Gene DDB0229957 (Slime mold)

DDB0229957

Species: Slime mold
Alias: DdisK244, DDB0229957
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
DDB0229957.AA Protein None 1555 None Fasta, JSON
DDB0229957.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of DDB0229957.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH DDB0229957.AA PH 59-240 13 9e-16 59.64 SMART 1-82 (82) Show / Hide 
Range on Protein: 59-240
Range on HMM: 1-82/82
Sequence Identity: 13% (25 aa)

VLHTGYLTKQGGRIQNWKIRWFVLKRGTLSYYLSPINWEYTKPRGVIYLTKKTELKEVDHRNRRHCFAVNPNYISENQSIIQQQQNQPILRSSSDSVNNN
|.. |.|.|..    .|| |||||....|.|| ..      ||.|.| |..  ...| .                                         
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK------KPKGSIPLSDC-TVRE-P-----------------------------------------

NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSKLYPNSTR-IYLISAQTVFDKSKWIEMIKLAISSD
                                                 ..  .    |.... .  .. .|.. |. ||.. 
------------------------------------------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN
PH DDB0229957.AA PH 59-238 14 1.5e-15 58.67 Pfam 1-92 (92) Show / Hide 
Range on Protein: 59-238
Range on HMM: 1-92/92
Sequence Identity: 14% (26 aa)

VLHTGYLTKQGGRIQNWKIRWFVLKRGTLSYYLSPINWEYTKPRGVIYLTKKTELKEVDHRNRRHCFAVNPNYISENQSIIQQQQNQPILRSSSDSVNNN
| . |.|.|.| .. .|| |||||....|.|| ..      .|.|.| | .  ....|.                                         
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK----YRPKGSIPLSDC-QVTKVPDN---------------------------------------

NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSKLYPNSTRIYLISAQTVFDKSKWIEMIKLAIS
                                          ....  ..   . | |...| .  ..  |.. |. |..
------------------------------------------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
Kinase DDB0229957.AA TKL-Unique 1051-1305 40 2.4e-136 459.28 In-house 16-290 (290) Show / Hide 
Range on Protein: 1051-1305
Range on HMM: 16-290/290
Sequence Identity: 40% (115 aa)

GSGPQIIVAVKKLHPLADPSPEMIQDFYNEVRVLSMFN-HPNVVKYVGGCT----KIANWSIVMEYVPGGNLMDVLA---------NPVLVIPYKLVLRM
| .....||.|..||..|.|.||.|.|.|||....... |||.|.|.|.|.    ...|..|||||.|||.|.|||.         |. . ........|
GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM

ALDIAKGLHYLHSLG--ILHLDMKSPNLLVSSLSTSAKVNIKVADFNTCINRSRITAGFFNRHTGSGDNNKVEKDSKKGTTLWMAPEVIRG--AMYSEKC
|.|||.|..|||...  |.|.|.||.|.||.. |..|..|||..||......|.|.....|.|.|..      .....|...||||||.|.  ..||||.
AIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR------NQTRCGSFRWMAPEVLRMNFCQYSEKS

DVYSFAIIMWEMVTRKL------PYSHIAFN--CEVEDQVLKGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSI
|||||.|..||..|||.      ||......  ||.........|||||.||.|.|.||..|||..||..||.||.|||..
DVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase DDB0229957.AA TKL 992-1305 25 5e-86 292.1 In-house 1-364 (364) Show / Hide 
Range on Protein: 992-1305
Range on HMM: 1-364/364
Sequence Identity: 25% (107 aa)

LGTGATGDIYRGLISQDNLNRHISNQDSSGSNSSGSGSGHNWLIARNPSNDIINKDAIIGSGPQ----IIVAVKKLHPLA--------------------
.| |. | .|.|   . .  .                                                 |||||..                       
IGSGGFGEVYKGKWRGWGG-KC-----------------------------------------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDM

---DPSPEMIQDFYNEVR-VLSMFNHPNVVKYVGGCTKIAN-------------WSIVMEYVPGGNLMDVLANPVLVIPYKLVLRMALDIAKGLHYLHSL
   || .. ...| .|.  ..|...|||.|...| |. . .               |||||.|||.| ..|          . .|.|||||.|..|||| 
QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSM

G--------ILHLDMKSPNLLVSSLSTS---------AKVNIKVADFNTCINRSRITAGFFNRHTGS-----GDNNKVEKDSKKGTTLWMAPEVIRGA--
.        |.| | ||.|.|| .  |          | ...|..|| .. . |. .    . .|.        ||.  . .. ||. ||||||.||.  
NPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMN

--------------MYSEKCDVYSFAIIMWEMVTRKLPYSHIAFNCEV---------EDQVLKGLRPPIP------------MHCNKNYTDLMEQCWDDD
               ||||||||||.|..||..||..||... .. ..         .  ..||||||||             .| . . .||..||| |
YTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHD

PENRPYFDTIIHSI
||.|| |..|.. .
PEKRPSFQEILKRL
TyrKc DDB0229957.AA TyrKc 986-1305 27 6.7e-53 182.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 986-1305
Range on HMM: 1-280/280
Sequence Identity: 27% (94 aa)

VVLHERLGTGATGDIYRGLISQDNLNRHISNQDSSGSNSSGSGSGHNWLIARNPSNDIINKDAIIGSGPQIIVAVKKLHPLADPSPEMIQDFYNEVRVLS
..| . || || | .|.|  .                                                 | ||||.|.. |      ..||..| |...
ITLGKKLGEGAFGEVYKGTWK-------------------------------------------------IQVAVKMLKEDA------REDFMREARIMC

MF--NHPNVVKYVGGCTKI-------ANWSIVMEYVPGGNLMDVLANPVLVIPYKLVLRMALDIAKGLHYLHSLGILHLDMKSPNLLVSSLSTSAKVNIK
..  .|||.|. .| ||.            |||||.|.|.| | | ..   .. |  | ....||.|  |||| .. | |    | ||..        .|
KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVK

VADFNTCINRSRI-TAGFFNRHTGSGDNNKVEK-DSKK--GTTLWMAPEVIRGAMYSEKCDVYSFAIIMWEMVTR-KLPYSHI----AFNCEVEDQVLKG
..||  . .     ..|       |.|  .. . ...|      |||||.|.  ....| ||.|| . |||. |. . ||. .      | ||  .| .|
ISDFGLSRDIYDDDQQG------ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG

LRPPIPMH--------CNKNYTDLMEQCWDDDPENRPYFDTIIHSI
 |.|.| .        | .   ..|.|||. |||.|| | .|.. .
YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc DDB0229957.AA S_TKc 986-1309 19 1.2e-46 162.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 986-1309
Range on HMM: 1-231/231
Sequence Identity: 19% (65 aa)

VVLHERLGTGATGDIYRGLISQDNLNRHISNQDSSGSNSSGSGSGHNWLIARNPSNDIINKDAIIGSGPQIIVAVKKLHPLADPSPEMIQDFYNEVRVLS
  ... .| || |  |..                                                   . |||.|...          .....|...|.
YEILRKIGKGAFGKVYKCRHKK----------------------------------------------TGRIVAIKIIK----------EHIRREIQILK

MFNHPNVVKYVGGCTKIANWSIVMEYVPG--GNLMDVLANPVLV-----IPYKLVLRMALDIAKGLHYLHSLGILHLDMKSPNLLVSSLSTSAKVNIKVA
. .|||.||. . .    .  .||||..|  |.|.|.. .         .|   . ...  |...| |.||.||.| | |  |.|...       .||..
K-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKIC

DFNTCINRSRITAGFFNRHTGSGDNNKVEKDSKKGTTLWMAPEVIRGAMYSE-KCDVYSFAIIMWEMVTRKLPYSHIAFNCEVEDQVLKGLRPPIPMHCN
||  .                         ..  ||  .|||||.    |.  |||..|. .|..||.... |..        .....| ..        
DFGLARQL----------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-------S

KNYTDLMEQCWDDDPENRPYFDTIIHSI-----SKMI
.   |....|.. |||.||    . ..         .
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase DDB0229957.AA Pkinase 986-1305 19 2.3e-41 147.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 986-1305
Range on HMM: 1-293/293
Sequence Identity: 19% (69 aa)

VVLHERLGTGATGDIYRGLISQDNLNRHISNQDSSGSNSSGSGSGHNWLIARNPSNDIINKDAIIGSGPQIIVAVKKLHPLADPSPEMIQDFY-NEVRVL
 ......| |. |  |..    ..                                               |||||..    . | . ....  .|....
YHIGRKIGSGSFGCVYKCHHKGTGK----------------------------------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIM

SMFNHPNVVKYVGGCTKIANWSIVMEYVPGG----NLMDVLA---NPVLVIPYKLVLRMALDIAKGLHYLHSLGILHLDMKSPNLLVS-SLSTSAKVNIK
 ..||||.|.. . ..   .  .||||..||     |.|..    . ..  ... . .... |..|| |.|| ||.| |.|. |.|..    ..|   .|
KRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVK

VADFNTCINRSRITAGFFNRHTGSGDNNKVEKDSKKGTTLWMAPEVIR-GAMYSEKCDVYSFAIIMWEMVTRKLPYSHI----AFNCEVEDQVLKGLRPP
..||  .   .                |..  ..  ||  .||||||| | .|. |.|..|. .|..||.....|...       ... .  . . ..||
ICDFGLAKQFD--------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQ-MICRIMGPP

IPMHCN-----------------------KNYTDLMEQCWDDDPENRPYFDTIIHS--I
.. ..                        ..  |... |.. ||. || .. | ..  .
LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDB0229957.AA MLK 1210-1305 46 1.2e-39 135.19 In-house 192-291 (291) Show / Hide 
Range on Protein: 1210-1305
Range on HMM: 192-291/291
Sequence Identity: 46% (46 aa)

SKKGTTLWMAPEVI---RGAMYSEKCDVYSFAIIMWEMVTRKLPYS-HIAFNCEVEDQVLKGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSI
|..||  |||||||   |. .|||||||.|.....|||.||..||. |.         ...|||||||  |..    ||.|||..||..|| |. |.   
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase DDB0229957.AA LRRK 1213-1307 37 2.3e-38 133.35 In-house 241-351 (351) Show / Hide 
Range on Protein: 1213-1307
Range on HMM: 241-351/351
Sequence Identity: 37% (42 aa)

GTTLWMAPEVIRGA---MYSEKCDVYSFAIIMWEMVTRK-LPYSHIA------FNCEVEDQVLKGLRPPIPMH-CNK-----NYTDLMEQCWDDDPENRP
|. .|||||..|.     |.|| |.|||..|.|| .||. .|. ..       .. ..|| ...||||.|| | |.       | ||...||. ||..||
GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRP

YFDTIIHSISK
 | .|.  .| 
HFSQIVKRLSQ
Kinase DDB0229957.AA Dicty4 1212-1307 44 1e-36 120.09 In-house 178-277 (277) Show / Hide 
Range on Protein: 1212-1307
Range on HMM: 178-277/277
Sequence Identity: 44% (44 aa)

KGTTLWMAPEVIRGAMYSEKCDVYSFAIIMWEMVTRKLPYS--HIAFNCEVEDQVLKGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHS--ISK
.||..|||||| ..  | || |||||.|. ||..||. ||.  |. .   |.  . |.||||||  | .....|.. ||| ||..|| |  ||       
CGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase DDB0229957.AA Dicty4 1044-1180 31 3.5e-33 108.14 In-house 1-158 (277) Show / Hide 
Range on Protein: 1044-1180
Range on HMM: 1-158/277
Sequence Identity: 31% (52 aa)

INKDAIIGSGP----------QIIVAVKKLHPLADP-SPEMIQDFYNEVRVLSMFNHPNVVKYVGGCT----KIANWSIVMEYVPGGNLMDVLAN-----
||....||.|           ...||||||  . .  . .|...| .||  ..   |||...  | ||    .    .||.||.| |||  .| .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-PVLVIPYKLVLR---MALDIAKGLHYLHS--LGILHLDMKSPNLLVSSLSTSAKVNIKVADF
 .   ... |..|   ||.|.|.|. .||.    |.|.| || ||||     ..  ..||.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV-----DKNWRVKVCDF
Kinase DDB0229957.AA Dicty5 1213-1309 45 6.6e-32 107.11 In-house 165-260 (260) Show / Hide 
Range on Protein: 1213-1309
Range on HMM: 165-260/260
Sequence Identity: 45% (44 aa)

GTTLWMAPEVIRGAMYSEKCDVYSFAIIMWEMVTRKLPYSHIAFNCEVEDQVLKGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSISKMI
||  |||.|.  |  | .|||||||.|. ||| ||| ||  |. | .    | || || ||  |   .  | . || . | ||| |  |.  . ..|
GTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNIN-NWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase DDB0229957.AA TKL-ciliate2 1211-1306 42 6.2e-30 96.66 In-house 178-273 (273) Show / Hide 
Range on Protein: 1211-1306
Range on HMM: 178-273/273
Sequence Identity: 42% (41 aa)

KKGTTLWMAPEVIRGAMYSEKCDVYSFAIIMWEMVTRKLPYSHIAFNCEVEDQVLKGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSIS
| ||  |||||||.  .| || ||.|..||.||.  |  ||  .  .   |. . . ||| ||  |   ..|||..|||.. . || |. ||. . 
KIGTYQWMAPEVIKAFYYTEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase DDB0229957.AA TK 1217-1305 27 7e-29 93.33 In-house 351-486 (486) Show / Hide 
Range on Protein: 1217-1305
Range on HMM: 351-486/486
Sequence Identity: 27% (37 aa)

WMAPEVIRGAM---------YSEKCDVYSFAIIMWEMVT--RKLPYSHIAF--------NCEVEDQVLKG--------------LRPPIPMHCN------
|||||....           ...| ||.|| . |||..|  .. .|  .          | || ... .|              .|.| |.||       
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR

--------KNYTDLMEQCWDDDPENRPYFDTIIHSI
        . | ||| |||. ||| || |... . .
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDB0229957.AA DRK 1213-1307 43 7.1e-29 94.95 In-house 164-258 (258) Show / Hide 
Range on Protein: 1213-1307
Range on HMM: 164-258/258
Sequence Identity: 43% (42 aa)

GTTLWMAPEVIRGAMYSEKCDVYSFAIIMWEMVTRKLPYSHIAFNCEVEDQVLK-GLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSISK
||. | |||| |   | || |||||||. ||.|||. ||  .     |   | . |.|||.|  |   |. ||  ||. ||  || .. ..  .  
GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMP-TFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase DDB0229957.AA TK 1051-1180 19 6.7e-27 86.57 In-house 48-295 (486) Show / Hide 
Range on Protein: 1051-1180
Range on HMM: 48-295/486
Sequence Identity: 19% (48 aa)

GSGPQIIVAVKKLHPLADPSPEMIQD-----------FYNEVRVLSMFN-----HPNVVKYVGGCTKIAN------------WSIVMEYVPGGN----LM
..| .. |||| |.. .. |.|. .|           |..|.....|..     |||.|. .| ||. ..            | |||||.|.|.    | 
KEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLR

DVLANPVLV---------------------------------------------------------------------------IPYKLVLRMALDIAKG
| | .                                                                               .. .  | |...||.|
DYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACG

LHYLHSL------GILHLDMKSPNLLVSSLSTSAK------VNIKVADF
. ||||.      .. | |    | ||..  . ..        .|.|||
MEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADF
Kinase DDB0229957.AA DRK 1056-1164 34 2.3e-26 86.34 In-house 23-133 (258) Show / Hide 
Range on Protein: 1056-1164
Range on HMM: 23-133/258
Sequence Identity: 34% (38 aa)

IIVAVKKLHPLADPSPEMIQDFYNEVRVLSMFNHPNVVKYVGGCTKIANWSIVMEYVPGGNLMDVLANPVLVIPYKLVLRMALDIAKGLHYLHSLG--IL
..||||.|  .     .....|  |. ...   |||.. . | |.      |.||| | | |  .| .. . .   |...|..|.|||. |||.    |.
TQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIII

HLDMKSPNLLV
| | || ||||
HRDLKSHNLLV
Pkinase_Tyr DDB0229957.AA Pkinase_Tyr 986-1154 25 2.6e-26 89.72 Pfam 1-134 (270) Show / Hide 
Range on Protein: 986-1154
Range on HMM: 1-134/270
Sequence Identity: 25% (45 aa)

VVLHERLGTGATGDIYRGLISQDNLNRHISNQDSSGSNSSGSGSGHNWLIARNPSNDIINKDAIIGSGPQIIVAVKKLHPLADPSPEM--IQDFYNEVRV
... . || || |..|.|                                               .....| ||||.|    . ..|   ..|| .|...
ITFGKKLGEGAFGEVYKGTWKG------------------------------------------DPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKI

LSMF-NHPNVVKYVGGCT-KIAN--WSIVMEYVPGGNLMDVLANP---VLVIPYKLVLRMALDIAKGLHYLHSLGILH
.. . .|||.|...| || .     . |||||.|.|.| | | ..      .. |  | |...||||. ||.| .. |
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase DDB0229957.AA MLK 1057-1180 29 3.4e-26 87.93 In-house 29-177 (291) Show / Hide 
Range on Protein: 1057-1180
Range on HMM: 29-177/291
Sequence Identity: 29% (45 aa)

IVAVKKLHPLADPSPEM----IQDFYNEVRVLSMFNHPN----VVKYVGGCTKIAN-WSIVMEYVPGGNLMDVLAN-PV------------LVIPYKLVL
|||||. .  .. .       ..||  |.| |....|||    ... .|.|..  .   |||||..|| | .||.. .              |..  ...
IVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAM

RMALDIAKGLHYLHSLG---ILHLDMKSPNLLVSS--LSTSAKVNIKVADF
. ||..|.|.|||||.    | | | ||.|.|..       .. . |..||
NWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDF
Kinase DDB0229957.AA Dicty4-Unclassified 1058-1180 36 3.7e-26 86.56 In-house 25-153 (263) Show / Hide 
Range on Protein: 1058-1180
Range on HMM: 25-153/263
Sequence Identity: 36% (50 aa)

VAVKKLHPLADPSP-EMIQDFYNEVRVLSMFNHPNVVKYVGGCTKIAN------WSIVMEYVPGGNLMDVLA------NPVLVIPYKLVLRMALDIAKGL
|||||.    .    ||||||  || .|    ||| ||  | |  |.         ||||  . |||. |        .  .     |....|.|||.|.
VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYC--INPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGM

HYLHSLGILHLDMKSPNLLVSSLSTSAKVNIKVADF
 .||.  . | |.|| |.|.         |||.|||
QHLHTRNFIHRDIKSSNILM-----DKHFNIKIADF
Kinase DDB0229957.AA LRRK 1058-1180 30 2.3e-25 86.66 In-house 54-222 (351) Show / Hide 
Range on Protein: 1058-1180
Range on HMM: 54-222/351
Sequence Identity: 30% (53 aa)

VAVKKLHP-------------------------------LADPSPEMIQDFYNEVRVLSMFNHPNVVKYVGGCTKIANWSIVMEYVPGGNLMDVLANPV-
||.||..                                ... ...  . | .|| ..| .||||.|. .| |  |    .||||.| |.| ..| |.  
VAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQ

--L-----VIPYKLVLRMALDIAKGLHYLHSLG--ILHLDMKSPNLLVSSLSTS-------AKVNIKVADF
  .     .|.  |.|. ||.||||. ||||    |.| | |||| |. |...        | |..|.|||
DGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADF
Kinase DDB0229957.AA Pkinase_Tyr 1217-1305 41 3e-25 86.14 Pfam 180-270 (270) Show / Hide 
Range on Protein: 1217-1305
Range on HMM: 180-270/270
Sequence Identity: 41% (38 aa)

WMAPEVIRGAMYSEKCDVYSFAIIMWEMVT-RKLP-YSHIAFNCEVEDQV-LKGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSI
|||||.|.   ...| ||.|| . |||..|  . | |  .  | || ...  .| | |.|..| .   ||| |||. |||.|| |  |.. .
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DDB0229957.AA Dicty4-Unclassified 1213-1305 36 3e-22 72.97 In-house 170-263 (263) Show / Hide 
Range on Protein: 1213-1305
Range on HMM: 170-263/263
Sequence Identity: 36% (34 aa)

GTTLWMAPEVIRGAMYSEKCDVYSFAIIMWEMVTRKLPYSHIAFNCEVEDQVL-KGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSI
||  | .||. ..  |  | ||||.|....|..|   ||  |    ..   |  |.||| ||  |  ..  |   || .||  || .. ||   
GTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase DDB0229957.AA TKL-ciliate2 1056-1158 43 2.7e-21 67.33 In-house 23-126 (273) Show / Hide 
Range on Protein: 1056-1158
Range on HMM: 23-126/273
Sequence Identity: 43% (46 aa)

IIVAVKKLHPLADPSPEMIQDFYNEVRVLSMFNHPNVVKYVGGCTKIANWSIVMEYVPGGNLMDVLANPVLVIPYKLVLRMALDIAKGLHYLHSLG--IL
|.|||||     |   . |.|| ||   .    |||.| ..| |||| |..|.|||   | |  .| |    . .    |.|||||.| |||||    |.
IVVAVKKFKMDHDNQ-QQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLHSSNPPII

HLDMK
| |.|
HRDLK
Kinase DDB0229957.AA Dicty5 1074-1164 34 1.1e-19 64.37 In-house 40-137 (260) Show / Hide 
Range on Protein: 1074-1164
Range on HMM: 40-137/260
Sequence Identity: 34% (34 aa)

IQDFYNEVRVLSMFN--HPNVVKYVGGCTKIANW-SIVMEYVPGGNLMDVLANPVL----VIPYKLVLRMALDIAKGLHYLHSLGILHLDMKSPNLLV
...|| || ..|.|   |||.... |  ..  .   .| ||.  | | . |          | | . | ||.|||... .||| .| | |.|| | |.
WNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLI
Kinase DDB0229957.AA TK 986-1009 29 0.045918 1.85 In-house 82-108 (486) Show / Hide 
Range on Protein: 986-1009
Range on HMM: 82-108/486
Sequence Identity: 29% (8 aa)

VVLHERLGTGATG---DIYRGLISQDN
..| . || |. |   ..|.|.  ..|
ITLGKKLGEGQFGSFGEVYKGEWRGRN
Kinase DDB0229957.AA MLK 986-1003 33 0.087433 2.13 In-house 1-18 (291) Show / Hide 
Range on Protein: 986-1003
Range on HMM: 1-18/291
Sequence Identity: 33% (6 aa)

VVLHERLGTGATGDIYRG
  .|| .| |. |. ..|
IQFHEWIGSGSFGKVWKG
Kinase DDB0229957.AA LRRK 986-1003 31 0.189482 0.87 In-house 66-84 (351) Show / Hide 
Range on Protein: 986-1003
Range on HMM: 66-84/351
Sequence Identity: 31% (6 aa)

VVLHERLGTGATG-DIYRG
..  | .| |..|  .||.
LKIEEQIGRGGFGTFVYRA