Roco10

Species: Slime mold
Alias: Roco10, DDB0201665, DdisK230
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
Roco10.AA Protein None 2646 None Fasta, JSON
Roco10.kin_dom Protein Kinase Domain None 244 None Fasta, JSON

Protein domain

Protein domains of Roco10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RhoGAP Roco10.AA RhoGAP 663-748 25 3.2e-10 36.2 Pfam 28-124 (156) Show / Hide
Range on Protein: 663-748
Range on HMM: 28-124/156
Sequence Identity: 25% (25 aa)

KLEVENICNQYDQGIEV---SLKKCNVHVVSEILIEFFNRLPEPIISVEFYETLLN--YYQT------ETLLHLMIRKMNNPNKSILCRLMKYLKDI
| ... .....|.| .|    ..  .||.|. .| ..|  ||||... |.||....   ...         ....|||.  || ..|..||. |. .
KSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMRELIRKLPPPNYDTLRYLMRHLHRV

RhoGAP Roco10.AA RhoGAP 624-804 15 3.1e-07 11.55 SMART 1-193 (193) Show / Hide
Range on Protein: 624-804
Range on HMM: 1-193/193
Sequence Identity: 15% (34 aa)

NSSPNIINQLQQQQQPQPTTTTTTNTNTSPHQYLSQKS-IKLEVENICNQYDQGIEVS--------------LKKCNVHVVSEILIEFFNRLPEPIISVE
   | |. .. .  . .  .|            . .|.  . ... ..|..|.| . .              . . .||.|. .|  .|. ||||.|  |
SHIPIIVRKCIEYIEKHGMDTE----------GIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFE

FYETLLNYYQT--------------------ETLLHLMIRKMNNPNKSILCRLMKYLKDIMVYTNFNDVTLELLVERFHKFILRPTIGTIAQSKEISESH
 || ... ..                        ||. |..   .... | .||  |. .  .  .|  ... |   |   ...|            ...
LYEEFIEAMKCYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP-----------MMD

LKTIKDIVTMFIQQAD
 . .. .| ..|...|
MRHQNKCVEFLIEHYD

LRR_1 Roco10.AA LRR_1 989-1010 25 0.05162 11.31 Pfam 1-26 (26) Show / Hide
Range on Protein: 989-1010
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

DLQELNLNR-N--KF-KLLPGD-LARL
 ||.|.|.. |  .. . .| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP Roco10.AA LRR_TYP 987-1009 33 0.052951 10.31 SMART 1-24 (24) Show / Hide
Range on Protein: 987-1009
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LKDLQELNLNRNKFKLLPGDL-AR
|  |.||.|..|... || .. . 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP Roco10.AA LRR_TYP 1010-1033 25 0.12442 7.27 SMART 1-24 (24) Show / Hide
Range on Protein: 1010-1033
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

LTSLRTICIEENNLTEISSEMADF
|..||.   . |.||.. ... . 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 Roco10.AA LRR_1 1012-1034 25 2.491584 5.34 Pfam 1-26 (26) Show / Hide
Range on Protein: 1012-1034
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLRTICIEE-N--NLT-EISSEMADFL
.|... .   |  ||| .|...    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 Roco10.AA LRR_1 1062-1083 25 0.010934 13.7 Pfam 1-26 (26) Show / Hide
Range on Protein: 1062-1083
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KLKTLNISN-N--YLT-KLPID-IFQI
.|..|..|. |   || ..| . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP Roco10.AA LRR_TYP 1038-1061 41 0.102489 7.96 SMART 1-24 (24) Show / Hide
Range on Protein: 1038-1061
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LSNLENVTLSSNRLVVLPPLYTWL
|.||.   ||.|.|  |||   . 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP Roco10.AA LRR_TYP 1062-1083 50 0.102778 7.95 SMART 3-24 (24) Show / Hide
Range on Protein: 1062-1083
Range on HMM: 3-24/24
Sequence Identity: 50% (11 aa)

KLKTLNISNNYLTKLPIDIFQI
.|..|. ||| || || ..|| 
NLRELDLSNNQLTHLPPGAFQG

LRR_1 Roco10.AA LRR_1 1040-1060 29 0.231366 9.0 Pfam 1-26 (26) Show / Hide
Range on Protein: 1040-1060
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLENVTLSS-N--RLV-VLPP--LYTW
||.   ||. |  .|.  .||  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 Roco10.AA LRR_1 1109-1130 40 0.000139 20.42 Pfam 1-26 (26) Show / Hide
Range on Protein: 1109-1130
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLRSLDLRK-N--HLT-SIPEG-IINL
.|..|||.  |  .|| .||.. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP Roco10.AA LRR_TYP 1199-1222 41 0.000192 22.01 SMART 1-24 (24) Show / Hide
Range on Protein: 1199-1222
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

MQSLIELRLTNNNISRLPPGIVAL
. .| ||.| ||....||||. . 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP Roco10.AA LRR_TYP 1153-1175 41 0.000856 19.85 SMART 1-24 (24) Show / Hide
Range on Protein: 1153-1175
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LTSLTELNLNGNQIQSLPPQL-LL
|..|.||.|..||...|||..   
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP Roco10.AA LRR_TYP 1176-1198 37 0.002064 18.58 SMART 1-24 (24) Show / Hide
Range on Protein: 1176-1198
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LTNLKKLYLDNNQLQSISSAI-HR
|.||..|.|.||||... . . . 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 Roco10.AA LRR_1 1155-1176 29 0.002984 15.7 Pfam 1-26 (26) Show / Hide
Range on Protein: 1155-1176
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLTELNLNG-N--QIQ-SLPPQ-LLLL
.|..|.|.| |  ... ..||  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 Roco10.AA LRR_1 1178-1199 25 0.004182 15.18 Pfam 1-26 (26) Show / Hide
Range on Protein: 1178-1199
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

NLKKLYLDN-N--QLQ-SISSA-IHRM
||..|.|.. |  .|. .|..  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 Roco10.AA LRR_1 1201-1222 29 0.004182 15.18 Pfam 1-26 (26) Show / Hide
Range on Protein: 1201-1222
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLIELRLTN-N--NIS-RLPPG-IVAL
.| .| | . |  |..  .||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP Roco10.AA LRR_TYP 1130-1152 37 0.007289 16.76 SMART 1-24 (24) Show / Hide
Range on Protein: 1130-1152
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LVELQVLTLADNQISHLTSDI-QK
|..|..| | .||..|| ... | 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 Roco10.AA LRR_1 1132-1153 25 0.056902 11.16 Pfam 1-26 (26) Show / Hide
Range on Protein: 1132-1153
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ELQVLTLAD-N--QIS-HLTSD-IQKL
 ||.| | . |  ... |. .. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP Roco10.AA LRR_TYP 1108-1129 43 0.065743 9.54 SMART 2-24 (24) Show / Hide
Range on Protein: 1108-1129
Range on HMM: 2-24/24
Sequence Identity: 43% (10 aa)

TKLRSLDLRKNHLTSIPEGI-IN
..||.|||  |.||..|.|.  .
PNLRELDLSNNQLTHLPPGAFQG

LRR_1 Roco10.AA LRR_1 1085-1107 24 1.687619 5.94 Pfam 1-26 (26) Show / Hide
Range on Protein: 1085-1107
Range on HMM: 1-26/26
Sequence Identity: 24% (7 aa)

TLEVLRVSN-N--DL-DDNGIPK--ICTS
.|..| .|. |   | ..  ||.  .   
NLQHLDLSGCNCCNLTGH--IPPSCF-NL

LRR_1 Roco10.AA LRR_1 1224-1242 38 32.354535 1.39 Pfam 1-21 (26) Show / Hide
Range on Protein: 1224-1242
Range on HMM: 1-21/26
Sequence Identity: 38% (8 aa)

KLNSLELTG-N-KPLKDNIPE
.| .| | | |  .| ..||.
NLQHLDLSGCNCCNLTGHIPP

ROC Roco10.AA ROC 1266-1354 20 1.6e-07 21.87 In-house 192-267 (215) Show / Hide
Range on Protein: 1266-1354
Range on HMM: 192-267/215
Sequence Identity: 20% (19 aa)

CYRTRIIMLGDKSTGKSNLIKCLKKLPKSSFSSSSSNLPSLNNLNSNNSNNSGNSKTNILD-IQDWQCPIN---VDGPDGKKKKTITIHLWEF
|.. .....|.   ||. |.|.|.. ..|  |..|                . ...|.  . ||.|  ...         ||.. |....|.|
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSC-------------DKGNHPTTHGIEPIQQWVLDCKDMMF----RKKEDEIKFNVWDF

COR Roco10.AA COR 1460-1573 17 3e-05 12.6 In-house 313-435 (434) Show / Hide
Range on Protein: 1460-1573
Range on HMM: 313-435/434
Sequence Identity: 17% (23 aa)

IRKLRRDIKQ--MIAKNPILKQTYPASFMFLEDYLKEESNLM----SPPLVTKKTLQQMARTME----------LHNEPHFTQLKSLFNSLGSIALFE--
||| .. ||.  | .    ..|  | |.. ....|.|....|    . |. ..| ..|... .           .. |  . ..  . ..||.|  |.  
IRKTAKKIKHKQMFED--YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIW

-QFIRMEPGSTPQKTEMIALNPIWIAKAIASLV
 ..            . . |.| |.........
DHDPML--------KDFVVLDPQWFCQMMYHIF

ROC Roco10.AA ROC 1403-1463 20 0.0002 11.43 In-house 143-215 (215) Show / Hide
Range on Protein: 1403-1463
Range on HMM: 143-215/215
Sequence Identity: 20% (15 aa)

KKATIIIIGTHLDEISSNSKK--QVDKVFDCLSLKYKQLFPTL----------NLVFHAVSTLK-SDADGIRKL
... .||.|||.|... . .|  |...    .  |... ||            . .||. ..   .. |..|. 
QPSPVIIVGTHWDKVPRQDNKVYQHKQCC-RMWQKLRNKFPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH

COR Roco10.AA COR 1783-1814 16 0.090599 1.14 In-house 235-284 (434) Show / Hide
Range on Protein: 1783-1814
Range on HMM: 235-284/434
Sequence Identity: 16% (8 aa)

RRFSL------DVIPNGLFGRLLSRLMQHAHLYK------------CWKD
|.. .      ...|.|.. |.. ||   .| .             .|..
RHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRN

COR Roco10.AA COR 1863-1963 13 1.3e-09 27.06 In-house 289-434 (434) Show / Hide
Range on Protein: 1863-1963
Range on HMM: 289-434/434
Sequence Identity: 13% (20 aa)

QFREE---RILVNVDHDSNTIEITIRFIR------PSTLSSQVYSIFESLVSKW---YKVS-------FKTFIPCSHCIEKKIV-TPH--LFKLEECEAQ
.....    .||  |.. | | ||.|  .      .. | ..... .....  |    ..        .. .||| |||...    ..   .....|...
KWEGHNKNEALVKCDNHDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRA

IFKGELGIYCQYKP----------------------NNNNS-SNDT
  .|.. ..|. .                       |.... . ..
EEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD

Kinase Roco10.AA LRRK 2108-2342 31 5.70000000001e-105 355.04 In-house 96-351 (351) Show / Hide
Range on Protein: 2108-2342
Range on HMM: 96-351/351
Sequence Identity: 31% (82 aa)

NCARILSSFRHEALSLYNFRHSNVLSIIGISMNPIAIITENPTFGSKGSTTLSEYIQDRQKHP------EIPWNIKLKIALDIARAMDKLNSHSPPFLLT
.|.|....||||.  .....|.|..|..|....|.....|....|.     |...........      .|.|..||||||.||..|..|.||.||.. .
DCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGD-----LYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHR

NLTSSGIILEKSNDHQSSGNGLEIEPFVNAKIIDFSQSS----FLPSLFPTSTTPKSYHSPEVLQK---LNYHENSDVYSFGIILYELLTRS-IAFQDHD
.|.| .|.|..|....|..   .....|.|||.||..|.    |............ ...||....    .|.|..|.||||.||.|||||. ..|..||
DLKSPNILLWSSPQNHSPN---YPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHD

---------RFSNIVISGQRPSIPLD-CLP-----SFADLIKDCWSGEPLNRPSPSKIISQLYT
         ......|.|.||.|| . |.|     .. |||..||...|..||..|.|...| .
FFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase Roco10.AA TKL 2116-2340 22 1.6e-51 177.48 In-house 72-364 (364) Show / Hide
Range on Protein: 2116-2340
Range on HMM: 72-364/364
Sequence Identity: 22% (69 aa)

FRHEALSLYNFRHSNVLSIIG---------ISMNP------IAIITENPTFGSKGSTTLSEYIQDRQKHPEIPWNIKLKIALDIARAMDKLNSHS-----
.. |.... ..|| |.....|         ..|.|      ..|..|    ||  .. .              |. ....||||||.|. | |.      
EEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT

-PPFLLTNLTSSGIILEKSNDHQS-------SGNGLEIEPFVNAKIIDFSQSSFLPS--------------LFPTSTTPKSYHSPEVLQKL---------
 || .  .|.|. | . . . ..|       .   . |  |  .. .. |...   .                 |    . . .||||..          
KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI

-------NYHENSDVYSFGIILYELLTRSIAFQDHDRF------------SNIVISGQRPSIP------------LDCLPSFADLIKDCWSGEPLNRPSP
        | | .|||||||.|.|.||| . ..|.. .            . ..  |.|| ||             ||.||...|..|||. .| .||| 
DEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSF

SKIISQL
..|...|
QEILKRL

Kinase Roco10.AA TKL-Unique 2116-2340 27 1.4e-34 119.44 In-house 42-290 (290) Show / Hide
Range on Protein: 2116-2340
Range on HMM: 42-290/290
Sequence Identity: 27% (72 aa)

FRHEALSLYNFR-HSNVLSIIGISM----NPI--AIITENPTFGSKGSTTLSEYIQD--------RQKHPEIPWNIKLKIALDIARAMDKLNSHSPPFLL
|. |   . ... | |.. ..|..|     |.   |..|   . . ||  | .....        ..... .... ..|.|.|||..|. | . .|| . 
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVME---YCPGGS--LYDVLHQNNNNNNNNNNNCK-LNMQQRVKMAIDIAQGMYYLHHCEPPIIH

TNLTSSGIILEKSNDHQSSGNGLEIEPFVNAKIIDFSQSSFLPSLFPTSTTPK------------SYHSPEVLQK--LNYHENSDVYSFGIILYELLTRS
..|.|| . .          |.. | . .|.||.||. | |. .   .... .             . .||||      | | ||||||||.|.|..|| 
RDLKSSNFLVD---------NNSNIAE-WNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRK

I------AFQDHDRF--SNIVIS---GQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL
|       .|. |.     .| .   ..|| || .| ... |||..||  .| .||| . ||. |
ITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase Roco10.AA Dicty4 2255-2342 40 6.3e-32 103.89 In-house 183-277 (277) Show / Hide
Range on Protein: 2255-2342
Range on HMM: 183-277/277
Sequence Identity: 40% (38 aa)

YHSPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQ-DHDRFSNIVIS----GQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQ--LYT
. .|||...  | | .|||||||.|.|.||| . .|  |. . ..|..    . ||.|| .|.||...||..||. .| .||| . ||..  | .
WMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase Roco10.AA MLK 2257-2340 34 1.1e-25 86.2 In-house 201-291 (291) Show / Hide
Range on Protein: 2257-2340
Range on HMM: 201-291/291
Sequence Identity: 34% (31 aa)

SPEVL---QKLNYHENSDVYSFGIILYELLTRSIAFQ-DHD---RFSNIVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL
.|||.   .   | | .||.|.|..|.|.||| . .. ..|   ..  ..  |.|| || .| .... |.|.||. .| .||| . |...|
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase Roco10.AA Dicty5 2255-2344 36 4.9e-25 83.1 In-house 169-260 (260) Show / Hide
Range on Protein: 2255-2344
Range on HMM: 169-260/260
Sequence Identity: 36% (34 aa)

YHSPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDHDRFS--NIVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQLYTIK
. ..|. .   ||.  |||||||.|.|..||  .. .  . .  ..| .| || || ||  ... ||| ||   | ||||  .|.  .  | 
WMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII

Kinase Roco10.AA Shk 2258-2345 41 1.5e-22 77.74 In-house 175-269 (269) Show / Hide
Range on Protein: 2258-2345
Range on HMM: 175-269/269
Sequence Identity: 41% (39 aa)

PEVLQKLNYHENSDVYSFGIILYELLTRSIAFQ----DHDRFSN-IVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQ--LYTIKK
|||...  | | .|||||||||.|.||.   .     . | | . |.    ||.|| ||..|  .||  ||  .| .||| . ||..  | .|  
PEVMMNHPYNEKADVYSFGIILWEILTCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI

Kinase Roco10.AA DRK 2257-2342 37 5.9e-21 67.75 In-house 170-258 (258) Show / Hide
Range on Protein: 2257-2342
Range on HMM: 170-258/258
Sequence Identity: 37% (34 aa)

SPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDHDRFSNIVIS-GQ---RPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQLYT
.||||    | |  |||||.|.| |..|| . ..    |  .|.| |.   || .|  | | .. |..|||. .|  |||   ..  |  
APEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTF-QVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA

Kinase Roco10.AA MLK 2258-2340 33 2.7e-20 63.6 In-house 195-280 (280) Show / Hide
Range on Protein: 2258-2340
Range on HMM: 195-280/280
Sequence Identity: 33% (29 aa)

PEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDHDRFS---NIVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL
|||...  . . ||| |.|..| ||||.   .. .|  .    . . ..  .||  |   .| |..|||  .|  ||. |.|. ||
PEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL

Kinase Roco10.AA Dicty4-Unclassified 2110-2340 30 3.7e-20 65.69 In-house 37-263 (263) Show / Hide
Range on Protein: 2110-2340
Range on HMM: 37-263/263
Sequence Identity: 30% (75 aa)

AR--ILSSFRHEALSLYNFRHSNVLSIIGISMNP------IAIITENPTFGSKGSTTLSEYIQ----DRQKHPEIPWNIKLKIALDIARAMDKLNSHSPP
.|  ..  |. |   |    | | . . | ..||      . |..|   |  ||  .| | |     ..|.       . .|.|.|||. |  |  |.  
FREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVME---FMHKG--NLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHL--HTRN

FLLTNLTSSGIILEKSNDHQSSGNGLEIEPFVNAKIIDFSQS---SFLPSLFPTSTTPKSYHSPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDHDR
|    . || | . | .               |.|| ||  |   .|   .     |||   |||.|    |   |||||....||||.|    .|.   
FIHRDIKSSNILMDKHF---------------NIKIADFGISRVIDFNFNMTTIAGTPK-WESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQS

FSNIVIS----GQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL
  |. .|    . || ||  | . .  |||.||. .|  ||.  .||  |
IMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL

TyrKc Roco10.AA TyrKc 2082-2340 15 5.1e-13 -12.22 SMART 16-280 (280) Show / Hide
Range on Protein: 2082-2340
Range on HMM: 16-280/280
Sequence Identity: 15% (50 aa)

MMGMYGKQFVNIKVFNAPLLGADFQNNCARILSSFRHEALSLYNF--RHSNVLSIIGISM---------NPIAIITENPTFGSKGSTTLSEYIQDRQKHP
. |..  . | .|. ..              .  |..||  . ..  .| |.. ..|. .          |. |..|   . ..|.  | .|....... 
YKGTWK-IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME---YMPHGD--LKDYLRKHRPK-

EIPWNIKLKIALDIARAMDKLNSHSPPFLLTNLTSSGIILEKSNDHQSSGNGLEIEPFV---------------NAKIIDFSQSSFLPSL----FPTSTT
 ...  .|.....||. |. | |.                                ...                .|| ||  | .. .       ... 
-LCMKDLLSFCWQIACGMEYLHSK--------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYY

PK----SYH--------SPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDH--------DRFSNIVISGQRPSIPLD--------CLPSFADLIKDCW
 |    . .        .||....  . . |||.|||. ..|..|.               ..  . | .| |. .| .        | .   ...|.||
RKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCW

SGEPLNRPSPSKIISQL
  .| .||. | |....
HEDPEDRPTFSEIHECF

Kinase Roco10.AA Pkinase_Tyr 2257-2340 29 1.8e-12 42.88 Pfam 182-270 (270) Show / Hide
Range on Protein: 2257-2340
Range on HMM: 182-270/270
Sequence Identity: 29% (26 aa)

SPEVLQKLNYHENSDVYSFGIILYELLT---RS-IAFQDHDRFSNIV-ISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL
.||...   . . |||.|||. ..|..|       .  .  .. . .  .|.|  .| .| .   ||.|.||  .| .||. | |..||
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase Roco10.AA Pkinase 2255-2340 23 8.5e-11 39.25 Pfam 177-293 (293) Show / Hide
Range on Protein: 2255-2340
Range on HMM: 177-293/293
Sequence Identity: 23% (27 aa)

YHSPEVLQ-KLNYHENSDVYSFGIILYELLTRSIAFQDH------DRFSNIVISGQ---RPSIPLDCL-------------------PSFADLIKDCWSG
| .|||..    |   .|..|.|.||||.|..   |..|      |    |.  ..   . ..| .|                    ... |.||.|.  
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

EPLNRPSPSKIISQ--L
 |  ||..  |     .
DPKKRPTAEQILQHPWF

S_TKc Roco10.AA S_TKc 2060-2342 17 3.8e-10 -28.04 SMART 1-231 (231) Show / Hide
Range on Protein: 2060-2342
Range on HMM: 1-231/231
Sequence Identity: 17% (53 aa)

YREIEVLPDHSNQNENGTSTQSMMGMYGK--QFVNIKVFNAPLLGADFQNNCARILSSFRHEALSLYNFRHSNVLSIIGISM-NPIAIITENPTFGSKGS
|. ....         |.  . . .   |  . | ||. .                 ..| |   | . .| |.  ....   . . ...|        .
YEILRKI-------GKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVME------YCD

T---TLSEYIQDRQKHPE---IPWNIKLKIALDIARAMDKLNSHSPPFLLTNLTSSGIILEKSNDHQSSGNGLEIEPFVNAKIIDFSQSSFLPSLFPTST
.   .| .||..|..|.    .|     ...  |..|.. . ||   ..   |  . | | .                 . ||.||  . .|     |  
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-----------------HIKICDFGLARQL----TTFC

TPKSYHSPEVLQKLNYHE-NSDVYSFGIILYELLTRSIAFQDHDRFSNIVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIIS-------QLYT
    | .||||    |    .|..|.|.||||.|..   |.....  ...             |.. |.|. |.  .| .||.  ..           . 
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF





Kinase Roco10.AA Pkinase_Tyr 2112-2189 19 0.00032 14.92 Pfam 145-224 (270) Show / Hide
Range on Protein: 2112-2189
Range on HMM: 145-224/270
Sequence Identity: 19% (17 aa)

ILSSFRHEALSLYNF-RHSNVLSIIGISM---NP--IAIITENPTFGSKGSTTLSEYIQDR---QKHPEIPWNIKLKIALDIARAMD
.. .| .||  . .. .| |... .|. .    |  | |..|    |      | .| ...   .... ...  .|.....||..|.
CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-----DLLDYLRKHREDKQPLTMKD--LLQMCWQIAKGME

Kinase Roco10.AA MLK 2116-2189 18 0.001339 8.51 In-house 52-138 (291) Show / Hide
Range on Protein: 2116-2189
Range on HMM: 52-138/291
Sequence Identity: 18% (17 aa)

FRHEALSLYNFRHSN----VLSIIGISMNP---IAIITENPTFGSKGSTTLSEYIQDRQKHPE-----------IPWNIKLKIALDIARAMD
|. |.  |  ..| |    .  . |.. .|    .|..|   . ..||  |.... .......           ..   ....||..||.|.
FEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVME---YCEGGS--LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMH

Kinase Roco10.AA Dicty5 2158-2188 28 0.028451 3.62 In-house 85-117 (260) Show / Hide
Range on Protein: 2158-2188
Range on HMM: 85-117/260
Sequence Identity: 28% (10 aa)

TLSEYIQDRQK----HPEIPWNIKLKIALDIARAM
.|..|  |. |     . ..   .| .|.|||..|
SLFNYLNDQRKTTGQPIAYF--QQLHMAIDIAQSM

Kinase Roco10.AA Dicty4 2112-2186 25 0.268959 0.28 In-house 41-123 (277) Show / Hide
Range on Protein: 2112-2186
Range on HMM: 41-123/277
Sequence Identity: 25% (22 aa)

ILSSFRHEALSLYNFRHSNVLSIIGISM----NP--IAIITENPTFGSKGSTTLSEYIQD----RQKHPEIPWNIKLK---IALDIAR
.|..||.|.  . . || |..   | .     .|  . | ||   . .||.  | . . |     |.  ...|   ..   .|.|.||
MLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTE---YMPKGN--LYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAAR

Kelch_1 Roco10.AA Kelch_1 2368-2404 18 0.982233 6.4 Pfam 1-35 (45) Show / Hide
Range on Protein: 2368-2404
Range on HMM: 1-35/45
Sequence Identity: 18% (7 aa)

PLPSGGSIIYQDKIIHFGGWNNSSKPHSKVFALNLSS
|  . |.  ...||  .||...   . ..|.......
PRCGHGVCVHNGKIYVIGGCDG--QYLNSVECYDPET

RGS Roco10.AA RGS 2430-2525 25 1.7e-10 36.69 Pfam 20-115 (124) Show / Hide
Range on Protein: 2430-2525
Range on HMM: 20-115/124
Sequence Identity: 25% (25 aa)

MQSEFNE-ENLMFYEAIKTFKSLPNQTPDDREIIKIQ-SKKIYQVFIGENAPKEI-NLPFLLKKELKNKIDFPDGPSVTVFNDTLTFVISSIE-DSFHRF
..||| | ||. |..|.. ||  .   .|..| .. .  ..||. .| ...|.|. |... .........  .  |. ..|..  . . . .| ||. ||
LESEFCEYENIEFWLACEDFKKMF---SDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQA-QPTPDCFDEAQRHIYTLMEKDSYPRF





RGS Roco10.AA RGS 2410-2528 19 3.2e-08 34.54 SMART 1-121 (121) Show / Hide
Range on Protein: 2410-2528
Range on HMM: 1-121/121
Sequence Identity: 19% (26 aa)

KLMVVLNNKQSTTYKAFYTHMQSEFNE--ENLMFYEAIKTFKSLPNQTPDDREIIKIQSKKIYQVFIGENAPK--EINLPFLLKKELKNKIDFPDGPSVT
 .  ..  ..   .  |.  ...|| |  ||| |..|.. || ...      | ..   ..||. .| .|||.  ..|... ....... ..    |. .
SFHHLCD-NDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMED------EERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN---PHPD

VFNDTLTFVISSI-EDSFHRF-------KFT
.|.. .. | .   .||..||       .. 
CFDEAQRHVYQLMEKDSYPRFLRSDYYKRYL

Kelch_1 Roco10.AA Kelch_1 2549-2595 27 0.000346 18.78 Pfam 1-45 (45) Show / Hide
Range on Protein: 2549-2595
Range on HMM: 1-45/45
Sequence Identity: 27% (13 aa)

PMVGHSSILWNNSLIVIGGWFNKARLLNQIHILNLETFEWNQFVCTG
| .||..   |. . ||||. .  . || . ....|| .| .    .
PRCGHGVCVHNGKIYVIGGCDG--QYLNSVECYDPETNQWTRCPPMP

LRR_1 Roco10.AA LRR_1 2582-2605 33 28.052265 1.61 Pfam 1-26 (26) Show / Hide
Range on Protein: 2582-2605
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLETFEWNQF---VCTGDIPPSSIAAL
||..   . .     ||.||||.. .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL