Gene DDB0229867 (Slime mold)

DDB0229867

Species: Slime mold
Alias: DdisK224, DDB0229867
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: LISK-DD1

Sequence

Name Sequence Type Origin Length Description Download
DDB0229867.AA Protein None 1311 None Fasta, JSON
DDB0229867.kin_dom Protein Kinase Domain None 301 None Fasta, JSON

Protein domain

Protein domains of DDB0229867.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0229867.AA LISK-DD1 23-313 42 9.80000000001e-179 600.08 In-house 1-290 (290) Show / Hide 
Range on Protein: 23-313
Range on HMM: 1-290/290
Sequence Identity: 42% (139 aa)

IIGKGNFGCVYRGNYLGVEVAIKQIPS----FDDPDYCKYTEREVKALRY---IRHPFVVHFFGACKH-------------ESGFYLITEFIEGLDLRRY
.||||.||.||.|.|.|..||||.|..    ..||||.|...||.|.|..   ||||..|.|.|.|.|             ||..|..||||||.||..|
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

LKSVPK------------PPKWLSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDIS---RNQIKLCDFGFARVGSQYSNGSDSSSSEDESDSECVNG
||..|.            |..| .||.|||..|... .|||||..||||||||||.|..   ...||.|||||||...|..|..                
LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQ----------------

AAGGGGDDVYKNNGNGKPANYRLRRMSICGTPSFMPPEILLQQKYDWSVDVFSFGILCTELITLKRPGKDYWVRSQNNGFDINIEELN-VNIPSPNDCPI
                     ..|.|.||||...|.||..|...||||.||||||....|||| |.|.|..|.||..|.|||..||.. ..||..||||.
---------------------NNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITRKKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPR

QFYDLALKCCSYKHTNRPMFSTIVTIL
.|.||...||.|...|||.|..||..|
EFMDLCMWCCKYDPNNRPSFKEIVQTL
Kinase DDB0229867.AA LISK 23-313 43 5.9e-173 566.5 In-house 1-296 (296) Show / Hide 
Range on Protein: 23-313
Range on HMM: 1-296/296
Sequence Identity: 43% (132 aa)

IIGKGNFGCVYRGNYL--GVEVAIKQIPS----FDDPDYCKYTEREVKALRYIRHPFVVHFFGACKH-ESGFYLITEFIEGLDLRRYLKSVPK---PPKW
.||||.||.||.|...  | ..|||.|..    ..||.|.|...|||. ....|||..|.|.|.|.| .......||.|.| ||..|||...|   |..|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

LSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDIS---RNQIKLCDFGFARVGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYR
  ||.|||..|... .|||.| .||||||||.|....   ...||.|||||||. ....|.......||||| .|      ...|...|.....|..|.|
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESD-PC------MDNDMPMKRKIPKKCMNQR

LRRMSICGTPSFMPPEILLQQKYDWSVDVFSFGILCTELITLKRPGKDYWVRSQNNGFDINIEELN-VNIPSPNDCPIQFYDLALKCCSYKHTNRPMFST
 |||.|||||..|.||.||.|.||.|.|||||||...|.|| .....|||.|.....|....||..  ..|.  ||| .|.||...||.|...|||.|..
KRRMTICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPD--DCPPPFLDLCFDCCKYDPKNRPSFKE

IVTIL
||..|
IVQWL
Kinase DDB0229867.AA TKL 24-313 24 1e-88 301.08 In-house 1-364 (364) Show / Hide 
Range on Protein: 24-313
Range on HMM: 1-364/364
Sequence Identity: 24% (98 aa)

IGKGNFGCVYRGNYLG----------VEVAIKQIPSFD-----------------------DPDYCKYTEREVKALRY---IRHPFVVHFFGACKHESG-
||.| ||.||.|.. |           .||.|...| .                       ||..... ..|.. ..    .||| .|.| |.|. ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FYLITEFIEGLDLRRYLKSVPKPPKWLSRVNIALGVAKTFLFLHS--------KNLLHRDLKSKNILLDISRN-------------QI
            .....|...| .|. ||        |  |...||..|.   .|||        ....||||||||||.|   .              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLCDFGFARVGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMSICGTPSFMPPEILLQQ----------------KYDWSVD
|.||||..|. || .| .|..... |  |                   . .. |.| ..|..|||| .|.||.| .|                .|. ..|
KICDFGLSRFMSQSGNMNDTMTTMME--SA------------------E-HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

VFSFGILCTELITLKRPGKDYWVRSQN------NGFDINI-EELNVNIP----------SPNDCPIQFYDLALKCCSYKHTNRPMFSTIVTIL
|.||||.  |..| .|| .||. ...         | ... . |   ||           ..||| .. .|. .|.... ..|| |..|. .|
VYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase DDB0229867.AA TKL-Unique 20-313 25 7.8e-49 168.55 In-house 1-290 (290) Show / Hide 
Range on Protein: 20-313
Range on HMM: 1-290/290
Sequence Identity: 25% (84 aa)

FKDIIGKGNFGCVYRGNYLGVEVAIKQIPSFDDPDYCKYT--EREVKALRYIR-HPFVVHFFGACK----HESGFYLITEFIEGLDLRRYLK--------
|   || | .| ||.| . | .|||||.    |.   .    |.||. .  .. ||..||..|.|.    ... .....|...|  |. .|         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-SVPKPPKWLSRVNIALGVAKTFLFLHSKN--LLHRDLKSKNILLDIS----RNQIKLCDFGFARVGSQYSNGSDS--SSSEDESDSECVNGAAGGGGDD
 .  ... .. ||..|. .|.   .||...   .||||||.|.|.|       ..||.||||.... |. .... .  . .                   
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR------------------

VYKNNGNGKPANYRLRRMSICGTPSFMPPEILLQ--QKYDWSVDVFSFGILCTELITLKR------PGKDYWVRSQNNGFDINIE-ELNVNIPSPNDCPI
                  . ||..  |.||.| .   .|. ..||.||||   |..| |.      |   |   .|.  . .  . | |   | ||.|| 
----------------NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP---YQGMDQEQWCEMVHYMEENYRPPIPNHCPK

QFYDLALKCCSYKHTNRPMFSTIVTIL
.. ||  .|.   ...|| |..|.. |
EYRDLIQQCWHHDPSQRPSFDEIIHRL
S_TKc DDB0229867.AA S_TKc 18-316 21 3.5e-48 167.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-316
Range on HMM: 1-231/231
Sequence Identity: 21% (66 aa)

LVFKDIIGKGNFGCVYRGNYLG--VEVAIKQIPSFDDPDYCKYTEREVKALRYIRHPFVVHFFGACKHESGFYLITEFIEG--LDLRRYLKSVPKPP--K
  . ..|||| ||.||..   .   .||||.|.        . ..||.. |.  .||..|...... . . .|...|...|   ||..|.|. ....  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

WLSR--VNIALGVAKTFLFLHSKNLLHRDLKSKNILLDISRNQIKLCDFGFARVGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYR
...     ..  ...   ..||.. .|||||  |||||    .||.||||.||.                                              
PFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------------------------------------------

LRRMSICGTPSFMPPEILLQQKYDW-SVDVFSFGILCTELITLKRPGKDYWVRSQNNGFDINIEELNVNIPSPNDCPIQFYDLALKCCSYKHTNRPMFST
   ...|||| .|.||.|   .|.  ..|. |.|..  |... . |        ..  |..               . .. |.  ||. .  ..||    
---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-E

IVT------ILESI
. .      . . .
ALQDEWDIKCHPWF
Pkinase DDB0229867.AA Pkinase 18-304 20 1.3e-47 169.31 Pfam 1-282 (293) Show / Hide 
Range on Protein: 18-304
Range on HMM: 1-282/293
Sequence Identity: 20% (67 aa)

LVFKDIIGKGNFGCVYRGNYLGVE--VAIKQIPSFDDPDYCKYTER---EVKALRYIRHPFVVHFFGACKHESGFYLITEFIEGL----DLRRYLK-SVP
.... .||.|.|||||..   | .  ||.|.|.  .. . ...| |   |.. .. ..||..| .....  ..  |...|. ||     || .|.. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPP--KWLSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDISRNQI----KLCDFGFARVGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNG
..    .    .... ...   ..||.. .|||||. |||.| ....|    |.||||.|.. .                                    
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------------------------------------

NGKPANYRLRRMSICGTPSFMPPEILL-QQKYDWSVDVFSFGILCTELITLKRPGKDYWVRS------QNNGFDINIEELNVNIPSPNDCP---------
     |..   ...|||| .|.||... .|.|. .||..|.|... |...    |.  .  .        .    .| .  .  ..|..|.         
---Y-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC----GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW

----------IQFYDLALKCCSYKHTNRP
            . |.  .|. .. . ||
HFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase DDB0229867.AA STE 18-254 21 4.1e-45 156.2 In-house 1-267 (359) Show / Hide 
Range on Protein: 18-254
Range on HMM: 1-267/359
Sequence Identity: 21% (65 aa)

LVFKDIIGKGNFGCVYRGNYL-----------------GVEVAIKQIPSFDD----------------PDYCKYTEREVKALRYIR--HPFVVHFFGACK
. . ..||||.|| ||.. .                  |. .||||..  ..                ..  .  ..|.| ..  .  ||..|...|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HE-------SGFYLITEFIEGLDLRRYLKSVPKPPKWLS-------------RVNIALGVAKT-FLFLHSKNLLHRDLKSKNILLDISRNQIKLCDFGFA
.|       .  ... |...|  |.  .|.. ...| |.                |.  . |    .|||..  |||.|. ||||      .||||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

R--VGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMSICGTPSFMPPEILLQ------QKYDWSVDVFSFGILCTELITLKR
   . |  .. . |      .  .|.                    ..   .| ...||| .| ||...|      ..|| ..|. |.|... |..| | 
GQLTDSMANI-Q-S---NN-I-IDCI--------------------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP

P
|
P
Kinase DDB0229867.AA Ciliate-E2 18-304 17 3.4e-42 142.64 In-house 1-353 (365) Show / Hide 
Range on Protein: 18-304
Range on HMM: 1-353/365
Sequence Identity: 17% (71 aa)

LVFKDIIGKGNFGCVYRG--NYLGVEVAIKQIPSFD--------------------DPDYCKYTEREVKALRYIR----------------HPFVVHFFG
  |  .||.||||.||..     . ..|||.|  .                      ..  .....| . .| |.                ||... .. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

ACK--HESGFYLITEFIEGLDLRRYLKSVPK----------PPKWLSRVNIALGVAK---------------TFLFLHSKN-LLHRDLKSKNILLDISRN
. .   .. .||..|...| ||. |.|. .|          ....  . .|   ...                . .|||||  .|||.|  |||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

QIKLCDFGFAR--------------------------------VGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMS---IC
 ||..|||...                                                                              ..  .    ||
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQ---------------------------------------------IIQQNMFNTIC

GTPSFMPPEILLQQK---------YDWSVDVFSFGILCTELITLKRPGKDYWVRSQNNGFDINIEELNVNIP----------------SPNDCPIQFYDL
||| .|.||||  .|         || ..|..|.|..  |... |.|              ..|.. ....|                |..... .  ||
GTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDL

ALK----CCSYKHTNRP
  |    .  ..  .|.
IKKFGKRMLQKDPEKRI
Kinase DDB0229867.AA TESK 61-315 32 9.7e-41 126.09 In-house 42-292 (292) Show / Hide 
Range on Protein: 61-315
Range on HMM: 42-292/292
Sequence Identity: 32% (83 aa)

REVKALRYIRHPFVVHFFGACKHESGFYLITEFIEGLDLRRYLKSVPKPPKWLSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLD-ISRNQIK--LCD
|||. .   .|| .. | |.| |.     .||.| |  |   |   . .  |  ... |...|.   .||||.  |||| |||.|      || .  . |
REVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGD

FGFARVGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMSICGTPSFMPPEILLQQKYDWSVDVFSFGILCTELITLKRPGKD
|| |||     .    |    ||    .  |  ||           .    |  .|.. |.|  | ||.|  ..||  .|||||||   |.|       |
FGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGG---PMLEKIPVYCMDSRKEKMAVVGSPYWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPD

YWVRSQNNGFDINIEELNVNIPSPNDCPIQFYDLALKCCSYKHTNRPMFSTIVTILES
|  | .. | |..     .    |.|||  |  || .||..    || |  |.  || 
YMPRTEKFGLDYQAFKEMC----PMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHLEW
Kinase DDB0229867.AA TK 18-313 13 3.1e-39 128.67 In-house 1-486 (486) Show / Hide 
Range on Protein: 18-313
Range on HMM: 1-486/486
Sequence Identity: 13% (74 aa)

LVFKDIIGKGNFG---CVYRGNYLG---------------------------VEVAIKQIPSFDDPDYCKYTE-------------REVKALRYIR----
... . .|.|.||    ||.| . |                           ..||.|.. . |. .     .             .|. ..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPFVVHFFGACKHESG------------FYLITEFIEGLD----LRRYLKSVPKP--------------------------------------------
 || .|...|.| .. .            .....|. .. |    || ||.. ...                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PKWLSRVNIALGVAKTFLFLHSK------NLLHRDLKSKNILLDISRN----------QIKLCDFGFAR
                               .    .. ... .|.   .||||      |. ||||   |.|.. . .          ..|..||| .|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMSI------CGTPSF----------------------------MPPEILL
.||                                           . |..         ....                             |.|| |.
QGS-G----------------------------------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLN

QQK---------YDWSVDVFSFGILCTELITLKRPG-KDYWVRSQN------NGFDINIEELNVNI-----------------PSPNDCP----------
 ..         .    ||.|||.|. |. |.   | . |     |      .  .  . |. ..                  | | .||          
DRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY---GQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPP

----IQFYDLALKCCSYKHTNRPMFSTIVTIL
      .||| ..|..|.   || ||...  |
HCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDB0229867.AA ULK 18-244 21 1.7e-37 128.52 In-house 1-245 (329) Show / Hide 
Range on Protein: 18-244
Range on HMM: 1-245/329
Sequence Identity: 21% (61 aa)

LVFKDIIGKGNFGCVYRG----N--YLGVEVAIKQIPSF-DDPDY--------CKYTEREVKALRYIR--------HPFVVHFFGACKHE--SGFYLITE
 . ....||| || ||.|    .  | .. ||.|.|...  . ..         .  ..|.| .. .         || .| ..  ..      .|.|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FIEGLDLRRYLKSVPK------PPKWLS---RVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDISR-----------NQIKLCDFGFARVGSQYSNGSD
. .| ||. |.|   |       .| ||    ...    .  | .||..|  |||.|  |||..              ...|..|||||.. .  ..  .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

SSSSED-ESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMSICGTPSFMPPEILL----QQKYDWS-VDVFSFGIL
   .   |   .                               .|||| .| |.||     |..|. . .|..|.|..
MMMTCVNE---K------------------------------RLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCI
Kinase DDB0229867.AA Pkinase_Tyr 18-162 27 9.3e-32 108.18 Pfam 1-159 (270) Show / Hide 
Range on Protein: 18-162
Range on HMM: 1-159/270
Sequence Identity: 27% (44 aa)

LVFKDIIGKGNFGCVYRGNYL------GVEVAIKQI-PSFDDPD--YCKYTEREVKALRYI-RHPFVVHFFGACK-HESG--FYLITEFIEGLDLRRYLK
..|   .|.|.|| ||.| .       ...||.| . .. ....    .  . |.| .. . .|| .| . |.|  ..     |...|. .. ||. ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SV---PKPPKWLSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDISRNQIKLCDFGFAR
.    ..|..    ..... .||   .|.|||. ||||  .|.|.. .. ..| |||| ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLAR
Kinase DDB0229867.AA TyrKc 18-313 21 1.2e-31 112.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-313
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

LVFKDIIGKGNFGCVYRGNYLGVEVAIKQIPSFDDPDYCKYTEREVKALRYI--RHPFVVHFFGACKHE-------SGFYLITEFIEGLDLRRYLKSVPK
.......| |.|| ||.| .  ..||.| . .       .   || . .. .  .|| .| ..|.| ..          ....|. .. ||. ||..  .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

PPKWLSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDISRNQIKLCDFGFARVGSQY-SNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNG--NGK-
  ..   ..... .|.   .|||||. ||||   |.|..  . ..| .||| .| .  . ..|                       .|.|.  .  .|| 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQG---------------------ESKDYYRKKEHKGGKT

PANYRLRRMSICGTPSFMPPEILLQQKYDWSVDVFSFGILCTELITLKRPGKDYWVRSQ--NNGFDI--NIEELNVNIPSPND-------CPIQFYDLAL
.  .|            |.|| .   |.    ||.|||... |. |.   .. |.   |   . ...  .... .   . |||       ||   |.. .
MLPIR-----------WMAPECINYGKFTTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK

KCCSYKHTNRPMFSTIVTIL
.|. ..  .|| ||.|. ..
QCWHEDPEDRPTFSEIHECF
Kinase DDB0229867.AA MLK 18-162 28 3.7e-31 105.4 In-house 1-181 (291) Show / Hide 
Range on Protein: 18-162
Range on HMM: 1-181/291
Sequence Identity: 28% (51 aa)

LVFKDIIGKGNFGCVYRGNYLGVE-----VAIKQIPSFDDPDYCKY------TEREVKALRYIRHPF----VVHFFGACKHE-SGFYLITEFIEGLDLRR
. |. .||.| || |..|.. . .     ||.|.. .  . |  .        |.|.. || ..||     .. | |.|. . ..|....|..||  | .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

YLKS-VPKPP------------KWLSRVNIALGVAKTFLFLHSKN---LLHRDLKSKNILLDI-----SRNQIKLCDFGFAR
.|..  .|.             .  . .|.|| .|.   .|||.    . ||||||.|||.|         . | |||| .|
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase DDB0229867.AA MLK 212-313 30 4.9e-11 34.64 In-house 190-291 (291) Show / Hide 
Range on Protein: 212-313
Range on HMM: 190-291/291
Sequence Identity: 30% (32 aa)

RMSICGTPSFMPPEILLQ---QKYDWSVDVFSFGILCTELITLKRPGKDYWVRSQNNGFDINIEELNVNIPSPNDCPIQFYDLALKCCSYKHTNRPMFST
.|| .||. .| ||.. |   .||. ..||.|.|..  |..| . | |...  ..  .. .  ..|.. |||   ||  .  |  .| . .  .|| |. 
MMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMA-IAWWVAYNGLRPPIPST--CPEHWKKLMKQCWNQDPHKRPSFRQ

IVTIL
||..|
IVQHL
Kinase DDB0229867.AA Pkinase_Tyr 279-313 42 2e-06 22.37 Pfam 236-270 (270) Show / Hide 
Range on Protein: 279-313
Range on HMM: 236-270/270
Sequence Identity: 42% (15 aa)

PSPNDCPIQFYDLALKCCSYKHTNRPMFSTIVTIL
| | .||   ||| ..|  |.  .|| || |. .|
PCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DDB0229867.AA Pkinase_Tyr 222-251 40 0.000336 14.85 Pfam 181-210 (270) Show / Hide 
Range on Protein: 222-251
Range on HMM: 181-210/270
Sequence Identity: 40% (12 aa)

MPPEILLQQKYDWSVDVFSFGILCTELITL
|.|| .   |.    || |||.|. |..|.
MAPECINYGKFTTKSDVWSFGVLMWEIFTY
Med15 DDB0229867.AA Med15 318-458 21 0.085964 5.36 Pfam 402-461 (945) Show / Hide 
Range on Protein: 318-458
Range on HMM: 402-461/945
Sequence Identity: 21% (32 aa)

LQLELFENQQQQQQL-------QQQQQLQQQQQQQQQQQQQQQQQLQLQQQQSSESSSSSSSQPLVNNNNNNSNCNNNNFNNSSNNNNSIANNDSISNVS
.| ..   ||||  .       |...|.||||||||||||.|.|. | ||||                                                
MQQQVMSAQQQQNKQMQAMNMRQHCDQQQQQQQQQQQQQQHQAQHQQQQQQQ------------------------------------------------

TTTTSIPTTTTTTTTTTTTTNNITAINGTSNKYLQPLSKHQQQQQRNQ
                                        |||||. |
----------------------------------------QQQQQHQQ
Med15 DDB0229867.AA Med15 495-643 18 0.002263 10.9 Pfam 414-461 (945) Show / Hide 
Range on Protein: 495-643
Range on HMM: 414-461/945
Sequence Identity: 18% (28 aa)

NKLIRANTINILIGQQQQQQQQQQQQQQQQQDNQSSSQNQLIEREGVIKLDTTKYPNGWKEFGIDNSTNKIWIIYQSNIIKIGSNNNNNLIEMTCGTIIK
||...|  .     ||||||||||||||.|.  |   | |                                                            
NKQMQAMNMRQHCDQQQQQQQQQQQQQQHQAQHQQQQQQQ------------------------------------------------------------

LKKHSITLSIVDSNLISGANIINVKSYLKDYPYVNKPIKVNQQQQQQQQ
                                         |||||.||
-----------------------------------------QQQQQHQQ
IQ DDB0229867.AA IQ 651-671 38 4.9e-07 26.66 Pfam 1-21 (21) Show / Hide 
Range on Protein: 651-671
Range on HMM: 1-21/21
Sequence Identity: 38% (8 aa)

LNLIIKLQSRIRGWLVRRRYK
   .||.|...||.|.|..|.
HRAAIKIQAWWRGYLARKHYR
IQ DDB0229867.AA IQ 649-671 39 1e-06 29.09 SMART 1-23 (23) Show / Hide 
Range on Protein: 649-671
Range on HMM: 1-23/23
Sequence Identity: 39% (9 aa)

YELNLIIKLQSRIRGWLVRRRYK
 .   .|..|...||.|.|.|||
RMHRAAIIIQAWWRGYLARKRYK
RhoGEF DDB0229867.AA RhoGEF 695-926 19 2e-19 68.37 Pfam 1-196 (196) Show / Hide 
Range on Protein: 695-926
Range on HMM: 1-196/196
Sequence Identity: 19% (48 aa)

LFNQLISSELEYKKQLDQVIKSYLLPIQSKFRINKPLLNYKEIGSIFSNIESLSEIHNELLKIVNQISKSPFFIMNFENEKDDRSNQNNTSATTDIFGDS
  . .|..|  | ..|  .|. |. |.. .   |.|.|. .|| .||||||.. |.|...|.   ..                                 
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA--NPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEER---------------------------------

SIQFTNISINTKDSS--NQINS--ITQFI--VKNISQIKNQYGIYAFNFKYSTNIYNWCRLNPD-FSIFCDTIRSQLNQQFPDQEND-LASLLSLPINKI
         .  . .  ... .  | . .  .|  .. .. |. |  |. ..  ... || ..  |  |.. ...  |..   .  | | |.| .|.  |
---------DRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMYSEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE-NDPCC-RRLDLLQSFLIKPVQRI

QKYLLVFEKLAQITPI-THS-EYKDIKSAFTLIRETSNYIQS
 .| | .. | . ||  .|  .|.|.. |. ...|  ..|  
PRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHINE
RhoGEF DDB0229867.AA RhoGEF 695-926 18 3.5e-08 34.42 SMART 1-211 (211) Show / Hide 
Range on Protein: 695-926
Range on HMM: 1-211/211
Sequence Identity: 18% (46 aa)

LFNQLISSELEYKKQLDQVIKSYLLPIQSKFRINK-PLLNYKEIGSIFS-NIESLSEIHNELLKIVNQISKSP-FFIMNFENEKDDRSNQNNTSATTDIF
  . |. .| .| ..|  ... |. |.|.  . .| |.|  .|. .||. |||.. |.|...|.  .....    ..                       
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSM-----------------------

GDSSIQFTNISINTKDSSNQINSITQFIVKNISQI------KNQYGIYAFNFKYSTNIYNW---CRLNPDFSIFCDTIRSQLNQQFPDQ-----ENDLAS
          .   ... .||. |.. |    ...      .. |. |. |..|. .....   |. ||.|. ||. .      . . .       .| .
----------DW-KSFRNFQIRDICDRIGDCFMKWFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKEC----ESHPNCRSNSEHRLTLED

LLSLPINKIQKYLLVFEKLAQITPITHSEYKDIKSAFTLIRETSNYIQS
.|..|.  | || | .. . . ||  |..|.|.. |  ....  .... 
FLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKALDCMKDVAQHCNE