNAGVGSIPLSFNEIVNSNNSPNINNNGIINTSSNNNINNTNASING
                                                                                                    
----------------------------------------------------------------------------------------------------

SANQLFNNPMTFSGNEIVLPPIVQSSGGSLFTDSPLSSPKRIHFHNGIGNGDLLNNRAVLHSTVSNNNNINSNNNNNNNNNNNNNNNNNNNNNNNNNNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NNNSNNNNGNDSLAILQKLIANGGSLKNAIYSLNNRSNSSNNLMSNNNINNSNIPNRLLNNRSNSSNSLMSSNNKNNYNNYNSNNNHIYSNEELTEIHQQ
                                                                                                  ||
--------------------------------------------------------------------------------------------------QQ

QQLQQQQ
|| .|||
QQQHQQQ
SprA-related DDB0229847.AA SprA-related 1168-1517 9 3e-06 23.2 Pfam 104-273 (321) Show / Hide 
Range on Protein: 1168-1517
Range on HMM: 104-273/321
Sequence Identity: 9% (39 aa)

SI-TASSSSTSINNNT---TTATATTVTTPVIVHQRHHSSTVSGHYGGHRNHLQHVKLSHSNSPSPSSSPPDSYTSNQPLIFNGSPLGVSGSDYSFNKFG
.| | |..|.|...     |.|.... |                                                                        
MIITNSYPSISYYSGSPQGTEAARRNNT------------------------------------------------------------------------

NNSLVPPNLNISQASGGGSGNSNNNNNNELIINIKGLSPPTSHISSPPLSPRLSMIRPHFTNGSMKSSLFQQQLQPTGSINSSPINNHQVSGGCGGDQTT
                                                                                                    
----------------------------------------------------------------------------------------------------

ELQTETLDDFIPHGVAFGFKRGACKPPCDCLTYQSEGDKGGACLNCGHYPALHKNLGKISNSNNSIDIDSLQQQQQHQ----------------------
                                                               .. .| ....... .                      
---------------------------------------------------------------PRENIPQPSSSENSNNFPNSSSDATATSQTSTAVAND

QIHHQSNLLPNTLLNLSNVTMAS--------GALSPSTLNQQQH-------QILQQQQQQQQQQQQQ-----QQQQQQQQ-----------QQQQQQQQQ
|   ||.  ..   . .......        .. .| .  |..        ....|.|..|||.|..     ||.||.||           ||.||||||
QS-KQSEDGST-QPQFAKIFGQAQTQNGQASQEQQPQASQQNDEDKQEQERDEVGQEQPEQQQAQAGFENATQQSQQRQQQDQQTRQQQAQQQEQQQQQQ

QHQQHQQ
| ||.||
QQQQQQQ
SprA-related DDB0229847.AA SprA-related 1628-1903 10 0.019275 9.77 Pfam 1-171 (321) Show / Hide 
Range on Protein: 1628-1903
Range on HMM: 1-171/321
Sequence Identity: 10% (38 aa)

EI-VNSNNSPNINNNGIINTSSNNNINNTNASINGSANQLFNNPMTFSGNEIVLPPIVQSSGGSLFTDSPLSSPKRIHFHNGIGNGDLLNNRAVLHSTVS
 | .||  | ....   ..|.   . |                                                                         
MIITNSYPSISYYSGSPQGTEAARRNNT------------------------------------------------------------------------

NNNNINSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNGNDSLAILQKLIANGGSLKNAIYSLNNRSNSSNNLMSNNNINNSNIPNRLLNNRSNS
                                                                                                    
----------------------------------------------------------------------------------------------------

SNSLMSSNNKNNYNNYNSNNNHIYSN------------------------------------------------EELTEIHQQQ--------QLQQQQQQ
     .. |...  .  ..||.  |.                                                .  .. ....        ...|.|..
-----PRENIPQPSSSENSNNFPNSSSDATATSQTSTAVANDQSKQSEDGSTQPQFAKIFGQAQTQNGQASQEQQPQASQQNDEDKQEQERDEVGQEQPE

QQQLQQQ----QQQQQQQQQ-----------QQQQQQQQQQQQQQQQQ
||| |..    .||.||.||           ||.||||||||||||||
QQQAQAGFENATQQSQQRQQQDQQTRQQQAQQQEQQQQQQQQQQQQQQ
Med15 DDB0229847.AA Med15 689-1442 3 2.089034 0.5 Pfam 860-899 (945) Show / Hide 
Range on Protein: 689-1442
Range on HMM: 860-899/945
Sequence Identity: 3% (26 aa)

IQQQQLQLQHQHQQHQQAHQHQHQQQQQHQQQLKSRSNTTNTPLMMFSVSENNSPNNSPPVSPPSSPMLSPLSSSPPSWISGTSPARKLRGRAATGSLLS
..|.. |.| | || ||. ||| |.||| |||                                                                    
MRQHCDQQQQQQQQQQQQQQHQAQHQQQQQQQ--------------------------------------------------------------------

GSSSNNNTTTTTTTTTSNSNSLSNNNRSNSFVDSRPFLPPVKTMPNIGGGQYNTTPPLLPSQTGDHVVKTPKDYHRKPKLLIAKLLKNNSLYMEKEKEKE
                                                                                                    
----------------------------------------------------------------------------------------------------

KEKEKNESSKLDIKNFAASGGQLSLSSNQIISNNSNSSSNNNNNNNNNNNNNNNNNNGLSNNIVINNSNNNSNNNSASSSPTSSNSGYLNESNFILSSSS
                                                                                                    
----------------------------------------------------------------------------------------------------

KESLSALMKDRIGYDLFKIFCKELVNKQGTNLVNILLFIEEVESFQSGIFNTDQLVLEETDRIFYKFILESTAAEFDINIPKRYFYQINHHIKEKIPNKY
                                                                                                    
----------------------------------------------------------------------------------------------------

VFEKVLKALKDETSADAFKRFCILHSTTNGTSAPTNSTTIHSPSLAVPLSSSSWNGLSKETSNSLVNNNTTPNTSTASPSITASSSSTSINNNTTTATAT
                                                                                                    
----------------------------------------------------------------------------------------------------

TVTTPVIVHQRHHSSTVSGHYGGHRNHLQHVKLSHSNSPSPSSSPPDSYTSNQPLIFNGSPLGVSGSDYSFNKFGNNSLVPPNLNISQASGGGSGNSNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NNNELIINIKGLSPPTSHISSPPLSPRLSMIRPHFTNGSMKSSLFQQQLQPTGSINSSPINNHQVSGGCGGDQTTELQTETLDDFIPHGVAFGFKRGACK
                                                                                                    
----------------------------------------------------------------------------------------------------

PPCDCLTYQSEGDKGGACLNCGHYPALHKNLGKISNSNNSIDIDSLQQQQQHQQ
                                              ||||||||
----------------------------------------------QQQQQHQQ
Kinase DDB0229847.AA ARK 1949-2206 55 1.7e-198 665.73 In-house 1-280 (280) Show / Hide 
Range on Protein: 1949-2206
Range on HMM: 1-280/280
Sequence Identity: 55% (156 aa)

IVFLNKLGEGTSAKVYRATWRNQEVAVKVLRS-EPESQKLLDFLKELEIMSSLRSPHVVYFYGMVLDP-----KICMIMEYCSNQTLYHLMH-LQMNFTW
. ...|.|.|.|.|||....|..|||.|||.| ...|.....|.||..||||.||||||||||....|     |.||.|||||...|||.|.  .|.|.|
LEYTCKIGSGSSCKVYKGKYRGKEVAIKVLKSIMTDSMQIEEFKKEFQIMSSIRSPHVVYFYGACIEPEPQKQKLCMVMEYCSRGSLYHIMNNNKMDFGW

DWVFKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDNWTIKVADFGLSRFAT-AKSASNRTTRGTFAYCAPEVFY-----------GIHTT-KGDIFS
|..||....||||.||||.|.|.|||||||||||||..|||.||.|||||||.| .........|||||||||||.|           |.|.| |.|..|
DRFFKWMMQMVRGINCLHNWTPQIVHRDLKSLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDVYS

IGIILWELAVRCIKSKYEKPFSEFKHIQ--YDFQILVQTSKFNLRPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILDS
.|||.||...|||...|..|.||.|||.  .|||||.||||.||||||||||||...|||..||...|||||||.||. .
MGIIMWEMVYRCINGCYMRPYSEYKHIKNAFDFQILIQTSKNNLRPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE
Kinase DDB0229847.AA TKL 1955-2207 26 1.5e-100 340.38 In-house 1-364 (364) Show / Hide 
Range on Protein: 1955-2207
Range on HMM: 1-364/364
Sequence Identity: 26% (99 aa)

LGEGTSAKVYRATWRN----------QEVAVKVLRSEP--------------------------ESQKLLDFLKELEIMSSLRSPHVVYFYGMVLDPK--
.|.|....||...||.          ..||||...|.                            |.    . .|. .||.|| |..| |.| ...|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------ICMIMEYCSNQTLYHLMHLQMNFTWDWVFKFAIEMVRGVNCLHSWK------PVIVHRDLKSLNLLVSDNWT--------------IK
            .|..||||.. .|.|..|      |.  ...|... ||.| |||..      | |.|||||| |.|| .|||              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

VADFGLSRFATAKSASNRT-------------------TRGTFAYCAPEVFY-----------------GIHTTKGDIFSIGIILWELAVRCIKSKYEKP
..||||||| . .. .|.|                    .||....||||.                  .  ..| |..| ||.|||.. ||.      |
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------P

FSEFKHIQYDFQ-----ILVQTSKFNLRPTIP------------QNCPEAFSNLISNCWESSPDNRPSCPEILDSL
........ .||     .... .. .|||.||             .||. ...|.  ||.. |..|||. |||. |
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase DDB0229847.AA TKL-Unique 1951-2207 32 8.2e-82 278.1 In-house 1-290 (290) Show / Hide 
Range on Protein: 1951-2207
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)

FLNKLGEGTSAKVYRATWRNQEVAVKVLR--SEPESQKLLDFLKELEIMSSLR-SPHVVYFYGMVLD-----PKICMIMEYCSNQTLYHLMH--------
|.||.|||....||...||  .||.|..   ........ .| .|. .|. |. .| .| ..|   |     |. |..||||.  .|| . |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--LQMNFTWDWVFKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDN-----WTIKVADFGLSRFATAKSASNRTTR---------GTFAYCAPEVFYG
    .....  . |.|| ...| . ||. .| | ||||||.|.||. |     | ||..|||||.|..  .... ..          |.| . ||||. .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

---IHTTKGDIFSIGIILWELAVRCIKSKYEKPFSEFKHIQYDFQILVQTSKFNLRPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILDSL
     ..| |..| ||.|||.| |.|   | ||.... ..|. .... .. . |.||.||..||. ...||  || . |..|||  ||. .|
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQW-CEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase DDB0229847.AA MLK 1949-2207 30 1.4e-66 227.53 In-house 1-291 (291) Show / Hide 
Range on Protein: 1949-2207
Range on HMM: 1-291/291
Sequence Identity: 30% (92 aa)

IVFLNKLGEGTSAKVYRATWRNQE-----VAVKVLR--------SEPESQKLLDFLKELEIMSSLR-SPHVVYFYGMVLDP-K-ICMIMEYCSNQTLYHL
| |. ..|.|.. ||....|||..     ||||  |        .. |....  . ..| |.| .  .| ...|||  |.| .  | .||||..  ||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

MHLQ--------------MNFTWDWVFKFAIEMVRGVNCLHSWKPV-IVHRDLKSLNLLVSD------NWTIKVADFGLSRFATAKSASNRTT-RGTFAY
 | .               . . | ....|  . ||.. ||| .|. |.|||||| |.|...      . | |..|||.||. . .  .|..  .||.|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

CAPEVF----YGIHTTKGDIFSIGIILWELAVRCIKSKYEKPFSEFKHIQYDFQILVQTSKFNLRPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILDS
 ||||.     .  . | |..|.|..|||.  |      | |..    ... ..|. .    .|||.||..||| ...|...||.. | .|||  .|.  
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR------EVPYK---QHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQH

L
|
L
Kinase DDB0229847.AA Dicty4 1949-2137 36 1.1e-57 191.07 In-house 1-211 (277) Show / Hide 
Range on Protein: 1949-2137
Range on HMM: 1-211/277
Sequence Identity: 36% (78 aa)

IVFLNKLGEGTSAKVYRATWRNQEVAVKVL--RSEP-ESQKLLDFLKELEIMSSLRSPHVVYFYGMVL----DP-KICMIMEYCSNQTLYHLMHL-----
|.. ...|.|  ..||..||| .|||||.|  . .  ..  | .|.|| .||...| |... |.|  .     | |.|  .||..  .|| | |      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

QMNFTWD--WVFK---FAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDNWTIKVADFGLSR-FATAKSASN--RTTRGTFAYCAPEVFYGIH-TTKGDI
| . . |   . .    |.  .||.| ||.  |||.|||||| ||||..||..||.|||||. . . .. .    |. || .. ||||  .   . | | 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

FSIGIILWELA
.| ||.|||..
YSFGIVLWEIL
Kinase DDB0229847.AA LRRK 1949-2209 26 6.3e-56 192.12 In-house 1-351 (351) Show / Hide 
Range on Protein: 1949-2209
Range on HMM: 1-351/351
Sequence Identity: 26% (95 aa)

IVFLNKLGEGTSA-KVYRATWRN----------------------------QEVAVKVLRSEP---------------------------------ESQK
... ...|.|... .||||.||.                            |.||.|..  .|                                  . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LLDFLKELEIMSSLRSPHVVYFYGMVLDPKICMIMEYCSNQTLYHLMH--LQMN-------FTWDWVFKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLV
.  | .|. |||.|. |..|  .|  ..| .||.||| .. .|||..|   |.        ..|  . | |..  .|.. ||| .| |.|||||| | |.
FREFRHEVWIMSHLNHPNIVSLKGFCIHP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

-SD-----------NWTIKVADFGLSR-FATAKSASNRTTRGTFAYCAPEVFYG----IHTTKGDIFSIGIILWELAVRCIKSKYE-KPFSEFK-HIQYD
 |            . ..|.||||.|| |.. ...  ..  |.. ..|||.  .      |.| |..| |.|||||  |      .  || |..   .. 
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR------QHHPFDEHDFFDHMQ

FQILVQT-SKFNLRPTIPQN-CPE-----AFSNLISNCWESSPDNRPSCPEILDSLLD
......   .  |||||||. ||.      ...||  ||.  |..||.  .|.. | .
WMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase DDB0229847.AA TKL-ciliate2 1949-2208 36 2.2e-53 176.29 In-house 1-273 (273) Show / Hide 
Range on Protein: 1949-2208
Range on HMM: 1-273/273
Sequence Identity: 36% (104 aa)

IVFLNKLGEGTSAKVYRATWRNQEVAVKVLRSEPESQ-KLLDFLKELEIMSSLRSPHVVYFYGMVLD-PKICMIMEYCSNQTLYHLMHL-QMNFTWDWVF
.   ||. ||    .|.| ||   ||||  . . . | .. ||. | . |  || | .| | |   . |  |.|||||    |. |.   ..  ||.   
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRR

KFAIEMVRGVNCLHSWKPVIVHRDLK--------------------SLNLLVSDNWTIKVADFGLSRFATAKSASNRTTR--GTFAYCAPEVFYG-IHTT
. |... |||  ||| .| |.|||||                    |||.|| ||   |..|||  |    |   |  |   ||. . ||||    . | 
RIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRV---KPQDNYMTNKIGTYQWMAPEVIKAFYYTE

KGDIFSIGIILWELAVRCIKSKYEKPFSEFKHIQYDFQILVQTSKFNLRPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILDSLL
| |.|| .|||||.| |      | |. . |      ... .    |||||||.|||  |..|.  ||.   . |||  ||.  | 
KADVFSYSIILWEIASR------EPPYRNKKGDVVAEKVMCN----NLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase DDB0229847.AA S_TKc 1949-2208 23 1e-52 182.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 1949-2208
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

IVFLNKLGEGTSAKVYRATWRN--QEVAVKVLRSEPESQKLLDFLKELEIMSSLRSPHVVYFYGMVLDPKICMIMEYCSN--QTLYHLMHLQMN------
  .|.|.|.|. .|||......  ..||.|...         ....|..|... . |..| .|..  | ...|.||||..   .|..... .        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FTWDWVFKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDNWTIKVADFGLSRFATAKSASNRTTRGTFAYCAPEVFYGIHTT-KGDIFSIGIILWELA
|.  .. ... ....... .|| .  |.|||||  |.|...  .||..||||.|.        .|  ||  |.||||.   ... | |. |.|.||.|..
FPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEML

VRCIKSKYEKPFSEFKHIQYDFQILVQTSKFNLRPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILD--------SLL
...       ..  ||.|                       .. . ..|..|..  |..||.. |.|           .
CGYPPFP--QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0229847.AA Pkinase 1949-2207 24 1.7e-51 182.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1949-2207
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

IVFLNKLGEGTSAKVYRATWRNQE--VAVKVLRSEPESQKLL--DFL-KELEIMSSLRSPHVVYFYGMVL-DPKICMIMEYCSNQ----TLYHLMH--LQ
.... |.|.|....||...... .  ||||... . |. . .  ...  |..|| .|..|..| .|...  ...|.|.|||| .      |.....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

MNF--TWDWVFKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDNWTI----KVADFGLSRFA-TAKSASNRTTRGTFAYCAPEV--FYGIHTTKGDIF
 .|  ... . ... ...||.. .|| .  |.|||||. |.|...| .|    |..||||.... . ..  . |  ||  |.||||  ..  ...| |..
GCFYFSEWECKFYMYQILRGLEYCHS-M-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SIGIILWELAVRCIKSKYEKPFSEF---KHIQYDFQILVQTSKFNLRPTIPQNCP-------------------EAFSNLISNCWESSPDNRPSCPEILD
|.|.||.|.. .        ||..    ..   . |..... .  |.  .|. |.                   |..  .|..|..  |  ||....|| 
SCGCILYEMLCGR------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

S--L
.  .
HPWF
Kinase DDB0229847.AA STE 1949-2199 18 1.3e-46 161.19 In-house 1-347 (359) Show / Hide 
Range on Protein: 1949-2199
Range on HMM: 1-347/359
Sequence Identity: 18% (68 aa)

IVFLNKLGEGTSAKVYRATWR-----------------NQEVAVKVLRSEPES----------------QKLLDFLKELEIMSSLR--SPHVVYFYGMVL
  .. |.|.|.. .||.|  .                 .. .|.|... |...                ... ..|||..||. ..  .|..| .||. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

--------DPKICMIMEYCSNQTLYHLMH------LQMN--------FTWDWVFKFAIEMVRG-VNCLHSWKPVIVHRDLKSLNLLVSDNWTIKVADFGL
        | .....|||... .|  ...       ..|        |  ... ... . ..|  . ||| .  |.|||.|. | |.     .| .|||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

SRFATAKSA----------------SNRTTRGTFAYCAPEVFYG-I------HTTKGDIFSIGIILWELAVRCIKSKYEKPFSEFKHIQYDFQILVQTSK
.   | ..|                 . |  ||  . ||||  .        ..|| || |.|. ..|.|  .       |...... .  |.|.  . .
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP------PWHDMHPMRAMFMIPFNYHM

FN----------LRPTIPQ-------------------NCPEAFSNLISNCWESSPDNRPS
..            |..|.                   .. . | . |..| .  |..||.
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase DDB0229847.AA DRK 1949-2141 38 1.6e-46 155.58 In-house 1-200 (258) Show / Hide 
Range on Protein: 1949-2141
Range on HMM: 1-200/258
Sequence Identity: 38% (76 aa)

IVFLNKLGEGTSAKVYRATWRNQEVAVKVLRSEPES-QKLL-DFLKELEIMSSLRSPHVVYFYGMVLDP-KICMIMEYCSNQTLYHLMHLQ-MNFTWDWV
|.  |  | |  . |.| |||  .|||| |    .   ..| .| .| ..|. || | .. | |  . |  || .||| .   ||   | . .   |  .
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

FKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDNWTIKVADFGLS-RFATAKS-ASNRTTRGTFAYCAPEVF-YGIHTTKGDIFSIGIILWELAVRCI
 . ..   .|.. ||.  |.|.|||||| |||| ..| .|||||||| ||   |.    .|  ||    ||||      | | |..| .|.|||.. | .
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD
Kinase DDB0229847.AA Dicty4-Unclassified 1949-2207 30 3.2e-46 156.29 In-house 1-263 (263) Show / Hide 
Range on Protein: 1949-2207
Range on HMM: 1-263/263
Sequence Identity: 30% (84 aa)

IVFLNKLGEGTSAKVYRATWRNQEVAVKVLRSEPESQK---LLDFLKELEIMSSLRSPHVVYFYGMVLDP-----KICMIMEYCSNQTLYHLMH-----L
|  .  .|.|  .||..  |.  .|||| . .   .     . ||.|| ||. |.  |  |  ||  . |      .| .||     .|  . |      
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

QMNFTWDW--VFKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDNWTIKVADFGLSRFATAKSASNRTTRG-TFAYCAPEVFYG-IHTTKGDIFSIGI
|     |   . |.|..  .|   ||.    ..|||.|| |.|.  .  ||.||||.||        | || . | .  .||.  .   . | |..| ..
QQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVIDF--NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAM

ILWELAVRCIKSKYEKPFSEFKHIQ--YDFQILVQTSKFNLRPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILDSL
.|.|||        . |. |   ||   .  ..|  .|  ||| || ||.  .. ||  ||  .|  ||.  .| . |
MLYELATG------DEPYQE---IQSIMNAARSV-CDK-KLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase DDB0229847.AA Pkinase_Tyr 1949-2136 30 7.2e-37 125.49 Pfam 99-305 (270) Show / Hide 
Range on Protein: 1949-2136
Range on HMM: 99-305/270
Sequence Identity: 30% (64 aa)

IVFLNKLGEGTSAKVYRATWR------NQEVAVKVLRSEPESQK--LLDFLKELEIMSSL-RSPHVVYFYGMVL--DPK--ICMIMEYCSNQTLYHLMHL
|.|. |||||   .||..||.      ...||||.|.    ..   . ||..|..||..| . |..| .|| ..  .    |...|||. .  |..  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----QMNFTWDWVFKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDNWTIKVADFGLSRFATAKSASNRTTRG----TFAYCAPE-VFYGIHTTKGDI
    . ..|  .  .....  .| . |.| .  ..||||   | ||..| ..|..||||.|  . ..    ..||        .|||  .||. ||| |.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

FSIGIILWEL
 | |. .||.
WSFGVLMWEI
Kinase DDB0229847.AA TyrKc 1949-2207 26 2.4e-35 124.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 1949-2207
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

IVFLNKLGEGTSAKVYRATWRNQEVAVKVLRSEPESQKLLDFLKELEIMSSL--RSPHVVYFYGMVLD--------PKICMIMEYCSNQTLYHLMHLQMN
|... |||||   .||..||. ..||||.|...     . ||..|..||..|  . |..| .|| ...        . ....|||...  | .  .   .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-FTWDWVFKFAIEMVRGVNCLHSWKPVIVHRDLKSLNLLVSDNWTIKVADFGLSRFATAK------SASNRT-----TR--GTFAYCAPEVF-YGIHTTK
 ....   .|..   .| . ||| .  ..||||   | ||..| |.|..||||||. . .      .   |.     ..       .|||.. ||. |||
KLCMKDLLSFCWQIACGMEYLHSKN--CIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

GDIFSIGIILWELAVRCIKSKYE-----KPFSEFKHIQYDFQILVQTSKFNLRPTIPQN--------CPEAFSNLISNCWESSPDNRPSCPEILDSL
 |..| |. .||.  .. .  ..     .. .|          ...  |   |. .|.|        ||..  .... ||.  |..||.  || . .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE----------VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DDB0229847.AA Dicty4 2170-2210 42 1.6e-11 34.87 In-house 236-277 (277) Show / Hide 
Range on Protein: 2170-2210
Range on HMM: 236-277/277
Sequence Identity: 42% (18 aa)

LRPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILDS-LLDM
||| ||..||  .. ||  ||. .| .||| .||.   .|. 
LRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase DDB0229847.AA DRK 2159-2209 35 4e-11 33.96 In-house 208-258 (258) Show / Hide 
Range on Protein: 2159-2209
Range on HMM: 208-258/258
Sequence Identity: 35% (18 aa)

FQILVQTSKFNLRPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILDSLLD
||.     .  .|| .||.||  .  |.  ||.  |  ||| .|.|  |  
FQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase DDB0229847.AA Pkinase_Tyr 2171-2207 37 9.1e-07 23.55 Pfam 234-270 (270) Show / Hide 
Range on Protein: 2171-2207
Range on HMM: 234-270/270
Sequence Identity: 37% (14 aa)

RPTIPQNCPEAFSNLISNCWESSPDNRPSCPEILDSL
|  .|.|||.   .|.  ||.  |..||.  ||.  |
RMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL